DE871724T1 - Expression von prozessierten, rekombinierten lactoferrin und dessen polypeptiden durch ein fusionsprodukt in aspergillus - Google Patents
Expression von prozessierten, rekombinierten lactoferrin und dessen polypeptiden durch ein fusionsprodukt in aspergillusInfo
- Publication number
- DE871724T1 DE871724T1 DE0871724T DE95941350T DE871724T1 DE 871724 T1 DE871724 T1 DE 871724T1 DE 0871724 T DE0871724 T DE 0871724T DE 95941350 T DE95941350 T DE 95941350T DE 871724 T1 DE871724 T1 DE 871724T1
- Authority
- DE
- Germany
- Prior art keywords
- lactoferrine
- recombined
- aspergillus
- polypeptides
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000228212 Aspergillus Species 0.000 title 1
- 230000004927 fusion Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/303,009 US5571697A (en) | 1989-05-05 | 1994-11-02 | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
PCT/US1995/014174 WO1996014413A1 (en) | 1994-11-02 | 1995-11-01 | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in aspergillus |
Publications (1)
Publication Number | Publication Date |
---|---|
DE871724T1 true DE871724T1 (de) | 1999-06-02 |
Family
ID=23170177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0871724T Pending DE871724T1 (de) | 1994-11-02 | 1995-11-01 | Expression von prozessierten, rekombinierten lactoferrin und dessen polypeptiden durch ein fusionsprodukt in aspergillus |
Country Status (11)
Country | Link |
---|---|
US (3) | US5571697A (de) |
EP (1) | EP0871724A1 (de) |
JP (1) | JPH10509317A (de) |
KR (1) | KR100443307B1 (de) |
CN (1) | CN1230537C (de) |
AU (1) | AU4279896A (de) |
CA (1) | CA2204246A1 (de) |
DE (1) | DE871724T1 (de) |
ES (1) | ES2127164T1 (de) |
MX (1) | MX9703244A (de) |
WO (1) | WO1996014413A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL94183A (en) * | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
US6066469A (en) | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
AT404838B (de) * | 1995-11-24 | 1999-03-25 | Immuno Ag | Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen |
US6111081A (en) * | 1996-05-31 | 2000-08-29 | Baylor College Of Medicine | Lactoferrin variants and uses thereof |
US5811381A (en) * | 1996-10-10 | 1998-09-22 | Mark A. Emalfarb | Cellulase compositions and methods of use |
US7883872B2 (en) * | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
AU767146B2 (en) * | 1998-08-19 | 2003-10-30 | Monsanto Technology Llc | Plant expression vectors |
US6592814B2 (en) * | 1998-10-02 | 2003-07-15 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with antimicrobial coatings |
AU771539C (en) * | 1998-10-06 | 2005-01-13 | Dyadic International (Usa), Inc. | Transformation system in the field of filamentous fungal hosts |
US6399570B1 (en) | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
US20080050503A1 (en) * | 2000-05-02 | 2008-02-28 | Ning Huang | Expression of human milk proteins in transgenic plants |
US7417178B2 (en) * | 2000-05-02 | 2008-08-26 | Ventria Bioscience | Expression of human milk proteins in transgenic plants |
US7138150B2 (en) * | 2000-05-02 | 2006-11-21 | Ventria Bioscience | Method of making an anti-infective composition for treating oral infections |
EP1478379A4 (de) * | 2001-12-28 | 2005-12-21 | Campina Bv | Humanisiertes lactoferrin und seine anwendungen |
CN101044154A (zh) * | 2002-02-14 | 2007-09-26 | 威廉·J·鲁特 | 治疗宿主中切割的嵌合分子 |
CN1659187A (zh) * | 2002-05-10 | 2005-08-24 | 新世纪药品有限公司 | 融合铁蛋白在疫苗和其他方面的应用 |
ATE519499T1 (de) * | 2002-05-10 | 2011-08-15 | Agennix Inc | Lactoferrin bei der behandlung maligner neoplasien und anderer hyperproliferativer erkrankungen |
AU2003233583A1 (en) * | 2002-05-24 | 2003-12-12 | Agennix Incorporated | Oral lactoferrin in the treatment of respiratory disorders |
