DE69931892T2 - Test auf Antibiotikumempfindlichkeit - Google Patents
Test auf Antibiotikumempfindlichkeit Download PDFInfo
- Publication number
- DE69931892T2 DE69931892T2 DE69931892T DE69931892T DE69931892T2 DE 69931892 T2 DE69931892 T2 DE 69931892T2 DE 69931892 T DE69931892 T DE 69931892T DE 69931892 T DE69931892 T DE 69931892T DE 69931892 T2 DE69931892 T2 DE 69931892T2
- Authority
- DE
- Germany
- Prior art keywords
- bacteria
- culture
- adenylate kinase
- antibiotic
- lysing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 60
- 238000012360 testing method Methods 0.000 title claims abstract description 53
- 230000035945 sensitivity Effects 0.000 title claims description 20
- 102000002281 Adenylate kinase Human genes 0.000 claims abstract description 79
- 108020000543 Adenylate kinase Proteins 0.000 claims abstract description 79
- 241000894006 Bacteria Species 0.000 claims abstract description 79
- 238000000034 method Methods 0.000 claims abstract description 61
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 29
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 28
- 230000001580 bacterial effect Effects 0.000 claims abstract description 28
- 230000012010 growth Effects 0.000 claims abstract description 27
- 230000000694 effects Effects 0.000 claims abstract description 19
- 230000002599 biostatic effect Effects 0.000 claims abstract description 18
- 230000002934 lysing effect Effects 0.000 claims description 36
- 239000003153 chemical reaction reagent Substances 0.000 claims description 27
- 241001515965 unidentified phage Species 0.000 claims description 27
- 229940088710 antibiotic agent Drugs 0.000 claims description 20
- 230000009089 cytolysis Effects 0.000 claims description 17
- 238000003312 immunocapture Methods 0.000 claims description 12
- 238000000021 kinase assay Methods 0.000 claims description 12
- 239000001963 growth medium Substances 0.000 claims description 9
- 230000003834 intracellular effect Effects 0.000 claims description 8
- 238000004113 cell culture Methods 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 5
- 239000003599 detergent Substances 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 claims description 4
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 claims description 4
- 108060001084 Luciferase Proteins 0.000 claims description 4
- 239000005089 Luciferase Substances 0.000 claims description 4
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 claims description 4
- 230000027455 binding Effects 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 230000003698 anagen phase Effects 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 239000013043 chemical agent Substances 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000003556 assay Methods 0.000 abstract description 17
- 230000036541 health Effects 0.000 abstract description 4
- 238000000338 in vitro Methods 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 50
- 239000000523 sample Substances 0.000 description 36
- 241000588724 Escherichia coli Species 0.000 description 16
- 229960000723 ampicillin Drugs 0.000 description 14
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 14
- 229960005091 chloramphenicol Drugs 0.000 description 13
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 13
- 208000015181 infectious disease Diseases 0.000 description 9
- 238000011534 incubation Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- 239000011324 bead Substances 0.000 description 5
- 230000006037 cell lysis Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 4
- 239000006152 selective media Substances 0.000 description 4
- 230000005526 G1 to G0 transition Effects 0.000 description 3
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 3
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 229910001425 magnesium ion Inorganic materials 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 229930182555 Penicillin Natural products 0.000 description 2
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 2
- 238000003149 assay kit Methods 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 description 2
- 238000005415 bioluminescence Methods 0.000 description 2
- 230000029918 bioluminescence Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- 230000002101 lytic effect Effects 0.000 description 2
- 150000002960 penicillins Chemical class 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000002132 β-lactam antibiotic Substances 0.000 description 2
- 229940124586 β-lactam antibiotics Drugs 0.000 description 2
- 231100000582 ATP assay Toxicity 0.000 description 1
- 230000002407 ATP formation Effects 0.000 description 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000353754 Bacillus subtilis subsp. niger Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- 241000254158 Lampyridae Species 0.000 description 1
- 101001094044 Mus musculus Solute carrier family 26 member 6 Proteins 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- 238000002829 antibacterial sensitivity test Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000009699 differential effect Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- -1 for example Substances 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000004260 plant-type cell wall biogenesis Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000003239 susceptibility assay Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9801126.5A GB9801126D0 (en) | 1998-01-21 | 1998-01-21 | Antibiotic sensitivity testing |
| GB9801126 | 1998-01-21 | ||
| GB9816993 | 1998-08-06 | ||
| GBGB9816993.1A GB9816993D0 (en) | 1998-01-21 | 1998-08-06 | Antibiotic sensitivity testing |
| PCT/GB1999/000089 WO1999037799A1 (en) | 1998-01-21 | 1999-01-12 | Antibiotic sensitivity testing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69931892D1 DE69931892D1 (de) | 2006-07-27 |
| DE69931892T2 true DE69931892T2 (de) | 2006-12-21 |
Family
ID=26312981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69931892T Expired - Lifetime DE69931892T2 (de) | 1998-01-21 | 1999-01-12 | Test auf Antibiotikumempfindlichkeit |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6861230B1 (https=) |
| EP (1) | EP1049798B1 (https=) |
| JP (1) | JP2002500892A (https=) |
| CN (1) | CN1152963C (https=) |
| AT (1) | ATE330025T1 (https=) |
| AU (1) | AU751388C (https=) |
| BR (1) | BR9907161A (https=) |
| CA (1) | CA2318367C (https=) |
| DE (1) | DE69931892T2 (https=) |
| DK (1) | DK1049798T3 (https=) |
| ES (1) | ES2262308T3 (https=) |
| GB (1) | GB2348702B (https=) |
| HU (1) | HUP0101276A3 (https=) |
| NO (1) | NO20003708L (https=) |
| NZ (1) | NZ505847A (https=) |
| WO (1) | WO1999037799A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9911095D0 (en) | 1999-05-13 | 1999-07-14 | Secr Defence | Microbiological test method and reagents |
| GB0030727D0 (en) | 2000-12-15 | 2001-01-31 | Lumitech Uk Ltd | Methods and kits for detecting kinase activity |
| GB0122790D0 (en) | 2001-09-21 | 2001-11-14 | Secr Defence | Method of determining the presence of target bacteria |
| GB0308199D0 (en) * | 2003-04-09 | 2003-05-14 | Acolyte Biomedica Ltd | Combined microbiology system |
| GB2400659B8 (en) | 2003-04-17 | 2007-07-09 | Cambrex Bio Science Nottingham | Assay methods and materials |
| ES2661168T3 (es) | 2003-07-12 | 2018-03-27 | Accelerate Diagnostics, Inc. | Biodetección sensible y rápida |
| US20120077206A1 (en) | 2003-07-12 | 2012-03-29 | Accelr8 Technology Corporation | Rapid Microbial Detection and Antimicrobial Susceptibility Testing |
| EP1663265B1 (en) | 2003-07-23 | 2015-09-23 | Biocontrol Limited | Bacteriophage-containing therapeutic agents |
| GB0324650D0 (en) * | 2003-10-22 | 2003-11-26 | Acolyte Biomedica Ltd | Using nucleic acids for clinical microbiology testing |
| WO2008157384A2 (en) * | 2007-06-15 | 2008-12-24 | Microphage Incorporated | Method of detection of microorganisms with enhanced bacteriophage amplification |
| WO2006005190A1 (en) * | 2004-07-14 | 2006-01-19 | Inimex Pharmaceuticals Inc. | Method of screening for protection from microbial infection |
| PL1812585T3 (pl) * | 2004-11-01 | 2015-03-31 | Erber Ag | Bakteriofagi jako czynniki selekcyjne |
| ES2624685T3 (es) * | 2004-12-16 | 2017-07-17 | Accelerate Diagnostics, Inc. | Detección microbiana rápida y prueba de susceptibilidad antimicrobiana |
| GB2432660A (en) | 2005-11-29 | 2007-05-30 | Bacterioscan Ltd | System for counting bacteria and determining their susceptibility to antibiotics |
| US20080220465A1 (en) * | 2007-03-05 | 2008-09-11 | Pocared Diagnostics, Inc. | Antibiotic Sensitivity Testing Method |
| GB0704553D0 (en) * | 2007-03-09 | 2007-04-18 | Harper David R | Beneficial effects of bacteriophage treatments |
| US9005579B2 (en) | 2010-01-05 | 2015-04-14 | Contrafect Corporation | Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria |
| US9434937B2 (en) | 2011-03-07 | 2016-09-06 | Accelerate Diagnostics, Inc. | Rapid cell purification systems |
| US10254204B2 (en) | 2011-03-07 | 2019-04-09 | Accelerate Diagnostics, Inc. | Membrane-assisted purification |
| US9677109B2 (en) | 2013-03-15 | 2017-06-13 | Accelerate Diagnostics, Inc. | Rapid determination of microbial growth and antimicrobial susceptibility |
| CN113025732A (zh) * | 2013-07-03 | 2021-06-25 | 克维拉公司 | 靶向抗生素敏感性测试的方法 |
