WO2002055075A3 - Compounds and methods for regulating cell differentiation - Google Patents
Compounds and methods for regulating cell differentiation Download PDFInfo
- Publication number
- WO2002055075A3 WO2002055075A3 PCT/US2001/047309 US0147309W WO02055075A3 WO 2002055075 A3 WO2002055075 A3 WO 2002055075A3 US 0147309 W US0147309 W US 0147309W WO 02055075 A3 WO02055075 A3 WO 02055075A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cell differentiation
- methods
- compounds
- regulating cell
- cell
- Prior art date
Links
- 0 CC1C2C1CC*C2 Chemical compound CC1C2C1CC*C2 0.000 description 3
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002249795A AU2002249795A1 (en) | 2000-11-10 | 2001-11-13 | Compounds and methods for regulating cell differentiation |
EP01998033A EP1404318A2 (en) | 2000-11-10 | 2001-11-13 | Compounds and methods for regulating cell differentiation |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24729900P | 2000-11-10 | 2000-11-10 | |
US60/247,299 | 2000-11-10 | ||
US26223301P | 2001-01-17 | 2001-01-17 | |
US60/262,233 | 2001-01-17 | ||
US26481401P | 2001-01-29 | 2001-01-29 | |
US60/264,814 | 2001-01-29 | ||
US09/977,866 US6908732B2 (en) | 2000-10-13 | 2001-10-15 | Compounds and methods for regulating cell differentiation |
US09/977,866 | 2001-10-15 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002055075A2 WO2002055075A2 (en) | 2002-07-18 |
WO2002055075A3 true WO2002055075A3 (en) | 2003-12-31 |
WO2002055075A9 WO2002055075A9 (en) | 2004-02-26 |
Family
ID=27500253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/047309 WO2002055075A2 (en) | 2000-11-10 | 2001-11-13 | Compounds and methods for regulating cell differentiation |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1404318A2 (en) |
AU (1) | AU2002249795A1 (en) |
WO (1) | WO2002055075A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8709434B2 (en) | 2006-11-13 | 2014-04-29 | Pcb Associates, Inc. | Compositions for inhibiting NADPH oxidase activity |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5381611A (en) * | 1976-12-28 | 1978-07-19 | Kimihiko Okazaki | Hepatic medicine |
JPH0347166A (en) * | 1989-04-11 | 1991-02-28 | Nippon Ham Kk | Agent for suppressing proliferation of aids virus |
JPH06183969A (en) * | 1992-05-22 | 1994-07-05 | Nippon Ham Kk | Anticomplementary agent |
CN1185956A (en) * | 1996-12-23 | 1998-07-01 | 周德 | A cancer medicine |
WO2001082932A2 (en) * | 2000-05-01 | 2001-11-08 | Healthpartners Research Foundation | Methods and compositions for enhancing cellular function through protection of tissue components |
WO2001096345A1 (en) * | 2000-06-14 | 2001-12-20 | Duke University | Tetrapyrroles |
-
2001
- 2001-11-13 WO PCT/US2001/047309 patent/WO2002055075A2/en not_active Application Discontinuation
- 2001-11-13 EP EP01998033A patent/EP1404318A2/en not_active Withdrawn
- 2001-11-13 AU AU2002249795A patent/AU2002249795A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5381611A (en) * | 1976-12-28 | 1978-07-19 | Kimihiko Okazaki | Hepatic medicine |
JPH0347166A (en) * | 1989-04-11 | 1991-02-28 | Nippon Ham Kk | Agent for suppressing proliferation of aids virus |
JPH06183969A (en) * | 1992-05-22 | 1994-07-05 | Nippon Ham Kk | Anticomplementary agent |
CN1185956A (en) * | 1996-12-23 | 1998-07-01 | 周德 | A cancer medicine |
WO2001082932A2 (en) * | 2000-05-01 | 2001-11-08 | Healthpartners Research Foundation | Methods and compositions for enhancing cellular function through protection of tissue components |
WO2001096345A1 (en) * | 2000-06-14 | 2001-12-20 | Duke University | Tetrapyrroles |
Non-Patent Citations (12)
Title |
---|
DATABASE WPI Section Ch Week 197834, Derwent World Patents Index; Class B02, AN 1978-61136A, XP002240174 * |
DATABASE WPI Section Ch Week 199115, Derwent World Patents Index; Class A96, AN 1991-105697, XP002240176 * |
DATABASE WPI Section Ch Week 199431, Derwent World Patents Index; Class B03, AN 1994-252704, XP002240177 * |
DATABASE WPI Section Ch Week 200268, Derwent World Patents Index; Class B04, AN 2002-628432, XP002240175 * |
JANES C ET AL: "BILIRUBIN INHIBITS PROLIFERATION IN CULTURED NORMAL HUMAN OSTEOBLAST-LIKE CELLS A POSSIBLE MECHANISM FOR BONE LOSS IN PRIMARY BILIARY CIRRHOSIS", GASTROENTEROLOGY, vol. 102, no. 4 PART 2, 1992, pages A827, XP008016617, ISSN: 0016-5085 * |
PETERS JEFFREY M ET AL: "Evidence that murine preimplantation embryos express aryl hydrocarbon receptor.", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 134, no. 2, 1995, pages 214 - 221, XP001151814, ISSN: 0041-008X * |
PHELAN D ET AL: "Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin.", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 357, no. 1, pages 155 - 163, XP001151649, ISSN: 0003-9861 * |
THALER M M: "Bilirubin toxicity in hepatoma cells.", NATURE: NEW BIOLOGY. ENGLAND 14 APR 1971, vol. 230, no. 15, 14 April 1971 (1971-04-14), pages 218 - 219, XP008016632, ISSN: 0090-0028 * |
VASSILOPOULOU-SELLIN R ET AL: "Bilirubin as an inhibitor of cartilage metabolism: effect on avian chondrocyte proliferation in cell culture.", JOURNAL OF BONE AND MINERAL RESEARCH: THE OFFICIAL JOURNAL OF THE AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH. UNITED STATES JUL 1990, vol. 5, no. 7, July 1990 (1990-07-01), pages 769 - 774, XP008016636, ISSN: 0884-0431 * |
ZAHER HANI ET AL: "The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis.", MOLECULAR PHARMACOLOGY, vol. 54, no. 2, August 1998 (1998-08-01), pages 313 - 321, XP001151653, ISSN: 0026-895X * |
ZHOU X F ET AL: "Photosensitization of bilirubin on proliferation and DNA synthesis in ascitic hepatoma cells.", ZHONGGUO YAO LI XUE BAO = ACTA PHARMACOLOGICA SINICA. CHINA MAR 1996, vol. 17, no. 2, March 1996 (1996-03-01), pages 164 - 166, XP008016634, ISSN: 0253-9756 * |
ZUCKER STEPHEN D ET AL: "Inhibition of breast cancer cell proliferation by unconjugated bilirubin is associated with enhanced expression of apolipoprotein D and increased nuclear translocation of transcription factor NF-kappaB.", HEPATOLOGY, vol. 30, no. 4 PART 2, October 1999 (1999-10-01), 50th Annual Meeting and Postgraduate Courses of the American Association for the Study of Liver Diseases;Dallas, Texas, USA; November 5-9, 1999, pages 498A, XP008016620, ISSN: 0270-9139 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002055075A9 (en) | 2004-02-26 |
AU2002249795A1 (en) | 2002-07-24 |
EP1404318A2 (en) | 2004-04-07 |
WO2002055075A2 (en) | 2002-07-18 |
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