ATE405297T1 - Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz - Google Patents
Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanzInfo
- Publication number
- ATE405297T1 ATE405297T1 AT98952931T AT98952931T ATE405297T1 AT E405297 T1 ATE405297 T1 AT E405297T1 AT 98952931 T AT98952931 T AT 98952931T AT 98952931 T AT98952931 T AT 98952931T AT E405297 T1 ATE405297 T1 AT E405297T1
- Authority
- AT
- Austria
- Prior art keywords
- magnetic resonance
- sample
- imaging agent
- hydrogen
- nuclear spin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Dispersion Chemistry (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9723920.6A GB9723920D0 (en) | 1997-11-12 | 1997-11-12 | Method |
GBGB9800158.9A GB9800158D0 (en) | 1998-01-05 | 1998-01-05 | Method |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE405297T1 true ATE405297T1 (de) | 2008-09-15 |
Family
ID=26312589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98952931T ATE405297T1 (de) | 1997-11-12 | 1998-11-12 | Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz |
Country Status (11)
Country | Link |
---|---|
US (2) | US6574495B1 (de) |
EP (1) | EP1047455B1 (de) |
JP (1) | JP2001522819A (de) |
KR (1) | KR100600670B1 (de) |
CN (1) | CN100571787C (de) |
AT (1) | ATE405297T1 (de) |
AU (1) | AU1047399A (de) |
DE (1) | DE69839924D1 (de) |
NO (1) | NO320225B1 (de) |
RU (1) | RU2218182C2 (de) |
WO (1) | WO1999024080A1 (de) |
Families Citing this family (80)
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JP2001522819A (ja) * | 1997-11-12 | 2001-11-20 | ナイコムド イメージング エーエス | パラ水素で標識された作用剤およびその磁気共鳴イメージングにおける使用 |
GB9911681D0 (en) * | 1999-05-19 | 1999-07-21 | Nycomed Imaging As | Process |
GB9911679D0 (en) * | 1999-05-19 | 1999-07-21 | Nycomed Imaging As | Magnetic resonance imaging |
GB0009353D0 (en) * | 2000-04-14 | 2000-05-31 | Nycomed Imaging As | Method |
GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
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GB0219952D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
GB0219953D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | An arrangement and a method for providing contrast agents |
GB0219954D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
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US7725169B2 (en) * | 2005-04-15 | 2010-05-25 | The Board Of Trustees Of The University Of Illinois | Contrast enhanced spectroscopic optical coherence tomography |
JP2007021008A (ja) * | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Dnp過分極手段を備えた磁気共鳴イメージング装置 |
US8377419B2 (en) | 2005-09-28 | 2013-02-19 | The President And Fellows Of Harvard College | Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging |
ES2654520T3 (es) * | 2005-10-11 | 2018-02-14 | Huntington Medical Research Institutes | Agentes de formación de imágenes y métodos de uso de los mismos |
JP2009518440A (ja) * | 2005-12-10 | 2009-05-07 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 造影剤のインサイチュ過分極 |
EP1984757A4 (de) * | 2006-01-11 | 2009-11-04 | Harvard College | Ex-vivo-hyperpolarisation von abbildungsmitteln |
WO2007090147A2 (en) | 2006-01-31 | 2007-08-09 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for measurement of optical properties in tissue |
US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
AU2007254464B2 (en) | 2006-02-21 | 2013-02-21 | Avrum Belzer | Hyperpolarization methods, systems and compositions |
US8623327B2 (en) | 2006-06-19 | 2014-01-07 | Beth Israel Deaconess Medical Center, Inc. | Imaging agents for use in magnetic resonance blood flow/perfusion imaging |
