DK0578511T3 - Spirooxathiolan-quinuclidinderivat til behandling af Sjögrens syndrom - Google Patents
Spirooxathiolan-quinuclidinderivat til behandling af Sjögrens syndromInfo
- Publication number
- DK0578511T3 DK0578511T3 DK93305423T DK93305423T DK0578511T3 DK 0578511 T3 DK0578511 T3 DK 0578511T3 DK 93305423 T DK93305423 T DK 93305423T DK 93305423 T DK93305423 T DK 93305423T DK 0578511 T3 DK0578511 T3 DK 0578511T3
- Authority
- DK
- Denmark
- Prior art keywords
- spirooxathiolan
- sjögren
- syndrome
- treatment
- quinuclidine
- Prior art date
Links
- 208000021386 Sjogren Syndrome Diseases 0.000 title abstract 2
- UANSQQFYKHHDJM-KRWDZBQOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]naphthalene-1-carboxamide Chemical compound C1=CC=C2C(C(N[C@@H]3C4CCN(CC4)C3)=O)=CC=CC2=C1 UANSQQFYKHHDJM-KRWDZBQOSA-N 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4207485A JP2683783B2 (ja) | 1992-07-10 | 1992-07-10 | シェーグレン症候群治療剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0578511T3 true DK0578511T3 (da) | 2000-04-03 |
Family
ID=16540522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93305423T DK0578511T3 (da) | 1992-07-10 | 1993-07-09 | Spirooxathiolan-quinuclidinderivat til behandling af Sjögrens syndrom |
Country Status (15)
Country | Link |
---|---|
US (1) | US5340821A (ko) |
EP (1) | EP0578511B1 (ko) |
JP (1) | JP2683783B2 (ko) |
KR (1) | KR100331046B1 (ko) |
AT (1) | ATE184483T1 (ko) |
AU (1) | AU666734B2 (ko) |
CA (1) | CA2099970C (ko) |
DE (1) | DE69326395T2 (ko) |
DK (1) | DK0578511T3 (ko) |
ES (1) | ES2138613T3 (ko) |
IL (1) | IL106218A (ko) |
NO (1) | NO303765B1 (ko) |
NZ (1) | NZ248099A (ko) |
TW (1) | TW230750B (ko) |
ZA (1) | ZA934883B (ko) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2852608B2 (ja) * | 1994-06-27 | 1999-02-03 | 雪印乳業株式会社 | 口腔乾燥症治療剤 |
US6140374A (en) * | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
JP4447685B2 (ja) * | 1999-01-14 | 2010-04-07 | 第一三共株式会社 | 皮膚乾燥症治療剤 |
US20110150974A1 (en) * | 2004-08-06 | 2011-06-23 | Daiichi Pharmaceutical Co., Ltd. | Agent For Oral Mucosal Administration |
JP2006070027A (ja) * | 2004-08-06 | 2006-03-16 | Dai Ichi Seiyaku Co Ltd | 口腔粘膜投与剤 |
KR20070061578A (ko) * | 2004-10-05 | 2007-06-13 | 아스텔라스세이야쿠 가부시키가이샤 | 눈물 및 침 건조증 치료용 의약 조성물 |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US8143400B2 (en) * | 2008-01-10 | 2012-03-27 | Apotex Pharmachem Inc. | Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
WO2011058366A1 (en) | 2009-11-12 | 2011-05-19 | Acacia Pharma Limited | Use of bethanechol for treatment of xerostomia |
GB201107533D0 (en) | 2011-05-06 | 2011-06-22 | Acacia Pharma Ltd | Formulaiton |
CN102846607A (zh) * | 2012-04-09 | 2013-01-02 | 珠海亿邦制药股份有限公司 | 一种以盐酸西维美林为活性成分的固体制剂及其应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4001396A (en) * | 1971-08-04 | 1977-01-04 | Chinoin Pharmaceutical And Chemical Works Ltd. | Hormonal product extracted from parathyroid gland and process for the preparation thereof |
US4110441A (en) * | 1974-04-29 | 1978-08-29 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Gamma-l-glutamyl cholamine phosphate |
US4100271A (en) * | 1976-02-26 | 1978-07-11 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
