ES2146235T3 - Celulas endoteliales transformadas. - Google Patents
Celulas endoteliales transformadas.Info
- Publication number
- ES2146235T3 ES2146235T3 ES93924544T ES93924544T ES2146235T3 ES 2146235 T3 ES2146235 T3 ES 2146235T3 ES 93924544 T ES93924544 T ES 93924544T ES 93924544 T ES93924544 T ES 93924544T ES 2146235 T3 ES2146235 T3 ES 2146235T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- kappa
- endothelial cells
- activity
- endothelial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000002889 endothelial cell Anatomy 0.000 title abstract 4
- 102000008379 I-kappa B Proteins Human genes 0.000 abstract 3
- 108010021699 I-kappa B Proteins Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
- 238000002689 xenotransplantation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Husbandry (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biodiversity & Conservation Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE PUEDEN PREPARAR CELULAS ENDOTELIALES QUE PRESENTAN UNA PROTEINA QUE TIENE ACTIVIDAD IKB PARA QUE LA ACTIVACION DE NFKB DE LAS CELULAS ESTE SUBSTANCIALMENTE BLOQUEADA ALTERANDO EL MATERIAL GENETICO DE LAS CELULAS PARA QUE LA ACTIVIDAD IKB SE PRESENTE CONTINUAMENTE, INMEDIATAMENTE DESPUES DE QUE LAS CELULAS ENDOTELIALES ACTIVAN UN ESTIMULO O A PETICION EN RESPUESTA A UN ESTIMULO EXTERNO PREDETERMINADO V. G. INTRODUCIENDO IKB HETEROLOGO QUE CODIFICA SECUENCIAS O PROMOTORES EN LAS CELULAS. LOS ORGANOS Y TEJIDOS QUE COMPRENDEN TALES CELULAS ENDOTELIALES SON UTILES EN TRASPLANTES V. G. EXOTRANSPLANTES, PORQUE SON VENTAJOSAMENTE MENOS SUSCEPTIBLES DE RECHAZO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929222931A GB9222931D0 (en) | 1992-11-02 | 1992-11-02 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2146235T3 true ES2146235T3 (es) | 2000-08-01 |
Family
ID=10724398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93924544T Expired - Lifetime ES2146235T3 (es) | 1992-11-02 | 1993-10-29 | Celulas endoteliales transformadas. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0669977B1 (es) |
JP (1) | JPH08502653A (es) |
KR (1) | KR950704477A (es) |
AT (1) | ATE192492T1 (es) |
AU (1) | AU680636B2 (es) |
CA (1) | CA2143489A1 (es) |
DK (1) | DK0669977T3 (es) |
ES (1) | ES2146235T3 (es) |
FI (1) | FI952088A (es) |
GB (1) | GB9222931D0 (es) |
GR (1) | GR3033600T3 (es) |
NO (1) | NO951628L (es) |
NZ (1) | NZ257539A (es) |
PT (1) | PT669977E (es) |
RU (1) | RU2164415C2 (es) |
WO (1) | WO1994010305A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2726005B1 (fr) * | 1994-10-10 | 1997-01-03 | Adim | Lignees immortalisees de cellules endotheliales cerebrales et leurs applications au traitement de differents troubles ou maladies primaires et secondaires neurologiques ou psychiatriques |
EP0815252A1 (en) * | 1995-03-24 | 1998-01-07 | Novartis AG | Gene therapy for transplantation and inflammatory or thrombotic conditions |
WO1996032412A1 (fr) * | 1995-04-13 | 1996-10-17 | Chugai Seiyaku Kabushiki Kaisha | PEPTIDE SUPPRIMANT LA PHOSPHORYLATION IxB$g(a) |
JPH0959151A (ja) * | 1995-08-24 | 1997-03-04 | Kao Corp | NF−κB活性化抑制剤 |
EP0779361A3 (en) | 1995-12-15 | 1999-11-10 | F. Hoffmann-La Roche Ag | Truncated form of inhibitory kappa B protein (1kB), recombinant production and uses thereof |
CA2245503A1 (en) * | 1996-02-14 | 1997-08-21 | Novartis Ag | Gene therapy of entothelial cells with anti-apoptotic proteins for transplantation and inflammatory conditions |
WO2001052639A1 (en) | 2000-01-21 | 2001-07-26 | Beth Israel Deaconess Medical Center | Use of pro-apoptotic factors in treatment of atherosclerosis |
AU2004320466A1 (en) * | 2003-06-11 | 2006-02-02 | Jan Remmereit | Nuclear reprogramming of cells for therapeutic use |
TW201120210A (en) | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
US11028149B2 (en) | 2011-04-01 | 2021-06-08 | Chugai Seiyaku Kabushiki Kaisha | Recombinant polypeptide production method |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1341606C (en) * | 1988-03-01 | 2010-06-08 | Whitehead Institute For Biomedical Research | Activation of nf-kb precursor |
AU656544B2 (en) * | 1990-10-31 | 1995-02-09 | Brigham And Women's Hospital | Genetic modification of endothelial cells |
-
1992
- 1992-11-02 GB GB929222931A patent/GB9222931D0/en active Pending
-
1993
- 1993-10-29 DK DK93924544T patent/DK0669977T3/da active
- 1993-10-29 KR KR1019950701716A patent/KR950704477A/ko not_active Application Discontinuation
- 1993-10-29 NZ NZ257539A patent/NZ257539A/en unknown
- 1993-10-29 AT AT93924544T patent/ATE192492T1/de not_active IP Right Cessation
- 1993-10-29 ES ES93924544T patent/ES2146235T3/es not_active Expired - Lifetime
- 1993-10-29 EP EP93924544A patent/EP0669977B1/en not_active Expired - Lifetime
- 1993-10-29 JP JP6510706A patent/JPH08502653A/ja active Pending
- 1993-10-29 AU AU54404/94A patent/AU680636B2/en not_active Ceased
- 1993-10-29 RU RU95110697/14A patent/RU2164415C2/ru active
- 1993-10-29 PT PT93924544T patent/PT669977E/pt unknown
- 1993-10-29 WO PCT/EP1993/003015 patent/WO1994010305A1/en active IP Right Grant
- 1993-10-29 CA CA002143489A patent/CA2143489A1/en not_active Abandoned
-
1995
- 1995-04-28 NO NO951628A patent/NO951628L/no not_active Application Discontinuation
- 1995-05-02 FI FI952088A patent/FI952088A/fi unknown
-
2000
- 2000-06-30 GR GR20000401135T patent/GR3033600T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO951628L (no) | 1995-07-03 |
FI952088A0 (fi) | 1995-05-02 |
NZ257539A (en) | 1996-08-27 |
DK0669977T3 (da) | 2000-08-07 |
FI952088A (fi) | 1995-05-02 |
EP0669977A1 (en) | 1995-09-06 |
EP0669977B1 (en) | 2000-05-03 |
GB9222931D0 (en) | 1992-12-16 |
RU2164415C2 (ru) | 2001-03-27 |
KR950704477A (ko) | 1995-11-20 |
NO951628D0 (no) | 1995-04-28 |
AU680636B2 (en) | 1997-08-07 |
GR3033600T3 (en) | 2000-09-29 |
AU5440494A (en) | 1994-05-24 |
CA2143489A1 (en) | 1994-05-11 |
JPH08502653A (ja) | 1996-03-26 |
ATE192492T1 (de) | 2000-05-15 |
WO1994010305A1 (en) | 1994-05-11 |
PT669977E (pt) | 2000-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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