ES2171401T3 - Metodos para estudios farmacocineticos de la expresion de insulina con un mamifero transgenico no-humano. - Google Patents
Metodos para estudios farmacocineticos de la expresion de insulina con un mamifero transgenico no-humano.Info
- Publication number
- ES2171401T3 ES2171401T3 ES93101772T ES93101772T ES2171401T3 ES 2171401 T3 ES2171401 T3 ES 2171401T3 ES 93101772 T ES93101772 T ES 93101772T ES 93101772 T ES93101772 T ES 93101772T ES 2171401 T3 ES2171401 T3 ES 2171401T3
- Authority
- ES
- Spain
- Prior art keywords
- mice
- gene
- insulin
- studies
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 108090001061 Insulin Proteins 0.000 title abstract 4
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 241000699670 Mus sp. Species 0.000 abstract 4
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
- 238000011830 transgenic mouse model Methods 0.000 abstract 3
- 241000699660 Mus musculus Species 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 206010013710 Drug interaction Diseases 0.000 abstract 1
- 102000051325 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 230000004634 feeding behavior Effects 0.000 abstract 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000014101 glucose homeostasis Effects 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000001850 reproductive effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Environmental Sciences (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Diabetes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Sampling And Sample Adjustment (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
SE PRESENTA UN PROCESO PARA PRODUCIR UN MAMIFERO TRANSGENICO, ESPECIALMENTE UN RATON QUE CONTIENE Y EXPRESA UN GEN HETEROLOGO ESPECIALMENTE EL GEN DE LA HORMONA DE LA INSULINA HUMANA. EL GEN DE LA INSULINA SE EXPRESA SOLAMENTE EN EL PANCREAS DEL RATON TRANSGENICO Y SE REGULA MEDIANTE GLUCOSA, GLUCAGON, U OTROS PRODUCTOS QUE AFECTAN A LA INSULINA DE UNA MANERA QUE ES INDISTINGUIBLE DE LA DE LOS RATONES NORMALES. LA PROGENIE DE LOS RATONES TRANSGENICOS HEREDA EL GEN DE LA INSULINA HUMANA EN LA MANERA DE "MENDELIAN", CON APROXIMADAMENTE EL 50% DE LOS RATONES EXPRESANDO EL GEN DE LA INSULINA HUMANA. LOS PESOS DE LOS RATONES TRANSGENICOS, LA VELOCIDAD DE CRECIMIENTO, EL COMPORTAMIENTO ALIMENTICIO, LA CAPACIDAD DE REPRODUCCION Y LA LONGEVIDAD PARECEN SER IGUALES A LA DE LOS RATONES NORMALES. LOS RATONES SON UTILES PARA ESTUDIOS FARMACOCINETICOS DE LA EXPRESION DE LA INSULINA Y PARA INVESTIGACIONES DE POSIBLES INTERACCIONES DE DROGAS CON LA HOMEOSTASIS DE LA GLUCOSA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86512086A | 1986-05-20 | 1986-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2171401T3 true ES2171401T3 (es) | 2002-09-16 |
Family
ID=25344768
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93101772T Expired - Lifetime ES2171401T3 (es) | 1986-05-20 | 1987-05-19 | Metodos para estudios farmacocineticos de la expresion de insulina con un mamifero transgenico no-humano. |
ES87107238T Expired - Lifetime ES2090006T3 (es) | 1986-05-20 | 1987-05-19 | Evaluacion de la expresion de preproinsulina, proinsulina o insulina. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87107238T Expired - Lifetime ES2090006T3 (es) | 1986-05-20 | 1987-05-19 | Evaluacion de la expresion de preproinsulina, proinsulina o insulina. |
Country Status (8)
Country | Link |
---|---|
US (1) | US6018097A (es) |
EP (2) | EP0247494B1 (es) |
JP (2) | JPH01502716A (es) |
AT (2) | ATE212662T1 (es) |
DE (2) | DE3751863T2 (es) |
ES (2) | ES2171401T3 (es) |
GR (1) | GR3021288T3 (es) |
WO (1) | WO1987007298A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4873316A (en) * | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
EP0370813A3 (en) * | 1988-11-25 | 1991-06-19 | Exemplar Corporation | Rapid screening mutagenesis and teratogenesis assay |
FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US6689610B1 (en) | 1989-08-22 | 2004-02-10 | University Of Utah Research Foundation | Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same |
US5744327A (en) * | 1990-02-20 | 1998-04-28 | Board Of Regents, The University Of Texas System | Methods for producing insulin in response to non-glucose secretagogues |
US5427940A (en) * | 1991-06-03 | 1995-06-27 | Board Of Regents, The University Of Texas System | Engineered cells producing insulin in response to glucose |
GB9003791D0 (en) * | 1990-02-20 | 1990-04-18 | Ludwig Inst Cancer Res | Transgenic animals,cell lines therefrom,and their use |
US5648597A (en) * | 1990-04-20 | 1997-07-15 | University Of South Carolina | Alpha-1-acid glycoprotein transgenic mice |
US5614396A (en) * | 1990-06-14 | 1997-03-25 | Baylor College Of Medicine | Methods for the genetic modification of endogenous genes in animal cells by homologous recombination |
US5569824A (en) * | 1991-01-04 | 1996-10-29 | Baylor College Of Medicine | Transgenic mice containing a disrupted p53 gene |
US5866759A (en) * | 1991-02-20 | 1999-02-02 | Ludwig Institute For Cancer Research | Transgenic mice expressing TSSV40 large T antigen |
US5792656A (en) * | 1991-06-03 | 1998-08-11 | Board Of Regents, The University Of Texas System | Methods of preparing genetically engineered cells that produce insulin in response to glucose |
DE4126968A1 (de) * | 1991-08-14 | 1993-02-18 | Detlev Prof Dr Med Ganten | Transgene ratten, die in ihrem genom mindestens ein menschliches gen enthalten, das an der blutdruckregulation beteiligt ist |
WO1993004171A1 (en) * | 1991-08-19 | 1993-03-04 | Symbicom Aktiebolag | Human beta-casein, process for producing it and use thereof |
DK8892D0 (da) | 1992-01-23 | 1992-01-23 | Symbicom Ab | Humant proteingen |
US5602307A (en) * | 1992-08-12 | 1997-02-11 | Baylor College Of Medicine | Non-human animal having predefined allele of a cellular adhesion gene |
WO1994026915A1 (en) * | 1993-05-10 | 1994-11-24 | The Regents Of The University Of Michigan | Gene transfer into pancreatic and biliary epithelial cells |
US5789651A (en) * | 1993-05-21 | 1998-08-04 | Martin Marietta Energy Systems, Inc. | Isolation and characterization of Agouti: a diabetes/obesity related gene |
US6310034B1 (en) | 1993-05-21 | 2001-10-30 | Ut-Battelle, Llc | Agouti polypeptide compositions |
US5907080A (en) * | 1995-11-30 | 1999-05-25 | Nexia Biotechnologies, Inc. | Method for development of transgenic dwarf goats |
US5854067A (en) * | 1996-01-19 | 1998-12-29 | Board Of Regents, The University Of Texas System | Hexokinase inhibitors |
US5891717A (en) * | 1996-01-19 | 1999-04-06 | Betagene, Inc. | Methods and compositions for inhibiting hexokinase |
US6077697A (en) | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US20030033617A1 (en) | 1996-04-10 | 2003-02-13 | Gyula Hadlaczky | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US20030013081A1 (en) | 2001-06-26 | 2003-01-16 | Olson William C. | Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection |
US20090214482A1 (en) * | 2005-04-13 | 2009-08-27 | Ximerex, Inc. | Transgenic Mammals Expressing Human Preproinsulin |
EP3003022B1 (en) | 2013-06-04 | 2017-11-22 | Virginia Commonwealth University | Use of a truncated ccn1 promoter for cancer diagnostics, therapeutics and theranostics |
US9701985B2 (en) | 2013-06-04 | 2017-07-11 | Virginia Commonwealth University | mda-9/syntenin promoter to image and treat metastatic cancer cells |
US11491241B2 (en) | 2017-11-07 | 2022-11-08 | The University Of North Carolina At Chapel Hill | Optimized AGA genes and expression cassettes and their use |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR70279B (es) * | 1979-09-12 | 1982-09-03 | Univ California | |
US4431740A (en) * | 1979-09-12 | 1984-02-14 | The Regents Of The University Of California | DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes |
US4423829A (en) * | 1980-08-28 | 1984-01-03 | Container Industries Inc. | Apparatus for containing and dispensing fluids under pressure and method of manufacturing same |
US4873191A (en) * | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
EP0081570A4 (en) * | 1981-06-12 | 1985-09-02 | Univ Ohio | GENETIC TRANSFORMATION OF ZYGOTS. |
ZA824218B (en) * | 1981-06-29 | 1983-04-27 | Cetus Corp | Plasmid for producing human insulin |
US4870009A (en) * | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
US4564517A (en) * | 1984-02-22 | 1986-01-14 | Fudenberg Herman H | Method for evaluating parameters related to the therapeutic and/or prophylactic treatment of solid neoplasms in humans |
US4736866A (en) * | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
-
1987
- 1987-05-19 DE DE3751863T patent/DE3751863T2/de not_active Expired - Fee Related
- 1987-05-19 AT AT93101772T patent/ATE212662T1/de not_active IP Right Cessation
- 1987-05-19 EP EP87107238A patent/EP0247494B1/en not_active Expired - Lifetime
- 1987-05-19 EP EP93101772A patent/EP0561140B1/en not_active Expired - Lifetime
- 1987-05-19 ES ES93101772T patent/ES2171401T3/es not_active Expired - Lifetime
- 1987-05-19 ES ES87107238T patent/ES2090006T3/es not_active Expired - Lifetime
- 1987-05-19 AT AT87107238T patent/ATE140846T1/de not_active IP Right Cessation
- 1987-05-19 DE DE3752347T patent/DE3752347T2/de not_active Expired - Fee Related
- 1987-05-20 WO PCT/US1987/001154 patent/WO1987007298A1/en unknown
- 1987-05-20 JP JP62503395A patent/JPH01502716A/ja active Pending
-
1995
- 1995-04-11 US US08/419,850 patent/US6018097A/en not_active Expired - Lifetime
-
1996
- 1996-10-09 GR GR960402659T patent/GR3021288T3/el unknown
-
1997
- 1997-07-07 JP JP9181034A patent/JPH10108587A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE140846T1 (de) | 1996-08-15 |
JPH01502716A (ja) | 1989-09-21 |
ATE212662T1 (de) | 2002-02-15 |
DE3751863T2 (de) | 1996-12-12 |
GR3021288T3 (en) | 1997-01-31 |
EP0247494B1 (en) | 1996-07-31 |
DE3752347T2 (de) | 2002-09-26 |
EP0561140B1 (en) | 2002-01-30 |
ES2090006T3 (es) | 1996-10-16 |
US6018097A (en) | 2000-01-25 |
EP0561140A1 (en) | 1993-09-22 |
WO1987007298A1 (en) | 1987-12-03 |
DE3751863D1 (de) | 1996-09-05 |
DE3752347D1 (de) | 2002-03-14 |
JPH10108587A (ja) | 1998-04-28 |
EP0247494A2 (en) | 1987-12-02 |
EP0247494A3 (en) | 1989-01-11 |
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