DE69942022D1 - Pyruvate carboxylase überexpression zur verstärkten produktion von oxalacetat abgeleiteten verbindungen in mikrobiellen zellen - Google Patents

Pyruvate carboxylase überexpression zur verstärkten produktion von oxalacetat abgeleiteten verbindungen in mikrobiellen zellen

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Publication number
DE69942022D1
DE69942022D1 DE69942022T DE69942022T DE69942022D1 DE 69942022 D1 DE69942022 D1 DE 69942022D1 DE 69942022 T DE69942022 T DE 69942022T DE 69942022 T DE69942022 T DE 69942022T DE 69942022 D1 DE69942022 D1 DE 69942022D1
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DE
Germany
Prior art keywords
oxalacetate
microbial cells
pyruvate carboxylase
derived compounds
overexpression
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69942022T
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English (en)
Inventor
Ravi R Gokarn
Mark A Eiteman
Elliot Altman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Georgia
University of Georgia Research Foundation Inc UGARF
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University of Georgia
University of Georgia Research Foundation Inc UGARF
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01001—Pyruvate carboxylase (6.4.1.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69942022T 1998-04-13 1999-04-13 Pyruvate carboxylase überexpression zur verstärkten produktion von oxalacetat abgeleiteten verbindungen in mikrobiellen zellen Expired - Lifetime DE69942022D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8159898P 1998-04-13 1998-04-13
US8285098P 1998-04-23 1998-04-23
PCT/US1999/008014 WO1999053035A1 (en) 1998-04-13 1999-04-13 Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells

Publications (1)

Publication Number Publication Date
DE69942022D1 true DE69942022D1 (de) 2010-04-01

Family

ID=26765732

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69942022T Expired - Lifetime DE69942022D1 (de) 1998-04-13 1999-04-13 Pyruvate carboxylase überexpression zur verstärkten produktion von oxalacetat abgeleiteten verbindungen in mikrobiellen zellen

Country Status (13)

Country Link
US (1) US6455284B1 (de)
EP (2) EP2194122B1 (de)
JP (1) JP2002511250A (de)
AR (1) AR015762A1 (de)
AT (1) ATE458040T1 (de)
AU (1) AU760575C (de)
BR (1) BR9909615A (de)
CA (1) CA2325598A1 (de)
DE (1) DE69942022D1 (de)
DK (2) DK2194122T3 (de)
HK (2) HK1034746A1 (de)
MY (1) MY121380A (de)
WO (1) WO1999053035A1 (de)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
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HK1144304A1 (zh) 2011-02-11
WO1999053035A1 (en) 1999-10-21
US6455284B1 (en) 2002-09-24
JP2002511250A (ja) 2002-04-16
BR9909615A (pt) 2000-12-12
AU760575B2 (en) 2003-05-15
AU3555999A (en) 1999-11-01
AU760575C (en) 2005-04-14
MY121380A (en) 2006-01-28
AR015762A1 (es) 2001-05-16
EP2194122A1 (de) 2010-06-09
CA2325598A1 (en) 1999-10-21
HK1034746A1 (en) 2001-11-02
DK2194122T3 (en) 2016-02-15
EP1073722B1 (de) 2010-02-17
EP2194122B1 (de) 2015-12-02
EP1073722A1 (de) 2001-02-07
DK1073722T3 (da) 2010-06-07

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