DK0555331T3 - N-substituerede imidazol-2-on-forbindelser til behandling af kredsløbsforstyrrelser - Google Patents
N-substituerede imidazol-2-on-forbindelser til behandling af kredsløbsforstyrrelserInfo
- Publication number
- DK0555331T3 DK0555331T3 DK91919894.5T DK91919894T DK0555331T3 DK 0555331 T3 DK0555331 T3 DK 0555331T3 DK 91919894 T DK91919894 T DK 91919894T DK 0555331 T3 DK0555331 T3 DK 0555331T3
- Authority
- DK
- Denmark
- Prior art keywords
- butyl
- compounds
- image
- treatment
- phenethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/606,806 US5087634A (en) | 1990-10-31 | 1990-10-31 | N-substituted imidazol-2-one compounds for treatment of circulatory disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0555331T3 true DK0555331T3 (da) | 1996-05-13 |
Family
ID=24429549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91919894.5T DK0555331T3 (da) | 1990-10-31 | 1991-10-28 | N-substituerede imidazol-2-on-forbindelser til behandling af kredsløbsforstyrrelser |
Country Status (12)
Country | Link |
---|---|
US (1) | US5087634A (da) |
EP (1) | EP0555331B1 (da) |
AT (1) | ATE137226T1 (da) |
AU (1) | AU8867291A (da) |
CA (1) | CA2094390C (da) |
DE (1) | DE69119089T2 (da) |
DK (1) | DK0555331T3 (da) |
ES (1) | ES2086003T3 (da) |
GR (1) | GR3019768T3 (da) |
IE (1) | IE913814A1 (da) |
PT (1) | PT99392B (da) |
WO (1) | WO1992007834A1 (da) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
US5187271A (en) * | 1991-02-28 | 1993-02-16 | G. D. Searle & Co. | N-substituted (α-imidazolyl-toluyl) pyrrole compounds for treatment of circulatory disorders |
US6008368A (en) * | 1993-04-28 | 1999-12-28 | G. D. Searle & Co. | Pharmaceutical compositions for treatment of circulatory disorders using N-substituted (α-imidazolyl-toluyl) pyrrole aniotensin II antagonists |
US5164403A (en) * | 1991-04-05 | 1992-11-17 | G. D. Searle & Co. | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
US5861420A (en) * | 1991-04-05 | 1999-01-19 | G. D. Searle & Co. | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
PH30449A (en) * | 1991-11-25 | 1997-05-28 | Lilly Co Eli | Substituted phenyl phenol leukotriene antagonists |
PT626969E (pt) * | 1992-02-11 | 2000-11-30 | Smithkline Beecham Corp | Inibidores de co.a-it e de p.a.f. |
US5663053A (en) * | 1992-02-11 | 1997-09-02 | Smithkline Beecham Corporation | Inhibition of inflammatory lipid mediators |
KR100261403B1 (ko) * | 1992-02-13 | 2000-07-01 | 로즈 암스트롱 | 키랄 에틸 (5-아미노-1,2-디히드로-2-메틸-3-페닐피리도(3,4-b)피라진-7-일)카르바메이트의 제조 방법 |
TW215434B (da) * | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
US5972990A (en) * | 1992-04-10 | 1999-10-26 | Brigham And Women's Hospital, Inc. | Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims |
WO1994008990A1 (en) * | 1992-10-13 | 1994-04-28 | G.D. Searle & Co. | N-arylheteroarylalkyl 1-phenyl-imidazol-2-one compounds for treatment of circulatory disorders |
WO1994008989A1 (en) * | 1992-10-13 | 1994-04-28 | G.D. Searle & Co. | N-arylheteroarylalkyl 1-cycloalkyl-imidazol-2-one compounds for treatment of circulatory disorders |
EP0690854B1 (en) * | 1993-03-24 | 2000-07-12 | G.D. Searle & Co. | 1-phenyl-imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders |
DE4317321A1 (de) * | 1993-05-25 | 1994-12-01 | Bayer Ag | Substituierte 2,4-Imidazolidindione |
US5451597A (en) * | 1993-05-27 | 1995-09-19 | G.D. Searle & Co. | Treatment of circulatory disorders using n-substituted (α-imidazolyl-toluyl) pyrrole angiotensin II antagonists |
EP0685467A4 (en) * | 1993-12-16 | 1996-04-17 | Nippon Kokan Kk | PYRIMID DERIVATIVES AND MEDICAL PREPARATION. |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
JP2003509478A (ja) * | 1999-09-21 | 2003-03-11 | エモリー・ユニバーシティ | 血小板関連障害を処置する方法および組成物 |
ATE429927T1 (de) | 2000-02-04 | 2009-05-15 | Children S Hospital Res Founda | Verwendung von lysosomal acid lipase zur behandlung von atherosklerose und ähnlichen krankheiten |
EP3425059A1 (en) | 2002-05-09 | 2019-01-09 | The Brigham and Women's Hospital, Inc. | 1l1rl-1 as a cardiovascular disease marker |
AU2004315596B2 (en) | 2003-08-29 | 2011-11-24 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis |
ATE546734T1 (de) | 2003-12-05 | 2012-03-15 | Cleveland Clinic Foundation | Risikomarker für eine herzkreislaufkrankheit |
US7803838B2 (en) * | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
EP1809759B1 (en) | 2004-10-06 | 2013-09-11 | The Brigham And Women's Hospital, Inc. | Relevance of achieved levels of markers of systemic inflammation following treatment |
US20070014733A1 (en) * | 2005-01-31 | 2007-01-18 | O'donnell John P | Hydroxylated nebivolol metabolites |
CA2610694A1 (en) | 2005-05-31 | 2006-12-07 | Mylan Laboratories, Inc. | Compositions comrising nebivolol |
WO2007030375A2 (en) * | 2005-09-08 | 2007-03-15 | Children's Hospital Medical Center | Lysosomal acid lipase therapy for nafld and related diseases |
US8119358B2 (en) | 2005-10-11 | 2012-02-21 | Tethys Bioscience, Inc. | Diabetes-related biomarkers and methods of use thereof |
CA2659082A1 (en) * | 2006-06-07 | 2007-12-21 | Tethys Bioscience, Inc. | Markers associated with arteriovascular events and methods of use thereof |
ES2434215T3 (es) | 2007-04-18 | 2013-12-16 | Tethys Bioscience, Inc. | Biomarcadores relacionados con la diabetes y métodos de uso de los mismos |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US7828840B2 (en) * | 2007-11-15 | 2010-11-09 | Med Institute, Inc. | Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
GB2462022B (en) * | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof |
CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
AU2011210508B2 (en) | 2010-02-01 | 2015-01-29 | The Hospital For Sick Children | Remote ischemic conditioning for treatment and prevention of restenosis |
SG10201908570RA (en) | 2010-03-31 | 2019-11-28 | Hospital For Sick Children | Use of remote ischemic conditioning to improve outcome after myocardial infarction |
EP2555692A2 (en) | 2010-04-08 | 2013-02-13 | The Hospital For Sick Children | Use of remote ischemic conditioning for traumatic injury |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
AU2012284039B2 (en) | 2011-07-18 | 2017-03-30 | Critical Care Diagnostics, Inc. | Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy |
TWI643845B (zh) | 2012-05-11 | 2018-12-11 | 重植治療公司 | 隱花色素調節劑之含咔唑磺醯胺類 |
WO2014022195A1 (en) | 2012-08-01 | 2014-02-06 | Tavakoli Zahra | Free flowing, frozen compositions comprising a therapeutic agent |
US9725452B2 (en) | 2013-03-15 | 2017-08-08 | Presidents And Fellows Of Harvard College | Substituted indoles and pyrroles as RIP kinase inhibitors |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP4424697A2 (en) | 2013-06-05 | 2024-09-04 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE160447C (da) * | ||||
BE621842A (da) * | 1962-08-27 | |||
IT1052119B (it) * | 1972-10-16 | 1981-06-20 | Sigma Tau Ind Farmaceuti | Derivati del triazolinone e procedimento per la loro preparazione |
US4294972A (en) * | 1978-06-15 | 1981-10-13 | Beecham Group Limited | 1,2-Disubstituted oxo triazolidine |
NZ215487A (en) * | 1985-03-16 | 1990-01-29 | Wellcome Found | Aryl derivatives, pharmaceutical compositions thereof and preservation of cut flowers |
US4677131A (en) * | 1985-11-01 | 1987-06-30 | Merck & Co., Inc. | Cyclic ureas as dermal penetration enhancers |
US4816463A (en) * | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
US5028610A (en) * | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
DE69024556T2 (de) * | 1989-07-28 | 1996-10-17 | Merck & Co Inc | Substituierte Triazolinone, Triazolinthione und Triazolinimine als Angiotensin II-Antagonisten |
FR2659967B1 (fr) * | 1990-03-20 | 1992-07-24 | Sanofi Sa | Derives d'imidazolinone n-substitues, leur preparation, les compositions pharmaceutiques en contenant. |
-
1990
- 1990-10-31 US US07/606,806 patent/US5087634A/en not_active Expired - Lifetime
-
1991
- 1991-10-28 DK DK91919894.5T patent/DK0555331T3/da active
- 1991-10-28 CA CA002094390A patent/CA2094390C/en not_active Expired - Fee Related
- 1991-10-28 WO PCT/US1991/007729 patent/WO1992007834A1/en active IP Right Grant
- 1991-10-28 DE DE69119089T patent/DE69119089T2/de not_active Expired - Fee Related
- 1991-10-28 AU AU88672/91A patent/AU8867291A/en not_active Abandoned
- 1991-10-28 ES ES91919894T patent/ES2086003T3/es not_active Expired - Lifetime
- 1991-10-28 AT AT91919894T patent/ATE137226T1/de not_active IP Right Cessation
- 1991-10-28 EP EP91919894A patent/EP0555331B1/en not_active Expired - Lifetime
- 1991-10-31 PT PT99392A patent/PT99392B/pt not_active IP Right Cessation
- 1991-10-31 IE IE381491A patent/IE913814A1/en unknown
-
1996
- 1996-04-25 GR GR960401028T patent/GR3019768T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IE913814A1 (en) | 1992-05-22 |
PT99392A (pt) | 1992-09-30 |
AU8867291A (en) | 1992-05-26 |
PT99392B (pt) | 1999-04-30 |
US5087634A (en) | 1992-02-11 |
GR3019768T3 (en) | 1996-07-31 |
CA2094390C (en) | 2002-01-29 |
EP0555331A1 (en) | 1993-08-18 |
WO1992007834A1 (en) | 1992-05-14 |
ES2086003T3 (es) | 1996-06-16 |
CA2094390A1 (en) | 1992-05-01 |
ATE137226T1 (de) | 1996-05-15 |
EP0555331B1 (en) | 1996-04-24 |
DE69119089T2 (de) | 1996-10-17 |
DE69119089D1 (de) | 1996-05-30 |
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