DE69929433T2 - Katheter zur entnahme von zellulärem material aus der brustdrüse - Google Patents
Katheter zur entnahme von zellulärem material aus der brustdrüse Download PDFInfo
- Publication number
- DE69929433T2 DE69929433T2 DE69929433T DE69929433T DE69929433T2 DE 69929433 T2 DE69929433 T2 DE 69929433T2 DE 69929433 T DE69929433 T DE 69929433T DE 69929433 T DE69929433 T DE 69929433T DE 69929433 T2 DE69929433 T2 DE 69929433T2
- Authority
- DE
- Germany
- Prior art keywords
- duct
- lumen
- fluid
- catheter
- milk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000000481 breast Anatomy 0.000 title abstract description 66
- 239000000463 material Substances 0.000 title abstract description 53
- 230000001413 cellular effect Effects 0.000 title abstract description 26
- 239000012530 fluid Substances 0.000 claims abstract description 172
- 238000011010 flushing procedure Methods 0.000 claims description 60
- 210000005075 mammary gland Anatomy 0.000 claims description 3
- 230000009977 dual effect Effects 0.000 claims description 2
- 239000008267 milk Substances 0.000 abstract description 121
- 210000004080 milk Anatomy 0.000 abstract description 121
- 238000000034 method Methods 0.000 abstract description 52
- 239000003550 marker Substances 0.000 abstract description 23
- 239000000126 substance Substances 0.000 abstract description 3
- 238000005406 washing Methods 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 description 65
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 39
- 239000002953 phosphate buffered saline Substances 0.000 description 39
- 239000007788 liquid Substances 0.000 description 38
- 210000002445 nipple Anatomy 0.000 description 33
- 230000006835 compression Effects 0.000 description 32
- 238000007906 compression Methods 0.000 description 32
- 210000000038 chest Anatomy 0.000 description 25
- 239000000523 sample Substances 0.000 description 17
- 238000011084 recovery Methods 0.000 description 16
- 235000013336 milk Nutrition 0.000 description 14
- 230000008569 process Effects 0.000 description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 210000002919 epithelial cell Anatomy 0.000 description 7
- 238000001802 infusion Methods 0.000 description 7
- 241001136792 Alle Species 0.000 description 6
- 208000006994 Precancerous Conditions Diseases 0.000 description 6
- 238000002405 diagnostic procedure Methods 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 230000002262 irrigation Effects 0.000 description 6
- 238000003973 irrigation Methods 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 206010006187 Breast cancer Diseases 0.000 description 4
- 208000026310 Breast neoplasm Diseases 0.000 description 4
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 4
- 210000004883 areola Anatomy 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 235000020256 human milk Nutrition 0.000 description 4
- 210000004251 human milk Anatomy 0.000 description 4
- 229960004194 lidocaine Drugs 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 2
- 229930182837 (R)-adrenaline Natural products 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241001631457 Cannula Species 0.000 description 2
- 101100453960 Drosophila melanogaster klar gene Proteins 0.000 description 2
- 208000037396 Intraductal Noninfiltrating Carcinoma Diseases 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 239000002771 cell marker Substances 0.000 description 2
- 238000011982 device technology Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000028715 ductal breast carcinoma in situ Diseases 0.000 description 2
- 229960005139 epinephrine Drugs 0.000 description 2
- 230000005021 gait Effects 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000002690 local anesthesia Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- NLUFDZBOHMOBOE-UHFFFAOYSA-M sodium;2-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,4-disulfonate Chemical compound [Na+].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC=C(C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 NLUFDZBOHMOBOE-UHFFFAOYSA-M 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 206010006223 Breast discharge Diseases 0.000 description 1
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
- 206010053459 Secretion discharge Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 208000030270 breast disease Diseases 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000007387 excisional biopsy Methods 0.000 description 1
