DE69100200D1 - Verfahren zur industriellen herstellung von 3-sulfamoyl-4-chlor-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-benzamide ausgehend von 2,3-dihydro-2-methyl-1h-indol und hydroxylamine-o-sulfonsaeure. - Google Patents

Verfahren zur industriellen herstellung von 3-sulfamoyl-4-chlor-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-benzamide ausgehend von 2,3-dihydro-2-methyl-1h-indol und hydroxylamine-o-sulfonsaeure.

Info

Publication number
DE69100200D1
DE69100200D1 DE9191401583T DE69100200T DE69100200D1 DE 69100200 D1 DE69100200 D1 DE 69100200D1 DE 9191401583 T DE9191401583 T DE 9191401583T DE 69100200 T DE69100200 T DE 69100200T DE 69100200 D1 DE69100200 D1 DE 69100200D1
Authority
DE
Germany
Prior art keywords
dihydro
methyl
indol
hydroxylamine
sulphonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE9191401583T
Other languages
English (en)
Other versions
DE69100200T2 (de
Inventor
Roger Thevignot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of DE69100200D1 publication Critical patent/DE69100200D1/de
Application granted granted Critical
Publication of DE69100200T2 publication Critical patent/DE69100200T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE91401583T 1990-06-14 1991-06-14 Verfahren zur industriellen Herstellung von 3-Sulfamoyl-4-chlor-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-Benzamide ausgehend von 2,3-Dihydro-2-methyl-1H-indol und Hydroxylamine-O-sulfonsäure. Expired - Lifetime DE69100200T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9007387A FR2663325B1 (fr) 1990-06-14 1990-06-14 Nouveau procede de preparation industrielle du 4-chloro 3-sulfamoyl n-(2,3-dihydro 2-methyl 1h-indol-1-yl) benzamide a partir de la 2,3-dihydro 2-methyl 1h-indole et de l'acide hydroxylamine-o-sulfonique.

Publications (2)

Publication Number Publication Date
DE69100200D1 true DE69100200D1 (de) 1993-09-02
DE69100200T2 DE69100200T2 (de) 1994-03-03

Family

ID=9397580

Family Applications (1)

Application Number Title Priority Date Filing Date
DE91401583T Expired - Lifetime DE69100200T2 (de) 1990-06-14 1991-06-14 Verfahren zur industriellen Herstellung von 3-Sulfamoyl-4-chlor-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-Benzamide ausgehend von 2,3-Dihydro-2-methyl-1H-indol und Hydroxylamine-O-sulfonsäure.

Country Status (15)

Country Link
US (1) US5110946A (de)
EP (1) EP0462017B1 (de)
JP (1) JPH0665198A (de)
AT (1) ATE92044T1 (de)
AU (1) AU630816B2 (de)
CA (1) CA2044186C (de)
DE (1) DE69100200T2 (de)
DK (1) DK0462017T3 (de)
ES (1) ES2060324T3 (de)
FR (1) FR2663325B1 (de)
IE (1) IE66022B1 (de)
NZ (1) NZ238525A (de)
OA (1) OA09366A (de)
PT (1) PT97954B (de)
ZA (1) ZA914568B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663324B1 (fr) * 1990-06-14 1992-09-04 Adir Nouveau procede de preparation industrielle du 4-chloro 3-sulfamoyl n-(2,3-dihydro 2-methyl 1h-indol-1-yl) benzamide.
CN100422146C (zh) * 2006-09-25 2008-10-01 天津力生制药股份有限公司 一种吲达帕胺的合成方法
CN103467355A (zh) * 2013-09-12 2013-12-25 迪沙药业集团有限公司 一种吲达帕胺的制备方法
CN112142643A (zh) * 2020-10-10 2020-12-29 天津和治药业集团有限公司 一种吲达帕胺的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203691A (en) * 1968-03-06 1970-09-03 Science Union & Cie New disubstituted n-amino indoline derivatives and process for preparing them
DE3172386D1 (en) * 1980-12-22 1985-10-24 Usv Pharma Corp Synthesis of indolines
US4570001A (en) * 1980-12-22 1986-02-11 Science Union Et Cie Process for synthesizing certain N-benzoylamino indolines
JPS57206657A (en) * 1981-06-16 1982-12-18 Mitsui Toatsu Chem Inc Sulfamoylbenzoic acid derivative and remedying composition containing said derivative as active component
JPH0233030B2 (ja) * 1982-01-18 1990-07-25 Mitsui Toatsu Chemicals Surufuamoiruansokukosanjudotaioyobisoreojukoseibuntoshitefukumuchiryoyososeibutsu
JPS58124767A (ja) * 1982-01-21 1983-07-25 Mitsui Toatsu Chem Inc スルファモイル安息香酸誘導体
US4564677A (en) * 1984-01-19 1986-01-14 Usv Pharmaceutical Corp. Preparation of N-amino compounds

Also Published As

Publication number Publication date
ATE92044T1 (de) 1993-08-15
CA2044186A1 (fr) 1991-12-15
DE69100200T2 (de) 1994-03-03
FR2663325B1 (fr) 1992-09-04
NZ238525A (en) 1992-05-26
DK0462017T3 (da) 1993-10-18
FR2663325A1 (fr) 1991-12-20
AU630816B2 (en) 1992-11-05
ZA914568B (en) 1992-03-25
IE912005A1 (en) 1991-12-18
CA2044186C (fr) 1999-04-13
IE66022B1 (en) 1995-11-29
ES2060324T3 (es) 1994-11-16
OA09366A (fr) 1992-09-15
AU7832691A (en) 1991-12-19
PT97954B (pt) 1998-11-30
EP0462017A1 (de) 1991-12-18
US5110946A (en) 1992-05-05
EP0462017B1 (de) 1993-07-28
JPH0665198A (ja) 1994-03-08
PT97954A (pt) 1992-03-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR