DE69929345D1 - Subtituierte isoxazole derivate als estrogen rezeptor modulatore - Google Patents
Subtituierte isoxazole derivate als estrogen rezeptor modulatoreInfo
- Publication number
- DE69929345D1 DE69929345D1 DE69929345T DE69929345T DE69929345D1 DE 69929345 D1 DE69929345 D1 DE 69929345D1 DE 69929345 T DE69929345 T DE 69929345T DE 69929345 T DE69929345 T DE 69929345T DE 69929345 D1 DE69929345 D1 DE 69929345D1
- Authority
- DE
- Germany
- Prior art keywords
- estrogen receptor
- subtitled
- receptor modulators
- isoxazole derivatives
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9577398P | 1998-08-07 | 1998-08-07 | |
US95773P | 1998-08-07 | ||
PCT/US1999/017798 WO2000008001A1 (en) | 1998-08-07 | 1999-08-06 | Substituted isoxazole as estrogen receptor modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69929345D1 true DE69929345D1 (de) | 2006-03-30 |
DE69929345T2 DE69929345T2 (de) | 2006-09-21 |
Family
ID=22253531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69929345T Expired - Lifetime DE69929345T2 (de) | 1998-08-07 | 1999-08-06 | Substituierte isoxal-derivate als östrogenrezeptormodulatoren |
Country Status (8)
Country | Link |
---|---|
US (4) | US6262098B1 (de) |
EP (1) | EP1102755B1 (de) |
JP (1) | JP2002522425A (de) |
AT (1) | ATE315033T1 (de) |
AU (1) | AU5467699A (de) |
DE (1) | DE69929345T2 (de) |
ES (1) | ES2255294T3 (de) |
WO (1) | WO2000008001A1 (de) |
Families Citing this family (80)
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US6632447B1 (en) | 1998-05-07 | 2003-10-14 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
US6413534B1 (en) | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
AU5467699A (en) * | 1998-08-07 | 2000-02-28 | Chiron Corporation | Substituted isoxazole as estrogen receptor modulators |
DE10039199A1 (de) * | 2000-08-10 | 2002-02-21 | Schering Ag | Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen |
JP2002069061A (ja) * | 2000-08-30 | 2002-03-08 | Canon Inc | オキサゾール化合物及びそれを用いた有機発光素子 |
CA2429426A1 (en) | 2000-11-17 | 2002-05-23 | Takeda Chemical Industries, Ltd. | Isoxazole derivatives |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
ATE381542T1 (de) * | 2001-08-13 | 2008-01-15 | Phenex Pharmaceuticals Ag | Nr1h4-kern-rezeptor-bindende verbindungen |
US20040044226A1 (en) * | 2001-10-15 | 2004-03-04 | Dininno Frank P. | Estrogen receptor modulators |
US7524866B2 (en) * | 2001-11-29 | 2009-04-28 | Gtx, Inc. | Prevention and treatment of androgen—deprivation induced osteoporosis |
US20050080143A1 (en) * | 2001-11-29 | 2005-04-14 | Steiner Mitchell S. | Treatment of androgen-deprivation induced osteoporosis |
US20060269611A1 (en) * | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
US20040214898A1 (en) * | 2001-11-29 | 2004-10-28 | Steiner Mitchell S. | Methods for treating hot flashes |
US20040213841A1 (en) * | 2001-11-29 | 2004-10-28 | Steiner Mitchell S | Methods for treating hot flashes and gynecomastia |
US20080249183A1 (en) * | 2001-11-29 | 2008-10-09 | Steiner Mitchell S | Treatment of androgen-deprivation induced osteoporosis |
US20040096510A1 (en) * | 2001-11-29 | 2004-05-20 | Steiner Mitchell S. | Prevention and treatment of androgen-deprivation induced osteoporosis |
BR0214801A (pt) * | 2001-11-29 | 2005-01-11 | Gtx Inc | Prevenção e tratamento de osteoporose induzida pela privação de andrógeno |
US20070197664A1 (en) * | 2001-11-29 | 2007-08-23 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
RU2004125594A (ru) * | 2002-01-22 | 2005-03-10 | Акцо Нобель Н.В. (NL) | Применение тиболона при лечение симптомов, связанных с введением лекарств, препятствующих синтезу эндогенного эстрогена |
AU2003290700A1 (en) * | 2002-11-22 | 2004-06-18 | Smithkline Beecham Corporation | Farnesoid x receptor agonists |
US7332525B2 (en) | 2003-01-17 | 2008-02-19 | Castle Erik P | Method of treatment of prostate cancer and composition for treatment thereof |
SI1611112T1 (sl) * | 2003-02-11 | 2012-12-31 | Vernalis (R&D) Limited | Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov |
ATE406364T1 (de) | 2003-03-07 | 2008-09-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
CN1756756A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
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DE295360C (de) | ||||
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-
1999
- 1999-08-06 AU AU54676/99A patent/AU5467699A/en not_active Abandoned
- 1999-08-06 AT AT99940916T patent/ATE315033T1/de not_active IP Right Cessation
- 1999-08-06 DE DE69929345T patent/DE69929345T2/de not_active Expired - Lifetime
- 1999-08-06 JP JP2000563634A patent/JP2002522425A/ja active Pending
- 1999-08-06 EP EP99940916A patent/EP1102755B1/de not_active Expired - Lifetime
- 1999-08-06 ES ES99940916T patent/ES2255294T3/es not_active Expired - Lifetime
- 1999-08-06 US US09/369,748 patent/US6262098B1/en not_active Expired - Fee Related
- 1999-08-06 WO PCT/US1999/017798 patent/WO2000008001A1/en active IP Right Grant
-
2001
- 2001-04-11 US US09/833,392 patent/US6387920B2/en not_active Expired - Fee Related
-
2002
- 2002-04-25 US US10/134,302 patent/US6743815B2/en not_active Expired - Fee Related
-
2003
- 2003-11-13 US US10/713,621 patent/US6869969B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2000008001A1 (en) | 2000-02-17 |
US6743815B2 (en) | 2004-06-01 |
US6869969B2 (en) | 2005-03-22 |
DE69929345T2 (de) | 2006-09-21 |
EP1102755A1 (de) | 2001-05-30 |
US20040102498A1 (en) | 2004-05-27 |
AU5467699A (en) | 2000-02-28 |
EP1102755B1 (de) | 2006-01-04 |
US6387920B2 (en) | 2002-05-14 |
JP2002522425A (ja) | 2002-07-23 |
US20010036956A1 (en) | 2001-11-01 |
ES2255294T3 (es) | 2006-06-16 |
US20030065012A1 (en) | 2003-04-03 |
ATE315033T1 (de) | 2006-02-15 |
US6262098B1 (en) | 2001-07-17 |
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Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US |