DE69609323T2 - Diuretische piperidine derivate - Google Patents

Diuretische piperidine derivate

Info

Publication number
DE69609323T2
DE69609323T2 DE69609323T DE69609323T DE69609323T2 DE 69609323 T2 DE69609323 T2 DE 69609323T2 DE 69609323 T DE69609323 T DE 69609323T DE 69609323 T DE69609323 T DE 69609323T DE 69609323 T2 DE69609323 T2 DE 69609323T2
Authority
DE
Germany
Prior art keywords
diuretic
piperidine derivatives
alkyl
excretion
increase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69609323T
Other languages
English (en)
Other versions
DE69609323D1 (de
Inventor
J Humphrey
T Curry
Jon Jacobsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of DE69609323D1 publication Critical patent/DE69609323D1/de
Application granted granted Critical
Publication of DE69609323T2 publication Critical patent/DE69609323T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69609323T 1995-04-27 1996-03-11 Diuretische piperidine derivate Expired - Fee Related DE69609323T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42975195A 1995-04-27 1995-04-27
US08/468,129 US5716970A (en) 1995-04-27 1995-06-06 Diuretic compound
PCT/US1996/002321 WO1996033985A1 (en) 1995-04-27 1996-03-11 Piperidine derivatives as diuretic

Publications (2)

Publication Number Publication Date
DE69609323D1 DE69609323D1 (de) 2000-08-17
DE69609323T2 true DE69609323T2 (de) 2000-12-14

Family

ID=27028330

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69609323T Expired - Fee Related DE69609323T2 (de) 1995-04-27 1996-03-11 Diuretische piperidine derivate

Country Status (11)

Country Link
US (1) US5716970A (de)
EP (1) EP0822932B1 (de)
JP (1) JPH11504322A (de)
AT (1) ATE194606T1 (de)
AU (1) AU5297296A (de)
DE (1) DE69609323T2 (de)
DK (1) DK0822932T3 (de)
ES (1) ES2148745T3 (de)
GR (1) GR3034511T3 (de)
PT (1) PT822932E (de)
WO (1) WO1996033985A1 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL254248A (de) * 1959-07-29
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles

Also Published As

Publication number Publication date
EP0822932B1 (de) 2000-07-12
PT822932E (pt) 2000-10-31
ATE194606T1 (de) 2000-07-15
US5716970A (en) 1998-02-10
DE69609323D1 (de) 2000-08-17
ES2148745T3 (es) 2000-10-16
GR3034511T3 (en) 2000-12-29
DK0822932T3 (da) 2000-10-02
EP0822932A1 (de) 1998-02-11
WO1996033985A1 (en) 1996-10-31
JPH11504322A (ja) 1999-04-20
AU5297296A (en) 1996-11-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee