DK0493608T3 - Quinoloncarboxylsyrederivat - Google Patents

Quinoloncarboxylsyrederivat

Info

Publication number
DK0493608T3
DK0493608T3 DK91913068.2T DK91913068T DK0493608T3 DK 0493608 T3 DK0493608 T3 DK 0493608T3 DK 91913068 T DK91913068 T DK 91913068T DK 0493608 T3 DK0493608 T3 DK 0493608T3
Authority
DK
Denmark
Prior art keywords
represents hydrogen
acid derivative
quinolonecarboxylic acid
lower alkyl
hydrogen
Prior art date
Application number
DK91913068.2T
Other languages
English (en)
Inventor
Fujiko Konno
Akihiro Shibata
Hideaki Matsuda
Takemitsu Asaoka
Ryuichi Kawahara
Naokata Taido
Tadayuki Kuraishi
Sunao Takeda
Original Assignee
Ss Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ss Pharmaceutical Co filed Critical Ss Pharmaceutical Co
Application granted granted Critical
Publication of DK0493608T3 publication Critical patent/DK0493608T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DK91913068.2T 1990-07-19 1991-07-17 Quinoloncarboxylsyrederivat DK0493608T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19133990 1990-07-19
JP7977491 1991-04-12

Publications (1)

Publication Number Publication Date
DK0493608T3 true DK0493608T3 (da) 1996-02-19

Family

ID=26420770

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91913068.2T DK0493608T3 (da) 1990-07-19 1991-07-17 Quinoloncarboxylsyrederivat

Country Status (12)

Country Link
US (2) US5385900A (da)
EP (1) EP0493608B1 (da)
JP (2) JP2613139B2 (da)
KR (1) KR100195070B1 (da)
AT (1) ATE128707T1 (da)
CA (1) CA2065846C (da)
DE (1) DE69113604T2 (da)
DK (1) DK0493608T3 (da)
ES (1) ES2080327T3 (da)
GR (1) GR3017651T3 (da)
HK (1) HK125296A (da)
WO (1) WO1992001676A1 (da)

Families Citing this family (35)

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TW222272B (da) * 1992-05-26 1994-04-11 Ss Seiyaku Kk
FR2706459B1 (fr) * 1993-06-17 1995-08-04 Bouchara Sa Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent.
CN1038326C (zh) * 1993-07-20 1998-05-13 爱斯制药株式会社 5－氨基喹诺酮羧酸衍生物及其含有该衍生物作为活性成分的抗菌剂
US6685958B2 (en) * 2001-04-25 2004-02-03 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
US6699492B2 (en) * 1999-03-31 2004-03-02 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
US6818654B2 (en) * 2002-03-12 2004-11-16 Abbott Laboratories Antibacterial compounds
US7576216B2 (en) * 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
EP2305666B1 (en) * 2004-07-30 2014-06-25 AbbVie Inc. Preparation of pyridonecarboxylic acid antibacterials
EP2286800A1 (en) * 2005-04-11 2011-02-23 Abbott Laboratories Pharmaceutical compositions having improved dissolution profiles for poorly soluble drugs
CN101522662A (zh) 2006-10-06 2009-09-02 博士伦公司 喹诺酮羧酸、其衍生物、及其制备方法和其用作抗菌剂的用途
US7632944B2 (en) 2007-01-24 2009-12-15 Bausch & Lomb Incorporated Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
US8252783B2 (en) 2007-01-24 2012-08-28 Bausch & Lomb Incorporated Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
US20080200442A1 (en) * 2007-02-16 2008-08-21 Srini Venkatesh Compositions and Methods for Treating, Reducing, Ameliorating, or Preventing Infections of the Ear or Upper Respiratory Tract
MX2009009657A (es) * 2007-03-21 2009-09-22 Bausch & Lomb Fluoroquinolonas para el tratamiento, reduccion, mejora, o prevencion de las infecciones provocadas por las bacterias resistentes a los farmacos antibacterianos.
US8173640B1 (en) * 2007-05-18 2012-05-08 Bausch & Lomb Incorporated Compositions and methods for treating, reducing, ameliorating, or preventing infections
JP2010529133A (ja) * 2007-06-11 2010-08-26 ボーシュ アンド ローム インコーポレイティド フルオロキノロンを用いて炎症を調節するための組成物と方法
US20090042936A1 (en) * 2007-08-10 2009-02-12 Ward Keith W Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
US20110166126A1 (en) * 2007-08-21 2011-07-07 Ward Keith W Compositions and Methods for Modulating Endophthalmitis Using Fluoroquinolones
US20090054406A1 (en) * 2007-08-21 2009-02-26 Ward Keith W Compositions and Methods for Modulating Endophthalmitis Using Fluoroquinolones
US20090082337A1 (en) * 2007-09-21 2009-03-26 Srini Venkastesh Compositions Comprising Quinolone and Methods for Treating or Controlling Infections
WO2009058585A2 (en) * 2007-11-01 2009-05-07 Bausch & Lomb Incorporated Non-aqueous water-miscible materials as vehicles for drug delivery
MX2010004366A (es) * 2007-11-05 2010-05-05 Bausch & Lomb Materiales inmiscibles en agua como vehiculos para suministro de farmacos.
US20090239836A1 (en) * 2008-03-24 2009-09-24 Mary Lee Ciolkowski Multifunctional Ophthalmic Compositions
US8415342B2 (en) * 2008-10-29 2013-04-09 Bausch & Lomb Incorporated Besifloxacin ophthalmic composition for the treatment or control of infection
US8481526B2 (en) * 2009-03-25 2013-07-09 Bausch & Lomb Incorporated Fluoroquinolone carboxylic acid molecular crystals
US20110077270A1 (en) * 2009-04-21 2011-03-31 Pfeffer Bruce A Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure
US8518935B2 (en) * 2009-12-11 2013-08-27 Bausch & Lomb Incorporated Amorphous besifloxacin solid
US20110319502A1 (en) 2010-06-25 2011-12-29 Coffey Martin J Compositions and Methods for Enhancing Reduction of Spore-Forming Microorganisms
KR101996697B1 (ko) * 2011-08-31 2019-07-04 오쓰까 세이야꾸 가부시키가이샤 퀴놀론 화합물
CN102659761B (zh) * 2012-04-27 2017-10-10 常州市亚邦医药研究所有限公司 盐酸贝西沙星的制备方法
WO2013169458A1 (en) 2012-05-11 2013-11-14 Bausch & Lomb Incorporated Pharmaceutical compositions and methods for treating, controlling, ameliorating, or reversing conditions of dry eye
CN103044397A (zh) * 2013-01-06 2013-04-17 安徽赛诺医药化工有限公司 一种合成贝西沙星的新方法
CN104592196A (zh) * 2015-01-07 2015-05-06 广州仁恒医药科技有限公司 一种盐酸贝西沙星的制备方法
CN104592197A (zh) * 2015-01-07 2015-05-06 广州仁恒医药科技有限公司 一种盐酸贝西沙星的制备方法
WO2016120813A1 (en) 2015-01-28 2016-08-04 Mankind Research Centre Fluoroquinolone carboxylic acid compounds and use thereof for the preparation of besifloxacin hydrochloride

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA85853B (en) * 1984-02-17 1986-09-24 Warner Lambert Co Antibacterial agents
DE3420770A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS63198664A (ja) * 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
JPS63132885A (ja) * 1986-11-25 1988-06-04 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
JPS63196580A (ja) * 1987-02-09 1988-08-15 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
DE3713672A1 (de) * 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
FI95130C (fi) * 1988-07-20 1995-12-27 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
JPH02115181A (ja) * 1988-10-21 1990-04-27 Yoshitomi Pharmaceut Ind Ltd ピリドンカルボン酸化合物
US4945160A (en) * 1988-11-22 1990-07-31 Warner-Lambert Company Preparation of certain 7-substituted quinolones
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5324735A (en) * 1989-07-21 1994-06-28 Ss Pharmaceutical Co., Ltd. Quinoline carboxylic acid derivatives

Also Published As

Publication number Publication date
US5385900A (en) 1995-01-31
DE69113604D1 (de) 1995-11-09
CA2065846A1 (en) 1992-01-20
EP0493608A4 (en) 1992-08-12
JPH054968A (ja) 1993-01-14
JPH08169880A (ja) 1996-07-02
ATE128707T1 (de) 1995-10-15
CA2065846C (en) 2002-07-02
US5447926A (en) 1995-09-05
KR100195070B1 (ko) 1999-06-15
JP2613139B2 (ja) 1997-05-21
WO1992001676A1 (en) 1992-02-06
HK125296A (en) 1996-07-19
DE69113604T2 (de) 1996-05-30
EP0493608A1 (en) 1992-07-08
ES2080327T3 (es) 1996-02-01
KR920702348A (ko) 1992-09-03
GR3017651T3 (en) 1996-01-31
EP0493608B1 (en) 1995-10-04
JP2805460B2 (ja) 1998-09-30

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