DE69133355T2 - Transgene tiere, zellen und zelllinien daraus und deren verwendung - Google Patents

Transgene tiere, zellen und zelllinien daraus und deren verwendung Download PDF

Info

Publication number
DE69133355T2
DE69133355T2 DE69133355T DE69133355T DE69133355T2 DE 69133355 T2 DE69133355 T2 DE 69133355T2 DE 69133355 T DE69133355 T DE 69133355T DE 69133355 T DE69133355 T DE 69133355T DE 69133355 T2 DE69133355 T2 DE 69133355T2
Authority
DE
Germany
Prior art keywords
sequence
cells
cell lines
differentiation
control
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133355T
Other languages
English (en)
Other versions
DE69133355D1 (de
Inventor
Mark David Noble
Parmjit Singh Jat
Dimitris Kioussis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Ludwig Institute for Cancer Research New York
Original Assignee
Medical Research Council
Ludwig Institute for Cancer Research New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council, Ludwig Institute for Cancer Research New York filed Critical Medical Research Council
Application granted granted Critical
Publication of DE69133355D1 publication Critical patent/DE69133355D1/de
Publication of DE69133355T2 publication Critical patent/DE69133355T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catching Or Destruction (AREA)
DE69133355T 1990-02-20 1991-02-20 Transgene tiere, zellen und zelllinien daraus und deren verwendung Expired - Lifetime DE69133355T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909003791A GB9003791D0 (en) 1990-02-20 1990-02-20 Transgenic animals,cell lines therefrom,and their use
PCT/GB1991/000262 WO1991013150A1 (en) 1990-02-20 1991-02-20 Transgenic animals, cells and cell lines therefrom, and their use

Publications (2)

Publication Number Publication Date
DE69133355D1 DE69133355D1 (de) 2004-02-26
DE69133355T2 true DE69133355T2 (de) 2004-10-21

Family

ID=10671295

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69133355T Expired - Lifetime DE69133355T2 (de) 1990-02-20 1991-02-20 Transgene tiere, zellen und zelllinien daraus und deren verwendung

Country Status (12)

Country Link
US (1) US5688692A (de)
EP (1) EP0516664B1 (de)
JP (1) JP3333902B2 (de)
AT (1) ATE258226T1 (de)
AU (2) AU660604B2 (de)
CA (1) CA2076345C (de)
DE (1) DE69133355T2 (de)
DK (1) DK0516664T3 (de)
ES (1) ES2213742T3 (de)
GB (1) GB9003791D0 (de)
IE (1) IE910572A1 (de)
WO (1) WO1991013150A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866759A (en) * 1991-02-20 1999-02-02 Ludwig Institute For Cancer Research Transgenic mice expressing TSSV40 large T antigen
US7361505B1 (en) * 1991-07-08 2008-04-22 Neurospheres Holdings Ltd. Multipotent neural stem cell compositions
US5489743A (en) * 1993-01-19 1996-02-06 Amgen Inc. Transgenic animal models for thrombocytopenia
US5700657A (en) * 1993-12-13 1997-12-23 Genzyme Corporation Vectors and vector systems including genes encoding tumor suppressor proteins and producer cells transformed thereby
US6392118B1 (en) * 1994-07-20 2002-05-21 Neurotech S.A. Mx-1 conditionally immortalized cells
US5935849A (en) * 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
AUPM710194A0 (en) * 1994-07-26 1994-08-18 Commonwealth Scientific And Industrial Research Organisation Virus vector
EP0804554A1 (de) * 1994-09-09 1997-11-05 ZymoGenetics, Inc. Herstellung von immortalisierten zellen
EP0792351B1 (de) * 1994-11-08 2004-03-10 Cellfactors PLC Methode zur herstellung einer menschlichen neuralen zelllinie
US6495364B2 (en) 1995-05-23 2002-12-17 Neurotech, S.A. Mx-1 conditionally immortalized cells
US5994619A (en) * 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
US5905042A (en) * 1996-04-01 1999-05-18 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Cultured inner cell mass cell lines derived from bovine or porcine embryos
GB9607953D0 (en) * 1996-04-17 1996-06-19 Univ Liverpool Transgenic rat
US6235969B1 (en) 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US6215041B1 (en) 1997-01-10 2001-04-10 University Of Mmassachusetts Cloning using donor nuclei from a non-quiesecent somatic cells
FR2761576B1 (fr) * 1997-04-04 2002-08-30 Inst Nat Sante Rech Med Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee
AU8284198A (en) 1997-07-02 1999-01-25 Board Of Regents, The University Of Texas System P53 as a regulator of cell differentiation
US6235527B1 (en) * 1997-11-29 2001-05-22 University Of Utah Research Foundation Lineage restricted glial precursors from the central nervous system
WO2000068359A1 (en) * 1999-05-07 2000-11-16 University Of Utah Research Foundation Lineage-restricted precursor cells isolated from mouse neural tube and mouse embryonic stem cells
US6498285B1 (en) * 1997-08-06 2002-12-24 Alexion Pharmaceuticals, Inc. Methods for producing transgenic pigs by microinjecting a blastomere
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
ATE317906T1 (de) * 1998-10-02 2006-03-15 Fact Co Ltd Methode zur herstellung von choroid plexus immortalisierten zelllinien
JP4321936B2 (ja) * 2000-02-16 2009-08-26 独立行政法人科学技術振興機構 不死化血管周皮細胞株
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US20050074747A1 (en) * 2000-09-08 2005-04-07 Wadih Arap Biopanning and rapid analysis of selective interactive ligands (brasil)
US7452964B2 (en) * 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
EP1418932A4 (de) * 2001-07-18 2006-03-15 Univ Texas Antiangiogener zustand bei mäusen und menschen mit retinaler photorezeptor-degeneration
US8507445B2 (en) * 2001-09-07 2013-08-13 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US7671010B2 (en) * 2002-08-30 2010-03-02 The Board Of Regents Of The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US20040048243A1 (en) * 2001-09-07 2004-03-11 Wadih Arap Methods and compositions for in vitro targeting
GB2387599B (en) * 2002-04-17 2005-08-10 Jason Peter Brown Methods for producing antibodies
WO2004092220A1 (en) * 2003-04-14 2004-10-28 Board Of Regents, The University Of Texas System Methods for ex vivo hybridoma-free production of polyclonal and monoclonal antibodies and generation of immortalized cell populations
JP2008501356A (ja) * 2004-06-09 2008-01-24 ザ・ユニバーシティ・コート・オブ・ザ・ユニバーシティ・オブ・エディンバラ 神経幹細胞
WO2010075500A1 (en) 2008-12-23 2010-07-01 Stemcells California, Inc Target populations of oligodendrocyte precursor cells and methods of making and using same
WO2016086197A1 (en) 2014-11-25 2016-06-02 The Brigham And Women's Hospital, Inc. Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
WO2016085876A1 (en) 2014-11-25 2016-06-02 The Broad Institute Inc. Clonal haematopoiesis
CN116590345B (zh) * 2023-05-06 2024-01-30 北京中医药大学 永生化小鼠足细胞系及其制备方法、分化方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870009A (en) * 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4736866B1 (en) * 1984-06-22 1988-04-12 Transgenic non-human mammals
US5087571A (en) * 1984-06-22 1992-02-11 President And Fellows Of Harvard College Method for providing a cell culture from a transgenic non-human mammal
FR2596414B1 (fr) * 1986-03-28 1989-10-06 Pasteur Institut Hybridomes obtenus a partir de lymphocytes d'animaux transgeniques portant un gene exprimant une proteine donnee et procede de preparation d'une telle proteine a partir de tels hybridomes
EP0247494B1 (de) * 1986-05-20 1996-07-31 The General Hospital Corporation Methode zur Bestimmung des Effektes eines heterologen Agens auf ein Tier
DE3681738D1 (de) * 1986-10-15 1991-10-31 Battelle Memorial Institute, Carouge, Genf/Geneve, Ch
ATE132266T1 (de) * 1987-05-01 1996-01-15 Stratagene Inc Mutagenesetest durch verwendung von nicht menschlichen lebewesen, die test-dns-sequenzen enthalten
FR2637613B1 (fr) * 1987-06-19 1991-09-27 Transgene Sa Procede de preparation de lignees cellulaires stables pour la production de proteines determinees, a partir d'animaux transgeniques; lignees cellulaires tumorales et proteines obtenues
AU2900389A (en) * 1987-12-15 1989-07-19 Trustees Of Princeton University, The Transgenic testing systems for mutagens and carcinogens
US5270191A (en) * 1988-04-12 1993-12-14 Massachusetts Institute Of Technology Method for manipulation of the cell types of eukaryotes
EP0428519B1 (de) * 1988-04-12 1993-06-16 Massachusetts Institute Of Technology Verfahren zur manipulation des zelltyps von eukaryonten
EP0351921A3 (de) * 1988-07-22 1991-07-17 Merck & Co. Inc. Modifizierter beta-adrenergischer Rezeptor
NZ230723A (en) * 1988-09-21 1992-07-28 Cambridge Animal Biotech Pluripotential embryonic stem cells isolated from an embryonic disc, methods of producing transgenic cells and a chimeric foetus
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
FR2649721B1 (fr) * 1989-07-13 1994-07-08 Univ Paris Construction immortalisante pour l'immortalisation cellulaire conditionnelle

