NO955192L - Imidazol[1,2-aÅpyrazin-4-on, fremstilling derav og medikament inneholdende forbindelsen - Google Patents

Imidazol[1,2-aÅpyrazin-4-on, fremstilling derav og medikament inneholdende forbindelsen

Info

Publication number
NO955192L
NO955192L NO955192A NO955192A NO955192L NO 955192 L NO955192 L NO 955192L NO 955192 A NO955192 A NO 955192A NO 955192 A NO955192 A NO 955192A NO 955192 L NO955192 L NO 955192L
Authority
NO
Norway
Prior art keywords
alk
alkyl
het
phenyl
receptor
Prior art date
Application number
NO955192A
Other languages
English (en)
Other versions
NO955192D0 (no
Inventor
Jean-Claude Aloup
Francois Audiau
Dominique Damour
Arielle Genevois-Borella
Patrick Jimonet
Serge Mignani
Yves Ribeil
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO955192L publication Critical patent/NO955192L/no
Publication of NO955192D0 publication Critical patent/NO955192D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Forbindelser med formelen: i RI der (l) enten B betyr OB3, ¿(£4)85 eller CH-Bf,, B! og E2 betyr hydrogen, halogen, alkyl, alkoksy, amlno, acylemlno, -NH-CO- NH-Ar, -N-CE-N(alk)alk'. nltro, cyano, fenyl, Imldazolyl eller SOsH, E3 betyr oksygen, NCB, NO-alk-COQX eller CB-Ry, 84 betyr en rest alkyl, -alk-Het eller -alk-Ar, £5 betyr en alkyl, -alk-Het eller -alk-Ar, eller også C(E4)RS betyr cykloalkyl, -alk-<JH, -alk-NRgRg. -alk-Ar eller -elk-Het, By betyr hydroksy, alkyl, fenyl, -alk-Ar, -alk-Het, -NRiøRii eller en heterocykel, Bg og 89 betyr alkyl, eller også Eg betyr hydrogen og £9 betyr hydrogen eller alkyl, -<XH12, -CSRso eller- betyr hydrokuy. alkyl, - Klo °8 RU betyr alkyl eller cykloalkyl, E12 betyr alkyl, cykloalkyl, fenyl, -COO-alk, -CHa-COQX, -CH2-NH2, -NH-alk, _NH-Ar, -NH2 eller -NH-Het, R13 betyr alkyl eller fenyl, ESQ betyr -NH-alk, -KH-Ar, -NH2 eller -KH-Het, eller E betyr en 2-imidazolylmetylrest og BI og B2 hver betyr et hydrogenatom, samt deres salter. Forblndelsenes fremstilling beskrives. Forbindelsene finner særlig anvendelse ved fremstilling av medikamenter som kan benyttes som antagonister mot reseptorene for ABJPA og MMQA.
NO955192A 1993-07-16 1995-12-20 Imidazol[1,2-aÅpyrazin-4-on, fremstilling derav og medikament inneholdende forbindelsen NO955192D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9308754A FR2707643B1 (fr) 1993-07-16 1993-07-16 Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant.
PCT/FR1994/000866 WO1995002601A1 (fr) 1993-07-16 1994-07-11 DERIVES D'IMIDAZO[1,2-a]PYRAZIN-4-ONE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT

Publications (2)

Publication Number Publication Date
NO955192L true NO955192L (no) 1995-12-20
NO955192D0 NO955192D0 (no) 1995-12-20

Family

ID=9449312

Family Applications (1)

Application Number Title Priority Date Filing Date
NO955192A NO955192D0 (no) 1993-07-16 1995-12-20 Imidazol[1,2-aÅpyrazin-4-on, fremstilling derav og medikament inneholdende forbindelsen

Country Status (18)

Country Link
US (1) US5753657A (no)
EP (1) EP0708774B1 (no)
JP (1) JPH09500873A (no)
AT (1) ATE177746T1 (no)
AU (1) AU681688B2 (no)
CA (1) CA2167169A1 (no)
DE (1) DE69417235T2 (no)
DK (1) DK0708774T3 (no)
ES (1) ES2130438T3 (no)
FI (1) FI960160A (no)
FR (1) FR2707643B1 (no)
GR (1) GR3029713T3 (no)
HU (1) HUT74678A (no)
IL (1) IL110329A0 (no)
NO (1) NO955192D0 (no)
PL (1) PL312571A1 (no)
WO (1) WO1995002601A1 (no)
ZA (1) ZA945045B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2717813B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Dérivés d'imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant .
FR2717805B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant .
FR2717812B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
FR2726275B1 (fr) * 1994-11-02 1996-12-06 Rhone Poulenc Rorer Sa Spiro heterocycle-imidazo(1,2-a)indeno(1,2-e)pyrazine)-4'- ones, leur preparation et les medicaments les contenants
FR2738821B1 (fr) * 1995-09-15 1997-11-21 Rhone Poulenc Rorer Sa Indeno[1,2-e]pyrazin-4-ones, leur preparation et les medicaments les contenant
EP1436258A4 (en) * 2001-03-08 2005-03-23 Univ Emory ANTAGONISTS OF THE NMDA RECEPTOR DEPENDENT OF PH
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
ES2633095T3 (es) * 2006-10-30 2017-09-19 Hybrigenics S.A. Inhibidores tetracíclicos de cisteína proteasas, las composiciones farmacéuticas de los mismos y sus aplicaciones terapéuticas
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
WO2008065141A1 (en) 2006-11-30 2008-06-05 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
EP2865670B1 (en) 2007-04-18 2017-01-11 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
CN101815518B (zh) * 2007-06-29 2013-01-09 埃莫里大学 用于神经保护的nmda受体拮抗剂
US8486940B2 (en) 2009-09-11 2013-07-16 Probiodrug Ag Inhibitors
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
EP2545047B9 (en) 2010-03-10 2015-06-10 Probiodrug AG Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
JP6050264B2 (ja) 2011-03-16 2016-12-21 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992011245A1 (en) * 1990-12-20 1992-07-09 Warner-Lambert Company 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
US5196421A (en) 1991-06-05 1993-03-23 Eli Lilly And Company Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
FR2696466B1 (fr) * 1992-10-02 1994-11-25 Rhone Poulenc Rorer Sa Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.

Also Published As

Publication number Publication date
CA2167169A1 (fr) 1995-01-26
US5753657A (en) 1998-05-19
JPH09500873A (ja) 1997-01-28
AU681688B2 (en) 1997-09-04
FI960160A0 (fi) 1996-01-12
ZA945045B (en) 1995-02-22
FR2707643B1 (fr) 1995-08-11
FI960160A (fi) 1996-01-12
DK0708774T3 (da) 1999-10-11
ES2130438T3 (es) 1999-07-01
EP0708774B1 (fr) 1999-03-17
PL312571A1 (en) 1996-04-29
DE69417235D1 (de) 1999-04-22
IL110329A0 (en) 1994-10-21
HU9503955D0 (en) 1996-03-28
WO1995002601A1 (fr) 1995-01-26
FR2707643A1 (fr) 1995-01-20
HUT74678A (en) 1997-01-28
ATE177746T1 (de) 1999-04-15
NO955192D0 (no) 1995-12-20
AU7265294A (en) 1995-02-13
GR3029713T3 (en) 1999-06-30
DE69417235T2 (de) 1999-07-08
EP0708774A1 (fr) 1996-05-01

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