DK0580641T3 - Hidtil ukendte thalidomidderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse i lægemidler - Google Patents

Hidtil ukendte thalidomidderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse i lægemidler

Info

Publication number
DK0580641T3
DK0580641T3 DK92907730.3T DK92907730T DK0580641T3 DK 0580641 T3 DK0580641 T3 DK 0580641T3 DK 92907730 T DK92907730 T DK 92907730T DK 0580641 T3 DK0580641 T3 DK 0580641T3
Authority
DK
Denmark
Prior art keywords
pharmaceuticals
novel
preparation
thalidomide derivatives
derivatives
Prior art date
Application number
DK92907730.3T
Other languages
Danish (da)
English (en)
Inventor
Kurt Prof Dr Eger
Gerhard Prof Dr Ehninger
Alfred Dr Stuhler
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK0580641T3 publication Critical patent/DK0580641T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK92907730.3T 1991-04-17 1992-04-08 Hidtil ukendte thalidomidderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse i lægemidler DK0580641T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4112566 1991-04-17

Publications (1)

Publication Number Publication Date
DK0580641T3 true DK0580641T3 (da) 1997-01-20

Family

ID=6429810

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92907730.3T DK0580641T3 (da) 1991-04-17 1992-04-08 Hidtil ukendte thalidomidderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse i lægemidler

Country Status (11)

Country Link
EP (1) EP0580641B1 (ja)
JP (1) JP3204972B2 (ja)
AT (1) ATE146787T1 (ja)
AU (1) AU661299B2 (ja)
CA (1) CA2104776C (ja)
DE (2) DE59207778D1 (ja)
DK (1) DK0580641T3 (ja)
ES (1) ES2098505T3 (ja)
GR (1) GR3022175T3 (ja)
HK (1) HK1005188A1 (ja)
WO (1) WO1992018496A1 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
CA2256669A1 (en) * 1996-05-29 1997-12-04 Prototek, Inc. Prodrugs of thalidomide and methods for using same as modulators of t-cell function
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
JP2002513391A (ja) 1996-11-05 2002-05-08 ザ チルドレンズ メディカル センター コーポレイション 血管形成の抑制のための方法と組成物
DE19703763C1 (de) * 1997-02-01 1998-10-01 Gruenenthal Gmbh Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione
DE19743968C2 (de) * 1997-10-06 2002-07-11 Gruenenthal Gmbh Intravenöse Applikationsform von Thalidomid zur Therapie immunologischer Erkrankungen
EP1064277B1 (en) 1998-03-16 2005-06-15 Celgene Corporation 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines
US6673828B1 (en) 1998-05-11 2004-01-06 Children's Medical Center Corporation Analogs of 2-Phthalimidinoglutaric acid
ATE235256T1 (de) 1999-03-31 2003-04-15 Gruenenthal Gmbh Stabile wässrige lösung von 3-(1-oxo-1,3-dihydro- isoindol-2-yl)-piperidin-2,6-dion
US7091353B2 (en) 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
US7320991B2 (en) 2001-02-27 2008-01-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Analogs of thalidomide as potential angiogenesis inhibitors
CN100488959C (zh) * 2003-03-27 2009-05-20 天津和美生物技术有限公司 水溶性的酞胺哌啶酮衍生物
CA2808646C (en) 2003-09-17 2016-08-23 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Thalidomide analogs as tnf-alpha modulators
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
NZ592425A (en) * 2008-10-29 2013-04-26 Celgene Corp Isoindoline compounds for use in the treatment of cancer
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB768821A (en) * 1954-05-17 1957-02-20 Gruenenthal Chemie Novel products of the amino-piperidine-2, 6-dione series
DE1670391A1 (de) * 1965-05-08 1970-11-05 Gruenenthal Chemie Dikarbonsaeureimidderivate und Verfahren zu ihrer Herstellung
DE1545706A1 (de) * 1965-05-08 1969-10-09 Gruenenthal Chemie Dicarbonsaeureimidderivate und Verfahren zu ihrer Herstellung
DE1545672B2 (de) * 1965-05-08 1974-11-07 Chemie Gruenenthal Gmbh, 5190 Stolberg Dikarbonsäureimidderivate und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
JPH06506671A (ja) 1994-07-28
DE4211812C2 (de) 1994-05-05
DE59207778D1 (de) 1997-02-06
GR3022175T3 (en) 1997-03-31
EP0580641B1 (de) 1996-12-27
AU1455592A (en) 1992-11-17
EP0580641A1 (de) 1994-02-02
JP3204972B2 (ja) 2001-09-04
CA2104776A1 (en) 1992-10-18
DE4211812A1 (de) 1992-10-22
ATE146787T1 (de) 1997-01-15
AU661299B2 (en) 1995-07-20
HK1005188A1 (en) 1998-12-24
CA2104776C (en) 2003-12-09
WO1992018496A1 (de) 1992-10-29
ES2098505T3 (es) 1997-05-01

