DE69904262T2 - Benzylalkohol enthaltene FSH und FSH-Varianten Formulierungen - Google Patents

Benzylalkohol enthaltene FSH und FSH-Varianten Formulierungen

Info

Publication number
DE69904262T2
DE69904262T2 DE69904262T DE69904262T DE69904262T2 DE 69904262 T2 DE69904262 T2 DE 69904262T2 DE 69904262 T DE69904262 T DE 69904262T DE 69904262 T DE69904262 T DE 69904262T DE 69904262 T2 DE69904262 T2 DE 69904262T2
Authority
DE
Germany
Prior art keywords
fsh
formulations
benzyl alcohol
alcohol containing
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69904262T
Other languages
English (en)
Other versions
DE69904262T3 (de
DE69904262D1 (de
Inventor
James Arthur Hoffmann
Jirong Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ares Trading SA
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27536687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69904262(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69904262D1 publication Critical patent/DE69904262D1/de
Application granted granted Critical
Publication of DE69904262T2 publication Critical patent/DE69904262T2/de
Publication of DE69904262T3 publication Critical patent/DE69904262T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69904262T 1998-07-23 1999-07-16 Benzylalkohol enthaltene FSH und FSH-Varianten Formulierungen Expired - Lifetime DE69904262T3 (de)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US9390698P 1998-07-23 1998-07-23
US93906P 1998-07-23
US9461198P 1998-07-30 1998-07-30
US94611P 1998-07-30
US9476798P 1998-07-31 1998-07-31
US94767P 1998-07-31
US9871198P 1998-09-01 1998-09-01
US98711P 1998-09-01
US10069698P 1998-09-17 1998-09-17
US100696P 1998-09-17

Publications (3)

Publication Number Publication Date
DE69904262D1 DE69904262D1 (de) 2003-01-16
DE69904262T2 true DE69904262T2 (de) 2003-07-24
DE69904262T3 DE69904262T3 (de) 2009-08-13

Family

ID=27536687

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69904262T Expired - Lifetime DE69904262T3 (de) 1998-07-23 1999-07-16 Benzylalkohol enthaltene FSH und FSH-Varianten Formulierungen
DE69928296T Expired - Lifetime DE69928296T2 (de) 1998-07-23 1999-07-16 Stabile FSH und FSH Varianten enthaltende Arzneimitteln

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69928296T Expired - Lifetime DE69928296T2 (de) 1998-07-23 1999-07-16 Stabile FSH und FSH Varianten enthaltende Arzneimitteln

Country Status (24)

Country Link
EP (2) EP1188444B1 (de)
JP (1) JP4719357B2 (de)
KR (1) KR20010083126A (de)
CN (1) CN1309567A (de)
AR (1) AR020618A1 (de)
AT (2) ATE308990T1 (de)
AU (1) AU776823B2 (de)
BR (1) BR9912243A (de)
CA (1) CA2335340C (de)
CO (1) CO5090905A1 (de)
DE (2) DE69904262T3 (de)
DK (1) DK0974359T4 (de)
ES (2) ES2183486T3 (de)
HK (1) HK1026615A1 (de)
ID (1) ID28747A (de)
IL (1) IL140984A0 (de)
MY (1) MY135913A (de)
NO (1) NO20010326L (de)
NZ (1) NZ508874A (de)
PE (1) PE20000939A1 (de)
PL (1) PL346127A1 (de)
PT (1) PT974359E (de)
SI (1) SI0974359T1 (de)
WO (1) WO2000004913A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
US7112341B1 (en) 1999-04-13 2006-09-26 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
TW201002201A (en) 2001-03-01 2010-01-16 Lonza Ag Preservative blends containing quaternary ammonium compounds
PT1610822E (pt) 2003-04-02 2011-01-05 Ares Trading Sa Formulações farmacêuticas líquidas ou liofilizadas de fsh e/ou lh em conjunto com o surfactante não iónico poloxâmero 188 e um agente bacteriostático
US7740884B2 (en) 2003-06-20 2010-06-22 Ares Trading S.A. Freeze-dried FSH/LH formulations
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
CA2685437C (en) 2007-02-08 2015-06-02 Aspenbio Pharma, Inc. Compositions and methods including expression and bioactivity of bovine follicle stimulating hormone
UA103598C2 (uk) 2007-06-28 2013-11-11 Биодженерикс Аг Клон клітин, що продукують fsh
DK2219607T3 (da) * 2007-11-01 2013-06-17 Merck Serono Sa Flydende LH-formuleringer
KR101573773B1 (ko) * 2008-02-08 2015-12-02 바이오제너릭스 게엠베하 Ｆｓｈ의 액체 포뮬레이션
CN102309745B (zh) * 2008-09-17 2013-05-08 上海天伟生物制药有限公司 一种卵泡刺激素冻干针剂
DK2445552T3 (da) 2009-06-24 2016-01-25 Tecpharma Licensing Ag Indgivelsesapparat med klargøringsfunktion
EP2325194A1 (de) 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
WO2011076281A1 (de) 2009-12-23 2011-06-30 Tecpharma Licensing Ag Entfernen einer nadelschutzkappe von einer nadel
EP2515973B1 (de) 2009-12-23 2018-02-21 Tecpharma Licensing AG Injektionsvorrichtung mit einer nadelschutzhülse
DK2534650T3 (en) 2010-02-11 2016-09-26 Finox Ag Injection Training Manikin
WO2011099036A2 (en) * 2010-02-12 2011-08-18 Intas Biopharmaceuticals Limited Liquid formulation of follicle stimulating hormone
EP2417982A1 (de) 2010-07-30 2012-02-15 Ferring B.V. Stabilisierung von Gonadotropinen
WO2012142961A1 (zh) * 2011-04-22 2012-10-26 上海天伟生物制药有限公司 一种低溶剂残留的糖蛋白组合物及其制备方法和用途
JP5750471B2 (ja) * 2013-05-22 2015-07-22 Ｊｃｒファーマ株式会社 組換え体ヒトｆｓｈの製造方法
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
WO2015075743A1 (en) * 2013-11-12 2015-05-28 Cadila Healthcare Limited Formulation for gonadotropins
BR112018003455A2 (pt) * 2015-09-17 2018-09-25 Glycotope Gmbh composição ou composição farmacêutica e uso da composição
GB201603280D0 (en) * 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB839300A (en) * 1957-09-05 1960-06-29 Organon Labor Ltd Adrenocorticotropic hormone preparations and process for making same
US4659696A (en) † 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use
US5162306A (en) * 1987-01-23 1992-11-10 Donaldson Lloyd E Composition and method for producing superovulation in mammals
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
FR2623715B1 (fr) * 1987-11-26 1990-12-21 Lafon Labor Structures peptidiques, immunogenes les contenant et leurs applications au controle de la fertilite
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
DK0652766T4 (da) * 1992-07-31 2008-06-09 Genentech Inc Vandigt præparat indeholdende humant væksthormon
US5661125A (en) * 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions
DE69508985T2 (de) † 1994-02-21 1999-08-19 Takeda Chemical Industries Ltd Polyester Matrix für eine pharmazeutische Zusammensetzung mit verzögerter Freigabe
TW426523B (en) * 1995-04-06 2001-03-21 Hoffmann La Roche Interferon solution
WO1997017087A1 (en) * 1995-11-07 1997-05-15 Genentech, Inc. Stabilizing formulation for ngf
GB2317010A (en) * 1996-09-04 1998-03-11 Eev Ltd Gas sensor detecting only non-reflected light
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
US6287587B2 (en) † 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
ZA9811127B (en) * 1997-12-09 2000-07-11 Lilly Co Eli Stabilized teriparatide solutions.
JP2000151148A (ja) * 1998-11-13 2000-05-30 Mitsumi Electric Co Ltd 携帯用電子機器のコード接続構造

Also Published As

Publication number Publication date
DE69904262T3 (de) 2009-08-13
DE69928296D1 (de) 2005-12-15
AU4998099A (en) 2000-02-14
ATE308990T1 (de) 2005-11-15
CO5090905A1 (es) 2001-10-30
MY135913A (en) 2008-07-31
JP2002521342A (ja) 2002-07-16
ATE228850T1 (de) 2002-12-15
NZ508874A (en) 2004-03-26
ES2250290T3 (es) 2006-04-16
ID28747A (id) 2001-06-28
PL346127A1 (en) 2002-01-28
NO20010326D0 (no) 2001-01-19
PE20000939A1 (es) 2000-09-20
SI0974359T1 (en) 2003-04-30
PT974359E (pt) 2003-02-28
EP1188444B1 (de) 2005-11-09
DE69904262D1 (de) 2003-01-16
DE69928296T2 (de) 2006-07-27
EP0974359A3 (de) 2001-02-07
IL140984A0 (en) 2002-02-10
CN1309567A (zh) 2001-08-22
ES2183486T3 (es) 2003-03-16
HK1026615A1 (en) 2000-12-22
DK0974359T3 (da) 2003-03-03
EP1188444A1 (de) 2002-03-20
EP0974359B1 (de) 2002-12-04
AU776823B2 (en) 2004-09-23
KR20010083126A (ko) 2001-08-31
JP4719357B2 (ja) 2011-07-06
CA2335340C (en) 2013-03-05
EP0974359B2 (de) 2009-04-22
EP0974359A2 (de) 2000-01-26
AR020618A1 (es) 2002-05-22
NO20010326L (no) 2001-03-20
BR9912243A (pt) 2001-10-16
WO2000004913A1 (en) 2000-02-03
CA2335340A1 (en) 2000-02-03
DK0974359T4 (da) 2009-06-29

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: ARES TRADING S.A., AUBONNE, CH

8366 Restricted maintained after opposition proceedings
8328 Change in the person/name/address of the agent

Representative=s name: WEICKMANN & WEICKMANN, 81679 MUENCHEN