DE69928110D1 - Trägerhilfstoff - Google Patents
TrägerhilfstoffInfo
- Publication number
- DE69928110D1 DE69928110D1 DE69928110T DE69928110T DE69928110D1 DE 69928110 D1 DE69928110 D1 DE 69928110D1 DE 69928110 T DE69928110 T DE 69928110T DE 69928110 T DE69928110 T DE 69928110T DE 69928110 D1 DE69928110 D1 DE 69928110D1
- Authority
- DE
- Germany
- Prior art keywords
- support material
- material help
- help
- whiteness
- trehalose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 abstract 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20029598 | 1998-07-15 | ||
JP20029598 | 1998-07-15 | ||
JP32356098 | 1998-11-13 | ||
JP32356098 | 1998-11-13 | ||
PCT/JP1999/003775 WO2000003735A1 (fr) | 1998-07-15 | 1999-07-13 | Excipient |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69928110D1 true DE69928110D1 (de) | 2005-12-08 |
DE69928110T2 DE69928110T2 (de) | 2006-07-27 |
Family
ID=26512084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69928110T Expired - Lifetime DE69928110T2 (de) | 1998-07-15 | 1999-07-13 | Trägerhilfstoff |
Country Status (10)
Country | Link |
---|---|
US (1) | US6699845B2 (de) |
EP (1) | EP1097722B1 (de) |
JP (1) | JP4748627B2 (de) |
KR (1) | KR100421264B1 (de) |
CN (1) | CN1185013C (de) |
AT (1) | ATE308343T1 (de) |
AU (1) | AU743109B2 (de) |
CA (1) | CA2337015C (de) |
DE (1) | DE69928110T2 (de) |
WO (1) | WO2000003735A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US20040131672A1 (en) * | 2003-01-07 | 2004-07-08 | Nilobon Podhipleux | Direct compression pharmaceutical composition containing a pharmaceutically active ingredient with poor flowing properties |
EP1460080A1 (de) * | 2003-03-21 | 2004-09-22 | Cargill Incorporated | Direkt komprimierbare Trehalose in fester Form |
CN1764388B (zh) * | 2003-03-26 | 2010-05-05 | 株式会社林原生物化学研究所 | 非糖质成分的粉末化方法及粉末化基剂 |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
JP2007131587A (ja) * | 2005-11-11 | 2007-05-31 | Activas Pharma:Kk | キノリノン誘導体を有効成分とする医薬組成物、及びその製造方法 |
EP1962806B1 (de) * | 2005-12-07 | 2010-09-01 | Nycomed Pharma AS | Vorkompaktierte calciumhaltige zusammensetzungen |
CN100391541C (zh) * | 2006-03-16 | 2008-06-04 | 南台科技大学 | 以胶质类食材制造赋形剂的方法 |
AU2007232098A1 (en) * | 2006-03-31 | 2007-10-11 | Rubicon Research Private Limited | Directly compressible composite for orally disintegrating tablets |
EA030606B1 (ru) | 2006-05-04 | 2018-08-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Способы приготовления лекарственного средства, содержащего полиморфы |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
EP1852108A1 (de) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Zusammensetzungen von DPP-IV-Inhibitoren |
CA2656181C (en) * | 2006-06-27 | 2011-09-06 | Daiichi Sankyo Company, Limited | Compressed preparation of compositions comprising olmesartan medoxomil |
WO2008079342A2 (en) * | 2006-12-21 | 2008-07-03 | Mallinckrodt Inc. | Composition of and method for preparing orally disintegrating tablets |
PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
JP5344938B2 (ja) * | 2009-01-29 | 2013-11-20 | 旭化成ケミカルズ株式会社 | 崩壊性固形製剤 |
ES2760917T3 (es) | 2009-11-27 | 2020-05-18 | Boehringer Ingelheim Int | Tratamiento de pacientes diabéticos genotipificados con inhibidores DPP-IV como la linagliptina |
JP6034781B2 (ja) | 2010-05-05 | 2016-11-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 併用療法 |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
CN103946386B (zh) | 2011-09-21 | 2018-01-02 | 株式会社林原 | 含有α,α‑海藻糖二水合物晶体的粉末的制备方法 |
US9522964B2 (en) * | 2012-04-03 | 2016-12-20 | Development, Inc. | Micronized starch and methods for manufacturing same |
EP3685839A1 (de) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin zur verwendung in der behandlung von albuminuria und nierenbedingten erkrankungen |
EP3556220A4 (de) | 2017-10-03 | 2020-06-03 | Mizkan Holdings Co., Ltd. | Zusammensetzung mit lebensmittelmikropartikelkomplexen und verfahren zur herstellung davon |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4678812A (en) | 1986-05-30 | 1987-07-07 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
US4762857A (en) | 1986-05-30 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
JP3069458B2 (ja) | 1992-01-29 | 2000-07-24 | 武田薬品工業株式会社 | 口腔内崩壊型錠剤およびその製造法 |
DE627218T1 (de) | 1992-02-18 | 1995-08-24 | Nippon Shinyaku Co Ltd | Schnelllösliche tablette. |
JPH069382A (ja) * | 1992-04-17 | 1994-01-18 | Takeda Chem Ind Ltd | 安定化された固型製剤およびその製造方法 |
DE69325700T2 (de) | 1992-12-28 | 1999-12-30 | Hayashibara Biochem Lab | Nichtreduzierendes saccharidbildendes Enzym, und dessen Herstellung und Verwendungen |
JP3773062B2 (ja) * | 1993-01-29 | 2006-05-10 | 味の素株式会社 | 製剤用添加剤 |
JP3559585B2 (ja) * | 1993-06-03 | 2004-09-02 | 株式会社林原生物化学研究所 | トレハロース遊離酵素とその製造方法並びに用途 |
NZ278678A (en) | 1994-01-31 | 1998-03-25 | Yamanouchi Pharma Co Ltd | Compressed moulded tablet with quick disintegration/dissolution in the mouth, mixture of low and high moldable saccharides as carriers |
JP3534130B2 (ja) * | 1994-03-01 | 2004-06-07 | 旭化成ケミカルズ株式会社 | 医薬品組成物 |
TW426737B (en) * | 1994-06-27 | 2001-03-21 | Hayashibara Biochem Lab | Saccharide composition with reduced reducibility, and preparation and uses thereof |
JP3616166B2 (ja) | 1994-07-19 | 2005-02-02 | 株式会社林原生物化学研究所 | トレハロースとその製造方法並びに用途 |
JP2919771B2 (ja) | 1995-04-17 | 1999-07-19 | 佐藤製薬株式会社 | 速溶解性錠剤の製造方法及び該製造方法により製造した速溶解性錠剤 |
JP3418274B2 (ja) | 1995-06-05 | 2003-06-16 | 日本化薬株式会社 | 口腔内感触の良好な錠剤 |
JPH0948726A (ja) | 1995-08-07 | 1997-02-18 | Tanabe Seiyaku Co Ltd | 口腔内速崩壊性製剤およびその製法 |
CA2204599A1 (en) | 1995-09-07 | 1997-03-13 | Otsuka Pharmaceutical Co., Ltd. | Low-pressure tableted effervescent preparation |
JP3624038B2 (ja) * | 1995-12-11 | 2005-02-23 | 株式会社林原生物化学研究所 | 糖衣固形物及びその製造方法 |
CN1213299A (zh) * | 1996-02-09 | 1999-04-07 | 剑桥夸准脱控股有限公司 | 包含海藻糖的固体制剂 |
JPH09316006A (ja) | 1996-05-29 | 1997-12-09 | Yatsuken:Kk | 口腔内溶解性固形製剤 |
ATE297191T1 (de) | 1996-06-14 | 2005-06-15 | Kyowa Hakko Kogyo Kk | Im munde schnellzerfallende tablette |
GB9616536D0 (en) * | 1996-08-06 | 1996-09-25 | Quadrant Holdings Cambridge | Co-amoxiclav dosage form |
JPH11116464A (ja) | 1997-10-09 | 1999-04-27 | Ss Pharmaceut Co Ltd | 迅速溶解性固形製剤およびその製造法 |
TW527195B (en) * | 1997-10-09 | 2003-04-11 | Ssp Co Ltd | Fast-soluble solid pharmaceutical combinations |
-
1999
- 1999-07-13 WO PCT/JP1999/003775 patent/WO2000003735A1/ja active IP Right Grant
- 1999-07-13 CN CNB998086274A patent/CN1185013C/zh not_active Expired - Lifetime
- 1999-07-13 DE DE69928110T patent/DE69928110T2/de not_active Expired - Lifetime
- 1999-07-13 AT AT99929812T patent/ATE308343T1/de not_active IP Right Cessation
- 1999-07-13 KR KR10-2001-7000538A patent/KR100421264B1/ko not_active IP Right Cessation
- 1999-07-13 EP EP99929812A patent/EP1097722B1/de not_active Expired - Lifetime
- 1999-07-13 CA CA002337015A patent/CA2337015C/en not_active Expired - Lifetime
- 1999-07-13 JP JP2000559869A patent/JP4748627B2/ja not_active Expired - Lifetime
- 1999-07-13 AU AU46516/99A patent/AU743109B2/en not_active Expired
-
2001
- 2001-01-12 US US09/759,104 patent/US6699845B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1097722A1 (de) | 2001-05-09 |
CN1185013C (zh) | 2005-01-19 |
US6699845B2 (en) | 2004-03-02 |
ATE308343T1 (de) | 2005-11-15 |
AU4651699A (en) | 2000-02-07 |
EP1097722B1 (de) | 2005-11-02 |
CN1309570A (zh) | 2001-08-22 |
DE69928110T2 (de) | 2006-07-27 |
WO2000003735A1 (fr) | 2000-01-27 |
EP1097722A4 (de) | 2002-03-20 |
KR20010071883A (ko) | 2001-07-31 |
KR100421264B1 (ko) | 2004-03-18 |
JP4748627B2 (ja) | 2011-08-17 |
AU743109B2 (en) | 2002-01-17 |
US20020042393A1 (en) | 2002-04-11 |
CA2337015A1 (en) | 2000-01-27 |
CA2337015C (en) | 2004-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |