DE69912956D1 - Biomedizinisches polyurethan, seine herstellung und verwendung - Google Patents

Biomedizinisches polyurethan, seine herstellung und verwendung

Info

Publication number
DE69912956D1
DE69912956D1 DE69912956T DE69912956T DE69912956D1 DE 69912956 D1 DE69912956 D1 DE 69912956D1 DE 69912956 T DE69912956 T DE 69912956T DE 69912956 T DE69912956 T DE 69912956T DE 69912956 D1 DE69912956 D1 DE 69912956D1
Authority
DE
Germany
Prior art keywords
production
biomedical polyurethane
biomedical
polyurethane
diol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69912956T
Other languages
English (en)
Other versions
DE69912956T2 (de
Inventor
Coenraad Jan Spaans
Jacqueline Hermina De Groot
Folkert Gerhardus Dekens
Albert Johan Pennings
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polyganics BV
Original Assignee
Polyganics BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyganics BV filed Critical Polyganics BV
Publication of DE69912956D1 publication Critical patent/DE69912956D1/de
Application granted granted Critical
Publication of DE69912956T2 publication Critical patent/DE69912956T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/80—Masked polyisocyanates
    • C08G18/8003—Masked polyisocyanates masked with compounds having at least two groups containing active hydrogen
    • C08G18/8006—Masked polyisocyanates masked with compounds having at least two groups containing active hydrogen with compounds of C08G18/32
    • C08G18/8009—Masked polyisocyanates masked with compounds having at least two groups containing active hydrogen with compounds of C08G18/32 with compounds of C08G18/3203
    • C08G18/8012—Masked polyisocyanates masked with compounds having at least two groups containing active hydrogen with compounds of C08G18/32 with compounds of C08G18/3203 with diols
    • C08G18/8016—Masked aliphatic or cycloaliphatic polyisocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30—Low-molecular-weight compounds
    • C08G18/32—Polyhydroxy compounds; Polyamines; Hydroxyamines
    • C08G18/3203—Polyhydroxy compounds
    • C08G18/3206—Polyhydroxy compounds aliphatic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
    • C08G18/4277—Caprolactone and/or substituted caprolactone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/428—Lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2230/00—Compositions for preparing biodegradable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Polyurethanes Or Polyureas (AREA)
DE69912956T 1998-06-05 1999-06-04 Biomedizinisches polyurethan, seine herstellung und verwendung Expired - Lifetime DE69912956T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98201868 1998-06-05
EP98201868 1998-06-05
PCT/NL1999/000352 WO1999064491A1 (en) 1998-06-05 1999-06-04 Biomedical polyurethane, its preparation and use

Publications (2)

Publication Number Publication Date
DE69912956D1 true DE69912956D1 (de) 2003-12-24
DE69912956T2 DE69912956T2 (de) 2004-11-11

Family

ID=8233784

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69912956T Expired - Lifetime DE69912956T2 (de) 1998-06-05 1999-06-04 Biomedizinisches polyurethan, seine herstellung und verwendung

Country Status (15)

Country Link
US (1) US6784273B1 (de)
EP (2) EP1093483B1 (de)
JP (1) JP4335448B2 (de)
AT (1) ATE254636T1 (de)
AU (1) AU756740B2 (de)
BR (1) BR9910968B1 (de)
CA (1) CA2334110C (de)
DE (1) DE69912956T2 (de)
ES (1) ES2212602T3 (de)
ID (1) ID28196A (de)
IL (2) IL140049A0 (de)
NO (1) NO332315B1 (de)
NZ (1) NZ508907A (de)
WO (1) WO1999064491A1 (de)
ZA (1) ZA200007439B (de)

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EP1382628A1 (de) * 2002-07-16 2004-01-21 Polyganics B.V. Bioabbaubare phasenseparierte segmentierte oder Blockcopolyester
US20060216267A1 (en) * 2002-08-20 2006-09-28 Kovacs Stephen G Hydrophobic elastomeric polymer chemistry device for inhibiting the growth of onychomycosis and urushiol-induced allergic contact dermatitis
WO2004078023A2 (en) * 2002-10-23 2004-09-16 The Biomerix Corporation Aneurysm treatment devices and methods
JP5528656B2 (ja) * 2003-01-09 2014-06-25 ポリガニックス ビー． ブイ． 生体医用フォーム
EP2570440A3 (de) 2003-02-19 2014-06-11 Orteq B.V. Verfahren zur Herstellung neuer segmentierter Polyurethane mit hohen Bruch- und Zugfestigkeiten sowie Verfahren zur Herstellung poröser Gerüste
EP1633275B1 (de) 2003-05-15 2017-11-29 Biomerix Corporation Retikulüre elastomere matrizen, ihre herstellung und verwendung in implantierbaren vorrichtungen
US7763077B2 (en) 2003-12-24 2010-07-27 Biomerix Corporation Repair of spinal annular defects and annulo-nucleoplasty regeneration
WO2006009443A1 (en) * 2004-07-21 2006-01-26 Stichting Voor De Technische Wetenschappen Polyacylurethanes based on diisocyanates and polyesterpolyols
US20060135725A1 (en) * 2004-12-21 2006-06-22 Scimed Life Systems, Inc. New balloon materials
WO2006100844A1 (ja) * 2005-03-18 2006-09-28 Mitsui Chemicals, Inc. 生分解性を有する水環境応答型ポリマー、その製造方法および水崩壊性材料
US20100113734A1 (en) * 2006-09-29 2010-05-06 Total Petrochemicals Research Feluy Process for producing polylactide-urethane copolymers
WO2008122044A2 (en) * 2007-04-02 2008-10-09 Georgia Tech Research Corporation Implantable device for communicating with biological tissue
US8182647B2 (en) 2007-07-23 2012-05-22 Cohera Medical, Inc. Hydrophilic biodegradable adhesives
US20090035350A1 (en) 2007-08-03 2009-02-05 John Stankus Polymers for implantable devices exhibiting shape-memory effects
US8771725B2 (en) * 2007-10-12 2014-07-08 Chesson Laboratory Associates, Inc. Poly(urea-urethane) compositions useful as topical medicaments and methods of using the same
US20090123519A1 (en) * 2007-11-12 2009-05-14 Surmodics, Inc. Swellable hydrogel matrix and methods
US20090226531A1 (en) * 2008-03-07 2009-09-10 Allergan, Inc. Methods and composition for intraocular delivery of therapeutic sirna
US9259515B2 (en) * 2008-04-10 2016-02-16 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from polyurethanes with grafted radiopaque groups
WO2009141732A2 (en) * 2008-05-19 2009-11-26 Orteq B.V. Polyurethane foam for use in medical implants
EP2413838A4 (de) * 2009-04-03 2012-09-19 Biomerix Corp Zumindest teilweise resorbierbare retikulierte elastomermatrixpartikel und herstellungsverfahren
AU2010249558A1 (en) 2009-05-20 2011-12-08 Arsenal Medical, Inc. Medical implant
GB2475778B (en) * 2009-05-20 2013-03-13 Arsenal Medical Inc Medical implant
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
US20110319987A1 (en) 2009-05-20 2011-12-29 Arsenal Medical Medical implant
NL2002931C2 (en) 2009-05-27 2010-11-30 Polyganics Bv HEMOSTATIC FOAMS.
WO2012097381A1 (en) 2011-01-14 2012-07-19 Biomerix Corporation At least partially resorbable reticulated elastomeric matrix elements and methods of making same
GB201110601D0 (en) 2011-06-23 2011-08-03 Controlled Therapeutics Scotland Ltd Improved bioresorbable
WO2013151991A1 (en) 2012-04-02 2013-10-10 Surmodics, Inc. Hydrophilic polymeric coatings for medical articles with visualization moiety
US20160032239A1 (en) * 2013-03-12 2016-02-04 Northeastern University Deterministic Manufacturing Process For Creating 3D Living Tissues Based on 2D Directed Assembly And Origami Techniques
EP2842583A1 (de) 2013-08-29 2015-03-04 Ella-CS, s.r.o. Biologisch abbaubare und biologisch erodierbare Polyurethane, Verfahren zu ihrer Herstellung und Verwendung
WO2015087741A1 (ja) * 2013-12-09 2015-06-18 株式会社ダイセル ラクトン重合体の製造方法
ES2950392T3 (es) 2015-02-27 2023-10-09 Polyganics Ip B V Espumas de elución de fármacos y producción de las mismas
NL2016527B1 (en) * 2016-03-31 2017-11-02 Polyganics Ip B V Tissue-adhesive biomedical materials.
NL2016526B1 (en) 2016-03-31 2017-11-02 Polyganics Ip B V Improved biomedical polyurethanes
NL2016524B1 (en) 2016-03-31 2017-10-17 Polyganics Ip B V Tissue-adhesive material
JP7298153B2 (ja) * 2017-08-17 2023-06-27 東レ株式会社 ポリエステルコポリマーおよびその製造方法
NL2019652B1 (en) * 2017-09-29 2019-04-08 Polyganics Ip B V Tissue-adhesive sealant device
EP3727482B1 (de) 2017-12-20 2023-09-13 Stryker European Operations Holdings LLC Biomedizinischer schaum
AU2019403377A1 (en) 2018-12-20 2021-07-08 Stryker European Operations Limited Skull base closure systems and methods
NL2022710B1 (en) 2019-03-11 2020-09-18 Polyganics Ip B V Tissue-adhesive hydrogels
KR20210152529A (ko) 2019-04-16 2021-12-15 스트리커 유로피안 오퍼레이션즈 리미티드 부비강 스텐트, 환자의 부비강 내에 스텐트를 전개하는 시스템 및 방법
NL2023358B1 (en) 2019-06-21 2021-02-01 Polyganics Ip B V Dopamine-functionalized polymers
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Also Published As

Publication number Publication date
BR9910968A (pt) 2001-02-13
EP1093483A1 (de) 2001-04-25
BR9910968B1 (pt) 2009-05-05
AU4293299A (en) 1999-12-30
EP1308473A1 (de) 2003-05-07
CA2334110A1 (en) 1999-12-16
IL140049A0 (en) 2002-02-10
DE69912956T2 (de) 2004-11-11
EP1093483B1 (de) 2003-11-19
NO332315B1 (no) 2012-08-27
ID28196A (id) 2001-05-10
WO1999064491A1 (en) 1999-12-16
NO20006180D0 (no) 2000-12-05
IL140049A (en) 2008-03-20
NZ508907A (en) 2004-12-24
CA2334110C (en) 2011-09-20
ATE254636T1 (de) 2003-12-15
ES2212602T3 (es) 2004-07-16
JP2002517577A (ja) 2002-06-18
NO20006180L (no) 2001-01-22
ZA200007439B (en) 2001-08-08
JP4335448B2 (ja) 2009-09-30
US6784273B1 (en) 2004-08-31
AU756740B2 (en) 2003-01-23

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