DK0547102T3 - Opløseliggørelse af proteiner på aktiv form - Google Patents

Opløseliggørelse af proteiner på aktiv form

Info

Publication number
DK0547102T3
DK0547102T3 DK91915661T DK91915661T DK0547102T3 DK 0547102 T3 DK0547102 T3 DK 0547102T3 DK 91915661 T DK91915661 T DK 91915661T DK 91915661 T DK91915661 T DK 91915661T DK 0547102 T3 DK0547102 T3 DK 0547102T3
Authority
DK
Denmark
Prior art keywords
protein
active form
solubilization
proteins
refolding
Prior art date
Application number
DK91915661T
Other languages
Danish (da)
English (en)
Inventor
Kumar Puri Nirdosh
Enzo Crivelli
Original Assignee
Natinco Nv
Southern Cross Biotech Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natinco Nv, Southern Cross Biotech Pty Ltd filed Critical Natinco Nv
Application granted granted Critical
Publication of DK0547102T3 publication Critical patent/DK0547102T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK91915661T 1990-09-05 1991-08-29 Opløseliggørelse af proteiner på aktiv form DK0547102T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPK215990 1990-09-05
PCT/AU1991/000395 WO1992004382A1 (en) 1990-09-05 1991-08-29 Solubilization of proteins in active forms

Publications (1)

Publication Number Publication Date
DK0547102T3 true DK0547102T3 (da) 1999-04-19

Family

ID=3774938

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91915661T DK0547102T3 (da) 1990-09-05 1991-08-29 Opløseliggørelse af proteiner på aktiv form

Country Status (8)

Country Link
EP (1) EP0547102B1 (https=)
AT (1) ATE168115T1 (https=)
AU (1) AU664021B2 (https=)
CA (1) CA2090701C (https=)
DE (1) DE69129747T2 (https=)
DK (1) DK0547102T3 (https=)
ES (1) ES2119779T3 (https=)
WO (1) WO1992004382A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001453A1 (en) * 1992-07-02 1994-01-20 Pitman-Moore, Inc. A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
DE69432231T2 (de) * 1993-09-22 2004-02-05 Ajinomoto Co., Inc. Peptide mit antithrombotischer aktivität und verfahren zu ihrer herstellung
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form
DE10309691B4 (de) * 2003-02-28 2018-10-04 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Gewinnung von löslichen Proteinen aus der Biomasse rekombinanter Mikroorganismen
EA020621B1 (ru) 2009-06-22 2014-12-30 Амген Инк. Рефолдинг белков с использованием химически контролируемого окислительно-восстановительного состояния
LT3660032T (lt) 2009-06-25 2026-02-25 Amgen Inc. Ne žinduolių sistemoje ekspresuotų baltymų surišamojo gryninimo būdai
EP3744728A1 (en) 2013-02-12 2020-12-02 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
ES2870802T3 (es) 2013-02-12 2021-10-27 Bristol Myers Squibb Co Métodos de replegado de proteínas a elevado pH
WO2014155349A2 (en) 2013-03-29 2014-10-02 Dr. Reddy's Laboratories Refolding of proteins
US10745457B2 (en) 2015-09-02 2020-08-18 Merck Sharp & Dohme Corp. Process for obtaining insulin with correctly formed disulfide bonds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6079000A (ja) * 1983-10-04 1985-05-04 Takeda Chem Ind Ltd ヒトγ型インタ−フエロン単量体の製造法
DE3587526T3 (de) * 1984-12-06 2002-08-08 Amgen Inc.(N.D.Ges D. Staates Delaware), Thousand Oaks Serinproteaseinhibitoren und isolierungsverfahren dazu.
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
DE3611817A1 (de) * 1986-04-08 1987-10-15 Boehringer Mannheim Gmbh Verfahren zur renaturierung von proteinen
AU612133B2 (en) * 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
EP0295859B1 (en) * 1987-06-15 1994-11-17 Southern Cross Biotech Pty.Ltd. Production of proteins in active forms
AU2257488A (en) * 1987-07-29 1989-03-01 Schering Biotech Corporation Purification of human interleukin-4 expressed in escherichia coli
CA1340586C (en) * 1988-09-23 1999-06-08 Cetus Corporation Process for recovering microbially produced interferon-beta
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
DE4113750A1 (de) * 1991-04-26 1992-10-29 Boehringer Mannheim Gmbh Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen

Also Published As

Publication number Publication date
ATE168115T1 (de) 1998-07-15
DE69129747T2 (de) 1998-11-12
AU8403591A (en) 1992-03-30
WO1992004382A1 (en) 1992-03-19
EP0547102B1 (en) 1998-07-08
DE69129747D1 (de) 1998-08-13
EP0547102A1 (en) 1993-06-23
EP0547102A4 (https=) 1994-04-27
CA2090701A1 (en) 1992-03-10
CA2090701C (en) 2000-05-16
AU664021B2 (en) 1995-11-02
ES2119779T3 (es) 1998-10-16

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