WO2008086534A1 (en) | 2007-01-11 | 2008-07-17 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
GB2450316A (en) | 2007-06-18 | 2008-12-24 | Univ York | Hyperpolarizing nuclei |
WO2009046457A2 (en) * | 2007-10-05 | 2009-04-09 | Huntington Medical Research Institutes | Imaging of genetic material with magnetic resonance |
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US8115934B2 (en) | 2008-01-18 | 2012-02-14 | The Board Of Trustees Of The University Of Illinois | Device and method for imaging the ear using optical coherence tomography |
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DE102008059313A1 (de) | 2008-11-27 | 2010-06-02 | Bruker Biospin Gmbh | NMR-Messaparatur mit Durchfluss-Probenkopf und druckgasbetriebener Mischkammer, insbesondere zur para-Wasserstoff-induzierten Polarisierung einer flüssigen NMR-Messprobe |
WO2010067076A2 (en) | 2008-12-10 | 2010-06-17 | University Of York | Pulse sequencing with hyperpolarisable nuclei |
BRPI1013677A2 (pt) | 2009-04-02 | 2016-04-26 | Ge Healthcare Ltd | método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. |
IN2012DN02418A (de) | 2009-08-31 | 2015-08-21 | Millikelvin Technologies Llc | |
CA2772489A1 (en) | 2009-08-31 | 2011-03-03 | Brain Watch Ltd. | Isotopically labeled neurochemical agents and uses thereof for diagnosing conditions and disorders |
US8968703B2 (en) | 2009-09-10 | 2015-03-03 | Ge Healthcare Limited | 13C-MR detection using hyperpolarised 13C-fructose |
EP2316492A1 (de) | 2009-10-30 | 2011-05-04 | Bracco Imaging S.p.A | Para-Wasserstoff markierte Kontrastmittel für Kernspintomographie |
US20120274324A1 (en) * | 2009-12-21 | 2012-11-01 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften, E.V. | Improved nmr measurement based on antiphase signals |
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US8970217B1 (en) | 2010-04-14 | 2015-03-03 | Hypres, Inc. | System and method for noise reduction in magnetic resonance imaging |
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WO2012056447A1 (en) | 2010-10-25 | 2012-05-03 | Brain Watch Ltd. | Isotopically labeled deoxy-glucose and derivatives thereof, compositions comprising them and uses thereof |
WO2012145733A1 (en) * | 2011-04-22 | 2012-10-26 | Vanderbilt University | Para-hydrogen polarizer |
US20140099262A1 (en) | 2011-06-01 | 2014-04-10 | Brain Watch Ltd. | Isotopically labeled cdp-choline and uses thereof |
WO2013053839A1 (en) | 2011-10-12 | 2013-04-18 | Bracco Imaging Spa | Process for the preparation of hyperpolarized derivatives for use in mri analysis |
US9693828B2 (en) | 2011-12-05 | 2017-07-04 | Bracco Imaging S.P.A. | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis |
US20150133341A1 (en) | 2012-05-07 | 2015-05-14 | Albeda Innovations Aps | Intra-Operative Cancer Diagnosis Based on a Hyperpolarized Marker |
US9566354B2 (en) | 2012-10-23 | 2017-02-14 | Vanderbilt University | Systems and methods of performing NMR spectroscopy and MRI |
US9404984B2 (en) | 2012-11-06 | 2016-08-02 | Bruker Uk Limited | Method of hyperpolarization applying brute force using particulate acceleration agents |
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US9642924B2 (en) | 2013-08-29 | 2017-05-09 | Duke University | Contrast agents based on long-lived nuclear singlet states and related methods |
EP2863229A1 (de) | 2013-10-15 | 2015-04-22 | Technische Universität München | pH-Biosensoren auf Basis von Verbindungen mit pH-sensiblen Enolgruppen zur Magnetresonanzbildgebung und Spektroskopie und deren Verwendungen |
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US11156684B2 (en) * | 2014-10-28 | 2021-10-26 | Duke University | Method for creating hyperpolarization at microTesla magnetic fields |
