DE69930271T8 - Medizinische zusammensetzungen zur behandlung von augenerkrankungen - Google Patents

Medizinische zusammensetzungen zur behandlung von augenerkrankungen Download PDF

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Publication number
DE69930271T8
DE69930271T8 DE69930271T DE69930271T DE69930271T8 DE 69930271 T8 DE69930271 T8 DE 69930271T8 DE 69930271 T DE69930271 T DE 69930271T DE 69930271 T DE69930271 T DE 69930271T DE 69930271 T8 DE69930271 T8 DE 69930271T8
Authority
DE
Germany
Prior art keywords
eye diseases
treatment
compositions
medical compositions
ocular tension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69930271T
Other languages
English (en)
Other versions
DE69930271D1 (de
DE69930271T2 (de
Inventor
Kazuki Narita-shi ENDO
Toichi Sawara-shi ABIRU
Tomokazu Sagamihara-shi HOSOKAWA
Miwa Suginami-ku MISAWA
Takashi Fukushima Research Laboratories Fukushima-shi KONNO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toa Eiyo Ltd
Yamasa Corp
Original Assignee
Toa Eiyo Ltd
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toa Eiyo Ltd, Yamasa Corp filed Critical Toa Eiyo Ltd
Publication of DE69930271D1 publication Critical patent/DE69930271D1/de
Application granted granted Critical
Publication of DE69930271T2 publication Critical patent/DE69930271T2/de
Publication of DE69930271T8 publication Critical patent/DE69930271T8/de
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69930271T 1998-09-01 1999-08-31 Medizinische zusammensetzungen zur behandlung von augenerkrankungen Expired - Fee Related DE69930271T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP24682698 1998-09-01
JP24682698A JP2002173427A (ja) 1998-09-01 1998-09-01 眼疾患治療用医薬組成物
PCT/JP1999/004709 WO2000012098A1 (fr) 1998-09-01 1999-08-31 Compositions medicinales pour le traitement des maladies oculaires

Publications (3)

Publication Number Publication Date
DE69930271D1 DE69930271D1 (de) 2006-05-04
DE69930271T2 DE69930271T2 (de) 2006-08-24
DE69930271T8 true DE69930271T8 (de) 2006-12-28

Family

ID=17154279

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69930271T Expired - Fee Related DE69930271T8 (de) 1998-09-01 1999-08-31 Medizinische zusammensetzungen zur behandlung von augenerkrankungen

Country Status (11)

Country Link
US (1) US6387889B1 (de)
EP (1) EP1110554B1 (de)
JP (1) JP2002173427A (de)
CN (1) CN1151794C (de)
AT (1) ATE319458T1 (de)
AU (1) AU5446299A (de)
CA (1) CA2342204A1 (de)
DE (1) DE69930271T8 (de)
DK (1) DK1110554T3 (de)
ES (1) ES2259842T3 (de)
WO (1) WO2000012098A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0007864A (pt) * 1999-02-01 2001-11-06 Univ Virginia Composto, e, uso de um composto
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6232297B1 (en) * 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
ES2173027B2 (es) * 2000-07-06 2005-12-16 Universidad Complutense De Madrid Uso de nucleotidos en el tratamiento del glaucoma y la hipertension ocular.
AU2001284485A1 (en) * 2000-09-08 2002-03-22 Toa Eiyo Ltd. Adenosine derivatives and use thereof
AU2001278708A1 (en) 2000-09-08 2002-03-22 Toa Eiyo Ltd. Adenosine derivatives and use thereof
SG176313A1 (en) * 2001-10-01 2011-12-29 Univ Virginia Patent Found 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
WO2003086408A1 (en) * 2002-04-10 2003-10-23 University Of Virginia Patent Foundation Use of a2a adenosine receptor agonists for the treatment of inflammatory diseases
JP2007531729A (ja) * 2004-04-02 2007-11-08 アデノシン、セラピューティックス、リミテッド、ライアビリティ、カンパニー Ａ２ａアデノシンレセプターの選択的アンタゴニスト
TWI346109B (en) 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
CA2576826C (en) * 2004-08-02 2014-09-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
WO2006023272A1 (en) * 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
WO2007120972A2 (en) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
WO2008133129A1 (ja) * 2007-04-16 2008-11-06 Santen Pharmaceutical Co., Ltd. アデノシンａ２ａ受容体アゴニストを有効成分として含有する緑内障治療剤
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
WO2011053569A1 (en) * 2009-10-26 2011-05-05 Inotek Pharmaceuticals Corporation Ophthalmic formulation and method of manufacture thereof
NZ703992A (en) 2012-08-01 2018-04-27 Lewis And Clark Pharmaceuticals Inc N-alkyl 2-(disubstituted)alkynyladenosine-5’-uronamides as a2a agonists
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07106983B2 (ja) * 1987-12-02 1995-11-15 三共株式会社 グリゼオール酸ジエステル誘導体
WO1990005526A1 (en) * 1988-11-15 1990-05-31 Yamasa Shoyu Kabushiki Kaisha Agent for treatment and prophylaxis of ischemic disease of heart or brain
US5039797A (en) * 1989-10-13 1991-08-13 Yale University 2'-O-(4-benzoyl)benzoyl nucleoside cyclic monophosphate
FR2685918B1 (fr) * 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista

Also Published As

Publication number Publication date
EP1110554A1 (de) 2001-06-27
ATE319458T1 (de) 2006-03-15
ES2259842T3 (es) 2006-10-16
WO2000012098A1 (fr) 2000-03-09
US6387889B1 (en) 2002-05-14
CA2342204A1 (en) 2000-03-09
EP1110554A4 (de) 2002-02-06
DE69930271D1 (de) 2006-05-04
DE69930271T2 (de) 2006-08-24
DK1110554T3 (da) 2006-04-10
CN1151794C (zh) 2004-06-02
EP1110554B1 (de) 2006-03-08
JP2002173427A (ja) 2002-06-21
CN1315862A (zh) 2001-10-03
AU5446299A (en) 2000-03-21

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: ENDO, KAZUKI, NARITA-SHI, CHIBA 286-0014, JP

Inventor name: ABIRU, TOICHI, SAWARA-SHI, CHIBA 287-0013, JP

Inventor name: HOSOKAWA, TOMOKAZU, SAGAMIHARA-SHI, KANAGAWA 229-1

Inventor name: MISAWA, MIWA, SUGINAMI-KU, TOKYO 167-0031, JP

Inventor name: KONNO, TAKASHI, FUKUSHIMA RESEARCH LABORATORIES, F

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee