DK0545966T3 - Phospholipidderivater af nucleosider, deres fremstilling samt deres anvendelse som anti-virale lægemidler - Google Patents
Phospholipidderivater af nucleosider, deres fremstilling samt deres anvendelse som anti-virale lægemidlerInfo
- Publication number
- DK0545966T3 DK0545966T3 DK91914553.2T DK91914553T DK0545966T3 DK 0545966 T3 DK0545966 T3 DK 0545966T3 DK 91914553 T DK91914553 T DK 91914553T DK 0545966 T3 DK0545966 T3 DK 0545966T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- nucleosides
- viral drugs
- phospholipid derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4026265A DE4026265A1 (de) | 1990-08-20 | 1990-08-20 | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
US08/661,038 US5756711A (en) | 1990-08-20 | 1996-06-10 | Phospholipid derivatives of nucleosides and their use as anti-viral medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0545966T3 true DK0545966T3 (da) | 1995-05-08 |
Family
ID=25896049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91914553.2T DK0545966T3 (da) | 1990-08-20 | 1991-08-14 | Phospholipidderivater af nucleosider, deres fremstilling samt deres anvendelse som anti-virale lægemidler |
Country Status (15)
Country | Link |
---|---|
US (1) | US5756711A (no) |
EP (1) | EP0545966B1 (no) |
CN (1) | CN1032258C (no) |
AT (1) | ATE114316T1 (no) |
CA (1) | CA2090024C (no) |
DE (2) | DE4026265A1 (no) |
DK (1) | DK0545966T3 (no) |
ES (1) | ES2066461T3 (no) |
FI (1) | FI104176B (no) |
HK (1) | HK35597A (no) |
IE (1) | IE64374B1 (no) |
NO (1) | NO179710C (no) |
PT (1) | PT98720B (no) |
SK (1) | SK281826B6 (no) |
WO (1) | WO1992003462A1 (no) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6252060B1 (en) | 1988-07-07 | 2001-06-26 | Nexstar Pharmaceuticals, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
US5817638A (en) * | 1988-07-07 | 1998-10-06 | Nexstar Pharmaceuticals, Inc. | Antiviral liponucleosides: treatment of hepatitis B |
US6599887B2 (en) | 1988-07-07 | 2003-07-29 | Chimerix, Inc. | Methods of treating viral infections using antiviral liponucleotides |
CA2001401A1 (en) * | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions |
DE4204031A1 (de) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | Neue lipidphosphonsaeure-nucleosid-konjugate sowie deren verwendung als antivirale arzneimittel |
DE4204032A1 (de) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel |
US6080734A (en) * | 1992-08-08 | 2000-06-27 | Roche Diagnostic Gmbh | Liponucleotides of seco-nucleosides, their production as well as their use as antiviral pharmaceutical agents |
DE4226279A1 (de) * | 1992-08-08 | 1994-02-10 | Boehringer Mannheim Gmbh | Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
ATE226437T1 (de) * | 1993-06-10 | 2002-11-15 | Univ Wake Forest | (phospho)lipide zum bekämpfen einer hepatitis b- infektion |
KR0125779B1 (ko) * | 1993-12-04 | 1997-12-19 | 김승호 | 뉴클레오시드 화합물 및 이의 제조방법 |
DE4418690A1 (de) * | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
CA2197319C (en) * | 1994-08-29 | 2009-01-27 | Louis S. Kucera | Lipid analogs for treating viral infections |
US7135584B2 (en) | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
EP0791056B1 (de) * | 1994-11-12 | 2005-03-30 | Heidelberg Pharma GmbH | Lipidspaltender enzymkomplex |
DE19505168A1 (de) * | 1995-02-16 | 1996-08-22 | Boehringer Mannheim Gmbh | Spezifische Lipidkonjugate von Nucleosid-Diphosphonaten und deren Verwendung als Arzneimittel |
DE19547022A1 (de) * | 1995-12-15 | 1997-06-19 | Boehringer Mannheim Gmbh | Kovalente Lipid-Phosphonocarbonsäure-Konjugate, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
TW343975B (en) * | 1995-12-15 | 1998-11-01 | Boehringer Mannheim Gmbh | New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents |
DE19602757A1 (de) * | 1996-01-26 | 1997-07-31 | Boehringer Mannheim Gmbh | Feste Instant-Release-Darreichungsformen und Verfahren zu ihrer Herstellung |
US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
ES2383673T3 (es) | 2000-09-22 | 2012-06-25 | Jpi Commercial, Llc | Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos |
US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