US10924408B2 (en) | 2014-11-07 | 2021-02-16 | Noction, Inc. | System and method for optimizing traffic in packet-switched networks with internet exchanges |
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EP3203256A1 (de) * | 2016-02-02 | 2017-08-09 | B. Braun Melsungen AG | Kalibrierung von mrt-systemen mit vorbestimmten konzentrationen von 19f-isotopen als referenz |
CA3033346A1 (en) * | 2016-08-09 | 2018-02-15 | Beth Israel Deaconess Medical Center, Inc. | System and method for microfluidic parahydrogen induced polarization hyperpolarizer for magnetic resonance imaging (mri) and nuclear magnetic resonance (nmr) applications |
WO2018158891A1 (ja) * | 2017-03-01 | 2018-09-07 | 国立大学法人九州大学 | 生体計測方法 |
US10775458B2 (en) | 2018-03-05 | 2020-09-15 | Texas Tech University System | Method and system for non-invasive measurement of metabolic health |
WO2021198776A2 (en) * | 2020-03-31 | 2021-10-07 | Nvision Imaging Technologies Gmbh | Systems and method for generation of hyperpolarized materials |
WO2023205400A1 (en) * | 2022-04-23 | 2023-10-26 | Wayne State University | Method and apparatus for magnetic resonance (mr) contrast agents |
WO2024057212A1 (en) * | 2022-09-13 | 2024-03-21 | Nvision Imaging Technologies Gmbh | Systems and methods for generation of hyperpolarized materials |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07502724A (ja) * | 1991-08-09 | 1995-03-23 | ニコムド イノベーション アーベー | 磁気共鳴造影における持続性フリーラジカルの使用 |
JPH0753967A (ja) * | 1993-08-18 | 1995-02-28 | Catalysts & Chem Ind Co Ltd | 重質油の水素化処理方法 |
US5611340A (en) * | 1995-10-02 | 1997-03-18 | General Electric Company | Apparatus and methods for magnetic resonance (MR) angiography using hydrogen polarized at low temperatures |
JP2001522819A (ja) * | 1997-11-12 | 2001-11-20 | ナイコムド イメージング エーエス | パラ水素で標識された作用剤およびその磁気共鳴イメージングにおける使用 |
US6574496B1 (en) * | 1999-05-19 | 2003-06-03 | Amersham Health As | Magnetic resonance imaging |
GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
-
1998
- 1998-11-12 JP JP2000520165A patent/JP2001522819A/ja active Pending
- 1998-11-12 AU AU10473/99A patent/AU1047399A/en not_active Abandoned
- 1998-11-12 WO PCT/GB1998/003399 patent/WO1999024080A1/en active IP Right Grant
- 1998-11-12 KR KR1020007005128A patent/KR100600670B1/ko not_active IP Right Cessation
- 1998-11-12 EP EP98952931A patent/EP1047455B1/de not_active Expired - Lifetime
- 1998-11-12 DE DE69839924T patent/DE69839924D1/de not_active Expired - Lifetime
- 1998-11-12 RU RU2000115296/14A patent/RU2218182C2/ru not_active IP Right Cessation
- 1998-11-12 CN CNB988130661A patent/CN100571787C/zh not_active Expired - Fee Related
- 1998-11-12 AT AT98952931T patent/ATE405297T1/de not_active IP Right Cessation
-
2000
- 2000-05-05 US US09/565,450 patent/US6574495B1/en not_active Expired - Lifetime
- 2000-05-10 NO NO20002429A patent/NO320225B1/no not_active IP Right Cessation
-
2003
- 2003-03-24 US US10/395,002 patent/US20040024307A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2218182C2 (ru) | 2003-12-10 |
WO1999024080A1 (en) | 1999-05-20 |
US20040024307A1 (en) | 2004-02-05 |
EP1047455B1 (de) | 2008-08-20 |
KR100600670B1 (ko) | 2006-07-13 |
NO320225B1 (no) | 2005-11-14 |
CN1306441A (zh) | 2001-08-01 |
NO20002429D0 (no) | 2000-05-10 |
DE69839924D1 (de) | 2008-10-02 |
EP1047455A1 (de) | 2000-11-02 |
KR20010024606A (ko) | 2001-03-26 |
NO20002429L (no) | 2000-05-10 |
JP2001522819A (ja) | 2001-11-20 |
US6574495B1 (en) | 2003-06-03 |
CN100571787C (zh) | 2009-12-23 |
AU1047399A (en) | 1999-05-31 |
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