DK0579766T3 - N-Arylheteroarylalkyl-imidazol-2-on-forbindelser til behandling af kredsløbsforstyrrelser - Google Patents

N-Arylheteroarylalkyl-imidazol-2-on-forbindelser til behandling af kredsløbsforstyrrelser

Info

Publication number
DK0579766T3
DK0579766T3 DK92911354T DK92911354T DK0579766T3 DK 0579766 T3 DK0579766 T3 DK 0579766T3 DK 92911354 T DK92911354 T DK 92911354T DK 92911354 T DK92911354 T DK 92911354T DK 0579766 T3 DK0579766 T3 DK 0579766T3
Authority
DK
Denmark
Prior art keywords
butyl
compounds
phenethyl
chem
treatment
Prior art date
Application number
DK92911354T
Other languages
English (en)
Inventor
David B Reitz
Robert E Manning
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0579766T3 publication Critical patent/DK0579766T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
DK92911354T 1991-04-05 1992-04-01 N-Arylheteroarylalkyl-imidazol-2-on-forbindelser til behandling af kredsløbsforstyrrelser DK0579766T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/681,011 US5164403A (en) 1991-04-05 1991-04-05 N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
PCT/US1992/002439 WO1992017469A2 (en) 1991-04-05 1992-04-01 N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders

Publications (1)

Publication Number Publication Date
DK0579766T3 true DK0579766T3 (da) 1999-06-23

Family

ID=24733424

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92911354T DK0579766T3 (da) 1991-04-05 1992-04-01 N-Arylheteroarylalkyl-imidazol-2-on-forbindelser til behandling af kredsløbsforstyrrelser

Country Status (11)

Country Link
US (4) US5164403A (da)
EP (2) EP0579766B1 (da)
AT (1) ATE180779T1 (da)
AU (1) AU1927892A (da)
CA (1) CA2104794A1 (da)
DE (1) DE69229341T2 (da)
DK (1) DK0579766T3 (da)
ES (1) ES2133142T3 (da)
GR (1) GR3030892T3 (da)
IE (2) IE921079A1 (da)
WO (1) WO1992017469A2 (da)

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DE69233208T2 (de) * 1991-11-18 2004-07-08 E.I. Du Pont De Nemours And Co., Wilmington Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten
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WO1994008990A1 (en) * 1992-10-13 1994-04-28 G.D. Searle & Co. N-arylheteroarylalkyl 1-phenyl-imidazol-2-one compounds for treatment of circulatory disorders
WO1994008989A1 (en) * 1992-10-13 1994-04-28 G.D. Searle & Co. N-arylheteroarylalkyl 1-cycloalkyl-imidazol-2-one compounds for treatment of circulatory disorders
WO1994021629A1 (en) * 1993-03-24 1994-09-29 G.D. Searle & Co. 1-phenyl-imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders
DE4316077A1 (de) * 1993-05-13 1994-11-17 Bayer Ag Substituierte Mono- und Bihydridylmethylpyridone
DE4320432A1 (de) * 1993-06-21 1994-12-22 Bayer Ag Substituierte Mono- und Bipyridylmethylderivate
US5780492A (en) * 1996-04-03 1998-07-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6093737A (en) * 1996-12-30 2000-07-25 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5939439A (en) * 1996-12-30 1999-08-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP1003374A4 (en) * 1996-12-30 2000-05-31 Merck & Co Inc INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
US6127390A (en) * 1997-10-02 2000-10-03 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
US7091232B2 (en) * 2002-05-21 2006-08-15 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7358269B2 (en) 2002-05-21 2008-04-15 Allergan, Inc. 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one
US7323485B2 (en) * 2002-05-21 2008-01-29 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
PT1509517E (pt) * 2003-01-16 2008-08-05 Teva Pharma Nova síntese de irbesartan
MY153263A (en) 2006-08-15 2015-01-29 Novartis Ag Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels
KR20110079776A (ko) 2006-10-19 2011-07-07 에프. 호프만-라 로슈 아게 당뇨병을 위한 11베타-에이치에스디1 억제제로서의 이미다졸론 및 이미다졸리딘온 유도체
US7803940B2 (en) 2006-11-24 2010-09-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same

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DD160447A1 (de) * 1981-03-26 1983-08-03 Johannes Dost Herbizide mittel, die 1,2,4-triazolinone-(5) enthalten
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US5087634A (en) * 1990-10-31 1992-02-11 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
US5164403A (en) * 1991-04-05 1992-11-17 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders

Also Published As

Publication number Publication date
EP0508393A1 (en) 1992-10-14
ATE180779T1 (de) 1999-06-15
CA2104794A1 (en) 1992-10-06
DE69229341T2 (de) 1999-10-14
US5643906A (en) 1997-07-01
IE921095A1 (en) 1992-10-07
ES2133142T3 (es) 1999-09-01
US5164403A (en) 1992-11-17
WO1992017469A3 (en) 1992-11-12
DE69229341D1 (de) 1999-07-08
EP0579766A1 (en) 1994-01-26
EP0579766B1 (en) 1999-06-02
AU1927892A (en) 1992-11-02
US5451592A (en) 1995-09-19
GR3030892T3 (en) 1999-11-30
WO1992017469A2 (en) 1992-10-15
US5441970A (en) 1995-08-15
IE921079A1 (en) 1992-10-07
EP0508393B1 (en) 1999-06-02

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