DK0516664T3 - Transgene dyr, celler og cellelinier derfra samt deres anvendelse - Google Patents

Transgene dyr, celler og cellelinier derfra samt deres anvendelse

Info

Publication number
DK0516664T3
DK0516664T3 DK91904013T DK91904013T DK0516664T3 DK 0516664 T3 DK0516664 T3 DK 0516664T3 DK 91904013 T DK91904013 T DK 91904013T DK 91904013 T DK91904013 T DK 91904013T DK 0516664 T3 DK0516664 T3 DK 0516664T3
Authority
DK
Denmark
Prior art keywords
sequence
cells
cell lines
differentiation
control
Prior art date
Application number
DK91904013T
Other languages
English (en)
Inventor
Mark David Noble
Parmjit Singh Jat
Dimitris Kioussis
Original Assignee
Ludwig Inst Cancer Res
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Inst Cancer Res, Medical Res Council filed Critical Ludwig Inst Cancer Res
Application granted granted Critical
Publication of DK0516664T3 publication Critical patent/DK0516664T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catching Or Destruction (AREA)
DK91904013T 1990-02-20 1991-02-20 Transgene dyr, celler og cellelinier derfra samt deres anvendelse DK0516664T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909003791A GB9003791D0 (en) 1990-02-20 1990-02-20 Transgenic animals,cell lines therefrom,and their use

Publications (1)

Publication Number Publication Date
DK0516664T3 true DK0516664T3 (da) 2004-05-24

Family

ID=10671295

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91904013T DK0516664T3 (da) 1990-02-20 1991-02-20 Transgene dyr, celler og cellelinier derfra samt deres anvendelse

Country Status (12)

Country Link
US (1) US5688692A (da)
EP (1) EP0516664B1 (da)
JP (1) JP3333902B2 (da)
AT (1) ATE258226T1 (da)
AU (2) AU660604B2 (da)
CA (1) CA2076345C (da)
DE (1) DE69133355T2 (da)
DK (1) DK0516664T3 (da)
ES (1) ES2213742T3 (da)
GB (1) GB9003791D0 (da)
IE (1) IE910572A1 (da)
WO (1) WO1991013150A1 (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866759A (en) * 1991-02-20 1999-02-02 Ludwig Institute For Cancer Research Transgenic mice expressing TSSV40 large T antigen
US7361505B1 (en) * 1991-07-08 2008-04-22 Neurospheres Holdings Ltd. Multipotent neural stem cell compositions
US5489743A (en) * 1993-01-19 1996-02-06 Amgen Inc. Transgenic animal models for thrombocytopenia
US5700657A (en) * 1993-12-13 1997-12-23 Genzyme Corporation Vectors and vector systems including genes encoding tumor suppressor proteins and producer cells transformed thereby
US5935849A (en) * 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5858747A (en) * 1994-07-20 1999-01-12 Cytotherapeutics, Inc. Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers
AUPM710194A0 (en) * 1994-07-26 1994-08-18 Commonwealth Scientific And Industrial Research Organisation Virus vector
AU3586595A (en) * 1994-09-09 1996-03-27 Zymogenetics Inc. Preparation of immortalized cells
NZ294906A (en) * 1994-11-08 2000-03-27 Cellfactors Plc Producing large population of neural cells and cell lines, typically human that are pleiotropic but will differentiate following specific treatment
US6495364B2 (en) 1995-05-23 2002-12-17 Neurotech, S.A. Mx-1 conditionally immortalized cells
US5994619A (en) * 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
US5905042A (en) * 1996-04-01 1999-05-18 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Cultured inner cell mass cell lines derived from bovine or porcine embryos
GB9607953D0 (en) 1996-04-17 1996-06-19 Univ Liverpool Transgenic rat
US6215041B1 (en) 1997-01-10 2001-04-10 University Of Mmassachusetts Cloning using donor nuclei from a non-quiesecent somatic cells
US6235969B1 (en) 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
FR2761576B1 (fr) * 1997-04-04 2002-08-30 Inst Nat Sante Rech Med Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee
AU8284198A (en) 1997-07-02 1999-01-25 Board Of Regents, The University Of Texas System P53 as a regulator of cell differentiation
US6235527B1 (en) * 1997-11-29 2001-05-22 University Of Utah Research Foundation Lineage restricted glial precursors from the central nervous system
WO2000068359A1 (en) * 1999-05-07 2000-11-16 University Of Utah Research Foundation Lineage-restricted precursor cells isolated from mouse neural tube and mouse embryonic stem cells
US6498285B1 (en) * 1997-08-06 2002-12-24 Alexion Pharmaceuticals, Inc. Methods for producing transgenic pigs by microinjecting a blastomere
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
CA2345442A1 (en) * 1998-10-02 2000-04-13 Ys New Technology Institute Inc. Established cells
JP4321936B2 (ja) * 2000-02-16 2009-08-26 独立行政法人科学技術振興機構 不死化血管周皮細胞株
US20050074747A1 (en) * 2000-09-08 2005-04-07 Wadih Arap Biopanning and rapid analysis of selective interactive ligands (brasil)
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US7420030B2 (en) * 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US20040176290A1 (en) * 2001-07-18 2004-09-09 Renata Pasqualini Anti-angiogenic state in mice and humans with retinal photorecptor cell degeneration
US7671010B2 (en) * 2002-08-30 2010-03-02 The Board Of Regents Of The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US8507445B2 (en) * 2001-09-07 2013-08-13 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US20040048243A1 (en) * 2001-09-07 2004-03-11 Wadih Arap Methods and compositions for in vitro targeting
GB2387599B (en) * 2002-04-17 2005-08-10 Jason Peter Brown Methods for producing antibodies
CA2522207A1 (en) * 2003-04-14 2004-10-28 Board Of Regents, The University Of Texas System Methods for ex vivo hybridoma-free production of polyclonal and monoclonal antibodies and generation of immortalized cell populations
US8785187B2 (en) 2004-06-09 2014-07-22 The University Court Of The University Of Edinburgh Neural stem cells
EP3187581A1 (en) 2008-12-23 2017-07-05 BOCO Silicon Valley, Inc. Target populations of oligodendrocyte precursor cells and methods of making and using same
US10683552B2 (en) 2014-11-25 2020-06-16 Presidents And Fellows Of Harvard College Clonal haematopoiesis
EP3224381B1 (en) 2014-11-25 2019-09-04 The Brigham and Women's Hospital, Inc. Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
CN116590345B (zh) * 2023-05-06 2024-01-30 北京中医药大学 永生化小鼠足细胞系及其制备方法、分化方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870009A (en) * 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4736866B1 (en) * 1984-06-22 1988-04-12 Transgenic non-human mammals
US5087571A (en) * 1984-06-22 1992-02-11 President And Fellows Of Harvard College Method for providing a cell culture from a transgenic non-human mammal
FR2596414B1 (fr) * 1986-03-28 1989-10-06 Pasteur Institut Hybridomes obtenus a partir de lymphocytes d'animaux transgeniques portant un gene exprimant une proteine donnee et procede de preparation d'une telle proteine a partir de tels hybridomes
ES2171401T3 (es) * 1986-05-20 2002-09-16 Gen Hospital Corp Metodos para estudios farmacocineticos de la expresion de insulina con un mamifero transgenico no-humano.
DE3681738D1 (da) * 1986-10-15 1991-10-31 Battelle Memorial Institute, Carouge, Genf/Geneve, Ch
EP0289121B1 (en) * 1987-05-01 1995-12-27 Stratagene Mutagenesis testing using transgenic non-human animals carrying test DNA sequences
FR2637613B1 (fr) * 1987-06-19 1991-09-27 Transgene Sa Procede de preparation de lignees cellulaires stables pour la production de proteines determinees, a partir d'animaux transgeniques; lignees cellulaires tumorales et proteines obtenues
AU2900389A (en) * 1987-12-15 1989-07-19 Trustees Of Princeton University, The Transgenic testing systems for mutagens and carcinogens
WO1989009816A1 (en) * 1988-04-12 1989-10-19 Massachusetts Institute Of Technology Method for manipulation of the cell types of eukaryotes
US5270191A (en) * 1988-04-12 1993-12-14 Massachusetts Institute Of Technology Method for manipulation of the cell types of eukaryotes
EP0351921A3 (en) * 1988-07-22 1991-07-17 Merck & Co. Inc. Modified beta adrenergic receptor
EP0435928A1 (en) * 1988-09-21 1991-07-10 Animal Biotechnology Cambridge Limited Derivation of pluripotential embryonic cell lines from domestic animals
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
FR2649721B1 (fr) * 1989-07-13 1994-07-08 Univ Paris Construction immortalisante pour l'immortalisation cellulaire conditionnelle