JP4714413B2 (ja) | 2001-08-31 | 2011-06-29 | トムソン ライセンシング | オーディオビジュアルストリームのためのシーケンスカウンタ |
US7045543B2 (en) | 2001-11-05 | 2006-05-16 | Enzrel Inc. | Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites |
DE10156910A1 (de) * | 2001-11-21 | 2003-06-05 | Heidelberg Pharma Holding Gmbh | Phospholipid-Derivate von Nucleosiden als antitumorale Arzneimittel |
EP1448579A1 (de) * | 2001-11-21 | 2004-08-25 | Heidelberg Pharma Holding GmbH | Phospholipid-derivate von nucleosiden als antitumorale arzneimittel |
EP1460082A1 (en) | 2003-03-19 | 2004-09-22 | Heidelberg Pharma Holding GmbH | Phospholipid esters of clofarabine derivatives |
WO2006068760A2 (en) * | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
ES2401285T3 (es) | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
BRPI0519306A2 (pt) | 2004-12-30 | 2009-01-06 | Medivir Ab | compostos éteis no tratamento de hiv |
EP2842559A3 (en) | 2005-04-08 | 2015-03-18 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
EP1868628B1 (en) | 2005-04-08 | 2014-06-11 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
NO324263B1 (no) | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser |
MX2008012928A (es) * | 2006-04-04 | 2009-03-06 | Univ California | Antagonistas de pi3-cinasa. |
GB0608876D0 (en) * | 2006-05-05 | 2006-06-14 | Medivir Ab | Combination therapy |
US7378401B2 (en) | 2006-07-14 | 2008-05-27 | Heidelberg Pharma Gmbh | Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases |
EP2205073A4 (en) | 2007-09-26 | 2013-03-06 | Sinai School Medicine | AZACYTIDINE ANALOGS AND USES THEREOF |
WO2009046448A1 (en) | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Chemical entities and therapeutic uses thereof |
EP2070938A1 (en) | 2007-12-13 | 2009-06-17 | Heidelberg Pharma AG | Clofarabine dietherphospholipid derivatives |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
CN104926815B (zh) | 2008-01-04 | 2017-11-03 | 英特利凯恩有限责任公司 | 某些化学实体、组合物和方法 |
CN105055432A (zh) * | 2008-01-25 | 2015-11-18 | 奇默里克斯公司 | 治疗病毒感染的方法 |
JP5547099B2 (ja) * | 2008-03-14 | 2014-07-09 | インテリカイン, エルエルシー | キナーゼ阻害剤および使用方法 |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
US20110224223A1 (en) * | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
BRPI0915231A2 (pt) | 2008-07-08 | 2018-06-12 | Intellikine Inc | compostos inibidores de quinase e métodos de uso |
WO2010036380A1 (en) | 2008-09-26 | 2010-04-01 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
US8697709B2 (en) | 2008-10-16 | 2014-04-15 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
US8476282B2 (en) * | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
EP2427195B1 (en) | 2009-05-07 | 2019-05-01 | Intellikine, LLC | Heterocyclic compounds and uses thereof |
WO2011011519A1 (en) | 2009-07-21 | 2011-01-27 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
US8980899B2 (en) | 2009-10-16 | 2015-03-17 | The Regents Of The University Of California | Methods of inhibiting Ire1 |
EP3216789A1 (en) | 2010-02-12 | 2017-09-13 | Chimerix, Inc. | Methods of treating viral infection |
EP2563367A4 (en) | 2010-04-26 | 2013-12-04 | Chimerix Inc | METHODS OF TREATING RETROVIRAL INFECTIONS AND ASSOCIATED DOSAGE REGIMES |
CN103002738A (zh) | 2010-05-21 | 2013-03-27 | 英特利凯恩有限责任公司 | 用于激酶调节的化学化合物、组合物和方法 |
AU2011326427B2 (en) | 2010-11-10 | 2016-01-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
BR112013017670B1 (pt) | 2011-01-10 | 2022-07-19 | Infinity Pharmaceuticals, Inc | Processos de preparação de isoquinolinonas e formas sólidas de isoquinolinonas |
WO2012148540A1 (en) | 2011-02-23 | 2012-11-01 | Intellikine, Llc | Combination of kanase inhibitors and uses threof |
WO2013012915A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
AR088218A1 (es) | 2011-07-19 | 2014-05-21 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos utiles como inhibidores de pi3k |
CA2846431A1 (en) | 2011-08-29 | 2013-03-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
WO2013077921A2 (en) | 2011-09-02 | 2013-05-30 | The Regents Of The University Of California | Substituted pyrazolo[3,4-d]pyrimidines and uses thereof |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
RU2015115631A (ru) | 2012-09-26 | 2016-11-20 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Модулирование ire1 |
ES2687958T3 (es) | 2013-03-15 | 2018-10-30 | The Regents Of The University Of California | Fosfonato diésteres de nucleósido acíclico |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
MY175778A (en) | 2013-10-04 | 2020-07-08 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN106456628A (zh) | 2014-03-19 | 2017-02-22 | 无限药品股份有限公司 | 用于治疗PI3K‑γ介导的障碍的杂环化合物 |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
SG11201701957XA (en) | 2014-09-15 | 2017-04-27 | Univ California | Nucleotide analogs |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2017048702A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
EP3350191B9 (en) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Nucleotide analogs |
CN105288648B (zh) * | 2015-10-14 | 2018-11-06 | 东南大学 | 一种亲水性药物的磷脂化合物、其药物组合物及应用 |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
MX2018016227A (es) | 2016-06-24 | 2019-07-08 | Infinity Pharmaceuticals Inc | Terapias de combinacion. |
WO2021198725A1 (de) | 2020-03-30 | 2021-10-07 | Chiracon Gmbh | Fosalvudin und fozivudintidoxil zur anwendung bei der behandlung der krankheit covid-19 und die verwendung von deren strukturvereinfachten derivaten |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4291024A (en) * | 1978-04-10 | 1981-09-22 | Turcotte Joseph G | Cytotoxic liponucleotide analogs |
US4283394A (en) * | 1979-08-06 | 1981-08-11 | Research Corporation | Cytotoxic nucleoside-corticosteroid phosphodiesters |
US4622392A (en) * | 1984-06-21 | 1986-11-11 | Health Research Inc. (Roswell Park Division) | Thiophospholipid conjugates of antitumor agents |
US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
EP0262876B1 (en) * | 1986-09-27 | 1992-04-29 | Toyo Jozo Kabushiki Kaisha | Nucleoside-phospholipid conjugate |
US5194654A (en) * | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
-
1990
- 1990-08-20 DE DE4026265A patent/DE4026265A1/de not_active Withdrawn
-
1991
- 1991-08-14 SK SK92-93A patent/SK281826B6/sk not_active IP Right Cessation
- 1991-08-14 EP EP91914553A patent/EP0545966B1/de not_active Expired - Lifetime
- 1991-08-14 CA CA002090024A patent/CA2090024C/en not_active Expired - Fee Related
- 1991-08-14 DK DK91914553.2T patent/DK0545966T3/da active
- 1991-08-14 AT AT91914553T patent/ATE114316T1/de not_active IP Right Cessation
- 1991-08-14 DE DE59103595T patent/DE59103595D1/de not_active Expired - Fee Related
- 1991-08-14 WO PCT/EP1991/001541 patent/WO1992003462A1/de active IP Right Grant
- 1991-08-14 ES ES91914553T patent/ES2066461T3/es not_active Expired - Lifetime
- 1991-08-20 PT PT98720A patent/PT98720B/pt not_active IP Right Cessation
- 1991-08-20 CN CN91105815A patent/CN1032258C/zh not_active Expired - Fee Related
-
1993
- 1993-02-19 FI FI930753A patent/FI104176B/fi active
- 1993-02-19 IE IE293091A patent/IE64374B1/en not_active IP Right Cessation
- 1993-02-19 NO NO930587A patent/NO179710C/no not_active IP Right Cessation
-
1996
- 1996-06-10 US US08/661,038 patent/US5756711A/en not_active Expired - Lifetime
-
1997
- 1997-03-20 HK HK35597A patent/HK35597A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE64374B1 (en) | 1995-07-26 |
FI930753A (fi) | 1993-02-19 |
DE59103595D1 (de) | 1995-01-05 |
NO930587D0 (no) | 1993-02-19 |
CA2090024A1 (en) | 1992-02-21 |
PT98720A (pt) | 1992-07-31 |
NO179710C (no) | 1996-12-04 |
FI104176B1 (fi) | 1999-11-30 |
AU654670B2 (en) | 1994-11-17 |
HK35597A (en) | 1997-03-27 |
EP0545966A1 (de) | 1993-06-16 |
PT98720B (pt) | 1999-02-26 |
EP0545966B1 (de) | 1994-11-23 |
US5756711A (en) | 1998-05-26 |
AU8325191A (en) | 1992-03-17 |
ATE114316T1 (de) | 1994-12-15 |
CN1032258C (zh) | 1996-07-10 |
NO930587L (no) | 1993-02-19 |
NO179710B (no) | 1996-08-26 |
FI104176B (fi) | 1999-11-30 |
CA2090024C (en) | 2000-05-02 |
FI930753A0 (fi) | 1993-02-19 |
DE4026265A1 (de) | 1992-02-27 |
SK281826B6 (sk) | 2001-08-06 |
SK9293A3 (en) | 1993-07-07 |
WO1992003462A1 (de) | 1992-03-05 |
ES2066461T3 (es) | 1995-03-01 |
CN1059149A (zh) | 1992-03-04 |
IE912930A1 (en) | 1992-02-26 |
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