ATE221078T1 - Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung - Google Patents

Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung

Info

Publication number
ATE221078T1
ATE221078T1 AT99306612T AT99306612T ATE221078T1 AT E221078 T1 ATE221078 T1 AT E221078T1 AT 99306612 T AT99306612 T AT 99306612T AT 99306612 T AT99306612 T AT 99306612T AT E221078 T1 ATE221078 T1 AT E221078T1
Authority
AT
Austria
Prior art keywords
azithromycin
isopropanol
clathrates
production
methods
Prior art date
Application number
AT99306612T
Other languages
English (en)
Inventor
Khashayar Karimian
Mehrnoush Motamedi
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Application granted granted Critical
Publication of ATE221078T1 publication Critical patent/ATE221078T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99306612T 1998-08-21 1999-08-20 Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung ATE221078T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002245398A CA2245398C (en) 1998-08-21 1998-08-21 Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Publications (1)

Publication Number Publication Date
ATE221078T1 true ATE221078T1 (de) 2002-08-15

Family

ID=4162751

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99306612T ATE221078T1 (de) 1998-08-21 1999-08-20 Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung

Country Status (5)

Country Link
US (2) US6245903B1 (de)
EP (1) EP0984020B1 (de)
AT (1) ATE221078T1 (de)
CA (1) CA2245398C (de)
DE (1) DE69902212T2 (de)

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HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
RU2240124C2 (ru) * 1998-11-30 2004-11-20 Тева Фармасьютикал Индастриз, Лтд. Этанолят азитромицина, процесс получения и содержащие его фармацевтические составы
ES2267549T3 (es) * 1999-06-29 2007-03-16 Sandoz Ag Procedimiento para la produccion de azitromicina.
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
CA2417353C (en) 2000-07-25 2009-09-01 Laboratorio Silanes,S.A. De C.V. Single-step process for preparing 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1)hexadeca-1(2)-en-8-one, and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
AU2001214115A1 (en) * 2000-08-01 2002-02-13 Habil F. Khorakiwala Process for the preparation of anhydrous azithromycin
EP1313749B1 (de) * 2000-08-23 2005-10-12 Wockhardt Limited Verfahren zur herstellung von wasserfreiem azithromycin
CA2429639C (en) 2000-11-27 2009-07-14 Biochemie S.A. Stable azithromycin monohydrate
UA76967C2 (uk) * 2000-11-27 2006-10-16 Сандоз Аг Азитроміцин у формі моногідрату, фармацевтична композиція та спосіб його одержання
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1671979B1 (de) * 2001-05-22 2008-08-13 Pfizer Products Inc. Neue Kristallforme von Azithromycin
NZ539801A (en) 2001-05-22 2006-10-27 Pfizer Prod Inc Crystal forms of azithromycin
JP2005515212A (ja) * 2001-12-21 2005-05-26 ファイザー・プロダクツ・インク アジスロマイシンの湿式造粒法
WO2003053416A1 (en) * 2001-12-21 2003-07-03 Pfizer Products Inc. Directly compressible formulations of azithromycin
BR0307331A (pt) * 2002-02-01 2004-12-07 Pfizer Prod Inc Formulações granuladas a seco de azitromicina
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
CA2422972A1 (en) * 2003-03-21 2004-09-21 Apotex Inc. Isopropanolate of azithromycin and method of manufacturing
EP1648472A2 (de) * 2003-07-01 2006-04-26 Ranbaxy Laboratories, Ltd. Stabile orale zusammensetzungen von azithromycin-monohydrat
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
US7572773B2 (en) 2003-07-24 2009-08-11 Pliva Hrvatska D.O.O. Single dose fast dissolving azithromycin
WO2005053656A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
WO2005053651A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
WO2005053640A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
DE602004014805D1 (de) * 2003-12-04 2008-08-14 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7235646B2 (en) * 2004-06-28 2007-06-26 Alembic Limited Process for the preparation of azithromycin monohydrate isopropanol clathrate
US20090130154A1 (en) * 2004-08-26 2009-05-21 Bioderm Research Topical Delivery of Biological and Cosmetic Agents by Zeolites
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
US20100048498A1 (en) * 2004-12-21 2010-02-25 Johnson Barbara A Stable non-dihydrate azithromycin oral suspensions
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US20100158821A1 (en) * 2008-12-22 2010-06-24 Eastman Chemical Company Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products
EP2405909A1 (de) 2009-03-13 2012-01-18 Da Volterra Zusammensetzungen und verfahren zur eliminierung von gram-negativen bakterien
US8106111B2 (en) * 2009-05-15 2012-01-31 Eastman Chemical Company Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
CA2784494C (en) 2009-12-18 2019-03-12 North-West University Composition comprising an amorphous non-crystalline glass form of roxithromycin
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate

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YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
JPS58157790A (ja) 1982-03-16 1983-09-19 Takeda Chem Ind Ltd ７−デアザプリン誘導体およびその製造法
CA1202620A (en) 1982-07-19 1986-04-01 Pfizer Inc. Intermediates for the preparation of n-methyl 11-aza- 10-deoxo-10-dihydroerythromycin a
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
RU2066324C1 (ru) 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
CN1093370A (zh) 1993-12-10 1994-10-12 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5808017A (en) * 1996-04-10 1998-09-15 Abbott Laboratories Process for preparing erythromycin A oxime
PT915899E (pt) 1996-07-29 2004-11-30 Abbott Lab Preparacao da forma cristalina ii da eritromicina
CA2295629A1 (en) * 1997-07-08 1999-01-21 Victor Centellas Erythromycin a oxime solvates
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
KR100377159B1 (ko) 1998-09-09 2003-08-19 한미약품공업 주식회사 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
RU2240124C2 (ru) 1998-11-30 2004-11-20 Тева Фармасьютикал Индастриз, Лтд. Этанолят азитромицина, процесс получения и содержащие его фармацевтические составы
ES2267549T3 (es) 1999-06-29 2007-03-16 Sandoz Ag Procedimiento para la produccion de azitromicina.
ES2177373B1 (es) 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina

Also Published As

Publication number Publication date
EP0984020A3 (de) 2000-10-04
CA2245398C (en) 2002-01-29
USRE39087E1 (en) 2006-05-02
US6245903B1 (en) 2001-06-12
EP0984020B1 (de) 2002-07-24
CA2245398A1 (en) 2000-02-21
DE69902212D1 (de) 2002-08-29
EP0984020A2 (de) 2000-03-08
DE69902212T2 (de) 2003-03-20

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