ATE301839T1 - Verfahren zur erzeugung von bildern und spektren der extracellulären ph unter verwendung der magnetischen resonanz mithilfe von 1h und 19f enthaltenden extrinsischen indikatorren - Google Patents

Verfahren zur erzeugung von bildern und spektren der extracellulären ph unter verwendung der magnetischen resonanz mithilfe von 1h und 19f enthaltenden extrinsischen indikatorren

Info

Publication number
ATE301839T1
ATE301839T1 AT98904180T AT98904180T ATE301839T1 AT E301839 T1 ATE301839 T1 AT E301839T1 AT 98904180 T AT98904180 T AT 98904180T AT 98904180 T AT98904180 T AT 98904180T AT E301839 T1 ATE301839 T1 AT E301839T1
Authority
AT
Austria
Prior art keywords
extracellular
spectra
images
magnetic resonance
resonance
Prior art date
Application number
AT98904180T
Other languages
English (en)
Inventor
Garcia Ballesteros
Conzalez M Gil
Partida Paula Zaderenko
Garcia-Esteller Sebasti Cerdan
Perez Jose Alvarez
Robert J Gillies
Raghunand Natarajan
Sluis Robert Van
Zaver Bhujwala
Original Assignee
Univ Nac De Educacion A Distan
Consejo Superior Investigacion
Univ Arizona
Hopkins J School Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nac De Educacion A Distan, Consejo Superior Investigacion, Univ Arizona, Hopkins J School Of Medicine filed Critical Univ Nac De Educacion A Distan
Application granted granted Critical
Publication of ATE301839T1 publication Critical patent/ATE301839T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4804—Spatially selective measurement of temperature or pH
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Image Processing (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98904180T 1997-03-06 1998-02-26 Verfahren zur erzeugung von bildern und spektren der extracellulären ph unter verwendung der magnetischen resonanz mithilfe von 1h und 19f enthaltenden extrinsischen indikatorren ATE301839T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09700496A ES2123449B1 (es) 1997-03-06 1997-03-06 Procedimiento para la obtencion de imagenes y espectros del ph extracelular por resonancia magnetica con indicadores extrinsecos conteniendo 1h o 19f.
PCT/ES1998/000045 WO1998039664A1 (es) 1997-03-06 1998-02-26 PROCEDIMIENTOS PARA LA OBTENCION DE IMAGENES Y ESPECTROS DEL pH EXTRACELULAR POR RESONANCIA MAGNETICA CON INDICADORES EXTRINSECOS CONTENIENDO 1H O 19F

Publications (1)

Publication Number Publication Date
ATE301839T1 true ATE301839T1 (de) 2005-08-15

Family

ID=8298536

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98904180T ATE301839T1 (de) 1997-03-06 1998-02-26 Verfahren zur erzeugung von bildern und spektren der extracellulären ph unter verwendung der magnetischen resonanz mithilfe von 1h und 19f enthaltenden extrinsischen indikatorren

Country Status (8)

Country Link
US (1) US6596258B1 (de)
EP (1) EP0977049B1 (de)
JP (1) JP2001513689A (de)
AT (1) ATE301839T1 (de)
AU (1) AU6215598A (de)
DE (1) DE69831147T2 (de)
ES (2) ES2123449B1 (de)
WO (1) WO1998039664A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066180A2 (en) * 1999-04-21 2000-11-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Method for enhancing contrast produced by mri
CA2331116A1 (en) 2001-01-15 2002-07-15 Chenomx, Inc. Compound identification and quantitation in liquid mixtures -- method and process using an automated nuclear magnetic resonance measurement system
US20030093911A1 (en) * 2001-09-12 2003-05-22 Roman Stephen John Compact disk titling stencil
WO2007014004A2 (en) * 2005-07-21 2007-02-01 Johns Hopkins University Non-invasive mri measurement of tissue glycogen
US7375811B2 (en) * 2005-08-24 2008-05-20 Tanita Corporation Fatigue-degree evaluation device
CN101466411B (zh) * 2006-06-09 2014-12-24 皇家飞利浦电子股份有限公司 消除mri中的造影剂浓度依赖性
US8933697B2 (en) * 2011-12-19 2015-01-13 General Electric Company Measurement of chemical equilibrium ratio using a magnetic resonance spectroscopy system
US9618596B2 (en) * 2012-07-02 2017-04-11 Syntheticmr Ab Methods and systems for improved magnetic resonance acquisition using a single acquisition type
EP2863229A1 (de) * 2013-10-15 2015-04-22 Technische Universität München pH-Biosensoren auf Basis von Verbindungen mit pH-sensiblen Enolgruppen zur Magnetresonanzbildgebung und Spektroskopie und deren Verwendungen
EP3058375B1 (de) * 2013-10-15 2018-12-26 Technische Universität München Ph-biosensoren auf der basis von verbindungen aus brenztraubensäure für magnetresonanzbildgebung und spektroskopie sowie deren verwendungen
US10295487B2 (en) * 2014-10-15 2019-05-21 The Curators Of The University Of Missouri In situ NMR parameter monitoring systems and methods for measuring pH and temperature
EP3877755A1 (de) * 2018-12-11 2021-09-15 Colgate-Palmolive Company Verfahren zur messung des ph-werts mittels nmr-verfahren
CN114910501A (zh) * 2021-02-10 2022-08-16 华东师范大学 一种非诊断目的的利用N-乙酰天门冬氨酸分子磁共振信号检测活体pH值的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3219832A1 (de) * 1982-05-26 1983-12-01 Bruker Medizintechnik Gmbh, 7512 Rheinstetten Verfahren zur nicht-invasiven ermittlung von messwerten innerhalb eines lebenden koerpers
DE3834704A1 (de) * 1988-10-07 1990-06-07 Schering Ag Fluorsubstituierte benzolderivate
US5248498A (en) * 1991-08-19 1993-09-28 Mallinckrodt Medical, Inc. Fullerene compositions for magnetic resonance spectroscopy and imaging
IT1265440B1 (it) * 1993-12-24 1996-11-22 Bracco Spa Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse
US5721265A (en) * 1994-08-05 1998-02-24 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
US5639906A (en) * 1994-10-11 1997-06-17 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent and NMR sensitive pH indicators

Also Published As

Publication number Publication date
ES2144367A1 (es) 2000-06-01
ES2123449A1 (es) 1999-01-01
DE69831147D1 (de) 2005-09-15
US6596258B1 (en) 2003-07-22
ES2123449B1 (es) 1999-09-16
EP0977049B1 (de) 2005-08-10
DE69831147T2 (de) 2006-06-29
WO1998039664A1 (es) 1998-09-11
EP0977049A1 (de) 2000-02-02
JP2001513689A (ja) 2001-09-04
AU6215598A (en) 1998-09-22
ES2144367B1 (es) 2001-01-01

Similar Documents

Publication Publication Date Title
ATE301839T1 (de) Verfahren zur erzeugung von bildern und spektren der extracellulären ph unter verwendung der magnetischen resonanz mithilfe von 1h und 19f enthaltenden extrinsischen indikatorren
Suzuki et al. Recent advances in fluorescent labeling techniques for fluorescence microscopy
Schroeder Imaging stem-cell-driven regeneration in mammals
DeBiasio et al. Five-parameter fluorescence imaging: wound healing of living Swiss 3T3 cells.
Burlage Techniques in microbial ecology
Yankeelov et al. Variation of the relaxographic “shutter‐speed” for transcytolemmal water exchange affects the CR bolus‐tracking curve shape
ATE405297T1 (de) Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz
ATE304706T1 (de) System zur messung des elektrischen potentials durch eine membrane
Taylor et al. Fluorescent analog cytochemistry
ATE266195T1 (de) Up-converting reporter molekül für biologische und andere testverfahren unter verwendung von laseranregungstechniken
DE69125445D1 (de) Verfahren und Apparat zur Messung der Transporteigenschaften eines Fluidums in porösen Medien durch Bilderzeugung mittels magnetischer Kernresonanz
Matsushita et al. 19F MRI monitoring of gene expression in living cells through cell‐surface β‐lactamase activity
ATE198313T1 (de) Heterocyclische methylfreie radikale als biloverbesserungsmittel
AU1880300A (en) Nmr spectroscopic in vitro assay using hyperpolarization
Mrđenović et al. Nanoscale Chemical Imaging of Human Cell Membranes Using Tip‐Enhanced Raman Spectroscopy
Urata et al. A three-dimensional structural dissection of Drosophila polytene chromosomes.
Krishnamoorthi et al. Hydrogen-1 nuclear magnetic resonance investigation of high-potential iron-sulfur proteins from Ectothiorhodospira halophila and Ectothiorhodospira vacuolata: a comparative study of hyperfine-shifted resonances
ATE359376T1 (de) Biochemische methode und apparat zur detektion genetischer charakteristika
ATE212727T1 (de) Ein verfahren zur bestimmung der konzentration von sauerstoff in einer probe
Blossfeld et al. The use of planar optodes in root studies for quantitative imaging
Charbaji et al. A 3D printed lightbox for enhancing nitrate detection in the field using microfluidic paper-based devices
Földes-Papp et al. A new concept for ultrasensitive fluorescence measurements of molecules in solution and membrane:: 1. Theory and a first application
Mytykh et al. Application of capillary electrophoresis to stereochemical conversions. A case study: the photoracemization/hydrolysis of Cr (diimine) 3 3+ species
Balzarini et al. Permeability estimation from NMR diffusion measurements in reservoir rocks
Opella et al. 19F longitudinal relaxation rates from dynamic negative nuclear overhauser effects

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0977049

Country of ref document: EP