DK0669977T3 - Transformerede endothelceller - Google Patents
Transformerede endothelcellerInfo
- Publication number
- DK0669977T3 DK0669977T3 DK93924544T DK93924544T DK0669977T3 DK 0669977 T3 DK0669977 T3 DK 0669977T3 DK 93924544 T DK93924544 T DK 93924544T DK 93924544 T DK93924544 T DK 93924544T DK 0669977 T3 DK0669977 T3 DK 0669977T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- kappa
- endothelial cells
- activity
- endothelial
- Prior art date
Links
- 210000002889 endothelial cell Anatomy 0.000 title abstract 4
- 102000008379 I-kappa B Proteins Human genes 0.000 abstract 3
- 108010021699 I-kappa B Proteins Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
- 238000002689 xenotransplantation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biodiversity & Conservation Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Animal Husbandry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929222931A GB9222931D0 (en) | 1992-11-02 | 1992-11-02 | Organic compounds |
| PCT/EP1993/003015 WO1994010305A1 (en) | 1992-11-02 | 1993-10-29 | Transformed endothelial cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0669977T3 true DK0669977T3 (da) | 2000-08-07 |
Family
ID=10724398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93924544T DK0669977T3 (da) | 1992-11-02 | 1993-10-29 | Transformerede endothelceller |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0669977B1 (da) |
| JP (1) | JPH08502653A (da) |
| KR (1) | KR950704477A (da) |
| AT (1) | ATE192492T1 (da) |
| AU (1) | AU680636B2 (da) |
| CA (1) | CA2143489A1 (da) |
| DK (1) | DK0669977T3 (da) |
| ES (1) | ES2146235T3 (da) |
| FI (1) | FI952088A (da) |
| GB (1) | GB9222931D0 (da) |
| GR (1) | GR3033600T3 (da) |
| NO (1) | NO951628L (da) |
| NZ (1) | NZ257539A (da) |
| PT (1) | PT669977E (da) |
| RU (1) | RU2164415C2 (da) |
| WO (1) | WO1994010305A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2726005B1 (fr) * | 1994-10-10 | 1997-01-03 | Adim | Lignees immortalisees de cellules endotheliales cerebrales et leurs applications au traitement de differents troubles ou maladies primaires et secondaires neurologiques ou psychiatriques |
| AU5147996A (en) * | 1995-03-24 | 1996-10-16 | New England Deaconess Hospital Corporation | Gene therapy for transplantation and inflammatory or thrombo tic conditions |
| US5981486A (en) * | 1995-04-13 | 1999-11-09 | Chugai Seiyaku Kabushiki Kaisha | Peptide suppressing IκBα phosphorylation |
| JPH0959151A (ja) * | 1995-08-24 | 1997-03-04 | Kao Corp | ＮＦ−κＢ活性化抑制剤 |
| EP0779361A3 (en) | 1995-12-15 | 1999-11-10 | F. Hoffmann-La Roche Ag | Truncated form of inhibitory kappa B protein (1kB), recombinant production and uses thereof |
| EP0886650A1 (en) * | 1996-02-14 | 1998-12-30 | Novartis AG | Gene therapy of entothelial cells with anti-apoptotic proteins for transplantation and inflammatory conditions |
| AU2001231009A1 (en) | 2000-01-21 | 2001-07-31 | Beth Israel Deaconess Medical Center | Use of pro-apoptotic factors in treatment of atherosclerosis |
| WO2006040615A2 (en) * | 2003-06-11 | 2006-04-20 | Jan Remmereit | Differenciation of stem cells for therapeutic use |
| TW201120210A (en) | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
| CN103459608B (zh) | 2011-04-01 | 2018-05-01 | 中外制药株式会社 | 重组多肽的制造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341606C (en) * | 1988-03-01 | 2010-06-08 | Whitehead Institute For Biomedical Research | Activation of nf-kb precursor |
| DE69123981T3 (de) * | 1990-10-31 | 2006-06-14 | Cell Genesys Inc | Nützliche retrovirale vektoren für die gentherapie |
-
1992
- 1992-11-02 GB GB929222931A patent/GB9222931D0/en active Pending
-
1993
- 1993-10-29 CA CA002143489A patent/CA2143489A1/en not_active Abandoned
- 1993-10-29 NZ NZ257539A patent/NZ257539A/en unknown
