DK0588858T3 - Imidazo[2,1-b][3]benzazepinderivater, præparater og anvendelsesmetode - Google Patents
Imidazo[2,1-b][3]benzazepinderivater, præparater og anvendelsesmetodeInfo
- Publication number
- DK0588858T3 DK0588858T3 DK92911635T DK92911635T DK0588858T3 DK 0588858 T3 DK0588858 T3 DK 0588858T3 DK 92911635 T DK92911635 T DK 92911635T DK 92911635 T DK92911635 T DK 92911635T DK 0588858 T3 DK0588858 T3 DK 0588858T3
- Authority
- DK
- Denmark
- Prior art keywords
- 4alkyl
- represents hydrogen
- 4alkyloxy
- halo
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71448691A | 1991-06-13 | 1991-06-13 | |
US85363192A | 1992-03-18 | 1992-03-18 | |
PCT/EP1992/001330 WO1992022551A1 (en) | 1991-06-13 | 1992-06-09 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0588858T3 true DK0588858T3 (da) | 2004-01-26 |
Family
ID=27109168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92911635T DK0588858T3 (da) | 1991-06-13 | 1992-06-09 | Imidazo[2,1-b][3]benzazepinderivater, præparater og anvendelsesmetode |
Country Status (28)
Country | Link |
---|---|
US (1) | US5468743A (de) |
EP (2) | EP0588858B1 (de) |
JP (1) | JP2845407B2 (de) |
KR (1) | KR0184017B1 (de) |
CN (2) | CN1033586C (de) |
AT (1) | ATE250061T1 (de) |
AU (1) | AU652840B2 (de) |
CA (1) | CA2103242C (de) |
DE (1) | DE69233205T2 (de) |
DK (1) | DK0588858T3 (de) |
DZ (1) | DZ1582A1 (de) |
ES (1) | ES2207632T3 (de) |
FI (1) | FI104175B (de) |
HR (1) | HRP920155A2 (de) |
HU (2) | HU221016B1 (de) |
IE (1) | IE921918A1 (de) |
IL (1) | IL101850A (de) |
MA (1) | MA22553A1 (de) |
MX (1) | MX9202856A (de) |
NO (2) | NO934492D0 (de) |
NZ (1) | NZ242774A (de) |
PT (1) | PT588858E (de) |
SG (1) | SG47823A1 (de) |
SI (1) | SI9200105B (de) |
TN (1) | TNSN92048A1 (de) |
TW (1) | TW218381B (de) |
WO (1) | WO1992022551A1 (de) |
YU (1) | YU61192A (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL101851A (en) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition |
GR1001393B (el) * | 1992-10-12 | 1993-10-29 | Janssen Pharmaceutica Nv | Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως. |
KR100251893B1 (ko) * | 1992-12-04 | 2000-04-15 | 디르크 반테 | 항앨러지성 트리아졸로벤즈아제핀 유도체 |
CN1042228C (zh) * | 1993-07-13 | 1999-02-24 | 詹森药业有限公司 | 抗过敏咪唑并吖庚因 |
TW382017B (en) * | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
TW527186B (en) | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
ATE233104T1 (de) | 1997-09-18 | 2003-03-15 | Janssen Pharmaceutica Nv | Kondensierte imidazolderivate zur erhöhung der oralen bioverfügbarkeit von pharmazeutika |
EA004500B1 (ru) * | 1998-12-19 | 2004-04-29 | Янссен Фармацевтика Н.В. | Антигистаминные спиросоединения |
ES2475240T3 (es) | 2001-06-12 | 2014-07-10 | Janssen Pharmaceutica Nv | Derivados de imidazol tetrac�clicos sustituidos novedosos, procesos para su preparación, composiciones farmacéuticas que los comprenden y su uso como medicamento |
CN1160557C (zh) * | 2001-09-03 | 2004-08-04 | 北京埃索特核电子机械有限公司 | 钴60γ射线源-碘化铯或钨酸镉阵列探测器集装箱检测设备 |
ES2350647T3 (es) | 2005-03-08 | 2011-01-25 | Janssen Pharmaceutica Nv | Derivados de diaza-espiro-[4.4]-nonano como antagonistas de neuroquininas (nk1). |
US20070077303A1 (en) * | 2005-09-30 | 2007-04-05 | Azaam Alli | Methods for providing oxidatively stable ophthalmic compositions |
US20070077302A1 (en) * | 2005-09-30 | 2007-04-05 | Azaam Alli | Methods for stabilizing ophthalmic compositions |
DK2004196T3 (en) * | 2006-03-31 | 2016-09-05 | Vistakon Pharmaceuticals Llc | Ocular allergy treatments |
US20080139531A1 (en) * | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
TW200902025A (en) * | 2007-04-11 | 2009-01-16 | Alcon Res Ltd | Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
MX2012003693A (es) * | 2009-10-01 | 2012-04-19 | Alcon Res Ltd | Composiciones de olopatadine y usos de las mismas. |
AR079170A1 (es) * | 2009-12-10 | 2011-12-28 | Lilly Co Eli | Compuesto de ciclopropil-benzamida-imidazo-benzazepina inhibidor de diacil-glicerol aciltransferasa, sal del mismo, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de obesidad o para mejorar la sensibilidad a insulina y compuesto intermedio par |
CN103764150A (zh) * | 2011-06-29 | 2014-04-30 | 阿勒根公司 | 阿卡他定在治疗荨麻疹中的用途 |
WO2014080259A1 (en) * | 2012-11-21 | 2014-05-30 | Enaltec Labs Pvt. Ltd. | Novel polymorphic forms of alcaftadine |
WO2014083571A1 (en) * | 2012-11-29 | 2014-06-05 | Neuland Laboratories Limited | A process for the preparation of alcaftadine |
WO2014087208A2 (en) * | 2012-12-06 | 2014-06-12 | Enaltec Labs Pvt. Ltd. | A process of preparing alcaftadine |
WO2014154620A1 (en) | 2013-03-25 | 2014-10-02 | Crystal Pharma S.A.U. | Methods for the preparation of alcaftadine |
CN103408549B (zh) * | 2013-06-14 | 2016-01-20 | 苏州汇和药业有限公司 | 一种阿卡他定中间体的制备方法 |
JP6769963B2 (ja) | 2014-08-29 | 2020-10-14 | ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ | α−アミノ−β−カルボキシムコン酸セミアルデヒド脱炭酸酵素の阻害剤 |
CN104710427A (zh) * | 2014-12-20 | 2015-06-17 | 威海法莫斯特医药技术开发有限公司 | 一种阿卡他定新晶型 |
CN104860920B (zh) * | 2015-04-15 | 2017-08-25 | 武汉武药科技有限公司 | 一种阿卡他定中间体的制备方法 |
CN105130993B (zh) * | 2015-07-28 | 2018-01-12 | 武汉武药科技有限公司 | 一种合成阿卡他定的新氧化方法 |
CN104987337B (zh) * | 2015-07-28 | 2018-01-12 | 武汉武药科技有限公司 | 一种制备阿卡他定的氧化方法 |
KR102275012B1 (ko) | 2016-08-12 | 2021-07-07 | 실크 테크놀로지스 리미티드 | 염증 치료용 실크 유래 단백질 |
CN108727384A (zh) * | 2018-07-07 | 2018-11-02 | 张正光 | 一种阿卡他定中间体的制备方法 |
AU2021291684A1 (en) | 2020-06-15 | 2022-12-08 | Alkem Laboratories Limited | Combination of alcaftadine and a corticosteroid |
AU2021437358A1 (en) | 2021-04-01 | 2023-09-14 | Alkem Laboratories Limited | Nasal compositions comprising alcaftadine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4148903A (en) * | 1977-07-28 | 1979-04-10 | Merck & Co., Inc. | Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines |
GB8900380D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
JPH089616B2 (ja) * | 1990-10-10 | 1996-01-31 | シェリング・コーポレーション | 置換されたイミダゾベンズアゼピン類およびイミダゾピリドアゼピン類 |
IL101851A (en) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition |
-
1992
- 1992-05-13 IL IL10185092A patent/IL101850A/en not_active IP Right Cessation
- 1992-05-15 NZ NZ242774A patent/NZ242774A/en not_active IP Right Cessation
- 1992-05-16 CN CN92105040A patent/CN1033586C/zh not_active Expired - Lifetime
- 1992-05-18 DZ DZ920051A patent/DZ1582A1/fr active
- 1992-05-21 TW TW081103954A patent/TW218381B/zh not_active IP Right Cessation
- 1992-06-09 HU HU9303553A patent/HU221016B1/hu unknown
- 1992-06-09 JP JP4510733A patent/JP2845407B2/ja not_active Expired - Lifetime
- 1992-06-09 ES ES92911635T patent/ES2207632T3/es not_active Expired - Lifetime
- 1992-06-09 EP EP92911635A patent/EP0588858B1/de not_active Expired - Lifetime
- 1992-06-09 DE DE69233205T patent/DE69233205T2/de not_active Expired - Lifetime
- 1992-06-09 AT AT92911635T patent/ATE250061T1/de active
- 1992-06-09 AU AU19001/92A patent/AU652840B2/en not_active Expired
- 1992-06-09 SG SG1996004579A patent/SG47823A1/en unknown
- 1992-06-09 US US08/142,474 patent/US5468743A/en not_active Expired - Lifetime
- 1992-06-09 CA CA002103242A patent/CA2103242C/en not_active Expired - Lifetime
- 1992-06-09 PT PT92911635T patent/PT588858E/pt unknown
- 1992-06-09 WO PCT/EP1992/001330 patent/WO1992022551A1/en active IP Right Grant
- 1992-06-09 EP EP92201666A patent/EP0518435A1/de active Pending
- 1992-06-09 KR KR1019930703788A patent/KR0184017B1/ko not_active IP Right Cessation
- 1992-06-09 DK DK92911635T patent/DK0588858T3/da active
- 1992-06-10 HR HR920155A patent/HRP920155A2/hr not_active Application Discontinuation
- 1992-06-11 MA MA22843A patent/MA22553A1/fr unknown
- 1992-06-12 MX MX9202856A patent/MX9202856A/es unknown
- 1992-06-12 SI SI9200105A patent/SI9200105B/sl unknown
- 1992-06-12 YU YU61192A patent/YU61192A/sh unknown
- 1992-06-15 TN TNTNSN92048A patent/TNSN92048A1/fr unknown
- 1992-07-01 IE IE191892A patent/IE921918A1/en not_active Application Discontinuation
-
1993
- 1993-12-09 NO NO934492D patent/NO934492D0/no unknown
- 1993-12-09 NO NO934492A patent/NO300636B1/no not_active IP Right Cessation
- 1993-12-10 FI FI935556A patent/FI104175B/fi not_active IP Right Cessation
-
1995
- 1995-06-06 HU HU95P/P00164P patent/HU211289A9/hu unknown
-
1996
- 1996-04-24 CN CN96106116A patent/CN1070368C/zh not_active Expired - Lifetime
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