DE69839924D1 - Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz - Google Patents
Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanzInfo
- Publication number
- DE69839924D1 DE69839924D1 DE69839924T DE69839924T DE69839924D1 DE 69839924 D1 DE69839924 D1 DE 69839924D1 DE 69839924 T DE69839924 T DE 69839924T DE 69839924 T DE69839924 T DE 69839924T DE 69839924 D1 DE69839924 D1 DE 69839924D1
- Authority
- DE
- Germany
- Prior art keywords
- magnetic resonance
- sample
- imaging agent
- nuclear spin
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Signal Processing (AREA)
- High Energy & Nuclear Physics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9723920.6A GB9723920D0 (en) | 1997-11-12 | 1997-11-12 | Method |
GBGB9800158.9A GB9800158D0 (en) | 1998-01-05 | 1998-01-05 | Method |
PCT/GB1998/003399 WO1999024080A1 (en) | 1997-11-12 | 1998-11-12 | Para-hydrogen labelled agents and their use in magnetic resonance imaging |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69839924D1 true DE69839924D1 (de) | 2008-10-02 |
Family
ID=26312589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69839924T Expired - Lifetime DE69839924D1 (de) | 1997-11-12 | 1998-11-12 | Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz |
Country Status (11)
Country | Link |
---|---|
US (2) | US6574495B1 (de) |
EP (1) | EP1047455B1 (de) |
JP (1) | JP2001522819A (de) |
KR (1) | KR100600670B1 (de) |
CN (1) | CN100571787C (de) |
AT (1) | ATE405297T1 (de) |
AU (1) | AU1047399A (de) |
DE (1) | DE69839924D1 (de) |
NO (1) | NO320225B1 (de) |
RU (1) | RU2218182C2 (de) |
WO (1) | WO1999024080A1 (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE405297T1 (de) * | 1997-11-12 | 2008-09-15 | Ge Healthcare As | Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz |
GB9911681D0 (en) * | 1999-05-19 | 1999-07-21 | Nycomed Imaging As | Process |
GB9911679D0 (en) * | 1999-05-19 | 1999-07-21 | Nycomed Imaging As | Magnetic resonance imaging |
GB0009353D0 (en) * | 2000-04-14 | 2000-05-31 | Nycomed Imaging As | Method |
GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
US7269157B2 (en) * | 2001-04-10 | 2007-09-11 | Internap Network Services Corporation | System and method to assure network service levels with intelligent routing |
GB0122049D0 (en) * | 2001-09-12 | 2001-10-31 | Nycomed Imaging As | Method |
US7222190B2 (en) * | 2001-11-02 | 2007-05-22 | Internap Network Services Corporation | System and method to provide routing control of information over data networks |
US7133365B2 (en) * | 2001-11-02 | 2006-11-07 | Internap Network Services Corporation | System and method to provide routing control of information over networks |
US7668966B2 (en) * | 2001-11-02 | 2010-02-23 | Internap Network Services Corporation | Data network controller |
GB0219954D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
GB0219952D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
GB0219953D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | An arrangement and a method for providing contrast agents |
US7623908B2 (en) * | 2003-01-24 | 2009-11-24 | The Board Of Trustees Of The University Of Illinois | Nonlinear interferometric vibrational imaging |
NO20031736D0 (no) * | 2003-04-15 | 2003-04-15 | Amersham Health As | Forbindelser |
JP3993127B2 (ja) * | 2003-04-24 | 2007-10-17 | 株式会社日立製作所 | Nmr装置用超電導プローブコイル |
WO2005015253A1 (en) * | 2003-07-28 | 2005-02-17 | University Of Southampton | Nmr spectroscopy using spin states with long lifetimes |
US7432014B2 (en) | 2003-11-05 | 2008-10-07 | Sony Corporation | Anode and battery |
