ATE192492T1 - Transformierte endothelzellen - Google Patents

Transformierte endothelzellen

Info

Publication number
ATE192492T1
ATE192492T1 AT93924544T AT93924544T ATE192492T1 AT E192492 T1 ATE192492 T1 AT E192492T1 AT 93924544 T AT93924544 T AT 93924544T AT 93924544 T AT93924544 T AT 93924544T AT E192492 T1 ATE192492 T1 AT E192492T1
Authority
AT
Austria
Prior art keywords
cells
kappa
endothelial cells
activity
endothelial
Prior art date
Application number
AT93924544T
Other languages
English (en)
Inventor
Fritz H Bach
Martin Rainer De
Original Assignee
Novartis Ag
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Erfind Verwalt Gmbh filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE192492T1 publication Critical patent/ATE192492T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT93924544T 1992-11-02 1993-10-29 Transformierte endothelzellen ATE192492T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929222931A GB9222931D0 (en) 1992-11-02 1992-11-02 Organic compounds
PCT/EP1993/003015 WO1994010305A1 (en) 1992-11-02 1993-10-29 Transformed endothelial cells

Publications (1)

Publication Number Publication Date
ATE192492T1 true ATE192492T1 (de) 2000-05-15

Family

ID=10724398

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93924544T ATE192492T1 (de) 1992-11-02 1993-10-29 Transformierte endothelzellen

Country Status (16)

Country Link
EP (1) EP0669977B1 (de)
JP (1) JPH08502653A (de)
KR (1) KR950704477A (de)
AT (1) ATE192492T1 (de)
AU (1) AU680636B2 (de)
CA (1) CA2143489A1 (de)
DK (1) DK0669977T3 (de)
ES (1) ES2146235T3 (de)
FI (1) FI952088A0 (de)
GB (1) GB9222931D0 (de)
GR (1) GR3033600T3 (de)
NO (1) NO951628L (de)
NZ (1) NZ257539A (de)
PT (1) PT669977E (de)
RU (1) RU2164415C2 (de)
WO (1) WO1994010305A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2726005B1 (fr) * 1994-10-10 1997-01-03 Adim Lignees immortalisees de cellules endotheliales cerebrales et leurs applications au traitement de differents troubles ou maladies primaires et secondaires neurologiques ou psychiatriques
AU5147996A (en) * 1995-03-24 1996-10-16 New England Deaconess Hospital Corporation Gene therapy for transplantation and inflammatory or thrombo tic conditions
WO1996032412A1 (fr) * 1995-04-13 1996-10-17 Chugai Seiyaku Kabushiki Kaisha PEPTIDE SUPPRIMANT LA PHOSPHORYLATION IxB$g(a)
JPH0959151A (ja) * 1995-08-24 1997-03-04 Kao Corp ＮＦ−κＢ活性化抑制剤
EP0779361A3 (de) 1995-12-15 1999-11-10 F. Hoffmann-La Roche Ag Verkürzte Form von Kappa B Inhibitor-Protein, rekombinanter Herstellung und Verwendung
CA2245503A1 (en) * 1996-02-14 1997-08-21 Novartis Ag Gene therapy of entothelial cells with anti-apoptotic proteins for transplantation and inflammatory conditions
WO2001052639A1 (en) 2000-01-21 2001-07-26 Beth Israel Deaconess Medical Center Use of pro-apoptotic factors in treatment of atherosclerosis
EP1702062A2 (de) * 2003-06-11 2006-09-20 Jan Remmereit Kern-umprogrammierung von zellen für die therapeutische verwendung
TW201120210A (en) 2009-11-05 2011-06-16 Hoffmann La Roche Glycosylated repeat-motif-molecule conjugates
CN108546295B (zh) 2011-04-01 2022-08-09 中外制药株式会社 重组多肽的制造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68910682T2 (de) * 1988-03-01 1994-06-01 Whitehead Biomedical Inst Aktivierung der nf-kappa b-vorstufe.
WO1992007573A1 (en) * 1990-10-31 1992-05-14 Somatix Therapy Corporation Genetic modification of endothelial cells

Also Published As

Publication number Publication date
GB9222931D0 (en) 1992-12-16
ES2146235T3 (es) 2000-08-01
PT669977E (pt) 2000-08-31
WO1994010305A1 (en) 1994-05-11
NO951628L (no) 1995-07-03
GR3033600T3 (en) 2000-09-29
EP0669977A1 (de) 1995-09-06
CA2143489A1 (en) 1994-05-11
NO951628D0 (no) 1995-04-28
KR950704477A (ko) 1995-11-20
FI952088A (fi) 1995-05-02
FI952088A0 (fi) 1995-05-02
RU2164415C2 (ru) 2001-03-27
JPH08502653A (ja) 1996-03-26
AU5440494A (en) 1994-05-24
DK0669977T3 (da) 2000-08-07
NZ257539A (en) 1996-08-27
AU680636B2 (en) 1997-08-07
EP0669977B1 (de) 2000-05-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee