DE69902212D1 - Azithromycinmonohydrat-Isopropanol-Clathrate und Methoden zu deren Herstellung - Google Patents

Azithromycinmonohydrat-Isopropanol-Clathrate und Methoden zu deren Herstellung

Info

Publication number
DE69902212D1
DE69902212D1 DE69902212T DE69902212T DE69902212D1 DE 69902212 D1 DE69902212 D1 DE 69902212D1 DE 69902212 T DE69902212 T DE 69902212T DE 69902212 T DE69902212 T DE 69902212T DE 69902212 D1 DE69902212 D1 DE 69902212D1
Authority
DE
Germany
Prior art keywords
preparation
azithromycin
isopropanol
clathrates
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69902212T
Other languages
English (en)
Other versions
DE69902212T2 (de
Inventor
Khashayar Karimian
Mehrnoush Motamedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Inc
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Publication of DE69902212D1 publication Critical patent/DE69902212D1/de
Application granted granted Critical
Publication of DE69902212T2 publication Critical patent/DE69902212T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69902212T 1998-08-21 1999-08-20 Azithromycinmonohydrat-Isopropanol-Clathrate und Methoden zu deren Herstellung Expired - Fee Related DE69902212T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002245398A CA2245398C (en) 1998-08-21 1998-08-21 Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Publications (2)

Publication Number Publication Date
DE69902212D1 true DE69902212D1 (de) 2002-08-29
DE69902212T2 DE69902212T2 (de) 2003-03-20

Family

ID=4162751

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69902212T Expired - Fee Related DE69902212T2 (de) 1998-08-21 1999-08-20 Azithromycinmonohydrat-Isopropanol-Clathrate und Methoden zu deren Herstellung

Country Status (5)

Country Link
US (2) US6245903B1 (de)
EP (1) EP0984020B1 (de)
AT (1) ATE221078T1 (de)
CA (1) CA2245398C (de)
DE (1) DE69902212T2 (de)

Families Citing this family (43)

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HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
AU768219B2 (en) * 1998-11-30 2003-12-04 Teva Pharmaceutical Industries Ltd. Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
DE60029589T2 (de) * 1999-06-29 2007-07-19 Sandoz Ag Verfahren zur herstellung von azithromycin
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
AU2000270425A1 (en) 2000-07-25 2002-02-13 Instituto De Investigacion En Quimica Aplicada S.C Single-step process for preparing 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydr oxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1)hexadeca-1(2)-en-8-ona and obtaining a new form of 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin
AU2001214115A1 (en) * 2000-08-01 2002-02-13 Habil F. Khorakiwala Process for the preparation of anhydrous azithromycin
ATE306491T1 (de) * 2000-08-23 2005-10-15 Wockhardt Ltd Verfahren zur herstellung von wasserfreiem azithromycin
WO2002042315A2 (en) 2000-11-27 2002-05-30 Biochemie S.A. Macrolide solvates
CN100341886C (zh) * 2000-11-27 2007-10-10 桑多斯股份公司 大环内酯类化合物的溶剂化物
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) * 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
KR100574153B1 (ko) 2001-05-22 2006-04-25 화이자 프로덕츠 인코포레이티드 아지트로마이신의 결정형
SI1390377T1 (sl) * 2001-05-22 2006-06-30 Pfizer Prod Inc Nova kristalna oblika azitromicina
BR0215175A (pt) * 2001-12-21 2004-12-28 Pfizer Prod Inc Métodos para a granulação úmida de azitromicina
BR0215193A (pt) * 2001-12-21 2004-11-16 Pfizer Prod Inc Formulações de azitromicina diretamente compressìveis
CN1646104A (zh) * 2002-02-01 2005-07-27 辉瑞产品公司 阿齐霉素的干颗粒制剂
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
CA2422972A1 (en) * 2003-03-21 2004-09-21 Apotex Inc. Isopropanolate of azithromycin and method of manufacturing
US20070185194A1 (en) * 2003-07-01 2007-08-09 Kamal Mehta Stable oral compositions of azithromycin monohydrate
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
WO2005009447A1 (en) 2003-07-24 2005-02-03 Pliva - Research And Development Ltd. Single dose fast dissolving azithromycin
CA2547774A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Method for making pharmaceutical multiparticulates
WO2005053656A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
RU2006119453A (ru) * 2003-12-04 2007-12-20 Пфайзер Продактс Инк. (Us) Получение посредством основанных на применении жидкостей способов лекарственные формы азитромицина с большим количеством частиц
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7235646B2 (en) * 2004-06-28 2007-06-26 Alembic Limited Process for the preparation of azithromycin monohydrate isopropanol clathrate
US20090130154A1 (en) * 2004-08-26 2009-05-21 Bioderm Research Topical Delivery of Biological and Cosmetic Agents by Zeolites
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
CA2591744A1 (en) * 2004-12-21 2006-06-29 Pfizer Products Inc. Stable non-dihydrate azithromycin oral suspensions
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US20100158821A1 (en) * 2008-12-22 2010-06-24 Eastman Chemical Company Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products
EA201101319A1 (ru) 2009-03-13 2012-04-30 Да Волтерра Композиции и способы элиминации грамотрицательных бактерий
US8106111B2 (en) * 2009-05-15 2012-01-31 Eastman Chemical Company Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
AU2010331867A1 (en) 2009-12-18 2012-07-12 North-West University Composition comprising an amorphous non- crystalline glass form of azithromycin
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
JPS58157790A (ja) 1982-03-16 1983-09-19 Takeda Chem Ind Ltd ７−デアザプリン誘導体およびその製造法
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
CA1202620A (en) 1982-07-19 1986-04-01 Pfizer Inc. Intermediates for the preparation of n-methyl 11-aza- 10-deoxo-10-dihydroerythromycin a
RO107257B1 (ro) 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
CN1093370A (zh) 1993-12-10 1994-10-12 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5808017A (en) * 1996-04-10 1998-09-15 Abbott Laboratories Process for preparing erythromycin A oxime
CA2261732C (en) 1996-07-29 2001-07-24 Abbott Laboratories Preparation of crystal form ii of clarithromycin
PT994889E (pt) * 1997-07-08 2004-10-29 Biochemie Sa Solvatos de oxima de eritromicina a
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
KR100377159B1 (ko) 1998-09-09 2003-08-19 한미약품공업 주식회사 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
AU768219B2 (en) 1998-11-30 2003-12-04 Teva Pharmaceutical Industries Ltd. Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
DE60029589T2 (de) 1999-06-29 2007-07-19 Sandoz Ag Verfahren zur herstellung von azithromycin
ES2177373B1 (es) 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina

Also Published As

Publication number Publication date
CA2245398C (en) 2002-01-29
CA2245398A1 (en) 2000-02-21
US6245903B1 (en) 2001-06-12
EP0984020A3 (de) 2000-10-04
EP0984020B1 (de) 2002-07-24
USRE39087E1 (en) 2006-05-02
EP0984020A2 (de) 2000-03-08
ATE221078T1 (de) 2002-08-15
DE69902212T2 (de) 2003-03-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee