DK0533047T3 - Fremgangsmåde til fremstilling af et cephalosporing-antibiotikum under anvendelse af den syn-isomere af et thiazolylmellemprodukt - Google Patents

Fremgangsmåde til fremstilling af et cephalosporing-antibiotikum under anvendelse af den syn-isomere af et thiazolylmellemprodukt

Info

Publication number
DK0533047T3
DK0533047T3 DK92115430T DK92115430T DK0533047T3 DK 0533047 T3 DK0533047 T3 DK 0533047T3 DK 92115430 T DK92115430 T DK 92115430T DK 92115430 T DK92115430 T DK 92115430T DK 0533047 T3 DK0533047 T3 DK 0533047T3
Authority
DK
Denmark
Prior art keywords
isomer
syn
antibiotic
cephalosporase
preparing
Prior art date
Application number
DK92115430T
Other languages
Danish (da)
English (en)
Inventor
Gary M F Lim
John M Roubie
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK0533047T3 publication Critical patent/DK0533047T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK92115430T 1991-09-10 1992-09-09 Fremgangsmåde til fremstilling af et cephalosporing-antibiotikum under anvendelse af den syn-isomere af et thiazolylmellemprodukt DK0533047T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75710891A 1991-09-10 1991-09-10

Publications (1)

Publication Number Publication Date
DK0533047T3 true DK0533047T3 (da) 2003-10-27

Family

ID=25046385

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92115430T DK0533047T3 (da) 1991-09-10 1992-09-09 Fremgangsmåde til fremstilling af et cephalosporing-antibiotikum under anvendelse af den syn-isomere af et thiazolylmellemprodukt

Country Status (29)

Country Link
EP (1) EP0533047B1 (no)
JP (1) JP3434839B2 (no)
KR (1) KR0177828B1 (no)
CN (2) CN1042536C (no)
AT (1) ATE239735T1 (no)
AU (1) AU654384B2 (no)
BG (1) BG61163B1 (no)
CZ (1) CZ282602B6 (no)
DE (1) DE69233042T2 (no)
DK (1) DK0533047T3 (no)
EG (1) EG20123A (no)
ES (1) ES2199215T3 (no)
FI (1) FI109126B (no)
HU (1) HU213267B (no)
IL (1) IL103110A (no)
MX (1) MX9205148A (no)
MY (1) MY108872A (no)
NO (2) NO301766B1 (no)
NZ (2) NZ272673A (no)
OA (1) OA09763A (no)
PH (1) PH30925A (no)
PL (1) PL175011B1 (no)
PT (1) PT533047E (no)
RO (1) RO109652B1 (no)
RU (1) RU2039059C1 (no)
SK (1) SK277992A3 (no)
TW (1) TW221442B (no)
UY (1) UY23476A1 (no)
ZA (1) ZA926870B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU81692A (sh) * 1991-09-10 1995-03-27 Bristol-Myers Co. Postupak za proizvodnju cefalosporinskog antibiotika
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
KR19980019860A (ko) * 1996-09-04 1998-06-25 김윤배 세팔로스포린 중간체의 신규한 제조방법
BG64828B1 (bg) * 2001-04-04 2006-05-31 "Векта" Оод Метод за получаване на горивна смес от дизелово гориво
CN1301240C (zh) * 2005-01-25 2007-02-21 江苏省原子医学研究所 一种荧光标记试剂2－萘氧基乙酰氯的制备和应用
KR100760429B1 (ko) * 2006-03-03 2007-10-04 한미약품 주식회사 세팔로스포린 제조용 중간체로 사용되는2-아미노티아졸-4-일 아세틸클로라이드 염산염의 개선된제조방법
US11542279B2 (en) 2016-06-06 2023-01-03 Merck Sharp & Dohme Llc Solid forms of ceftolozane and processes for preparing
CN108285436B (zh) * 2018-03-16 2020-10-16 河北合佳医药科技集团股份有限公司 一种ae-活性酯的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
YU81692A (sh) * 1991-09-10 1995-03-27 Bristol-Myers Co. Postupak za proizvodnju cefalosporinskog antibiotika

Also Published As

Publication number Publication date
CZ282602B6 (cs) 1997-08-13
SK281196B6 (sk) 2001-01-18
ATE239735T1 (de) 2003-05-15
MY108872A (en) 1996-11-30
NO301766B1 (no) 1997-12-08
IL103110A0 (en) 1993-02-21
CN1070406A (zh) 1993-03-31
AU654384B2 (en) 1994-11-03
FI109126B (fi) 2002-05-31
PL175011B1 (pl) 1998-10-30
EG20123A (en) 1997-07-31
HU9202885D0 (en) 1992-11-30
HUT62902A (en) 1993-06-28
NO306724B1 (no) 1999-12-13
UY23476A1 (es) 1992-10-08
SK277992A3 (en) 2001-01-18
BG96858A (bg) 1993-12-24
DE69233042T2 (de) 2004-02-26
PH30925A (en) 1997-12-23
JP3434839B2 (ja) 2003-08-11
KR930006033A (ko) 1993-04-20
ZA926870B (en) 1993-03-09
EP0533047A1 (en) 1993-03-24
IL103110A (en) 1997-04-15
RU2039059C1 (ru) 1995-07-09
TW221442B (no) 1994-03-01
ES2199215T3 (es) 2004-02-16
NZ244296A (en) 1997-01-29
MX9205148A (es) 1993-03-01
PL295872A1 (en) 1993-04-19
HU213267B (en) 1997-04-28
NO923496L (no) 1993-03-11
DE69233042D1 (de) 2003-06-12
NO923496D0 (no) 1992-09-09
FI924032A (fi) 1993-03-11
KR0177828B1 (ko) 1999-03-20
CN1042536C (zh) 1999-03-17
NO972098L (no) 1993-03-11
JPH05194531A (ja) 1993-08-03
CZ277992A3 (en) 1993-03-17
CN1140714A (zh) 1997-01-22
RO109652B1 (ro) 1995-04-28
BG61163B1 (bg) 1997-01-31
AU2284592A (en) 1993-03-11
PT533047E (pt) 2003-08-29
OA09763A (fr) 1993-11-30
NZ272673A (en) 1997-05-26
NO972098D0 (no) 1997-05-07
EP0533047B1 (en) 2003-05-07
FI924032A0 (fi) 1992-09-09

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