ATE137226T1 - N-substituierte imidazol-2-on-verbindungen zur behandlung von zirkulatorischen störungen - Google Patents

N-substituierte imidazol-2-on-verbindungen zur behandlung von zirkulatorischen störungen

Info

Publication number
ATE137226T1
ATE137226T1 AT91919894T AT91919894T ATE137226T1 AT E137226 T1 ATE137226 T1 AT E137226T1 AT 91919894 T AT91919894 T AT 91919894T AT 91919894 T AT91919894 T AT 91919894T AT E137226 T1 ATE137226 T1 AT E137226T1
Authority
AT
Austria
Prior art keywords
butyl
compounds
image
treatment
phenethyl
Prior art date
Application number
AT91919894T
Other languages
English (en)
Inventor
David B Reitz
Robert E Manning
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE137226T1 publication Critical patent/ATE137226T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91919894T 1990-10-31 1991-10-28 N-substituierte imidazol-2-on-verbindungen zur behandlung von zirkulatorischen störungen ATE137226T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/606,806 US5087634A (en) 1990-10-31 1990-10-31 N-substituted imidazol-2-one compounds for treatment of circulatory disorders

Publications (1)

Publication Number Publication Date
ATE137226T1 true ATE137226T1 (de) 1996-05-15

Family

ID=24429549

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91919894T ATE137226T1 (de) 1990-10-31 1991-10-28 N-substituierte imidazol-2-on-verbindungen zur behandlung von zirkulatorischen störungen

Country Status (12)