Also Published As

Publication number Publication date
EP0516664B1 (en) 2004-01-21
AU676118B2 (en) 1997-02-27
ES2213742T3 (es) 2004-09-01
CA2076345C (en) 2006-11-28
EP0516664A1 (en) 1992-12-09
GB9003791D0 (en) 1990-04-18
IE910572A1 (en) 1991-08-28
DE69133355T2 (de) 2004-10-21
AU7328691A (en) 1991-09-18
ATE258226T1 (de) 2004-02-15
WO1991013150A1 (en) 1991-09-05
CA2076345A1 (en) 1991-08-21
DE69133355D1 (de) 2004-02-26
US5688692A (en) 1997-11-18
JPH05504066A (ja) 1993-07-01
JP3333902B2 (ja) 2002-10-15
AU3305395A (en) 1996-01-11
AU660604B2 (en) 1995-07-06

Similar Documents

Publication Publication Date Title
DK0516664T3 (da) Transgene dyr, celler og cellelinier derfra samt deres anvendelse
Schwenk et al. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.
Nottoli et al. AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice
EP0591219A4 (en) Expression of active human protein c in mammary tissue of transgenic animals
De Murcia et al. Requirement of poly (ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
Jans et al. Powerful skin cancer protection by a CPD-photolyase transgene
Struhl A gene product required for correct initiation of segmental determination in Drosophila
Simske et al. Sequential signalling during Caenorhabditis elegans vulval induction
Jonsson et al. Insulin-promoter-factor 1 is required for pancreas development in mice
Korfhagen et al. Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice.
Namkung et al. Targeted disruption of the Ca2+ channel β3 subunit reduces N-and L-type Ca2+ channel activity and alters the voltagedependent activation of P/Q-type Ca2+ channels in neurons
Gröschel-Stewart Immunochemistry of cytoplasmic contractile proteins
Granadino et al. Evidence of a dual function in fl (2) d, a gene needed for Sex-lethal expression in Drosophila melanogaster.
ATE315085T1 (de) Transgene mäuse mit veränderter apolipoprotein e- expression und testverfahren.
DK650489D0 (da) Transgene organismer og celler samt fremgangsmaader til fremstilling deraf
EP0351585A3 (en) Vector containing a chicken b-actin gene promoter for the expression of a desired gene
De Looze et al. A new hypothesis on the evolution of sex determination in vertebrates; big females ZW, big males XY
Sasaoka et al. Analysis of the human tyrosine hydroxylase promoter-chloramphenicol acetyltransferase chimeric gene expression in transgenic mice
Roubertoux et al. Differences between CBA/H and NZB mice on intermale aggression. II. Maternal effects
Rottmann et al. Liposome‐mediated gene transfer via sperm cells. High transfer efficiency and persistence of transgenes by use of liposomes and sperm cells and a murine amplification element
ES2146235T3 (es) Celulas endoteliales transformadas.
Saito et al. ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma
Govind et al. Experimental induction of claw transformation in snapping shrimps
Yin et al. Development of a pituitary‐specific cre line targeted to the Pit‐1 lineage
Qu et al. Mutations at the Ser50 residue of translation factor eIF-2a dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster