ES2148745T3 - Derivados de piperidina usados como diureticos. - Google Patents

Derivados de piperidina usados como diureticos.

Info

Publication number
ES2148745T3
ES2148745T3 ES96909499T ES96909499T ES2148745T3 ES 2148745 T3 ES2148745 T3 ES 2148745T3 ES 96909499 T ES96909499 T ES 96909499T ES 96909499 T ES96909499 T ES 96909499T ES 2148745 T3 ES2148745 T3 ES 2148745T3
Authority
ES
Spain
Prior art keywords
diuretics
derivatives used
piperidine derivatives
alkyl
excretion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96909499T
Other languages
English (en)
Inventor
Stephen J Humphrey
James T Curry
Eric Jon Jacobsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of ES2148745T3 publication Critical patent/ES2148745T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE DESCUBRE UN COMPUESTO DIURETICO DE FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO EN EL QUE R SUP,1} ES UN ALQUILO C SUB,1-6}; R SUP,2} ES HALOGENO, ALQUILO C SUB,1-4}; Y R SUP,3} ES UN ALCOXI C SUB,1-4}, PREFERENTEMENTE MONOHIDROCLORURO DE 3 CLORO N (2 ETIL 2 (3 METOXIFENIL) 4 (1 PIPERIDINIL)BUTIL)BENZAMIDA. LOS COMPUESTOS SON DIURETICOS EFICACES QUE AUMENTAN LA EXCRECION DE AGUA CON UN AUMENTO REDUCIDO EN LA EXCRECION DE ELECTROLITOS.
ES96909499T 1995-04-27 1996-03-11 Derivados de piperidina usados como diureticos. Expired - Lifetime ES2148745T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42975195A 1995-04-27 1995-04-27
US08/468,129 US5716970A (en) 1995-04-27 1995-06-06 Diuretic compound

Publications (1)

Publication Number Publication Date
ES2148745T3 true ES2148745T3 (es) 2000-10-16

Family

ID=27028330

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96909499T Expired - Lifetime ES2148745T3 (es) 1995-04-27 1996-03-11 Derivados de piperidina usados como diureticos.

Country Status (11)

Country Link
US (1) US5716970A (es)
EP (1) EP0822932B1 (es)
JP (1) JPH11504322A (es)
AT (1) ATE194606T1 (es)
AU (1) AU5297296A (es)
DE (1) DE69609323T2 (es)
DK (1) DK0822932T3 (es)
ES (1) ES2148745T3 (es)
GR (1) GR3034511T3 (es)
PT (1) PT822932E (es)
WO (1) WO1996033985A1 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3103516A (en) * 1959-07-29 1963-09-10 J-tertiaryaminq-lower alkyl-jb-meta-
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles

Also Published As

Publication number Publication date
WO1996033985A1 (en) 1996-10-31
DE69609323T2 (de) 2000-12-14
EP0822932A1 (en) 1998-02-11
AU5297296A (en) 1996-11-18
ATE194606T1 (de) 2000-07-15
DE69609323D1 (de) 2000-08-17
US5716970A (en) 1998-02-10
DK0822932T3 (da) 2000-10-02
PT822932E (pt) 2000-10-31
GR3034511T3 (en) 2000-12-29
JPH11504322A (ja) 1999-04-20
EP0822932B1 (en) 2000-07-12

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