US7610074B2 (en) * | 2004-01-08 | 2009-10-27 | The Board Of Trustees Of The University Of Illinois | Multi-functional plasmon-resonant contrast agents for optical coherence tomography |
US7586618B2 (en) | 2005-02-28 | 2009-09-08 | The Board Of Trustees Of The University Of Illinois | Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering |
US7725169B2 (en) * | 2005-04-15 | 2010-05-25 | The Board Of Trustees Of The University Of Illinois | Contrast enhanced spectroscopic optical coherence tomography |
JP2007021008A (ja) * | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Dnp過分極手段を備えた磁気共鳴イメージング装置 |
US8377419B2 (en) | 2005-09-28 | 2013-02-19 | The President And Fellows Of Harvard College | Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging |
ES2654520T3 (es) * | 2005-10-11 | 2018-02-14 | Huntington Medical Research Institutes | Agentes de formación de imágenes y métodos de uso de los mismos |
EP1968442A4 (de) * | 2005-12-10 | 2009-11-04 | Harvard College | In-situ-hyperpolarisation von bildgebungsmitteln |
US20090252686A1 (en) * | 2006-01-11 | 2009-10-08 | President And Fellows Of Harvard College | Ex Vivo Hyperpolarization of Imaging Agents |
WO2007090147A2 (en) | 2006-01-31 | 2007-08-09 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for measurement of optical properties in tissue |
US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
KR101095943B1 (ko) | 2006-02-21 | 2011-12-19 | 밀리켈빈 테크놀로지스 엘엘씨 | 과분극화 방법, 시스템 및 조성물 |
US8623327B2 (en) | 2006-06-19 | 2014-01-07 | Beth Israel Deaconess Medical Center, Inc. | Imaging agents for use in magnetic resonance blood flow/perfusion imaging |
EP2117607A4 (de) | 2007-01-11 | 2012-08-08 | Huntington Medical Res Inst | Abbildungswirkstoffe und verfahren zu ihrer verwendung |
GB2450316A (en) | 2007-06-18 | 2008-12-24 | Univ York | Hyperpolarizing nuclei |
WO2009046457A2 (en) * | 2007-10-05 | 2009-04-09 | Huntington Medical Research Institutes | Imaging of genetic material with magnetic resonance |
EP2072061A1 (de) | 2007-12-19 | 2009-06-24 | GE Healthcare Limited | Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR |
US8983580B2 (en) | 2008-01-18 | 2015-03-17 | The Board Of Trustees Of The University Of Illinois | Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors |
US8115934B2 (en) | 2008-01-18 | 2012-02-14 | The Board Of Trustees Of The University Of Illinois | Device and method for imaging the ear using optical coherence tomography |
US7751057B2 (en) | 2008-01-18 | 2010-07-06 | The Board Of Trustees Of The University Of Illinois | Magnetomotive optical coherence tomography |
WO2009124250A1 (en) * | 2008-04-03 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for detecting tricarboxylic acid (tca) metabolic flux |
WO2009129265A1 (en) * | 2008-04-14 | 2009-10-22 | Huntington Medical Research Institutes | Methods and apparatus for pasadena hyperpolarization |
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IT1391330B1 (it) * | 2008-10-03 | 2011-12-05 | Bracco Imaging Spa | Processo per la preparazione di molecole iperpolarizzate. |
US20100092390A1 (en) * | 2008-10-09 | 2010-04-15 | President And Fellows Of Harvard College | Methods for Making Particles Having Long Spin-Lattice Relaxation Times |
DE102008059313A1 (de) * | 2008-11-27 | 2010-06-02 | Bruker Biospin Gmbh | NMR-Messaparatur mit Durchfluss-Probenkopf und druckgasbetriebener Mischkammer, insbesondere zur para-Wasserstoff-induzierten Polarisierung einer flüssigen NMR-Messprobe |
WO2010067076A2 (en) | 2008-12-10 | 2010-06-17 | University Of York | Pulse sequencing with hyperpolarisable nuclei |