Similar Documents

Publication Publication Date Title
DK0580641T3 (da) Hidtil ukendte thalidomidderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse i lægemidler
NO941678L (no) nor-gallesyrederivater, fremgangsmåte for fremstilling og anvendelse av dem som legemiddel
NO944700D0 (no) Nye tienotiazinderivater, fremgangsmåte for fremstilling derav samt farmasöytiske preparater inneholdende forbindelsene
HUT70851A (en) Organic salts of n,n`-diacetyl-cystine, pharmaceutical compositions containing them and process for preparing them
NO881164D0 (no) Substituerte 9-amino-tetrahydroakridiner og relaterte forbindelser, en fremgangsmaate for deres fremstilling og deres bruk som medikamenter.
HUT49601A (en) Process for producing piperazine derivatives and salts thereof, as well as pharmaceutical compositions comprising such piperazine deriatives and salts thereof
DK610284D0 (da) 2-phenyl-imidazolderivater, deres fremstilling og laegemidler indeholdende disse forbindelser
DK498988A (da) 3,7-diazabicyclooe3,3,1aanonan-forbindelser, fremgangsmaade til deres fremstilling og hjertevirksomme laegemidler indeholdende disse
DK53285A (da) (-)-trans-4(4-fluorphenyl)-3-(4-methoxyphenoxy)-methylpiperidin, farmaceutisk acceptable syreadditionssalte heraf og farmaceutisk praeparat indeholdende samme
DK168786D0 (da) Hidtil ukendte dopaminderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel
DK131887A (da) 1,2,3,4-tetrahydro-3-carbamoyl-2-thioxo/oxo-5-pyrimidencarboxylsyre-derivater og deres anvendelse som laegemidler
DK219685A (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som laegemidler
DK0443918T3 (da) Hidtil ukendte derivater af 20,21-dinoreburnamenin, deres fremstilling og anvendelse som lægemidler, samt mellemprodukter og farmaceutiske peæparater med indhold heraf
KR900007816A (ko) 사이클로프로필-치환된 아졸릴메틸카비놀, 이의 제조방법 및 약제로서의 이의 용도
BR9201540A (pt) Composto,processo para preparar,isolar e obter diritromicina,processo para preparar um solvato e diritomicina
IL89401A0 (en) Medicaments containing 1,4-dihydropyridine derivatives for the treatment of alcohol addiction
DK256689A (da) 1,2-dithiol-3-thion-s-oxid-forbindelser til anven delse som laegemidler
DK222888D0 (da) Anellerede heteroalkylenquinolinaminer, isomere og salte deraf, deres fremstilling og anvendelse som laegemidler smat mellemprodukter til fremstillingen
KR950703559A (ko) 신규한 축합 티아졸 유도체, 이의 제조방법 및 이를 함유하는 약제학적 조성물(Novel condensed thiazole derivative, process for producing the same, and pharmaceutical composition containing the same)
FI942675A0 (fi) Uudet substituoidut oksatsinoisokinoliinijohdannaiset, niitä sisältävät farmaseuttiset koostumukset sekä menetelmä niiden valmistamiseksi
IT8520674A0 (it) Processo per preparare derivati di 6-ammino-3-idrazinopiridazina.
DK37787A (da) 2,3-dioxabicyclooe3,3,0aaoctan-derivater og deres anvendelse som laegemidler
FI871479A (fi) Menetelmä lääkeaineina käyttökelpoisten perhydrotiatsepiini- ja perhydroatsepiinijohdannaisten valmistamiseksi
DK343187D0 (da) 1,4-piperazinderivater, fremgangsmaade til fremstilling deraf, samt laegemidler indeholdende disse
SE8900685D0 (sv) New compounds