DE69914192D1 - Stabiler antihistaminsirup enthaltend aminopolycarbonsäuren als stabilisatoren - Google Patents

Stabiler antihistaminsirup enthaltend aminopolycarbonsäuren als stabilisatoren

Info

Publication number
DE69914192D1
DE69914192D1 DE69914192T DE69914192T DE69914192D1 DE 69914192 D1 DE69914192 D1 DE 69914192D1 DE 69914192 T DE69914192 T DE 69914192T DE 69914192 T DE69914192 T DE 69914192T DE 69914192 D1 DE69914192 D1 DE 69914192D1
Authority
DE
Germany
Prior art keywords
stabilizers
stable
syrup containing
aminopolycarboxylic acids
antihistamine syrup
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69914192T
Other languages
English (en)
Other versions
DE69914192T2 (de
Inventor
J Munayyer
Frank Guazzo
I Stupak
A Chaudry
A Sequeira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22209512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69914192(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69914192D1 publication Critical patent/DE69914192D1/de
Application granted granted Critical
Publication of DE69914192T2 publication Critical patent/DE69914192T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69914192T 1998-06-01 1999-05-27 Stabiler antihistaminsirup enthaltend aminopolycarbonsäuren als stabilisatoren Expired - Lifetime DE69914192T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/088,128 US6132758A (en) 1998-06-01 1998-06-01 Stabilized antihistamine syrup
PCT/US1999/010469 WO1999062516A1 (en) 1998-06-01 1999-05-27 A stabilized antihistamine syrup containing aminopolycarboxylic acid as stabilizer

Publications (2)

Publication Number Publication Date
DE69914192D1 true DE69914192D1 (de) 2004-02-19
DE69914192T2 DE69914192T2 (de) 2004-10-21

Family

ID=22209512

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69914192T Expired - Lifetime DE69914192T2 (de) 1998-06-01 1999-05-27 Stabiler antihistaminsirup enthaltend aminopolycarbonsäuren als stabilisatoren

Country Status (29)

Country Link
US (4) US6132758A (de)
EP (1) EP1082117B1 (de)
JP (2) JP4166948B2 (de)
AR (1) AR019147A1 (de)
AT (1) ATE257705T1 (de)
AU (1) AU754469B2 (de)
CA (1) CA2333528C (de)
CO (1) CO5011119A1 (de)
CR (1) CR6035A (de)
DE (1) DE69914192T2 (de)
DK (1) DK1082117T3 (de)
EG (1) EG23908A (de)
ES (1) ES2211192T3 (de)
GC (1) GC0000330A (de)
GT (2) GT199900072AA (de)
HN (1) HN1999000081A (de)
JO (1) JO2099B1 (de)
ME (1) ME01664B (de)
MY (1) MY123325A (de)
NL (1) NL1012191C2 (de)
NO (1) NO329124B1 (de)
NZ (1) NZ508037A (de)
PA (1) PA8474201A1 (de)
PE (1) PE20000565A1 (de)
PT (1) PT1082117E (de)
RS (1) RS49609B (de)
SV (1) SV1999000068A (de)
TW (1) TW589197B (de)
WO (1) WO1999062516A1 (de)

