DK0462017T3 - Fremgangsmåde til industriel fremstilling af 3-sulfamoyl-4-chlor-N-(2,3-dihydro-2-methyl-1H-indol- 1H-indol-1-yl)-benzamid ved at gå ud fra 2,3-dihydro-2-methyl-1H-indol og hydroxylamin-O-sulfonsyre - Google Patents

Fremgangsmåde til industriel fremstilling af 3-sulfamoyl-4-chlor-N-(2,3-dihydro-2-methyl-1H-indol- 1H-indol-1-yl)-benzamid ved at gå ud fra 2,3-dihydro-2-methyl-1H-indol og hydroxylamin-O-sulfonsyre

Info

Publication number
DK0462017T3
DK0462017T3 DK91401583.9T DK91401583T DK0462017T3 DK 0462017 T3 DK0462017 T3 DK 0462017T3 DK 91401583 T DK91401583 T DK 91401583T DK 0462017 T3 DK0462017 T3 DK 0462017T3
Authority
DK
Denmark
Prior art keywords
dihydro
methyl
indol
benzamide
hydroxylamine
Prior art date
Application number
DK91401583.9T
Other languages
Danish (da)
English (en)
Inventor
Roger Thevignot
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0462017T3 publication Critical patent/DK0462017T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK91401583.9T 1990-06-14 1991-06-14 Fremgangsmåde til industriel fremstilling af 3-sulfamoyl-4-chlor-N-(2,3-dihydro-2-methyl-1H-indol- 1H-indol-1-yl)-benzamid ved at gå ud fra 2,3-dihydro-2-methyl-1H-indol og hydroxylamin-O-sulfonsyre DK0462017T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9007387A FR2663325B1 (fr) 1990-06-14 1990-06-14 Nouveau procede de preparation industrielle du 4-chloro 3-sulfamoyl n-(2,3-dihydro 2-methyl 1h-indol-1-yl) benzamide a partir de la 2,3-dihydro 2-methyl 1h-indole et de l'acide hydroxylamine-o-sulfonique.

Publications (1)

Publication Number Publication Date
DK0462017T3 true DK0462017T3 (da) 1993-10-18

Family

ID=9397580

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91401583.9T DK0462017T3 (da) 1990-06-14 1991-06-14 Fremgangsmåde til industriel fremstilling af 3-sulfamoyl-4-chlor-N-(2,3-dihydro-2-methyl-1H-indol- 1H-indol-1-yl)-benzamid ved at gå ud fra 2,3-dihydro-2-methyl-1H-indol og hydroxylamin-O-sulfonsyre

Country Status (15)

Country Link
US (1) US5110946A (de)
EP (1) EP0462017B1 (de)
JP (1) JPH0665198A (de)
AT (1) ATE92044T1 (de)
AU (1) AU630816B2 (de)
CA (1) CA2044186C (de)
DE (1) DE69100200T2 (de)
DK (1) DK0462017T3 (de)
ES (1) ES2060324T3 (de)
FR (1) FR2663325B1 (de)
IE (1) IE66022B1 (de)
NZ (1) NZ238525A (de)
OA (1) OA09366A (de)
PT (1) PT97954B (de)
ZA (1) ZA914568B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663324B1 (fr) * 1990-06-14 1992-09-04 Adir Nouveau procede de preparation industrielle du 4-chloro 3-sulfamoyl n-(2,3-dihydro 2-methyl 1h-indol-1-yl) benzamide.
CN100422146C (zh) * 2006-09-25 2008-10-01 天津力生制药股份有限公司 一种吲达帕胺的合成方法
CN103467355A (zh) * 2013-09-12 2013-12-25 迪沙药业集团有限公司 一种吲达帕胺的制备方法
CN112142643A (zh) * 2020-10-10 2020-12-29 天津和治药业集团有限公司 一种吲达帕胺的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203691A (en) * 1968-03-06 1970-09-03 Science Union & Cie New disubstituted n-amino indoline derivatives and process for preparing them
EP0054892B1 (de) * 1980-12-22 1985-09-18 SCIENCE UNION ET Cie Synthese von Indolinen
US4570001A (en) * 1980-12-22 1986-02-11 Science Union Et Cie Process for synthesizing certain N-benzoylamino indolines
JPS57206657A (en) * 1981-06-16 1982-12-18 Mitsui Toatsu Chem Inc Sulfamoylbenzoic acid derivative and remedying composition containing said derivative as active component
JPH0233030B2 (ja) * 1982-01-18 1990-07-25 Mitsui Toatsu Chemicals Surufuamoiruansokukosanjudotaioyobisoreojukoseibuntoshitefukumuchiryoyososeibutsu
JPS58124767A (ja) * 1982-01-21 1983-07-25 Mitsui Toatsu Chem Inc スルファモイル安息香酸誘導体
US4564677A (en) * 1984-01-19 1986-01-14 Usv Pharmaceutical Corp. Preparation of N-amino compounds

Also Published As

Publication number Publication date
EP0462017A1 (de) 1991-12-18
PT97954A (pt) 1992-03-31
JPH0665198A (ja) 1994-03-08
EP0462017B1 (de) 1993-07-28
ES2060324T3 (es) 1994-11-16
ZA914568B (en) 1992-03-25
FR2663325B1 (fr) 1992-09-04
CA2044186C (fr) 1999-04-13
AU630816B2 (en) 1992-11-05
NZ238525A (en) 1992-05-26
US5110946A (en) 1992-05-05
CA2044186A1 (fr) 1991-12-15
DE69100200T2 (de) 1994-03-03
AU7832691A (en) 1991-12-19
ATE92044T1 (de) 1993-08-15
IE912005A1 (en) 1991-12-18
PT97954B (pt) 1998-11-30
FR2663325A1 (fr) 1991-12-20
IE66022B1 (en) 1995-11-29
OA09366A (fr) 1992-09-15
DE69100200D1 (de) 1993-09-02

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