DK0551459T3 - Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-alkylpyridiner - Google Patents

Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-alkylpyridiner

Info

Publication number
DK0551459T3
DK0551459T3 DK92912917.9T DK92912917T DK0551459T3 DK 0551459 T3 DK0551459 T3 DK 0551459T3 DK 92912917 T DK92912917 T DK 92912917T DK 0551459 T3 DK0551459 T3 DK 0551459T3
Authority
DK
Denmark
Prior art keywords
chloro
amino
alkylpyridines
preparing
preparation
Prior art date
Application number
DK92912917.9T
Other languages
Danish (da)
English (en)
Inventor
Karl G Grozinger
Karl D Hargrave
Julian Adams
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24870473&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0551459(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK0551459T3 publication Critical patent/DK0551459T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK92912917.9T 1991-06-11 1992-05-29 Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-alkylpyridiner DK0551459T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71454991A 1991-06-11 1991-06-11

Publications (1)

Publication Number Publication Date
DK0551459T3 true DK0551459T3 (da) 1997-04-07

Family

ID=24870473

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92912917.9T DK0551459T3 (da) 1991-06-11 1992-05-29 Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-alkylpyridiner

Country Status (14)

Country Link
US (1) US5668287A (ja)
EP (1) EP0551459B1 (ja)
JP (1) JP3133331B2 (ja)
KR (1) KR100201725B1 (ja)
AT (1) ATE145397T1 (ja)
AU (1) AU652656B2 (ja)
CA (1) CA2082801C (ja)
DE (1) DE69215346T2 (ja)
DK (1) DK0551459T3 (ja)
ES (1) ES2094913T3 (ja)
GR (1) GR3022398T3 (ja)
HU (1) HU213257B (ja)
MX (1) MX9202769A (ja)
WO (1) WO1992022531A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69320759T2 (de) * 1992-11-18 1999-03-25 Boehringer Ingelheim Pharma Verbesserte Methode zur Herstellung von 4-Alkyl-3-Amino-2-Chlor-Pyridinen
JP3516454B2 (ja) * 1993-12-02 2004-04-05 ベーリンガー インゲルハイム コマンディトゲゼルシャフト ３‐アミノ‐２‐クロロ‐４‐アルキルピリジン又は‐４‐アリールピリジンの製造方法
CA2318412A1 (en) * 1999-01-22 2000-07-27 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate
ES2218109T3 (es) * 1999-01-22 2004-11-16 Boehringer Ingelheim Pharmaceuticals Inc. Sintesis de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo y acetona.
US6399781B1 (en) 2000-10-10 2002-06-04 Boehringer Ingelheim Chemicals, Inc. Process for making 3-amino-2-chloro-4-methylpyridine
JP2002322152A (ja) * 2001-04-24 2002-11-08 Koei Chem Co Ltd シアノピリジン類の製造方法
CN100358871C (zh) * 2005-08-02 2008-01-02 江阴暨阳医药化工有限公司 氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法
EP2604175B1 (en) 2011-12-13 2019-11-20 EndoChoice Innovation Center Ltd. Removable tip endoscope
EP4029853A4 (en) * 2019-09-11 2023-03-01 Chiral Quest (suzhou) Co., Ltd. SYNTHETIC METHOD APPLIED TO A HETEROCYCLIC INTERMEDIATE OF KRAS INHIBITOR DRUGS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2372690A (en) * 1940-11-15 1945-04-03 Merck & Co Inc Intermediates for the production of vitamin b6 and processes of preparing the same
US3703582A (en) * 1970-04-20 1972-11-21 Merck & Co Inc Aryl pyridine carboxylic acids in the treatment of inflammation
DE2310747A1 (de) * 1973-03-03 1974-09-12 Bayer Ag Verfahren zur herstellung von neuen amino-3,4-dihydropyridinen und ihre verwendung als arzneimittel
US4442100A (en) * 1979-12-11 1984-04-10 Bayer Aktiengesellschaft Substituted 2-amino-3,4-dihydropyridine derivatives, their production and their medicinal use
US4395554A (en) * 1981-12-01 1983-07-26 Mobil Oil Corporation Process for producing alpha-picoline
EP0407346A3 (en) * 1989-07-07 1991-10-02 Ciba-Geigy Ag Aminopyridines
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
US5200522A (en) * 1991-06-11 1993-04-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for preparing 3-amino-2-chloro-4-alkylpyridines

Also Published As

Publication number Publication date
DE69215346D1 (de) 1997-01-02
JPH06500800A (ja) 1994-01-27
KR930701405A (ko) 1993-06-11
EP0551459A4 (ja) 1994-03-16
DE69215346T2 (de) 1997-04-30
JP3133331B2 (ja) 2001-02-05
KR100201725B1 (ko) 1999-06-15
AU652656B2 (en) 1994-09-01
HU9300337D0 (en) 1993-05-28
CA2082801C (en) 2003-07-08
CA2082801A1 (en) 1992-12-12
WO1992022531A1 (en) 1992-12-23
US5668287A (en) 1997-09-16
GR3022398T3 (en) 1997-04-30
ATE145397T1 (de) 1996-12-15
AU2180792A (en) 1993-01-12
EP0551459A1 (en) 1993-07-21
ES2094913T3 (es) 1997-02-01
HU213257B (en) 1997-04-28
MX9202769A (es) 1993-01-01
EP0551459B1 (en) 1996-11-20
HUT64027A (en) 1993-11-29

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