DE69106975D1 - Verfahren zur Herstellung von Nitrilen. - Google Patents

Verfahren zur Herstellung von Nitrilen.

Info

Publication number
DE69106975D1
DE69106975D1 DE69106975T DE69106975T DE69106975D1 DE 69106975 D1 DE69106975 D1 DE 69106975D1 DE 69106975 T DE69106975 T DE 69106975T DE 69106975 T DE69106975 T DE 69106975T DE 69106975 D1 DE69106975 D1 DE 69106975D1
Authority
DE
Germany
Prior art keywords
nitriles
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69106975T
Other languages
English (en)
Inventor
David Anthony Roberts
Simon Thomas Russell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of DE69106975D1 publication Critical patent/DE69106975D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69106975T 1990-08-09 1991-08-05 Verfahren zur Herstellung von Nitrilen. Expired - Lifetime DE69106975D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909017480A GB9017480D0 (en) 1990-08-09 1990-08-09 Chemical process

Publications (1)

Publication Number Publication Date
DE69106975D1 true DE69106975D1 (de) 1995-03-09

Family

ID=10680407

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69106975T Expired - Lifetime DE69106975D1 (de) 1990-08-09 1991-08-05 Verfahren zur Herstellung von Nitrilen.

Country Status (5)

Country Link
EP (1) EP0470794B1 (de)
JP (1) JPH04244080A (de)
DE (1) DE69106975D1 (de)
GB (1) GB9017480D0 (de)
ZA (1) ZA915786B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5246944A (en) * 1991-08-13 1993-09-21 Merck & Co., Inc. Quinoline angiotensin ii antagonists incorporating a substituted benzyl element
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
US5312958A (en) * 1992-01-31 1994-05-17 Takeda Chemical Industries, Ltd. Process for producing 4-bromomethylbiphenyl compounds
FR2688781B1 (fr) * 1992-03-23 1994-07-01 Sanofi Elf Imidazolines n-substituees par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
FR2689887B1 (fr) * 1992-04-13 1995-06-23 Sanofi Elf Procede de preparation d'un derive de biphenyle.
US5380910A (en) * 1992-04-28 1995-01-10 Ihara Chemical Industry Co., Ltd. Method for producing an asymmetric biaryl derivative
TW259786B (de) * 1992-12-17 1995-10-11 Sankyo Co
ES2147798T3 (es) * 1994-01-28 2000-10-01 Takeda Chemical Industries Ltd Un procedimiento para la produccion de compuestos de tetrazolilo.
JP2928982B2 (ja) 1994-10-27 1999-08-03 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造法
FR2736562B1 (fr) * 1995-07-11 1997-09-19 Inst Francais Du Petrole Nouvelle composition catalytique pour catalyse biphasique, en particulier a base de complexes du nickel et procede pour l'oligomerisation des olefines
FR2753195B1 (fr) * 1996-09-09 1998-11-27 Sanofi Sa Procede pour la preparation d'un cyanobiphenyle
US6194599B1 (en) 1997-04-08 2001-02-27 Catalytica, Inc. Process for preparing biaryl compounds
US5922898A (en) * 1997-04-08 1999-07-13 Catalytica Pharmaceuticals, Inc. Process for preparing biaryl compounds
FR2804956B1 (fr) * 2000-02-14 2003-08-01 Rhodia Chimie Sa Procede de preparation d'un compose polyaromatique
DE60225486T2 (de) 2002-06-12 2009-04-02 Sumitomo Chemical Co., Ltd. Verfahren zur herstellung von 4'-brommethyl-2-cyanobiphenyl
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
US7105467B2 (en) 2003-07-08 2006-09-12 Pharmacore, Inc. Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
US7105707B2 (en) 2003-12-17 2006-09-12 Pharmacore, Inc. Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2810951B1 (de) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
CN101362730B (zh) * 2008-09-25 2011-09-21 北京赛科药业有限责任公司 一种制备沙坦侧链化合物的方法
JP5262642B2 (ja) * 2008-12-03 2013-08-14 エヌ・イーケムキャット株式会社 炭素−炭素結合の生成方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
AU2022380979A1 (en) 2021-11-02 2024-06-06 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
DE3632410A1 (de) * 1986-09-24 1988-03-31 Merck Patent Gmbh Verfahren zur herstellung von alkylen- bzw. ringverknuepften verbindungen
DE3736489A1 (de) * 1987-10-28 1989-05-11 Merck Patent Gmbh Kreuzkopplung von titanorganylen
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
PT94960A (pt) * 1989-08-11 1991-04-18 Ici Plc Processo para a preparacao de derivados de quinolina e de composicoes farmaceuticas que as contem

Also Published As

Publication number Publication date
GB9017480D0 (en) 1990-09-26
EP0470794B1 (de) 1995-01-25
JPH04244080A (ja) 1992-09-01
EP0470794A1 (de) 1992-02-12
ZA915786B (en) 1993-02-24

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Legal Events

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8332 No legal effect for de