WO2010112397A1 (en) | 2009-04-02 | 2010-10-07 | Ge Healthcare Limited | Use of a magnetic resonance imaging medium comprising hyperpolarized 13c pyruvate for the detection of inflammation or infection |
CA2772489A1 (en) | 2009-08-31 | 2011-03-03 | Brain Watch Ltd. | Isotopically labeled neurochemical agents and uses thereof for diagnosing conditions and disorders |
CA2772190A1 (en) | 2009-08-31 | 2011-03-03 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
SG10201405591YA (en) | 2009-09-10 | 2014-10-30 | Ge Healthcare Ltd | 13c-mr detection using hyperpolarised 13c-fructose |
EP2316492A1 (de) | 2009-10-30 | 2011-05-04 | Bracco Imaging S.p.A | Para-Wasserstoff markierte Kontrastmittel für Kernspintomographie |
WO2011076228A1 (en) * | 2009-12-21 | 2011-06-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Improved nmr measurement based on antiphase signals |
US9694090B2 (en) | 2010-04-08 | 2017-07-04 | Bracco Imaging S.P.A. | Process for preparing hyperpolarized substrates and method for MRI |
US8970217B1 (en) | 2010-04-14 | 2015-03-03 | Hypres, Inc. | System and method for noise reduction in magnetic resonance imaging |
JP5879333B2 (ja) | 2010-05-03 | 2016-03-08 | ジーイー・ヘルスケア・リミテッド | Ldh活性を決定するための過分極乳酸塩造影剤 |
WO2012056447A1 (en) | 2010-10-25 | 2012-05-03 | Brain Watch Ltd. | Isotopically labeled deoxy-glucose and derivatives thereof, compositions comprising them and uses thereof |
US9452409B2 (en) | 2011-04-22 | 2016-09-27 | Vanderbilt University | Para-hydrogen polarizer |
WO2012164563A1 (en) | 2011-06-01 | 2012-12-06 | Brain Watch Ltd. | Isotopically labeled cdp-choline and uses thereof |
EP2766050B1 (de) | 2011-10-12 | 2018-09-05 | Bracco Imaging S.p.A | Verfahren zur herstellung von hyperpolarisierten derivaten zur verwendung bei der mri-analyse |
EP2788035B1 (de) | 2011-12-05 | 2016-03-09 | Bracco Imaging S.p.A | Zusammensetzung mit essigsäureanhydrid und einem gadoliniumkomplex und verfahren zur verwendung in der hyperpolarisations-mri-analyse |
EP2847591A1 (de) | 2012-05-07 | 2015-03-18 | Albeda Innovation ApS | Intraoperative krebsdiagnose auf basis eines hyperpolarisierten markers |
US9566354B2 (en) | 2012-10-23 | 2017-02-14 | Vanderbilt University | Systems and methods of performing NMR spectroscopy and MRI |
US9404984B2 (en) | 2012-11-06 | 2016-08-02 | Bruker Uk Limited | Method of hyperpolarization applying brute force using particulate acceleration agents |
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US9642924B2 (en) | 2013-08-29 | 2017-05-09 | Duke University | Contrast agents based on long-lived nuclear singlet states and related methods |
EP2863229A1 (de) | 2013-10-15 | 2015-04-22 | Technische Universität München | pH-Biosensoren auf Basis von Verbindungen mit pH-sensiblen Enolgruppen zur Magnetresonanzbildgebung und Spektroskopie und deren Verwendungen |
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EP2891500B1 (de) | 2014-01-07 | 2018-08-01 | Cambridge Enterprise Limited | Kontrastmittel zur Bestimmung von Aldehyd-Dehydrogenase-(ALDH)-Aktivität |
EP3015855A1 (de) | 2014-10-27 | 2016-05-04 | Klinikum rechts der Isar der Technischen Universität München | Metall-Biosensoren auf Basis von Verbindungen mit metallempfindlichen chemischen Verschiebungen für magnetische Resonanzspektroskopie und Magnetresonanzbildgebung |
US11156684B2 (en) * | 2014-10-28 | 2021-10-26 | Duke University | Method for creating hyperpolarization at microTesla magnetic fields |
US10924408B2 (en) | 2014-11-07 | 2021-02-16 | Noction, Inc. | System and method for optimizing traffic in packet-switched networks with internet exchanges |