- 210000000497 foam cell Anatomy 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000001744 histochemical effect Effects 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 201000004933 in situ carcinoma Diseases 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000013101 initial test Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000007388 punch biopsy Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002023 somite Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000012128 staining reagent Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Surgical Instruments (AREA)
- Prostheses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/067,661 US6221622B1 (en) | 1998-04-28 | 1998-04-28 | Method and kit for obtaining fluids and cellular material from breast ducts |
| US67661 | 1998-04-28 | ||
| PCT/US1999/009141 WO1999055384A1 (en) | 1998-04-28 | 1999-04-28 | Method and kit for obtaining fluids and cellular material from breast ducts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69929433D1 DE69929433D1 (de) | 2006-04-06 |
| DE69929433T2 true DE69929433T2 (de) | 2006-08-24 |
Family
ID=22077527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69929433T Expired - Fee Related DE69929433T2 (de) | 1998-04-28 | 1999-04-28 | Katheter zur entnahme von zellulärem material aus der brustdrüse |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6221622B1 (enExample) |
| EP (2) | EP1656953A1 (enExample) |
| JP (1) | JP2002512853A (enExample) |
| AT (1) | ATE315418T1 (enExample) |
| AU (1) | AU753939B2 (enExample) |
| CA (1) | CA2327514C (enExample) |
| DE (1) | DE69929433T2 (enExample) |
| ES (1) | ES2258330T3 (enExample) |
| IL (2) | IL138773A0 (enExample) |
| NZ (1) | NZ507070A (enExample) |
| WO (1) | WO1999055384A1 (enExample) |
| ZA (1) | ZA200005020B (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500114B1 (en) | 1993-11-23 | 2002-12-31 | Dofi Technologies, Inc. | Method of extracting biopsy cells from the breast |
| US6890311B2 (en) * | 1997-09-16 | 2005-05-10 | The Regents Of The University Of California | Methods for performing medical procedures within a breast duct |
| US6168779B1 (en) * | 1997-09-16 | 2001-01-02 | The Regents Of The University Of California | Methods and kits for identifying ductal orifices |
| US6413228B1 (en) * | 1998-12-28 | 2002-07-02 | Pro Duct Health, Inc. | Devices, methods and systems for collecting material from a breast duct |
| CA2356963A1 (en) * | 1998-12-28 | 2000-07-06 | David Hung | Devices, methods and systems for collecting material from a breast duct |
| US20020110609A1 (en) * | 1998-12-28 | 2002-08-15 | David Hung | Increasing retrievable fluid from a breast duct |
| US6471660B1 (en) | 1999-01-21 | 2002-10-29 | Chandice Covington | Method and apparatus for measuring factors in mammary fluids |
| US6610484B1 (en) * | 1999-01-26 | 2003-08-26 | Cytyc Health Corporation | Identifying material from a breast duct |
| US6638727B1 (en) * | 1999-01-26 | 2003-10-28 | Cytyc Health Corporation | Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer |
| AU2003204883B9 (en) * | 1999-03-01 | 2006-09-28 | Atossa Genetics, Inc. | Apparatus, methods and kits for simultaneous delivery of a substance to multiple breast milk ducts |
| US6398765B1 (en) * | 1999-03-01 | 2002-06-04 | Pro Duct Health, Inc. | Apparatus, methods and kits for simultaneous delivery of a substance to multiple breast milk ducts |
| US6642009B2 (en) * | 1999-05-17 | 2003-11-04 | Cytyc Health Corporation | Isolated ductal fluid sample |
| ATE341345T1 (de) * | 1999-06-11 | 2006-10-15 | Cytyc Corp | Flüssige gelformulierung zum detektieren von milchkanälen in der brust vor einer chirurgischen ablation des brustgewebes |
| IL147486A0 (en) * | 1999-07-09 | 2002-08-14 | Burnham Inst | Methods and reagents for determining the prognosis of cancer patients by measuring bag proteins |
| US20040153001A1 (en) * | 1999-12-28 | 2004-08-05 | David Hung | Devices, methods and systems for collecting material from a breast duct |
| WO2001085023A2 (en) | 2000-05-10 | 2001-11-15 | Cytyc Health Corporation | Method for differentiating breast ducts for cancer risk status |
| EP1307738A2 (en) * | 2000-07-28 | 2003-05-07 | Cytyc Health Corporation | Cytological evaluation of breast duct epithelial cells retrieved by ductal lavage |
| US20020013539A1 (en) | 2000-07-28 | 2002-01-31 | David Hung | Methods and devices for diagnosis of precancer and cancer in breast milk ducts |
| EP1785727A3 (en) * | 2000-08-08 | 2007-08-29 | Cytyc Corporation | Identification of viral agents in breast ducts and antiviral therapy therefore |
| AU2001281161B2 (en) * | 2000-08-08 | 2007-08-23 | Atossa Genetics, Inc. | Identification of viral agents in breast ducts and antiviral therapy therefore |
| US20020117169A1 (en) | 2001-02-27 | 2002-08-29 | Kurz Daniel R. | Cover and applicator for a portion of a mammalian body |
| EP1379181B1 (en) * | 2001-04-16 | 2008-12-10 | Cytyc Corporation | Radially expandable dilator |
| US20050234497A1 (en) * | 2001-04-16 | 2005-10-20 | David Hung | Externally positioned medical dilator |
| US6866994B2 (en) | 2001-05-30 | 2005-03-15 | Neomatrix, Llc | Noninvasive intraductal fluid diagnostic screen |
| CA2448011C (en) * | 2001-05-30 | 2010-01-19 | Neomatrix, Inc. | Noninvasive intraductal fluid diagnostic screen |
| US20030073951A1 (en) * | 2001-05-30 | 2003-04-17 | Morton Kevin B. | Disposable patient interface for intraductal fluid aspiration system |
| US20040030264A1 (en) * | 2002-03-19 | 2004-02-12 | Cytyc Health Corporation | Method and apparatus for analyzing mammary gland fluid |
| US6878149B2 (en) | 2002-03-25 | 2005-04-12 | Acueity, Inc. | Apparatus and method for intraductal abalation |
| US6840909B2 (en) * | 2002-03-25 | 2005-01-11 | Acueity, Inc. | Apparatus and method for intraductal cytology |
| US6846311B2 (en) * | 2002-04-02 | 2005-01-25 | Acueity, Inc. | Method and apparatus for in VIVO treatment of mammary ducts by light induced fluorescence |
| WO2003089031A1 (en) * | 2002-04-19 | 2003-10-30 | Neuron Therapeutics | Subarachnoid spinal catheter for transporting cerebrospinal fluid |
| US6652442B2 (en) | 2002-04-23 | 2003-11-25 | Acueity, Inc. | Micro-endoscope assembly for intraductal brachytherapy of a mammary duct and method of using same |
| US7274809B2 (en) | 2002-08-29 | 2007-09-25 | Perceptronix Medical, Inc. And British Columbia Cancer Agency | Computerized methods and systems related to the detection of malignancy-associated changes (MAC) to detect cancer |
| CA2501330A1 (en) * | 2002-10-11 | 2004-04-22 | Sentina Biotechnology Incorporated | Methods for detection of breast cancer |
| US7534245B2 (en) * | 2002-12-02 | 2009-05-19 | Chappuis James L | Flexible tap apparatus and method of use |
| GB2400037A (en) * | 2003-03-31 | 2004-10-06 | Psimedica Ltd | Device made of silicon and method for collecting mammary fluid |
| US20050165288A1 (en) * | 2004-01-27 | 2005-07-28 | Scimed Life Systems, Inc. | Systems and methods for treating breast tissue |
| CA2575675A1 (en) * | 2004-07-30 | 2006-03-09 | Adeza Biomedical Corporation | Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin |
| US7226423B2 (en) * | 2004-10-22 | 2007-06-05 | Goldenberg Alec S | Aspiration needle with venting feature |
| US20060149141A1 (en) * | 2004-12-30 | 2006-07-06 | Ellen Sheets | Method of using pressure to determine the positioning of a catheter within a breast duct |
| US20070142744A1 (en) * | 2005-12-16 | 2007-06-21 | Provencher Kevin M | Tissue sample needle and method of using same |
| US20070142743A1 (en) * | 2005-12-16 | 2007-06-21 | Provencher Kevin M | Tissue sample needle actuator system and apparatus and method of using same |
| DE102007014634B3 (de) * | 2007-03-23 | 2008-12-11 | Karl-Heinz Bachmann | Instrument für die medizinische Untersuchung von engen Körperkanälen |
| US20100256464A1 (en) * | 2007-05-14 | 2010-10-07 | Dr. Susan Love Research Foundation | Device for determining risk of developing breast cancer and method thereof |
| US8814846B2 (en) | 2007-11-13 | 2014-08-26 | Covidien Lp | Dual lumen catheter and method for minimally invasive endoluminal surgery |
| EP2060295A1 (en) * | 2007-11-13 | 2009-05-20 | Tyco Healthcare Group LP | Dual lumen catheter and method for minimally invasive endoluminal surgery |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
| US20110190662A1 (en) * | 2008-10-01 | 2011-08-04 | Beacon Endoscopic Corporation | Rapid exchange fna biopsy device with diagnostic and therapeutic capabilities |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| US9119926B2 (en) * | 2009-07-31 | 2015-09-01 | Avent, Inc. | Subglottic suctioning system |
| WO2013165813A1 (en) * | 2012-04-30 | 2013-11-07 | The Regents Of The University Of Colorado, A Body Corporate | Cell collecting apparatus and method of use |
| DE102013216476A1 (de) * | 2013-08-20 | 2015-02-26 | Carl Zeiss Meditec Ag | Operationsmikroskop mit optischen Schnittstellen |
| US11589846B2 (en) * | 2014-09-12 | 2023-02-28 | Robert K Ackroyd | Dual needle core biopsy instrument |
| US11701174B2 (en) | 2016-01-29 | 2023-07-18 | Boston Scientific Scimed, Inc. | Medical device having a plurality of lumens and a port |
| EP3766039B1 (en) | 2018-03-15 | 2024-08-14 | Magic Leap, Inc. | Image correction due to deformation of components of a viewing device |
| WO2021016117A1 (en) * | 2019-07-19 | 2021-01-28 | The Board Of Regents Of The University Of Oklahoma | Endoscope biopsy system and method for ductoscopy |
| EP4033991A1 (en) * | 2019-09-25 | 2022-08-03 | Oxford University Innovation Limited | Needle and uses thereof |
| US20230190242A1 (en) * | 2020-05-18 | 2023-06-22 | Thomas Jefferson University | Viral sample collection |
| WO2023245180A1 (en) * | 2022-06-16 | 2023-12-21 | Claver Harold Nathanial | Multi-lumen central line |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3473832D1 (en) * | 1983-06-14 | 1988-10-13 | Fertility & Genetics Ass | Non-surgical apparatus for human embryo transfer |
| JPH02280061A (ja) * | 1989-04-20 | 1990-11-16 | Mochida Pharmaceut Co Ltd | 微量の乳頭分泌液中の腫瘍関連抗原の測定方法および測定用器材 |
| US5167622A (en) * | 1990-12-07 | 1992-12-01 | Smiths Industries Medical Systems, Inc. | Triple conduit suction catheter |
| US5413558A (en) * | 1991-09-09 | 1995-05-09 | New York University | Selective aortic perfusion system for use during CPR |
| US5443454A (en) * | 1992-12-09 | 1995-08-22 | Terumo Kabushiki Kaisha | Catheter for embolectomy |
| US5348536A (en) * | 1993-08-02 | 1994-09-20 | Quinton Instrument Company | Coextruded catheter and method of forming |
| WO1997005898A1 (en) | 1995-08-03 | 1997-02-20 | The Johns Hopkins University School Of Medicine | Delivery of an agent to the ductal epithelium in the prophylactic and therapeutic treatment of cancer |
| BR9601849A (pt) * | 1996-06-18 | 1998-09-01 | Newton Paes | Aperfeiçoamento em cateter de dupla via para lavagem drenagem monitoração e controle de pressão intracraniana |
| US6168779B1 (en) * | 1997-09-16 | 2001-01-02 | The Regents Of The University Of California | Methods and kits for identifying ductal orifices |
-
1998
- 1998-04-28 US US09/067,661 patent/US6221622B1/en not_active Expired - Lifetime
-
1999
- 1999-04-28 EP EP05027586A patent/EP1656953A1/en not_active Withdrawn
- 1999-04-28 WO PCT/US1999/009141 patent/WO1999055384A1/en not_active Ceased
- 1999-04-28 IL IL13877399A patent/IL138773A0/xx unknown
- 1999-04-28 DE DE69929433T patent/DE69929433T2/de not_active Expired - Fee Related
- 1999-04-28 NZ NZ507070A patent/NZ507070A/en unknown
- 1999-04-28 EP EP99920083A patent/EP1073476B1/en not_active Expired - Lifetime
- 1999-04-28 AT AT99920083T patent/ATE315418T1/de not_active IP Right Cessation
- 1999-04-28 AU AU37663/99A patent/AU753939B2/en not_active Ceased
- 1999-04-28 US US09/301,058 patent/US6494859B2/en not_active Expired - Lifetime
- 1999-04-28 JP JP2000545580A patent/JP2002512853A/ja not_active Ceased
- 1999-04-28 ES ES99920083T patent/ES2258330T3/es not_active Expired - Lifetime
- 1999-04-28 CA CA002327514A patent/CA2327514C/en not_active Expired - Fee Related
-
2000
- 2000-09-20 ZA ZA200005020A patent/ZA200005020B/en unknown
- 2000-09-28 IL IL138773A patent/IL138773A/en not_active IP Right Cessation
- 2000-12-19 US US09/740,561 patent/US20010001059A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200005020B (en) | 2002-06-20 |
| US6221622B1 (en) | 2001-04-24 |
| US6494859B2 (en) | 2002-12-17 |
| AU753939B2 (en) | 2002-10-31 |
| AU3766399A (en) | 1999-11-16 |
| EP1656953A1 (en) | 2006-05-17 |
| EP1073476B1 (en) | 2006-01-11 |
| DE69929433D1 (de) | 2006-04-06 |
| NZ507070A (en) | 2007-02-23 |
| CA2327514A1 (en) | 1999-11-04 |
| CA2327514C (en) | 2008-08-26 |
| WO1999055384A1 (en) | 1999-11-04 |
| ES2258330T3 (es) | 2006-08-16 |
| US20010001059A1 (en) | 2001-05-10 |
| IL138773A (en) | 2009-07-20 |
| EP1073476A1 (en) | 2001-02-07 |
| US20020019017A1 (en) | 2002-02-14 |
| ATE315418T1 (de) | 2006-02-15 |
| IL138773A0 (en) | 2001-10-31 |
| JP2002512853A (ja) | 2002-05-08 |
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| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |