ATE92044T1 - Verfahren zur industriellen herstellung von 3sulfamoyl-4-chlor-n-(2,3-dihydro-2-methyl-1hindol-1-yl)-benzamide ausgehend von 2,3-dihydro-2-methyl-1h-indol und hydroxylamine-o-sulfonsaeure. - Google Patents
Verfahren zur industriellen herstellung von 3sulfamoyl-4-chlor-n-(2,3-dihydro-2-methyl-1hindol-1-yl)-benzamide ausgehend von 2,3-dihydro-2-methyl-1h-indol und hydroxylamine-o-sulfonsaeure.Info
- Publication number
- ATE92044T1 ATE92044T1 AT91401583T AT91401583T ATE92044T1 AT E92044 T1 ATE92044 T1 AT E92044T1 AT 91401583 T AT91401583 T AT 91401583T AT 91401583 T AT91401583 T AT 91401583T AT E92044 T1 ATE92044 T1 AT E92044T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydro
- methyl
- hydroxylamine
- indole
- 3sulfamoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9007387A FR2663325B1 (fr) | 1990-06-14 | 1990-06-14 | Nouveau procede de preparation industrielle du 4-chloro 3-sulfamoyl n-(2,3-dihydro 2-methyl 1h-indol-1-yl) benzamide a partir de la 2,3-dihydro 2-methyl 1h-indole et de l'acide hydroxylamine-o-sulfonique. |
| EP91401583A EP0462017B1 (de) | 1990-06-14 | 1991-06-14 | Verfahren zur industriellen Herstellung von 3-Sulfamoyl-4-chlor-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-Benzamide ausgehend von 2,3-Dihydro-2-methyl-1H-indol und Hydroxylamine-O-sulfonsäure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE92044T1 true ATE92044T1 (de) | 1993-08-15 |
Family
ID=9397580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91401583T ATE92044T1 (de) | 1990-06-14 | 1991-06-14 | Verfahren zur industriellen herstellung von 3sulfamoyl-4-chlor-n-(2,3-dihydro-2-methyl-1hindol-1-yl)-benzamide ausgehend von 2,3-dihydro-2-methyl-1h-indol und hydroxylamine-o-sulfonsaeure. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5110946A (de) |
| EP (1) | EP0462017B1 (de) |
| JP (1) | JPH0665198A (de) |
| AT (1) | ATE92044T1 (de) |
| AU (1) | AU630816B2 (de) |
| CA (1) | CA2044186C (de) |
| DE (1) | DE69100200T2 (de) |
| DK (1) | DK0462017T3 (de) |
| ES (1) | ES2060324T3 (de) |
| FR (1) | FR2663325B1 (de) |
| IE (1) | IE66022B1 (de) |
| NZ (1) | NZ238525A (de) |
| OA (1) | OA09366A (de) |
| PT (1) | PT97954B (de) |
| ZA (1) | ZA914568B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2663324B1 (fr) * | 1990-06-14 | 1992-09-04 | Adir | Nouveau procede de preparation industrielle du 4-chloro 3-sulfamoyl n-(2,3-dihydro 2-methyl 1h-indol-1-yl) benzamide. |
| CN100422146C (zh) * | 2006-09-25 | 2008-10-01 | 天津力生制药股份有限公司 | 一种吲达帕胺的合成方法 |
| CN103467355A (zh) * | 2013-09-12 | 2013-12-25 | 迪沙药业集团有限公司 | 一种吲达帕胺的制备方法 |
| CN112142643A (zh) * | 2020-10-10 | 2020-12-29 | 天津和治药业集团有限公司 | 一种吲达帕胺的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1203691A (en) * | 1968-03-06 | 1970-09-03 | Science Union & Cie | New disubstituted n-amino indoline derivatives and process for preparing them |
| EP0054892B1 (de) * | 1980-12-22 | 1985-09-18 | SCIENCE UNION ET Cie | Synthese von Indolinen |
| US4570001A (en) * | 1980-12-22 | 1986-02-11 | Science Union Et Cie | Process for synthesizing certain N-benzoylamino indolines |
| JPS57206657A (en) * | 1981-06-16 | 1982-12-18 | Mitsui Toatsu Chem Inc | Sulfamoylbenzoic acid derivative and remedying composition containing said derivative as active component |
| JPH0233030B2 (ja) * | 1982-01-18 | 1990-07-25 | Mitsui Toatsu Chemicals | Surufuamoiruansokukosanjudotaioyobisoreojukoseibuntoshitefukumuchiryoyososeibutsu |
| JPS58124767A (ja) * | 1982-01-21 | 1983-07-25 | Mitsui Toatsu Chem Inc | スルファモイル安息香酸誘導体 |
| US4564677A (en) * | 1984-01-19 | 1986-01-14 | Usv Pharmaceutical Corp. | Preparation of N-amino compounds |
-
1990
- 1990-06-14 FR FR9007387A patent/FR2663325B1/fr not_active Expired - Lifetime
-
1991
- 1991-05-22 US US07/704,309 patent/US5110946A/en not_active Expired - Lifetime
- 1991-06-12 PT PT97954A patent/PT97954B/pt not_active IP Right Cessation
- 1991-06-13 CA CA002044186A patent/CA2044186C/fr not_active Expired - Lifetime
- 1991-06-13 NZ NZ238525A patent/NZ238525A/en not_active IP Right Cessation
- 1991-06-13 IE IE200591A patent/IE66022B1/en not_active IP Right Cessation
- 1991-06-13 AU AU78326/91A patent/AU630816B2/en not_active Expired
- 1991-06-13 JP JP3141712A patent/JPH0665198A/ja active Pending
- 1991-06-14 DE DE91401583T patent/DE69100200T2/de not_active Expired - Lifetime
- 1991-06-14 DK DK91401583.9T patent/DK0462017T3/da active
- 1991-06-14 ZA ZA914568A patent/ZA914568B/xx unknown
- 1991-06-14 AT AT91401583T patent/ATE92044T1/de not_active IP Right Cessation
- 1991-06-14 ES ES91401583T patent/ES2060324T3/es not_active Expired - Lifetime
- 1991-06-14 EP EP91401583A patent/EP0462017B1/de not_active Expired - Lifetime
- 1991-06-14 OA OA60020A patent/OA09366A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0462017A1 (de) | 1991-12-18 |
| PT97954A (pt) | 1992-03-31 |
| JPH0665198A (ja) | 1994-03-08 |
| EP0462017B1 (de) | 1993-07-28 |
| ES2060324T3 (es) | 1994-11-16 |
| ZA914568B (en) | 1992-03-25 |
| FR2663325B1 (fr) | 1992-09-04 |
| CA2044186C (fr) | 1999-04-13 |
| AU630816B2 (en) | 1992-11-05 |
| DK0462017T3 (da) | 1993-10-18 |
| NZ238525A (en) | 1992-05-26 |
| US5110946A (en) | 1992-05-05 |
| CA2044186A1 (fr) | 1991-12-15 |
| DE69100200T2 (de) | 1994-03-03 |
| AU7832691A (en) | 1991-12-19 |
| IE912005A1 (en) | 1991-12-18 |
| PT97954B (pt) | 1998-11-30 |
| FR2663325A1 (fr) | 1991-12-20 |
| IE66022B1 (en) | 1995-11-29 |
| OA09366A (fr) | 1992-09-15 |
| DE69100200D1 (de) | 1993-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |