DE69921982D1 - Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbank - Google Patents
Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbankInfo
- Publication number
- DE69921982D1 DE69921982D1 DE69921982T DE69921982T DE69921982D1 DE 69921982 D1 DE69921982 D1 DE 69921982D1 DE 69921982 T DE69921982 T DE 69921982T DE 69921982 T DE69921982 T DE 69921982T DE 69921982 D1 DE69921982 D1 DE 69921982D1
- Authority
- DE
- Germany
- Prior art keywords
- clones
- library
- desired biological
- biological property
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00387—Applications using probes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7059098A | 1998-04-30 | 1998-04-30 | |
US70590 | 1998-04-30 | ||
PCT/EP1999/002963 WO1999057311A2 (en) | 1998-04-30 | 1999-04-30 | Novel method for the identification of clones conferring a desired biological property from an expression library |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69921982D1 true DE69921982D1 (de) | 2004-12-23 |
DE69921982T2 DE69921982T2 (de) | 2005-12-29 |
Family
ID=22096239
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69921982T Expired - Lifetime DE69921982T2 (de) | 1998-04-30 | 1999-04-30 | Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbank |
DE1073770T Pending DE1073770T1 (de) | 1998-04-30 | 1999-04-30 | Neuartiges Verfahren zur Identifizierung von Klonen mit einer gewünschten Biologischen Eigenschaft, ausgehend von einer Expressionsgenbank (2001/06) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1073770T Pending DE1073770T1 (de) | 1998-04-30 | 1999-04-30 | Neuartiges Verfahren zur Identifizierung von Klonen mit einer gewünschten Biologischen Eigenschaft, ausgehend von einer Expressionsgenbank (2001/06) |
Country Status (8)
Country | Link |
---|---|
US (2) | US20050244854A1 (de) |
EP (1) | EP1073770B1 (de) |
JP (2) | JP4540846B2 (de) |
AT (1) | ATE282717T1 (de) |
AU (1) | AU770540B2 (de) |
CA (1) | CA2326390A1 (de) |
DE (2) | DE69921982T2 (de) |
WO (1) | WO1999057311A2 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002502977A (ja) | 1998-02-04 | 2002-01-29 | インビトロジェン コーポレイション | マイクロアレイとその使用 |
EP1198566A2 (de) * | 1999-07-05 | 2002-04-24 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Methode mit einer hohen durchsatzrate zur selektion von interagierenden molekülen |
US20020006664A1 (en) | 1999-09-17 | 2002-01-17 | Sabatini David M. | Arrayed transfection method and uses related thereto |
ATE346156T1 (de) | 1999-09-17 | 2006-12-15 | Whitehead Biomedical Inst | Umkehrtransfektionsverfahren |
DE19957827C2 (de) * | 1999-11-25 | 2003-06-12 | Epigenomics Ag | Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche |
JP2004511753A (ja) | 2000-05-04 | 2004-04-15 | イエール ユニバーシティー | タンパク質活性のスクリーニング用タンパク質チップ |
US20020055110A1 (en) * | 2000-06-23 | 2002-05-09 | Ian Tomlinson | Matrix screening method |
US7452964B2 (en) | 2001-09-07 | 2008-11-18 | Board Of Regents, The University Of Texas System | Compositions and methods of use of targeting peptides against placenta and adipose tissues |
US20040170955A1 (en) | 2000-09-08 | 2004-09-02 | Wadih Arap | Human and mouse targeting peptides identified by phage display |
US7420030B2 (en) | 2000-09-08 | 2008-09-02 | The Board Of Regents Of The University Of Texas System | Aminopeptidase A (APA) targeting peptides for the treatment of cancer |
US7981842B2 (en) | 2001-06-08 | 2011-07-19 | Panomics, Inc. | Method for detecting transcription factor-protein interactions |
US7993864B2 (en) | 2002-12-03 | 2011-08-09 | Ucb Pharma S.A. | Assay for identifying antibody producing cells |
DE102004056794B4 (de) * | 2004-11-24 | 2010-08-26 | Protagen Ag | Verwendung einer Anordnung und Verfahren zur Validierung von Bindern |
