DK0474691T3 - Monoklonale antistoffer til induktion af tolerance - Google Patents

Monoklonale antistoffer til induktion af tolerance

Info

Publication number
DK0474691T3
DK0474691T3 DK90908270.3T DK90908270T DK0474691T3 DK 0474691 T3 DK0474691 T3 DK 0474691T3 DK 90908270 T DK90908270 T DK 90908270T DK 0474691 T3 DK0474691 T3 DK 0474691T3
Authority
DK
Denmark
Prior art keywords
depleting
monoclonal antibodies
induce tolerance
monoclonal antibody
tolerance
Prior art date
Application number
DK90908270.3T
Other languages
Danish (da)
English (en)
Inventor
Stephen Paul Cobbold
Herman Waldmann
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of DK0474691T3 publication Critical patent/DK0474691T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK90908270.3T 1989-05-31 1990-05-31 Monoklonale antistoffer til induktion af tolerance DK0474691T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898912497A GB8912497D0 (en) 1989-05-31 1989-05-31 Monoclonal antibodies

Publications (1)

Publication Number Publication Date
DK0474691T3 true DK0474691T3 (da) 1996-12-02

Family

ID=10657649

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90908270.3T DK0474691T3 (da) 1989-05-31 1990-05-31 Monoklonale antistoffer til induktion af tolerance

Country Status (19)

Country Link
EP (1) EP0474691B1 (fr)
JP (1) JP2763197B2 (fr)
KR (1) KR0183029B1 (fr)
AT (1) ATE145246T1 (fr)
AU (1) AU657255B2 (fr)
CA (1) CA2055615C (fr)
DD (1) DD296843A5 (fr)
DE (1) DE69029134T2 (fr)
DK (1) DK0474691T3 (fr)
ES (1) ES2096588T3 (fr)
GB (1) GB8912497D0 (fr)
HU (1) HUT61341A (fr)
IE (1) IE80735B1 (fr)
IL (1) IL94566A0 (fr)
MY (1) MY135673A (fr)
NZ (1) NZ233889A (fr)
PT (1) PT94214B (fr)
WO (1) WO1990015152A1 (fr)
ZA (1) ZA904174B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100741D0 (en) * 1991-01-14 1991-02-27 Univ London Treatment of disease
US6136310A (en) * 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
ES2112431T3 (es) * 1992-08-21 1998-04-01 Genentech Inc Procedimiento para el tratamiento de un trastorno mediado por lfa-1.
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
PT840618E (pt) * 1995-05-18 2003-08-29 Ortho Mcneil Pharm Inc Inducao de tolerancia imunologica atraves de anticorpos anti-cd4 nao-depletores
KR100942863B1 (ko) 1999-08-24 2010-02-17 메다렉스, 인코포레이티드 인간 씨티엘에이-4 항체 및 그의 용도
US7011952B2 (en) 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
EP2026073B1 (fr) 2000-04-29 2016-03-30 University Of Iowa Research Foundation Diagnostics et thérapeutiques pour les maladies liées à la dégénérescence maculaire
JP4448906B2 (ja) * 2001-06-14 2010-04-14 イシス イノベーション リミテッド Ｃｄ４特異的抗体ｔｒｘ１およびその使用
US7541443B2 (en) 2001-06-14 2009-06-02 Tolerrx, Inc. Anti-CD4 antibodies
EP1460088A1 (fr) 2003-03-21 2004-09-22 Biotest AG Anticorps humanisé contre CD4 avec des caractéristiques immunosuppressives
GB0314461D0 (en) * 2003-06-20 2003-07-23 Isis Innovation Suppression of transplant rejection
JP2008503593A (ja) * 2004-06-22 2008-02-07 トーラーレックス， インク． 霊長類で寛容を誘導するための抗ｃｄ４抗体で最適化された投薬
MX2010010028A (es) 2008-03-13 2011-08-17 Biotest Ag Agente para tratar enfermedad.
SG190627A1 (en) 2008-03-13 2013-06-28 Biotest Ag Agent for treating disease
EP2262838B1 (fr) 2008-03-13 2016-04-13 Biotest AG Agent pour traiter une maladie
CN102112491A (zh) * 2008-06-06 2011-06-29 贝勒研究院 抗-cd8抗体阻断细胞毒素效应物的引发并导致调节性cd8+t细胞的产生
TW201016233A (en) * 2008-07-15 2010-05-01 Genentech Inc Methods of treating autoimmune diseases using CD4 antibodies
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
WO2024112867A1 (fr) 2022-11-23 2024-05-30 University Of Georgia Research Foundation, Inc. Compositions et méthodes d'utilisation de celles-ci pour augmenter les réponses immunitaires

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies

Also Published As

Publication number Publication date
AU5725890A (en) 1991-01-07
CA2055615C (fr) 2001-07-17
WO1990015152A1 (fr) 1990-12-13
DD296843A5 (de) 1991-12-19
PT94214A (pt) 1991-02-08
MY135673A (en) 2008-06-30
JPH04505919A (ja) 1992-10-15
KR0183029B1 (ko) 1999-04-01
ZA904174B (en) 1992-02-26
IL94566A0 (en) 1991-03-10
CA2055615A1 (fr) 1990-12-13
NZ233889A (en) 1997-06-24
HUT61341A (en) 1992-12-28
DE69029134D1 (de) 1996-12-19
HU905134D0 (en) 1992-02-28
PT94214B (pt) 1997-03-31
IE80735B1 (en) 1998-12-30
AU657255B2 (en) 1995-03-09
ES2096588T3 (es) 1997-03-16
EP0474691B1 (fr) 1996-11-13
IE901949L (en) 1990-11-30
ATE145246T1 (de) 1996-11-15
DE69029134T2 (de) 1997-03-06
EP0474691A1 (fr) 1992-03-18
JP2763197B2 (ja) 1998-06-11
GB8912497D0 (en) 1989-07-19

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