Country Link
US (1) US5087634A (de)
EP (1) EP0555331B1 (de)
AT (1) ATE137226T1 (de)
AU (1) AU8867291A (de)
CA (1) CA2094390C (de)
DE (1) DE69119089T2 (de)
DK (1) DK0555331T3 (de)
ES (1) ES2086003T3 (de)
GR (1) GR3019768T3 (de)
IE (1) IE913814A1 (de)
PT (1) PT99392B (de)
WO (1) WO1992007834A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
US5187271A (en) * 1991-02-28 1993-02-16 G. D. Searle & Co. N-substituted (α-imidazolyl-toluyl) pyrrole compounds for treatment of circulatory disorders
US6008368A (en) * 1993-04-28 1999-12-28 G. D. Searle & Co. Pharmaceutical compositions for treatment of circulatory disorders using N-substituted (α-imidazolyl-toluyl) pyrrole aniotensin II antagonists
US5861420A (en) * 1991-04-05 1999-01-19 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
US5164403A (en) * 1991-04-05 1992-11-17 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
US5663053A (en) * 1992-02-11 1997-09-02 Smithkline Beecham Corporation Inhibition of inflammatory lipid mediators
WO1993016674A1 (en) * 1992-02-11 1993-09-02 Smithkline Beecham Corporation CoA-IT AND PAF INHIBITORS
JP3208142B2 (ja) * 1992-02-13 2001-09-10 ワーナー−ランバート・コンパニー キラルなエチル（５−アミノ−１，２−ジヒドロ−２−メチル−３−フェニルピリド〔３，４−ｂ〕ピラジン−７−イル）カーバメートの調製方法
TW215434B (de) * 1992-03-07 1993-11-01 Hoechst Ag
US5972990A (en) * 1992-04-10 1999-10-26 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
JPH08502285A (ja) * 1992-10-13 1996-03-12 ジー．ディー．サール アンド カンパニー 循環系障害処置用ｎ−アリールヘテロアリールアルキル１−シクロアルキル−イミダゾール−２−オン化合物
DE69328108D1 (de) * 1992-10-13 2000-04-20 Searle & Co N-arylheteroarylalkyl-1-phenyl-imidazol-2-on verbindungen bei der behandlung von zirkulatorischen störungen
EP0690854B1 (de) * 1993-03-24 2000-07-12 G.D. Searle & Co. 1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungen
DE4317321A1 (de) * 1993-05-25 1994-12-01 Bayer Ag Substituierte 2,4-Imidazolidindione
US5451597A (en) * 1993-05-27 1995-09-19 G.D. Searle & Co. Treatment of circulatory disorders using n-substituted (α-imidazolyl-toluyl) pyrrole angiotensin II antagonists
WO1995016677A1 (fr) * 1993-12-16 1995-06-22 Nkk Corporation Nouveau derive de pyrimidine et composition medicinale
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
EP1216037A2 (de) * 1999-09-21 2002-06-26 Emory University Verfahren und zusammensetzungen zur behandlung von bluttplätchen-zusammenhängenden krankheiten, mit mpl hemmenden agenten
BR0108077A (pt) * 2000-02-04 2002-10-22 Children S Hospital Res Founda Processo para reduzir placas ateroscleróticas em um mamìfero, método para tratamento da aterosclerose em um mamìfero, composição, métodos para prover proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo ou mistura deles, para células de um mamìfero tendo deficiência na proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo , para prover lipase de ácido lisossomal biologicamente ativa para células de um mamìfero tendo deficiência de lipase de ácido lisossomal biologicamente ativa, para prover lipase de ácido lisossoal biologicamente ativa para células de um mamìfero com aterosclerose, para tratamento da doença de wolman em um mamìfero, para tratamento de doença de armazenagem de colesteril éster em um mamìfero, e, para tratamento da aterosclerose em um mamìfero
EP3072978B1 (de) 2002-05-09 2018-07-11 The Brigham and Women's Hospital, Inc. 1l1rl-1 als ein marker kardiovaskulärer krankheiten
AU2004315596B2 (en) 2003-08-29 2011-11-24 President And Fellows Of Harvard College Inhibitors of cellular necrosis
ATE546734T1 (de) 2003-12-05 2012-03-15 Cleveland Clinic Foundation Risikomarker für eine herzkreislaufkrankheit
US7803838B2 (en) * 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
US9164104B2 (en) 2004-10-06 2015-10-20 The Brigham And Women's Hospital, Inc. Relevance of achieved levels of markers of systemic inflammation following treatment
JP2008528626A (ja) * 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク． ヒドロキシル化されたネビボロールを含む薬学的組成物
EP1982711A1 (de) 2005-05-31 2008-10-22 Mylan Laboratories, Inc Zusammensetzungen mit Nebivolol
US20090297496A1 (en) * 2005-09-08 2009-12-03 Childrens Hospital Medical Center Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
US8119358B2 (en) 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
US20080057590A1 (en) 2006-06-07 2008-03-06 Mickey Urdea Markers associated with arteriovascular events and methods of use thereof
WO2008131224A2 (en) 2007-04-18 2008-10-30 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2531163A1 (de) 2010-02-01 2012-12-12 The Hospital For Sick Children Ischämische remote-konditionierung zur behandlung und prävention von restenosen
CA2795053A1 (en) 2010-03-31 2011-10-06 The Hospital For Sick Children Use of remote ischemic conditioning to improve outcome after myocardial infarction
US9393025B2 (en) 2010-04-08 2016-07-19 The Hospital For Sick Children Use of remote ischemic conditioning for traumatic injury
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2013012945A1 (en) 2011-07-18 2013-01-24 Critical Care Diagnostics, Inc. Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy
EP2855458B1 (de) 2012-05-11 2018-08-08 Reset Therapeutics, Inc. Carbazolhaltige sulfonamide als cryptochrome modulatoren
ES2786506T3 (es) 2012-08-01 2020-10-13 Zahra Tavakoli Composiciones congeladas fluidas que comprenden un agente terapéutico
EP2970384A1 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonisten der guanylatcyclase und deren verwendungen
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2968276A4 (de) 2013-03-15 2017-02-15 President and Fellows of Harvard College Hybride nekroptoseinhibitoren
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE160447C (de) *
BE621842A (de) * 1962-08-27
IT1052119B (it) * 1972-10-16 1981-06-20 Sigma Tau Ind Farmaceuti Derivati del triazolinone e procedimento per la loro preparazione
EP0007180B1 (de) * 1978-06-15 1983-03-30 Beecham Group Plc Prostaglandinanaloge Triazolderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung
NO165341C (no) * 1985-03-16 1991-01-30 Wellcome Found Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroksamsyrearylderivater.
US4677131A (en) * 1985-11-01 1987-06-30 Merck & Co., Inc. Cyclic ureas as dermal penetration enhancers
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
DE69024556T2 (de) * 1989-07-28 1996-10-17 Merck & Co Inc Substituierte Triazolinone, Triazolinthione und Triazolinimine als Angiotensin II-Antagonisten
FR2659967B1 (fr) * 1990-03-20 1992-07-24 Sanofi Sa Derives d'imidazolinone n-substitues, leur preparation, les compositions pharmaceutiques en contenant.