| EP2821499B1 (en) | 2013-07-04 | 2017-02-15 | ABM Technologies, LLC | Method for the rapid determination of susceptibility or resistance of bacteria to antibiotics |
| JP6479037B2 (ja) | 2013-12-06 | 2019-03-06 | バクテリオスキャン エルティーディー | 試料チャンバを有する光学測定キュベット |
| EP3077796B1 (en) | 2013-12-06 | 2024-09-18 | IP Specialists Ltd. | Optical measurements of liquids having free surface |
| US10233481B2 (en) | 2014-12-05 | 2019-03-19 | Bacterioscan Ltd | Multi-sample laser-scatter measurement instrument with incubation feature and systems for using the same |
| US20160161404A1 (en) | 2014-12-05 | 2016-06-09 | Bacterioscan Ltd | System Using Laser-Scatter Measurement Instrument For Organism Identification And Related Network |
| US10065184B2 (en) | 2014-12-30 | 2018-09-04 | Bacterioscan Ltd. | Pipette having integrated filtration assembly |
| EP3048174B1 (en) * | 2015-01-21 | 2018-11-07 | ABM Technologies, LLC | Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis |
| JP2018503842A (ja) | 2015-01-26 | 2018-02-08 | バクテリオスキャン エルティーディー | 回転木馬式流体サンプル配置を呈するレーザ散乱計測器具 |
| US10023895B2 (en) | 2015-03-30 | 2018-07-17 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing |
| US10253355B2 (en) | 2015-03-30 | 2019-04-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
| US11744859B2 (en) | 2017-07-07 | 2023-09-05 | Epicentrx, Inc. | Compositions and methods for parenteral administration of therapeutic agents |
| US11099121B2 (en) | 2019-02-05 | 2021-08-24 | BacterioScan Inc. | Cuvette device for determining antibacterial susceptibility |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3933592A (en) | 1965-02-17 | 1976-01-20 | Hazleton Laboratories, Incorporated | Method of detecting living microorganisms |
| JPH04370100A (ja) * | 1991-06-19 | 1992-12-22 | Mercian Corp | 微生物の薬剤感受性試験法 |
| GB9220027D0 (en) * | 1992-09-22 | 1992-11-04 | Mini Agriculture & Fisheries | Method and kits for detection of bacteria |
| GB9301118D0 (en) | 1993-01-21 | 1993-03-10 | Secr Defence | Enzyme linked assays |
| US5648232A (en) * | 1993-01-21 | 1997-07-15 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Microbiological best method and reagents |
| CA2165055C (en) * | 1993-07-12 | 1999-12-28 | Philip Earl Cothran | High lathering conditioning shampoos with improved deposition of insoluble, dispersed phase, fluid conditioning agent |
| GB9414096D0 (en) * | 1994-07-13 | 1994-08-31 | Secr Defence | Labelled capture assay |
| ATE215608T1 (de) * | 1994-07-13 | 2002-04-15 | Secr Defence Brit | Mikrobiologisches testverfahren und reagenzien |
-
1999
- 1999-01-12 BR BR9907161-4A patent/BR9907161A/pt not_active Application Discontinuation
- 1999-01-12 CN CNB998042692A patent/CN1152963C/zh not_active Expired - Fee Related
- 1999-01-12 DE DE69931892T patent/DE69931892T2/de not_active Expired - Lifetime
- 1999-01-12 ES ES99901020T patent/ES2262308T3/es not_active Expired - Lifetime
- 1999-01-12 DK DK99901020T patent/DK1049798T3/da active
- 1999-01-12 JP JP2000528706A patent/JP2002500892A/ja not_active Ceased
- 1999-01-12 WO PCT/GB1999/000089 patent/WO1999037799A1/en not_active Ceased
- 1999-01-12 NZ NZ505847A patent/NZ505847A/xx not_active IP Right Cessation
- 1999-01-12 EP EP99901020A patent/EP1049798B1/en not_active Expired - Lifetime
- 1999-01-12 AU AU20653/99A patent/AU751388C/en not_active Ceased
- 1999-01-12 AT AT99901020T patent/ATE330025T1/de active
- 1999-01-12 HU HU0101276A patent/HUP0101276A3/hu unknown
- 1999-01-12 CA CA2318367A patent/CA2318367C/en not_active Expired - Fee Related
- 1999-01-12 GB GB0017298A patent/GB2348702B/en not_active Expired - Fee Related
- 1999-01-12 US US09/600,398 patent/US6861230B1/en not_active Expired - Fee Related
-
2000
- 2000-07-19 NO NO20003708A patent/NO20003708L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2348702A (en) | 2000-10-11 |
| GB2348702B (en) | 2003-04-02 |
| WO1999037799A1 (en) | 1999-07-29 |
| DK1049798T3 (da) | 2006-10-09 |
| HUP0101276A3 (en) | 2006-03-28 |
| CN1152963C (zh) | 2004-06-09 |
| BR9907161A (pt) | 2000-10-24 |
| EP1049798B1 (en) | 2006-06-14 |
| EP1049798A1 (en) | 2000-11-08 |
| JP2002500892A (ja) | 2002-01-15 |
| GB2348702A8 (en) | 2001-02-08 |
| ES2262308T3 (es) | 2006-11-16 |
| ATE330025T1 (de) | 2006-07-15 |
| CA2318367A1 (en) | 1999-07-29 |
| CA2318367C (en) | 2011-04-26 |
| HUP0101276A2 (hu) | 2001-08-28 |
| AU751388B2 (en) | 2002-08-15 |
| NZ505847A (en) | 2002-09-27 |
| NO20003708D0 (no) | 2000-07-19 |
| AU2065399A (en) | 1999-08-09 |
| NO20003708L (no) | 2000-09-21 |
| DE69931892D1 (de) | 2006-07-27 |
| AU751388C (en) | 2004-01-15 |
| GB0017298D0 (en) | 2000-08-30 |
| US6861230B1 (en) | 2005-03-01 |
| CN1294634A (zh) | 2001-05-09 |
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