JP5601746B2 (ja) * | 2006-03-16 | 2014-10-08 | 日本ソフトウェアマネジメント株式会社 | 同一の試料を用いた二段階核酸検査方法 |
US8536115B2 (en) * | 2006-08-31 | 2013-09-17 | Centre For Addiction And Mental Health | Compositions and methods for modulating AMPA receptor-mediated excitotoxicity |
WO2008092442A1 (de) | 2007-02-01 | 2008-08-07 | Protagen Aktiengesellschaft | Stratifizierung und therapiesteuerung eines patienten mittels proteinbiochips |
DE102007028050A1 (de) | 2007-06-14 | 2008-12-18 | Protagen Ag | Hautchip |
DE102007041656A1 (de) | 2007-09-03 | 2009-05-07 | Protagen Ag | Markersequenzen für rheumatoide Arthritis und deren Verwendung |
CN101842705A (zh) | 2007-09-03 | 2010-09-22 | 普罗塔根股份公司 | 用于类风湿性关节炎的标记序列及其应用 |
DE102007041657A1 (de) | 2007-09-03 | 2009-03-05 | Protagen Ag | Markersequenzen für Multiple Sklerose und deren Verwendung |
DE102007041654A1 (de) | 2007-09-03 | 2009-07-23 | Protagen Ag | Markersequenzen für juvenile idiopathische Arthritis und deren Verwendung |
DE102007062847A1 (de) | 2007-12-21 | 2009-12-31 | Protagen Ag | Markersequenzen für neurodegenerative Erkrankungen und deren Verwendung |
DE102008031699A1 (de) | 2008-07-04 | 2010-01-14 | Protagen Ag | Markersequenzen für Prostataentzündungserkrankungen, Prostatakarzinom und deren Verwendung |
EP2275568A1 (de) | 2009-07-13 | 2011-01-19 | Universitätsklinikum Regensburg | Markersequenzen für Adipositas und deren Verwendung |
CA2775978A1 (en) | 2009-09-29 | 2011-04-07 | Protagen Ag | Marker sequences for pancreatic cancer diseases, pancreatic carcinoma and use thereof |
WO2011039366A1 (en) | 2009-10-01 | 2011-04-07 | Protagen Ag | Biomarkers for alzheimer's disease |
EP2437060A1 (de) | 2010-10-01 | 2012-04-04 | Protagen AG | Markersequenzen für Multiple Sklerose und deren Verwendung |
DE102010042359A1 (de) | 2010-10-12 | 2012-04-12 | Protagen Ag | Markersequenzen für Multiple Sklerose und deren Verwendung |
EP2441848A1 (de) | 2010-10-12 | 2012-04-18 | Protagen AG | Markersequenzen für systemischer Lupus Erythematodes und deren Verwendung |
EP2487251A1 (de) | 2011-02-13 | 2012-08-15 | Protagen AG | Markersequenzen für die Diagnose von Prostatakarzinom und deren Verwendung |
EP2745115B1 (de) | 2011-08-19 | 2016-05-18 | Protagen AG | Neues verfahren zur diagnostik von hochaffinen bindern und markersequenzen |
US20140371095A1 (en) | 2011-11-14 | 2014-12-18 | Protagen Ag | Novel method for identifying specific marker sequences for prostate cancer |
EP2605017A1 (de) | 2011-12-16 | 2013-06-19 | Protagen AG | Markersequenzen für gynäkologisches Malignom und deren Verwendung |
EP2607900A1 (de) | 2011-12-22 | 2013-06-26 | Protagen AG | Markersequenzen für Brustkrebs und deren Verwendung |
EP2831275A1 (de) | 2012-03-27 | 2015-02-04 | Protagen AG | Markersequenzen für rheumatoide arthritis |
EP2644704A1 (de) | 2012-03-27 | 2013-10-02 | Protagen AG | Markersequenzen für Rheumatoide Arthritis |
WO2014001576A2 (en) | 2012-06-30 | 2014-01-03 | Meyer Helmut E | Marker sequences for parkinson's disease and use thereof |
US20150226744A1 (en) | 2012-09-17 | 2015-08-13 | Ait Austrian Institute Of Technology Gmbh | Colon Cancer Diagnostic Method and Means |
EP2735875A1 (de) | 2012-11-27 | 2014-05-28 | Protagen AG | Markersequenzen für Neuromyelitis optica (NMO) und Verwendungen dafür |
EP2806274A1 (de) | 2013-05-24 | 2014-11-26 | AIT Austrian Institute of Technology GmbH | Lungenkrebsdiagnoseverfahren und -mittel |
EP2857839A1 (de) | 2013-10-01 | 2015-04-08 | AIT Austrian Institute of Technology GmbH | Brustkrebsdiagnoseverfahren und -mittel |
WO2015118184A1 (de) | 2014-02-10 | 2015-08-13 | Protagen Ag | Markersequenzen zur diagnose und stratifizierung von sle patienten |
US10677795B2 (en) | 2014-05-09 | 2020-06-09 | Protagen Ag | Marker sequences for the diagnosis and stratification of systemic sclerosis patients |
WO2017132574A1 (en) * | 2016-01-29 | 2017-08-03 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for screening pediatric gliomas and methods of treatment thereof |
EP3214444A1 (de) | 2016-03-04 | 2017-09-06 | AIT Austrian Institute of Technology GmbH | Prostatakrebs-diagnoseverfahren und -mittel |
WO2017168014A1 (de) | 2016-04-02 | 2017-10-05 | Protagen Ag | Markersequenzen für rheumatoide arthritis |
EP3258268A1 (de) | 2016-06-15 | 2017-12-20 | Protagen AG | Markersequenzen zur therapiesteuerung von patienten mit rheumatoider arthritis |
WO2018178975A1 (en) | 2017-03-28 | 2018-10-04 | Plantarcbio Ltd. | Methods for improving traits in plants |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6919211B1 (en) * | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
DE69333650T2 (de) * | 1992-02-19 | 2006-01-12 | The Public Health Research Institute Of The City Of New York, Inc. | Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren |
US6107059A (en) * | 1992-04-29 | 2000-08-22 | Affymax Technologies N.V. | Peptide library and screening method |
DE4237113B4 (de) * | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
US6335160B1 (en) * | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US6284459B1 (en) * | 1995-04-25 | 2001-09-04 | Discovery Partners International | Solid support matrices with memories and combinatorial libraries therefrom |
US5763263A (en) * | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
WO1997032017A1 (en) * | 1996-02-26 | 1997-09-04 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Novel method for the identification of nucleic acid sequences encoding two or more interacting (poly)peptides |
US6228326B1 (en) * | 1996-11-29 | 2001-05-08 | The Board Of Trustees Of The Leland Stanford Junior University | Arrays of independently-addressable supported fluid bilayer membranes |
DE69922365T2 (de) * | 1998-04-30 | 2005-04-14 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Neue methode zur selektion von klonen einer expressionsbibliothek mittels "rearraying" |
US6190908B1 (en) * | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
-
1999
- 1999-04-30 JP JP2000547262A patent/JP4540846B2/ja not_active Expired - Fee Related
- 1999-04-30 DE DE69921982T patent/DE69921982T2/de not_active Expired - Lifetime
- 1999-04-30 AT AT99924858T patent/ATE282717T1/de not_active IP Right Cessation
- 1999-04-30 EP EP99924858A patent/EP1073770B1/de not_active Expired - Lifetime
- 1999-04-30 WO PCT/EP1999/002963 patent/WO1999057311A2/en active Application Filing
- 1999-04-30 DE DE1073770T patent/DE1073770T1/de active Pending
- 1999-04-30 CA CA002326390A patent/CA2326390A1/en not_active Abandoned
- 1999-04-30 AU AU41369/99A patent/AU770540B2/en not_active Expired
-
2005
- 2005-01-27 US US11/045,173 patent/US20050244854A1/en not_active Abandoned
-
2009
- 2009-05-28 US US12/473,813 patent/US20100152051A1/en not_active Abandoned
-
2010
- 2010-05-13 JP JP2010110861A patent/JP2010227109A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2326390A1 (en) | 1999-11-11 |
DE1073770T1 (de) | 2002-07-04 |
JP2002513588A (ja) | 2002-05-14 |
AU4136999A (en) | 1999-11-23 |
AU770540B2 (en) | 2004-02-26 |
DE69921982T2 (de) | 2005-12-29 |
ATE282717T1 (de) | 2004-12-15 |
WO1999057311A2 (en) | 1999-11-11 |
US20050244854A1 (en) | 2005-11-03 |
JP2010227109A (ja) | 2010-10-14 |
WO1999057311A3 (en) | 2000-03-30 |
EP1073770A2 (de) | 2001-02-07 |
EP1073770B1 (de) | 2004-11-17 |
JP4540846B2 (ja) | 2010-09-08 |
US20100152051A1 (en) | 2010-06-17 |
Similar Documents
Publication | Publication Date | Title |
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