ES2224792B1 (es) * | 2002-06-28 | 2007-02-16 | Era Plantech, S.L. | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
DK2298338T3 (da) | 2002-09-16 | 2012-09-24 | Agennix Inc | Lactoferrin-sammensætninger og fremgangsmåder til behandling af hudsår |
EP1581243A4 (de) * | 2002-12-06 | 2008-01-02 | Agennix Inc | Orales lactoferrin für sepsisbehandlung |
AU2003296447A1 (en) * | 2002-12-10 | 2004-06-30 | Agennix Incorporated | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
AU2003293500A1 (en) * | 2002-12-12 | 2004-07-09 | Agennix Incorporated | Lactoferrin in the reduction of pain |
US7034126B2 (en) * | 2003-05-14 | 2006-04-25 | Agennix, Inc. | Lactoferrin in the treatment of diabetes mellitus |
JP2007524654A (ja) * | 2003-06-06 | 2007-08-30 | エイジェニックス インコーポレイテッド | 癌ワクチン中のアジュバントとしてのラクトフェリン |
US20040259770A1 (en) * | 2003-06-19 | 2004-12-23 | Rush University Medical Center | Method for determining leukocyte activation |
WO2005018542A2 (en) * | 2003-07-10 | 2005-03-03 | Agennix Incorporated | Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects |
EP1680503B1 (de) * | 2003-09-11 | 2011-06-22 | Novozymes Adenium Biotech A/S | Rekombinante Herstellung antimikrobieller Agentien |
US20070274988A1 (en) * | 2003-10-10 | 2007-11-29 | Five Prime Therapeautics, Inc. | Kiaa0779, Splice Variants Thereof, and Methods of Their Use |
AU2004297259A1 (en) * | 2003-12-09 | 2005-06-23 | Ventria Bioscience | High-level expression of fusion polypeptides in plant seeds utilizing seed-storage proteins as fusion carriers |
US7125963B2 (en) * | 2004-03-03 | 2006-10-24 | En N Tech Inc | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions |
WO2006047744A2 (en) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
JP4634809B2 (ja) * | 2005-01-05 | 2011-02-16 | 株式会社アップウェル | アポタンパク質の製造方法 |
US20060211089A1 (en) * | 2005-03-16 | 2006-09-21 | Novozymes A/S | Expression of defensins in filamentous fungi |
CN101505781A (zh) | 2006-06-22 | 2009-08-12 | 阿根尼克斯有限公司 | 作为辐射防护物质的乳铁蛋白 |
US9862956B2 (en) | 2006-12-10 | 2018-01-09 | Danisco Us Inc. | Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi |
EP2102366A4 (de) | 2006-12-10 | 2010-01-27 | Dyadic International Inc | Expression und hochdurchsatz-screening komplexer exprimierter dna-bibliotheken bei fadenpilzen |
NZ555163A (en) | 2007-05-14 | 2010-05-28 | Fonterra Co Operative Group | Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments |
CN101835801B (zh) | 2007-08-08 | 2014-09-10 | 诺维信生物制药丹麦公司 | 转铁蛋白变体和偶联物 |
EP2197893B1 (de) * | 2007-09-07 | 2013-07-24 | Dyadic International, Inc. | Neue pilzenzyme |
US9115211B2 (en) * | 2009-01-28 | 2015-08-25 | Jean-Paul Perraudin | Method for production of lactoferrin |
WO2010089385A1 (en) | 2009-02-06 | 2010-08-12 | Novozymes Biopharma Dk A/S | Purification process |
SG2014012918A (en) | 2009-02-11 | 2014-04-28 | Novozymes Biopharma Dk As | Albumin variants and conjugates |
US20120041171A1 (en) * | 2009-04-22 | 2012-02-16 | Dsm Ip Assets B.V. | Process for the production of a recombinant polypeptide of interest |
US20130225477A1 (en) | 2010-02-25 | 2013-08-29 | Agennix Ag | Oral Lactoferrin in the Treatment of Severe Sepsis |
US10047382B2 (en) | 2012-07-03 | 2018-08-14 | Kao Corporation | Useful microorganism and method for producing substance of interest |
CN103421794B (zh) * | 2013-08-08 | 2014-07-02 | 华南理工大学 | 一种黑曲霉组成型表达元件、表达载体、重组黑曲霉及其构建方法和应用 |
CN108893415B (zh) * | 2018-07-31 | 2022-12-27 | 上海凯圣生物科技有限公司 | 曲霉菌株及利用曲霉菌株发酵生产人乳铁蛋白的方法 |
WO2024056643A1 (en) * | 2022-09-15 | 2024-03-21 | Novozymes A/S | Fungal signal peptides |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
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US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US4652639A (en) * | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
US4710465A (en) * | 1984-04-19 | 1987-12-01 | Yale University | Junction-fragment DNA probes and probe clusters |
US4886747A (en) * | 1985-03-22 | 1989-12-12 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
US4965190A (en) * | 1986-07-31 | 1990-10-23 | Howard Hughes Medical Institute | Methods for the identification of mutations in the human phenylalanine hydroxylase gene using DNA probes |
US5019508A (en) * | 1987-08-27 | 1991-05-28 | Biotechnology Research Partners, Ltd. | Synovial phospholipases |
US5081227A (en) * | 1988-03-04 | 1992-01-14 | La Jolla Cancer Research Foundation | Germ cell alkaline phosphatase |
IL94183A (en) * | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
US5571691A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
EP0429628B1 (de) * | 1989-06-16 | 1998-09-02 | Genencor International, Inc. | Dna-sequenzen, vektoren und fusionspolypeptide zur erhöhung der sekretion gewünschter polypeptide von filamentösen fungi |
UA27702C2 (uk) * | 1989-09-27 | 2000-10-16 | Гіст-Брокейдс Н.В. | Фрагмент геномної днк, що кодує фітазу aspergillus niger,фрагмент кднк, що кодує фітазу aspergillus niger, рекомбінантна плазмідна днк для експресії фітази в aspergillus (варіанти), штам aspergillus-продуцент фітази aspergillus (варіанти), спосіб одержання фітази, рекомбінанта фітаза aspergillus niger |
IL95697A0 (en) * | 1989-09-28 | 1991-06-30 | Granada Biosciences Inc | Cdna sequence for porcine lactoferrin protein |
WO1991013982A1 (en) * | 1990-03-08 | 1991-09-19 | Ferrodynamics, Inc. | Genetically engineered human lactoferrin |
JP2818056B2 (ja) * | 1990-09-07 | 1998-10-30 | 森永乳業株式会社 | 抗菌性ペプチドおよび抗菌剤 |
JPH07502723A (ja) * | 1991-02-08 | 1995-03-23 | ザ・ユニバーシテイ・オブ・バーモント・アンド・ステイト・アグリカルチユラル・カレツジ | 組み替えトランスフェリン、トランスフェリン半−分子、及びそれらの突然変異体 |
AU664223B2 (en) * | 1991-12-09 | 1995-11-09 | Unilever Plc | Process for producing/secreting a protein by a transformed mould using expression/secretion regulating regions derived from an (aspergillus) endoxylanase II gene |
ZA932568B (en) * | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
-
1994
- 1994-11-02 US US08/303,009 patent/US5571697A/en not_active Expired - Lifetime
-
1995
- 1995-11-01 EP EP95941350A patent/EP0871724A1/de not_active Withdrawn
- 1995-11-01 DE DE0871724T patent/DE871724T1/de active Pending
- 1995-11-01 WO PCT/US1995/014174 patent/WO1996014413A1/en not_active Application Discontinuation
- 1995-11-01 JP JP8515400A patent/JPH10509317A/ja active Pending
- 1995-11-01 AU AU42798/96A patent/AU4279896A/en not_active Abandoned
- 1995-11-01 CN CNB951971158A patent/CN1230537C/zh not_active Expired - Fee Related
- 1995-11-01 KR KR1019970702908A patent/KR100443307B1/ko not_active IP Right Cessation
- 1995-11-01 CA CA002204246A patent/CA2204246A1/en not_active Abandoned
- 1995-11-01 ES ES95941350T patent/ES2127164T1/es active Pending
-
1996
- 1996-08-01 US US08/691,123 patent/US5955316A/en not_active Expired - Fee Related
-
1997
- 1997-05-02 MX MX9703244A patent/MX9703244A/es not_active IP Right Cessation
-
1998
- 1998-06-29 US US09/107,075 patent/US6080559A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6080559A (en) | 2000-06-27 |
CN1230537C (zh) | 2005-12-07 |
KR100443307B1 (ko) | 2004-11-08 |
JPH10509317A (ja) | 1998-09-14 |
MX9703244A (es) | 1998-07-31 |
EP0871724A1 (de) | 1998-10-21 |
ES2127164T1 (es) | 1999-04-16 |
US5955316A (en) | 1999-09-21 |
CA2204246A1 (en) | 1996-05-17 |
AU4279896A (en) | 1996-05-31 |
US5571697A (en) | 1996-11-05 |
KR970707283A (ko) | 1997-12-01 |
EP0871724A4 (de) | 1998-10-21 |
CN1171815A (zh) | 1998-01-28 |
WO1996014413A1 (en) | 1996-05-17 |
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