- 1993-10-29 PT PT93924544T patent/PT669977E/pt unknown
- 1993-10-29 DK DK93924544T patent/DK0669977T3/da active
- 1993-10-29 ES ES93924544T patent/ES2146235T3/es not_active Expired - Lifetime
- 1993-10-29 AU AU54404/94A patent/AU680636B2/en not_active Ceased
- 1993-10-29 WO PCT/EP1993/003015 patent/WO1994010305A1/en active IP Right Grant
- 1993-10-29 JP JP6510706A patent/JPH08502653A/ja active Pending
- 1993-10-29 KR KR1019950701716A patent/KR950704477A/ko not_active Application Discontinuation
- 1993-10-29 EP EP93924544A patent/EP0669977B1/en not_active Expired - Lifetime
- 1993-10-29 RU RU95110697/14A patent/RU2164415C2/ru active
- 1993-10-29 AT AT93924544T patent/ATE192492T1/de not_active IP Right Cessation
-
1995
- 1995-04-28 NO NO951628A patent/NO951628L/no not_active Application Discontinuation
- 1995-05-02 FI FI952088A patent/FI952088A/fi unknown
-
2000
- 2000-06-30 GR GR20000401135T patent/GR3033600T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR950704477A (ko) | 1995-11-20 |
| FI952088A0 (fi) | 1995-05-02 |
| ATE192492T1 (de) | 2000-05-15 |
| NO951628D0 (no) | 1995-04-28 |
| RU2164415C2 (ru) | 2001-03-27 |
| AU5440494A (en) | 1994-05-24 |
| PT669977E (pt) | 2000-08-31 |
| GB9222931D0 (en) | 1992-12-16 |
| AU680636B2 (en) | 1997-08-07 |
| EP0669977A1 (en) | 1995-09-06 |
| EP0669977B1 (en) | 2000-05-03 |
| CA2143489A1 (en) | 1994-05-11 |
| NO951628L (no) | 1995-07-03 |
| ES2146235T3 (es) | 2000-08-01 |
| WO1994010305A1 (en) | 1994-05-11 |
| NZ257539A (en) | 1996-08-27 |
| FI952088A (fi) | 1995-05-02 |
| GR3033600T3 (en) | 2000-09-29 |
| JPH08502653A (ja) | 1996-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3280479T2 (de) | Rekombinante DNS-Mittel und Verfahren | |
| DE69420726D1 (de) | Embryonische stammzelle zur herstellung von chimäre und transgen-ongulaten | |
| DE69333466D1 (de) | Herstellung von transplantatgeweben aus extrazellulärer matrix | |
| CA2063810A1 (en) | Production of vascular endothelial cell growth factor | |
| ES2093025T3 (es) | Produccion del factor de crecimiento de celulas endoteliales y adn de codificacion del mismo. | |
| DE69534227D1 (de) | Stoffe und verfahren zur beherrschung der hyperakuten abstossung von menschlichen transplantaten | |
| EE9700018A (et) | Bioloogilistesse tehiselunditesse kapseldatud rakkude kasvu kontrollimine | |
| ES2146235T3 (es) | Celulas endoteliales transformadas. | |
| DE69434312D1 (de) | Regulierung von pflanzenwachstum | |
| ATE211177T1 (de) | Expression von aktivem menschlichem protein c im milchdrüsengewebe transgener tiere | |
| ATE71298T1 (de) | Immunoregulation. | |
| ATE360701T1 (de) | Putrescin-n-methyltransferasepromotor | |
| DK0744891T3 (da) | Transgene fibrinogener | |
| ZA843015B (en) | Novel strain of trichoderma harzianum,method of isolating said strain,method of cultivating said strain,novel peptides or compounds produced from said strain,and application of said strain and of said novel peptides or of the product obtained by the cultivation method as a biologically active means in the form of a plant-disease control product | |
| ATE286129T1 (de) | Pflanzenwurzelspezifischer promotor, rekombinante vektoren und wirtszellen die diesen enthalten und korrespondierende transgene pflanzen | |
| ATE208422T1 (de) | Pflanzenverlängerungsfaktor, promotoren, kodierende sequenzen und verwendungen | |
| DE69331434D1 (de) | Mutanter AOX2 Promotor, diesen enthaltender Vektor, transformierte Zellen und Herstellung von heterologen Proteinen | |
| ATE377084T1 (de) | Transgene pflanzen und pflanzenzellen mit verminderter expression von invertaseinhibitoren | |
| ATE90969T1 (de) | Expression von fremden genen in drosophilazellen. | |
| ATE401001T1 (de) | Pflanzen zur kontrolle von schäden verursacht durch fressende insekten |