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US6132758A (en) * 1998-06-01 2000-10-17 Schering Corporation Stabilized antihistamine syrup
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US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
SK287684B6 (sk) * 1999-12-20 2011-06-06 Schering Corporation Pevná orálna farmaceutická dávková forma s predĺženým uvoľňovaním
WO2001045676A2 (en) 1999-12-20 2001-06-28 Schering Corporation Extended release oral dosage composition
CA2393837A1 (en) * 1999-12-21 2001-06-28 Schering Corporation Use of desloratadine for treating allergic and inflammatory conditions in pediatric patients
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
EP1276502A1 (de) * 2000-04-14 2003-01-22 J-Med Pharmaceuticals, Inc. Einzeldosis antihistamin/dekongestivum formulierungen zur behandlung von rhinitis
US20030216423A1 (en) * 2000-05-24 2003-11-20 Sergio Ulloa Stable liquid and solid formulations
AU2001264806A1 (en) * 2000-05-25 2001-12-03 Schering Corporation Stable liquid and solid formulations
US20020035107A1 (en) * 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
IN192160B (de) * 2000-07-17 2004-02-28 Ranbaxy Lab
AU2001275784A1 (en) * 2000-08-02 2002-02-13 Malope Company Limited Diagnosis and treatment of non-ulcer dyspepsia based on hypothalamic-pituitary-adrenal axis abnormality
US6720002B2 (en) 2001-07-20 2004-04-13 R.P. Scherer Technologies, Inc. Antihistamine formulations for soft capsule dosage forms
PE20030545A1 (es) 2001-10-31 2003-06-19 Schering Corp Formulaciones de jarabe de ribavirina
DE10161077A1 (de) 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion
US20040101563A1 (en) * 2002-07-18 2004-05-27 Kundu Subhas C. Storage stable antihistaminic syrup formulations
US20100092562A1 (en) * 2002-11-26 2010-04-15 Hollenbeck R Gary Sustained-release drug delivery compositions and methods
US6635654B1 (en) 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
US20040242619A1 (en) * 2003-03-12 2004-12-02 Toth Zoltan G. Processes for preparation of polymorphic forms of desloratadine
JP3881640B2 (ja) * 2003-08-08 2007-02-14 塩野義製薬株式会社 ロラタジンを含むドライシロップ剤
US20050069590A1 (en) 2003-09-30 2005-03-31 Buehler Gail K. Stable suspensions for medicinal dosages
US7758877B2 (en) * 2004-02-05 2010-07-20 Taro Pharmaceuticals U.S.A., Inc. Stable loratadine spill resistant formulation
EP1568369A1 (de) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam zur Behandlung von Atemwegserkrankungen bei Schweinen
GB0417909D0 (en) * 2004-08-11 2004-09-15 Novartis Consumer Health Sa Drop preparations
US20060093631A1 (en) * 2004-10-29 2006-05-04 Buehler Gail K Dye-free pharmaceutical suspensions and related methods
US20070009558A1 (en) * 2004-12-22 2007-01-11 David Harris Sugar-free storage-stable antihistaminic syrups
CA2591706A1 (en) * 2004-12-22 2006-06-29 Schering Corporation Pharmaceutical formulations
US20060205752A1 (en) * 2005-03-14 2006-09-14 Keith Whitehead Stabilized hydrocodone pharmaceutical compositions with ethylenediaminetetraacetic acid
US20060275516A1 (en) * 2005-06-02 2006-12-07 Ram A N S Compositions and methods for the treatment of allergic rhinitis
NZ588134A (en) * 2005-06-17 2010-11-26 Aft Pharmaceuticals Ltd Novel pharmaceutical for use in a method for treatment of upper respiratory mucosal congestion
DOP2006000274A (es) 2005-12-14 2007-10-15 Sanofi Aventis Us Llc Formulación de suspensión de fexofenadina
EP2023957A2 (de) * 2006-06-07 2009-02-18 Morton Grove Pharmaceuticals, Inc. Orale flüssige loratadinformulierungen und verfahren
CN101505750A (zh) * 2006-06-29 2009-08-12 先灵公司 无糖、贮藏稳定性抗组胺药糖浆剂
US20080014275A1 (en) * 2006-07-13 2008-01-17 Buehler Gail K Pharmaceutical suspensions and related methods
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PL2002733T3 (pl) * 2007-06-08 2017-06-30 The Procter And Gamble Company Kompozycja zawierająca miód naturalny i sposoby jej sporządzania
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JP5752578B2 (ja) * 2011-12-09 2015-07-22 ジェイ−メド ファーマシューティカルズ，インコーポレーティッド 鼻炎治療のための単一投与抗ヒスタミン薬／鬱血除去薬製剤
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Also Published As

Publication number Publication date
US20050261280A1 (en) 2005-11-24
SV1999000068A (es) 2000-06-23
PE20000565A1 (es) 2000-07-05
NO20006079L (no) 2000-11-30
NO329124B1 (no) 2010-08-30
US20030152595A1 (en) 2003-08-14
TW589197B (en) 2004-06-01
ME01664B (me) 2007-06-04
JO2099B1 (en) 2000-05-21
ATE257705T1 (de) 2004-01-15
AU4308599A (en) 1999-12-20
RS49609B (sr) 2007-06-04
US20020132805A1 (en) 2002-09-19
HN1999000081A (es) 1999-08-23
WO1999062516A1 (en) 1999-12-09
MY123325A (en) 2006-05-31
AU754469B2 (en) 2002-11-14
DK1082117T3 (da) 2004-05-03
JP4166948B2 (ja) 2008-10-15
PA8474201A1 (es) 2001-07-31
EG23908A (en) 2007-12-30
CA2333528A1 (en) 1999-12-09
AR019147A1 (es) 2001-12-26
CO5011119A1 (es) 2001-02-28
NL1012191C2 (nl) 2000-01-04
CR6035A (es) 2008-11-26
PT1082117E (pt) 2004-05-31
GT199900072A (es) 2000-11-16
GC0000330A (en) 2007-03-31
JP2005015485A (ja) 2005-01-20
US6132758A (en) 2000-10-17
NZ508037A (en) 2002-11-26
EP1082117B1 (de) 2004-01-14
US6514520B2 (en) 2003-02-04
CA2333528C (en) 2002-07-02
ES2211192T3 (es) 2004-07-01
DE69914192T2 (de) 2004-10-21
NL1012191A1 (nl) 1999-12-03
US6939550B2 (en) 2005-09-06
GT199900072AA (es) 2000-11-16
EP1082117A1 (de) 2001-03-14
YU23599A (sh) 2001-07-10
JP2002516860A (ja) 2002-06-11
NO20006079D0 (no) 2000-11-30

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