US9769070B2 (en) | 2015-01-28 | 2017-09-19 | Maxim Basunov | System and method of providing a platform for optimizing traffic through a computer network with distributed routing domains interconnected through data center interconnect links |
EP3203256A1 (de) * | 2016-02-02 | 2017-08-09 | B. Braun Melsungen AG | Kalibrierung von mrt-systemen mit vorbestimmten konzentrationen von 19f-isotopen als referenz |
US11366186B2 (en) * | 2016-08-09 | 2022-06-21 | Beth Israel Deaconess Medical Center, Inc. | System and method for microfluidic parahydrogen induced polarization hyperpolarizer for magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) applications |
US10918744B2 (en) * | 2017-03-01 | 2021-02-16 | Educational foundation Kyushu Bunka Gakuen | Biometric method |
US10775458B2 (en) | 2018-03-05 | 2020-09-15 | Texas Tech University System | Method and system for non-invasive measurement of metabolic health |
EP4127752A2 (de) * | 2020-03-31 | 2023-02-08 | NVision Imaging Technologies GmbH | Systeme und verfahren zur erzeugung von hyperpolarisierten materialien |
WO2023205400A1 (en) * | 2022-04-23 | 2023-10-26 | Wayne State University | Method and apparatus for magnetic resonance (mr) contrast agents |
WO2024057212A1 (en) * | 2022-09-13 | 2024-03-21 | Nvision Imaging Technologies Gmbh | Systems and methods for generation of hyperpolarized materials |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69224850T2 (de) * | 1991-08-09 | 1998-09-24 | Nycomed Innovation Ab | Verwendung von dauerhafte frei radikalen zur bilderzeugung mittels magnetischer resonanz |
JPH0753967A (ja) * | 1993-08-18 | 1995-02-28 | Catalysts & Chem Ind Co Ltd | 重質油の水素化処理方法 |
US5611340A (en) * | 1995-10-02 | 1997-03-18 | General Electric Company | Apparatus and methods for magnetic resonance (MR) angiography using hydrogen polarized at low temperatures |
ATE405297T1 (de) * | 1997-11-12 | 2008-09-15 | Ge Healthcare As | Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz |
US6574496B1 (en) * | 1999-05-19 | 2003-06-03 | Amersham Health As | Magnetic resonance imaging |
GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
-
1998
- 1998-11-12 AT AT98952931T patent/ATE405297T1/de not_active IP Right Cessation
- 1998-11-12 EP EP98952931A patent/EP1047455B1/de not_active Expired - Lifetime
- 1998-11-12 AU AU10473/99A patent/AU1047399A/en not_active Abandoned
- 1998-11-12 DE DE69839924T patent/DE69839924D1/de not_active Expired - Lifetime
- 1998-11-12 JP JP2000520165A patent/JP2001522819A/ja active Pending
- 1998-11-12 WO PCT/GB1998/003399 patent/WO1999024080A1/en active IP Right Grant
- 1998-11-12 CN CNB988130661A patent/CN100571787C/zh not_active Expired - Fee Related
- 1998-11-12 KR KR1020007005128A patent/KR100600670B1/ko not_active IP Right Cessation
- 1998-11-12 RU RU2000115296/14A patent/RU2218182C2/ru not_active IP Right Cessation
-
2000
- 2000-05-05 US US09/565,450 patent/US6574495B1/en not_active Expired - Lifetime
- 2000-05-10 NO NO20002429A patent/NO320225B1/no not_active IP Right Cessation
-
2003
- 2003-03-24 US US10/395,002 patent/US20040024307A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20002429D0 (no) | 2000-05-10 |
EP1047455B1 (de) | 2008-08-20 |
KR100600670B1 (ko) | 2006-07-13 |
CN100571787C (zh) | 2009-12-23 |
ATE405297T1 (de) | 2008-09-15 |
CN1306441A (zh) | 2001-08-01 |
NO320225B1 (no) | 2005-11-14 |
JP2001522819A (ja) | 2001-11-20 |
EP1047455A1 (de) | 2000-11-02 |
RU2218182C2 (ru) | 2003-12-10 |
US20040024307A1 (en) | 2004-02-05 |
KR20010024606A (ko) | 2001-03-26 |
US6574495B1 (en) | 2003-06-03 |
AU1047399A (en) | 1999-05-31 |
NO20002429L (no) | 2000-05-10 |
WO1999024080A1 (en) | 1999-05-20 |
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