Also Published As

Publication number Publication date
IE913814A1 (en) 1992-05-22
PT99392B (pt) 1999-04-30
DK0555331T3 (da) 1996-05-13
AU8867291A (en) 1992-05-26
PT99392A (pt) 1992-09-30
EP0555331A1 (de) 1993-08-18
ES2086003T3 (es) 1996-06-16
DE69119089D1 (de) 1996-05-30
CA2094390C (en) 2002-01-29
EP0555331B1 (de) 1996-04-24
DE69119089T2 (de) 1996-10-17
CA2094390A1 (en) 1992-05-01
WO1992007834A1 (en) 1992-05-14
US5087634A (en) 1992-02-11
GR3019768T3 (en) 1996-07-31

Similar Documents

Publication Publication Date Title
ATE137226T1 (de) N-substituierte imidazol-2-on-verbindungen zur behandlung von zirkulatorischen störungen
DK0579766T3 (da) N-Arylheteroarylalkyl-imidazol-2-on-forbindelser til behandling af kredsløbsforstyrrelser
DE69130671D1 (de) 1h-substituierte-1,2,4-triazolverbindungen zur behandlung von herzkrankheiten
DK0619819T3 (da) 1-Arylheteroarylalkyl-substituerede 1H-1,2,4-triazolforbindelser til behandling af kredsløbsforstyrrelser
EA200400154A1 (ru) Новые лекарственные формы замещенного бензимидазола и способ их применения
CA2272463A1 (en) Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives
NO955192L (no) Imidazol[1,2-aÅpyrazin-4-on, fremstilling derav og medikament inneholdende forbindelsen
DK0782567T3 (da) Isothiourinstofderivater og fremgangsmåder til deres fremstilling
ATE194613T1 (de) 1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungen
FI940324A (fi) 1-(N-(halo-3-pyridyylimetyyli))-N-metyyliamino-1-alkyyliamino-2-nitroetyleenijohdannaiset kirppujen torjumiseksi kotieläimissä
ATE20804T1 (de) Chinoloncarbonsaeure enthaltende bakterizide mittel.
FI943799A0 (fi) Fenoksifenyylisyklopentenyylihydroksiureoita
KR950700302A (ko) 안지오텐신 II(angiotensin II) 수용체 길항근(antagonists)인 피라졸로피리미딘(pyrazolopyrimidin) 유도체
ATE190613T1 (de) N-arylheteroarylalkyl-1-phenyl-imidazol-2-on verbindungen bei der behandlung von zirkulatorischen störungen
DK603688A (da) Middel til behandling af blodhoejtryk og hjerteinsufficiens
DK0606657T3 (da) Keterolacderivat med væsentligt nedsat gastrointestinal irritation og ulceration
NO963869L (no) Behandling av diabetisk nefropati med valsartan
ES2064229A1 (es) Nuevas 1,2-dihidro-2-oxopiridinas de formula i.
ES2009463A6 (es) Procedimiento de preparacion de derivados de 2-propanol.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee