DE69919143T2 - Nukleinsäure hybridisierung-testverfahren in lösung - Google Patents

Nukleinsäure hybridisierung-testverfahren in lösung Download PDF

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Publication number
DE69919143T2
DE69919143T2 DE69919143T DE69919143T DE69919143T2 DE 69919143 T2 DE69919143 T2 DE 69919143T2 DE 69919143 T DE69919143 T DE 69919143T DE 69919143 T DE69919143 T DE 69919143T DE 69919143 T2 DE69919143 T2 DE 69919143T2
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DE
Germany
Prior art keywords
label
capture
waveguide
target polynucleotide
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69919143T
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German (de)
English (en)
Other versions
DE69919143D1 (de
Inventor
Andreas Abel
Joseph James BECK
Markus Ehrat
Peter Oroszlan
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Novartis AG
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Novartis AG
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Publication date
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Publication of DE69919143D1 publication Critical patent/DE69919143D1/de
Application granted granted Critical
Publication of DE69919143T2 publication Critical patent/DE69919143T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69919143T 1998-03-19 1999-03-17 Nukleinsäure hybridisierung-testverfahren in lösung Expired - Lifetime DE69919143T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9805935 1998-03-19
GBGB9805935.5A GB9805935D0 (en) 1998-03-19 1998-03-19 Organic compounds
PCT/EP1999/001782 WO1999047705A1 (en) 1998-03-19 1999-03-17 Detection method

Publications (2)

Publication Number Publication Date
DE69919143D1 DE69919143D1 (de) 2004-09-09
DE69919143T2 true DE69919143T2 (de) 2005-08-11

Family

ID=10828909

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69919143T Expired - Lifetime DE69919143T2 (de) 1998-03-19 1999-03-17 Nukleinsäure hybridisierung-testverfahren in lösung

Country Status (8)

Country Link
US (1) US20060188873A1 (https=)
EP (1) EP1064406B1 (https=)
JP (1) JP2002506984A (https=)
AT (1) ATE272721T1 (https=)
AU (1) AU3414599A (https=)
DE (1) DE69919143T2 (https=)
GB (1) GB9805935D0 (https=)
WO (1) WO1999047705A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001079821A1 (de) * 2000-04-14 2001-10-25 Zeptosens Ag Gitter-wellenleiter-struktur zur verstärkung eines anregungsfeldes und deren verwendung
AU2001226796A1 (en) * 2000-05-06 2001-11-26 Zeptosens Ag Grating optical waveguide structure for multi-analyte determinations and the usethereof
US7158224B2 (en) 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
GB0106949D0 (en) * 2001-03-20 2001-05-09 Norchip As Detection of mycobacteria
JP3448654B2 (ja) 2001-11-22 2003-09-22 北陸先端科学技術大学院大学長 バイオチップ、バイオチップアレイ、及びそれらを用いたスクリーニング方法
JP2005519593A (ja) * 2002-01-18 2005-07-07 ユニバーシティ オブ ユタ リサーチ ファウンデーション 平面導波路を使用する1塩基多型の検出法
GB0507835D0 (en) * 2005-04-18 2005-05-25 Solexa Ltd Method and device for nucleic acid sequencing using a planar wave guide
EP1939622B1 (en) * 2005-09-27 2011-09-21 Eisai R&D Management Co., Ltd. Method of forming autoaggregate on microparticle and method of detecting target analyte
KR20100025328A (ko) * 2008-08-27 2010-03-09 삼성전자주식회사 이중가닥 영역과 말단 단일가닥 영역을 포함하는 이중가닥 핵산 프로브가 고정된 마이크로어레이를 제조하는 방법
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8300993B2 (en) 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9109793B2 (en) * 2009-07-20 2015-08-18 Crayola, Llc Illuminated display unit
TW201217783A (en) 2010-09-15 2012-05-01 Mbio Diagnostics Inc System and method for detecting multiple molecules in one assay
JP6206181B2 (ja) 2012-02-27 2017-10-04 東レ株式会社 核酸の検出方法
JP2022517957A (ja) * 2019-01-08 2022-03-11 アコヤ バイオサイエンス,インコーポレイテッド フレキシブル検出システム

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5200314A (en) * 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
GB9119735D0 (en) * 1991-09-16 1991-10-30 Secr Defence Gene probe biosensor method
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
TW302435B (https=) * 1995-05-12 1997-04-11 Ciba Geigy Ag
DE69719057T2 (de) * 1996-07-12 2003-12-04 Tm Technologies Inc., Woburn Verfahren zur signalverstärkung
US5832165A (en) * 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays

Also Published As

Publication number Publication date
AU3414599A (en) 1999-10-11
JP2002506984A (ja) 2002-03-05
DE69919143D1 (de) 2004-09-09
EP1064406B1 (en) 2004-08-04
GB9805935D0 (en) 1998-05-13
ATE272721T1 (de) 2004-08-15
WO1999047705A1 (en) 1999-09-23
US20060188873A1 (en) 2006-08-24
EP1064406A1 (en) 2001-01-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

8328 Change in the person/name/address of the agent

Representative=s name: LUETJENS, H., DIPL.-CHEM. DR. RER. NAT., PAT.-ANW.