US4701450A (en) * | 1984-03-21 | 1987-10-20 | Akzo N.V. | Steroids for use as immunomodulators |
US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
US4684727A (en) * | 1985-07-29 | 1987-08-04 | Schering Corporation | Zwitterionic 1,8-naphthyridine and pyrazino[2,3-b]pyridine containing compounds useful as anti-allergic, anti-inflammatory and cycloprotective agents |
ZA868369B (en) * | 1986-01-10 | 1987-11-25 | Israel State | Derivatives of quinuclidine |
GB8717446D0 (en) * | 1987-07-23 | 1987-08-26 | Merck Sharp & Dohme | Chemical compounds |
US4876260A (en) * | 1987-10-28 | 1989-10-24 | State Of Israel, Israel Institute Of Biological Research | Oxathiolanes |
CA1303503C (en) * | 1987-11-10 | 1992-06-16 | Marc Plamondon | Ophthalmic solution comprising iodine-polyvinylpyrrolidone complex |
WO1990005525A1 (en) * | 1988-11-23 | 1990-05-31 | Pfizer Inc. | Quinuclidine derivatives as substance p antagonists |
US4997654A (en) * | 1989-08-14 | 1991-03-05 | Warner-Lambert Company | Method for increasing salivation for xerostomia patients |
ATE154354T1 (de) * | 1991-02-11 | 1997-06-15 | Merck Sharp & Dohme | Azabicyclische verbindungen, diese enthaltende pharmazeutische zubereitungen und ihre therapeutische verwendung |
-
1992
- 1992-07-10 JP JP4207485A patent/JP2683783B2/ja not_active Expired - Lifetime
-
1993
- 1993-07-02 IL IL10621893A patent/IL106218A/xx not_active IP Right Cessation
- 1993-07-06 TW TW082105361A patent/TW230750B/zh active
- 1993-07-06 CA CA002099970A patent/CA2099970C/en not_active Expired - Lifetime
- 1993-07-06 KR KR1019930012594A patent/KR100331046B1/ko not_active IP Right Cessation
- 1993-07-07 ZA ZA934883A patent/ZA934883B/xx unknown
- 1993-07-07 US US08/088,304 patent/US5340821A/en not_active Expired - Lifetime
- 1993-07-07 AU AU41819/93A patent/AU666734B2/en not_active Expired
- 1993-07-07 NZ NZ248099A patent/NZ248099A/xx not_active IP Right Cessation
- 1993-07-09 EP EP93305423A patent/EP0578511B1/en not_active Expired - Lifetime
- 1993-07-09 NO NO932520A patent/NO303765B1/no not_active IP Right Cessation
- 1993-07-09 AT AT93305423T patent/ATE184483T1/de active
- 1993-07-09 DK DK93305423T patent/DK0578511T3/da active
- 1993-07-09 DE DE69326395T patent/DE69326395T2/de not_active Expired - Lifetime
- 1993-07-09 ES ES93305423T patent/ES2138613T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR940005274A (ko) | 1994-03-21 |
EP0578511B1 (en) | 1999-09-15 |
JP2683783B2 (ja) | 1997-12-03 |
AU666734B2 (en) | 1996-02-22 |
IL106218A (en) | 1997-02-18 |
US5340821A (en) | 1994-08-23 |
JPH0624981A (ja) | 1994-02-01 |
EP0578511A1 (en) | 1994-01-12 |
NO303765B1 (no) | 1998-08-31 |
NO932520L (no) | 1994-01-11 |
NZ248099A (en) | 1999-07-29 |
AU4181993A (en) | 1994-01-13 |
CA2099970A1 (en) | 1994-01-11 |
DE69326395D1 (de) | 1999-10-21 |
ATE184483T1 (de) | 1999-10-15 |
CA2099970C (en) | 2003-12-30 |
DE69326395T2 (de) | 2000-04-20 |
NO932520D0 (no) | 1993-07-09 |
KR100331046B1 (ko) | 2002-08-19 |
IL106218A0 (en) | 1993-11-15 |
TW230750B (ko) | 1994-09-21 |
ZA934883B (en) | 1994-02-03 |
ES2138613T3 (es) | 2000-01-16 |
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