Also Published As

Publication number Publication date
JPH05504066A (ja) 1993-07-01
GB9003791D0 (en) 1990-04-18
CA2076345A1 (en) 1991-08-21
AU7328691A (en) 1991-09-18
AU676118B2 (en) 1997-02-27
JP3333902B2 (ja) 2002-10-15
WO1991013150A1 (en) 1991-09-05
ATE258226T1 (de) 2004-02-15
EP0516664A1 (de) 1992-12-09
AU3305395A (en) 1996-01-11
US5688692A (en) 1997-11-18
IE910572A1 (en) 1991-08-28
DK0516664T3 (da) 2004-05-24
ES2213742T3 (es) 2004-09-01
DE69133355D1 (de) 2004-02-26
EP0516664B1 (de) 2004-01-21
CA2076345C (en) 2006-11-28
AU660604B2 (en) 1995-07-06

Similar Documents

Publication Publication Date Title
DE69133355D1 (de) Transgene tiere, zellen und zelllinien daraus und deren verwendung
Schwenk et al. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.
Jans et al. Powerful skin cancer protection by a CPD-photolyase transgene
Madison et al. Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
Nottoli et al. AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice
Lee et al. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
Jonsson et al. Insulin-promoter-factor 1 is required for pancreas development in mice
Namkung et al. Targeted disruption of the Ca2+ channel β3 subunit reduces N-and L-type Ca2+ channel activity and alters the voltagedependent activation of P/Q-type Ca2+ channels in neurons
Guo et al. A Cre recombinase transgene with mosaic, widespread tamoxifen‐inducible action
Shen et al. Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice
EP0591219A4 (en) Expression of active human protein c in mammary tissue of transgenic animals
ATE288484T1 (de) Transgene nicht-menschliche tiere ohne prionprotein
Sarao et al. Conditional transgene expression in endothelial cells
Cao et al. Regulated cutaneous gene delivery: the skin as a bioreactor
Sasaoka et al. Analysis of the human tyrosine hydroxylase promoter-chloramphenicol acetyltransferase chimeric gene expression in transgenic mice
Roubertoux et al. Differences between CBA/H and NZB mice on intermale aggression. II. Maternal effects
DK0669977T3 (da) Transformerede endothelceller
Saito et al. ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma
Jerecic et al. Studies on conditional gene expression in the brain
Yin et al. Development of a pituitary‐specific cre line targeted to the Pit‐1 lineage
BR0317765A (pt) Promotor artificial, fragmento de dna de um promotor artificial, cassete, vetor de dna, célula bacteriana, célula vegetal, planta transgência, descendência de plantas, e, purificação e utilização de uma proteìna recombinante
ATE313256T1 (de) Transgene schweine
Simoni Transgenic animals in male reproduction research
Qu et al. Mutations at the Ser50 residue of translation factor eIF-2a dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster
US20060064764A1 (en) Increasing gamete production with a gene switch

Legal Events

Date Code Title Description
8364 No opposition during term of opposition