TW218381B - - Google Patents

Info

Publication number
TW218381B
TW218381B TW081103954A TW81103954A TW218381B TW 218381 B TW218381 B TW 218381B TW 081103954 A TW081103954 A TW 081103954A TW 81103954 A TW81103954 A TW 81103954A TW 218381 B TW218381 B TW 218381B
Authority
TW
Taiwan
Prior art keywords
4alkyl
represents hydrogen
4alkyloxy
halo
substituted
Prior art date
Application number
TW081103954A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of TW218381B publication Critical patent/TW218381B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
TW081103954A 1991-06-13 1992-05-21 TW218381B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71448691A 1991-06-13 1991-06-13
US85363192A 1992-03-18 1992-03-18

Publications (1)

Publication Number Publication Date
TW218381B true TW218381B (zh) 1994-01-01

Family

ID=27109168

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081103954A TW218381B (zh) 1991-06-13 1992-05-21

Country Status (28)

Country Link
US (1) US5468743A (zh)
EP (2) EP0518435A1 (zh)
JP (1) JP2845407B2 (zh)
KR (1) KR0184017B1 (zh)
CN (2) CN1033586C (zh)
AT (1) ATE250061T1 (zh)
AU (1) AU652840B2 (zh)
CA (1) CA2103242C (zh)
DE (1) DE69233205T2 (zh)
DK (1) DK0588858T3 (zh)
DZ (1) DZ1582A1 (zh)
ES (1) ES2207632T3 (zh)
FI (1) FI104175B (zh)
HR (1) HRP920155A2 (zh)
HU (2) HU221016B1 (zh)
IE (1) IE921918A1 (zh)
IL (1) IL101850A (zh)
MA (1) MA22553A1 (zh)
MX (1) MX9202856A (zh)
NO (2) NO934492D0 (zh)
NZ (1) NZ242774A (zh)
PT (1) PT588858E (zh)
SG (1) SG47823A1 (zh)
SI (1) SI9200105B (zh)
TN (1) TNSN92048A1 (zh)
TW (1) TW218381B (zh)
WO (1) WO1992022551A1 (zh)
YU (1) YU61192A (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
GR1001393B (el) * 1992-10-12 1993-10-29 Janssen Pharmaceutica Nv Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως.
JP3572074B2 (ja) * 1992-12-04 2004-09-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗アレルギー性トリアゾロベンズアゼピン誘導体
ES2155092T3 (es) * 1993-07-13 2001-05-01 Janssen Pharmaceutica Nv Imidazoazepinas antialergicas.
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en) 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
EP1011726B1 (en) 1997-09-18 2003-02-26 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents
SI1144411T1 (en) * 1998-12-19 2005-10-31 Janssen Pharmaceutica N.V. Antihistaminic spiro compounds
US7476662B2 (en) 2001-06-12 2009-01-13 Janssen Pharmaceutica N.V. Substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
CN1160557C (zh) 2001-09-03 2004-08-04 北京埃索特核电子机械有限公司 钴60γ射线源-碘化铯或钨酸镉阵列探测器集装箱检测设备
CA2599186C (en) 2005-03-08 2014-12-09 Janssen Pharmaceutica N.V. Diaza-spiro-[4.4]-nonane derivatives as neurokinin (nk1) antagonists
US20070077302A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for stabilizing ophthalmic compositions
US20070077303A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for providing oxidatively stable ophthalmic compositions
CN102895234A (zh) 2006-03-31 2013-01-30 维斯塔肯药品有限责任公司 眼变态反应治疗
US20080139531A1 (en) * 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
AR066016A1 (es) * 2007-04-11 2009-07-15 Alcon Res Ltd Uso de un inhibidor del tnf alfa junto con una antihistamina para tratar la rinitis alergica y la conjuntivitis alergica
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
JP5721722B2 (ja) * 2009-10-01 2015-05-20 アルコン リサーチ， リミテッド オロパタジン組成物およびその使用
AR079170A1 (es) * 2009-12-10 2011-12-28 Lilly Co Eli Compuesto de ciclopropil-benzamida-imidazo-benzazepina inhibidor de diacil-glicerol aciltransferasa, sal del mismo, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de obesidad o para mejorar la sensibilidad a insulina y compuesto intermedio par
US20130005708A1 (en) * 2011-06-29 2013-01-03 Lalwani Dinusha N Histamine antagonist treatment of inflammatory skin disorders
WO2014080259A1 (en) * 2012-11-21 2014-05-30 Enaltec Labs Pvt. Ltd. Novel polymorphic forms of alcaftadine
WO2014083571A1 (en) * 2012-11-29 2014-06-05 Neuland Laboratories Limited A process for the preparation of alcaftadine
WO2014087208A2 (en) * 2012-12-06 2014-06-12 Enaltec Labs Pvt. Ltd. A process of preparing alcaftadine
JP6400672B2 (ja) * 2013-03-25 2018-10-03 クリスタル ファーマ エセ．ア．ウ． アルカフタジンの製造方法
CN103408549B (zh) * 2013-06-14 2016-01-20 苏州汇和药业有限公司 一种阿卡他定中间体的制备方法
MX2017002610A (es) 2014-08-29 2017-10-11 Tes Pharma S R L INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA.
CN104710427A (zh) * 2014-12-20 2015-06-17 威海法莫斯特医药技术开发有限公司 一种阿卡他定新晶型
CN104860920B (zh) * 2015-04-15 2017-08-25 武汉武药科技有限公司 一种阿卡他定中间体的制备方法
CN105130993B (zh) * 2015-07-28 2018-01-12 武汉武药科技有限公司 一种合成阿卡他定的新氧化方法
CN104987337B (zh) * 2015-07-28 2018-01-12 武汉武药科技有限公司 一种制备阿卡他定的氧化方法
JP2019531334A (ja) 2016-08-12 2019-10-31 シルク テクノロジーズ、リミテッド 炎症を治療するための絹由来タンパク質
CN108727384A (zh) * 2018-07-07 2018-11-02 张正光 一种阿卡他定中间体的制备方法
WO2021255622A1 (en) 2020-06-15 2021-12-23 Alkem Laboratories Limited Combination of alcaftadine and a corticosteroid
KR20230163413A (ko) 2021-04-01 2023-11-30 알켐 라보라토리즈 리미티드 알카프타딘을 포함하는 비강 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
AU8902591A (en) * 1990-10-10 1992-05-20 Schering Corporation Substituted imidazobenzazepines and imidazopyridoazepines
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition

Also Published As

Publication number Publication date
DE69233205D1 (de) 2003-10-23
CN1033586C (zh) 1996-12-18
HU221016B1 (hu) 2002-07-29
CN1142360A (zh) 1997-02-12
CN1070368C (zh) 2001-09-05
AU652840B2 (en) 1994-09-08
AU1900192A (en) 1993-01-12
CN1068118A (zh) 1993-01-20
PT588858E (pt) 2004-02-27
HU211289A9 (en) 1995-11-28
JP2845407B2 (ja) 1999-01-13
IE921918A1 (en) 1992-12-16
DZ1582A1 (fr) 2002-02-17
US5468743A (en) 1995-11-21
HU9303553D0 (en) 1994-04-28
EP0588858B1 (en) 2003-09-17
MA22553A1 (fr) 1992-12-31
DE69233205T2 (de) 2004-06-24
JPH06507889A (ja) 1994-09-08
NO934492L (no) 1994-01-04
CA2103242A1 (en) 1992-12-14
FI935556A0 (fi) 1993-12-10
CA2103242C (en) 2002-11-12
FI104175B1 (fi) 1999-11-30
DK0588858T3 (da) 2004-01-26
EP0588858A1 (en) 1994-03-30
SG47823A1 (en) 1998-04-17
EP0518435A1 (en) 1992-12-16
HRP920155A2 (en) 1994-08-31
IL101850A (en) 1996-01-31
WO1992022551A1 (en) 1992-12-23
KR0184017B1 (ko) 1999-05-01
YU61192A (sh) 1994-09-09
SI9200105A (en) 1992-12-31
ATE250061T1 (de) 2003-10-15
IL101850A0 (en) 1992-12-30
HUT70529A (en) 1995-10-30
FI104175B (fi) 1999-11-30
NZ242774A (en) 1995-02-24
ES2207632T3 (es) 2004-06-01
TNSN92048A1 (fr) 1993-06-08
SI9200105B (en) 2001-10-31
MX9202856A (es) 1992-12-01
NO934492D0 (no) 1993-12-09
FI935556A (fi) 1993-12-10
NO300636B1 (no) 1997-06-30

Similar Documents

Publication Publication Date Title
TW218381B (zh)
TW218382B (zh)
AU2174288A (en) Lactam derivatives
FI971609A0 (fi) Menetelmä 4a,5,9,10,11,12-heksahydro-6H-bentsofuro-(3a,3,2-ef)(2)-bentsatsepiinijohdannaisten valmistamiseksi
HU9501620D0 (en) Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepine derivatives

Legal Events

Date Code Title Description
MK4A Expiration of patent term of an invention patent