GR3034511T3 - Piperidine derivatives as diuretic - Google Patents

Piperidine derivatives as diuretic

Info

Publication number
GR3034511T3
GR3034511T3 GR20000402201T GR20000402201T GR3034511T3 GR 3034511 T3 GR3034511 T3 GR 3034511T3 GR 20000402201 T GR20000402201 T GR 20000402201T GR 20000402201 T GR20000402201 T GR 20000402201T GR 3034511 T3 GR3034511 T3 GR 3034511T3
Authority
GR
Greece
Prior art keywords
diuretic
piperidine derivatives
alkyl
excretion
increase
Prior art date
Application number
GR20000402201T
Other languages
Greek (el)
Inventor
Stephen J Humphrey
James T Curry
Eric Jon Jacobsen
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GR3034511T3 publication Critical patent/GR3034511T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A diuretic compound of Formula I <IMAGE> or pharmaceutically acceptable salt thereof where R1 is a C1-6 alkyl; R2 is halogen, C1-4 alkyl; and R3 is C1-4 alkoxy are disclosed, preferably, benzamide, 3-chloro-N-(2-ethyl-2-(3-methoxyphenyl)-4-(1-piperidinyl)butyl), monohydrochloride. The compounds are effective diuretics which increase the excretion of water with little increase in electrolyte excretion.
GR20000402201T 1995-04-27 2000-09-28 Piperidine derivatives as diuretic GR3034511T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42975195A 1995-04-27 1995-04-27
US08/468,129 US5716970A (en) 1995-04-27 1995-06-06 Diuretic compound
PCT/US1996/002321 WO1996033985A1 (en) 1995-04-27 1996-03-11 Piperidine derivatives as diuretic

Publications (1)

Publication Number Publication Date
GR3034511T3 true GR3034511T3 (en) 2000-12-29

Family

ID=27028330

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000402201T GR3034511T3 (en) 1995-04-27 2000-09-28 Piperidine derivatives as diuretic

Country Status (11)

Country Link
US (1) US5716970A (en)
EP (1) EP0822932B1 (en)
JP (1) JPH11504322A (en)
AT (1) ATE194606T1 (en)
AU (1) AU5297296A (en)
DE (1) DE69609323T2 (en)
DK (1) DK0822932T3 (en)
ES (1) ES2148745T3 (en)
GR (1) GR3034511T3 (en)
PT (1) PT822932E (en)
WO (1) WO1996033985A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL254248A (en) * 1959-07-29
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles

Also Published As

Publication number Publication date
US5716970A (en) 1998-02-10
ATE194606T1 (en) 2000-07-15
EP0822932A1 (en) 1998-02-11
ES2148745T3 (en) 2000-10-16
DE69609323D1 (en) 2000-08-17
WO1996033985A1 (en) 1996-10-31
JPH11504322A (en) 1999-04-20
PT822932E (en) 2000-10-31
EP0822932B1 (en) 2000-07-12
DK0822932T3 (en) 2000-10-02
AU5297296A (en) 1996-11-18
DE69609323T2 (en) 2000-12-14

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