NO320225B1 - Para-hydrogenmerkede midler og bruk av disse ved magnetresonansavbildning - Google Patents
Para-hydrogenmerkede midler og bruk av disse ved magnetresonansavbildning Download PDFInfo
- Publication number
- NO320225B1 NO320225B1 NO20002429A NO20002429A NO320225B1 NO 320225 B1 NO320225 B1 NO 320225B1 NO 20002429 A NO20002429 A NO 20002429A NO 20002429 A NO20002429 A NO 20002429A NO 320225 B1 NO320225 B1 NO 320225B1
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- Prior art keywords
- hydrogen
- nucleus
- imaging agent
- nuclear spin
- imaging
- Prior art date
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Classifications
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- A61K49/00—Preparations for testing in vivo
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Dispersion Chemistry (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9723920.6A GB9723920D0 (en) | 1997-11-12 | 1997-11-12 | Method |
| GBGB9800158.9A GB9800158D0 (en) | 1998-01-05 | 1998-01-05 | Method |
| PCT/GB1998/003399 WO1999024080A1 (en) | 1997-11-12 | 1998-11-12 | Para-hydrogen labelled agents and their use in magnetic resonance imaging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20002429L NO20002429L (no) | 2000-05-10 |
| NO20002429D0 NO20002429D0 (no) | 2000-05-10 |
| NO320225B1 true NO320225B1 (no) | 2005-11-14 |
Family
ID=26312589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20002429A NO320225B1 (no) | 1997-11-12 | 2000-05-10 | Para-hydrogenmerkede midler og bruk av disse ved magnetresonansavbildning |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6574495B1 (de) |
| EP (1) | EP1047455B1 (de) |
| JP (1) | JP2001522819A (de) |
| KR (1) | KR100600670B1 (de) |
| CN (1) | CN100571787C (de) |
| AT (1) | ATE405297T1 (de) |
| AU (1) | AU1047399A (de) |
| DE (1) | DE69839924D1 (de) |
| NO (1) | NO320225B1 (de) |
| RU (1) | RU2218182C2 (de) |
| WO (1) | WO1999024080A1 (de) |
Families Citing this family (80)
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| DE69839924D1 (de) * | 1997-11-12 | 2008-10-02 | Ge Healthcare As | Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz |
| GB9911681D0 (en) | 1999-05-19 | 1999-07-21 | Nycomed Imaging As | Process |
| GB9911679D0 (en) * | 1999-05-19 | 1999-07-21 | Nycomed Imaging As | Magnetic resonance imaging |
| GB0009353D0 (en) * | 2000-04-14 | 2000-05-31 | Nycomed Imaging As | Method |
| GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
| US7269157B2 (en) * | 2001-04-10 | 2007-09-11 | Internap Network Services Corporation | System and method to assure network service levels with intelligent routing |
| GB0122049D0 (en) * | 2001-09-12 | 2001-10-31 | Nycomed Imaging As | Method |
| US7133365B2 (en) * | 2001-11-02 | 2006-11-07 | Internap Network Services Corporation | System and method to provide routing control of information over networks |
| US7222190B2 (en) * | 2001-11-02 | 2007-05-22 | Internap Network Services Corporation | System and method to provide routing control of information over data networks |
| US7668966B2 (en) * | 2001-11-02 | 2010-02-23 | Internap Network Services Corporation | Data network controller |
| GB0219952D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
| GB0219953D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | An arrangement and a method for providing contrast agents |
| GB0219954D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
| US7623908B2 (en) * | 2003-01-24 | 2009-11-24 | The Board Of Trustees Of The University Of Illinois | Nonlinear interferometric vibrational imaging |
| NO20031736D0 (no) * | 2003-04-15 | 2003-04-15 | Amersham Health As | Forbindelser |
| JP3993127B2 (ja) | 2003-04-24 | 2007-10-17 | 株式会社日立製作所 | Ｎｍｒ装置用超電導プローブコイル |
| EP1706754A1 (de) * | 2003-07-28 | 2006-10-04 | University Of Southampton | Nmr-spektroskopie mit langlebigen spinzuständen |
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| JP2007021008A (ja) * | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Ｄｎｐ過分極手段を備えた磁気共鳴イメージング装置 |
| EP1940475A4 (de) | 2005-09-28 | 2010-05-26 | Harvard College | Hyperpolarisierte feste materialien mit langen spin-erholungszeiten zur verwendung als bildgebende mittel in der magnetresonanztomographie |
| ES2654520T3 (es) * | 2005-10-11 | 2018-02-14 | Huntington Medical Research Institutes | Agentes de formación de imágenes y métodos de uso de los mismos |
| US20080284429A1 (en) * | 2005-12-10 | 2008-11-20 | The President And Fellows Of Harvard College | Situ Hyperpolarization of Imaging Agents |
| WO2007082048A2 (en) * | 2006-01-11 | 2007-07-19 | The President And Fellows Of Harvard College | Ex vivo hyperpolarization of imaging agents |
| WO2007090147A2 (en) | 2006-01-31 | 2007-08-09 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for measurement of optical properties in tissue |
| AU2007254464B2 (en) | 2006-02-21 | 2013-02-21 | Avrum Belzer | Hyperpolarization methods, systems and compositions |
| US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| US8623327B2 (en) | 2006-06-19 | 2014-01-07 | Beth Israel Deaconess Medical Center, Inc. | Imaging agents for use in magnetic resonance blood flow/perfusion imaging |
| EP2117607A4 (de) | 2007-01-11 | 2012-08-08 | Huntington Medical Res Inst | Abbildungswirkstoffe und verfahren zu ihrer verwendung |
| GB2450316A (en) | 2007-06-18 | 2008-12-24 | Univ York | Hyperpolarizing nuclei |
| US20100233089A1 (en) * | 2007-10-05 | 2010-09-16 | Huntington Medical Research Institutes | Imaging of genetic material with magnetic resonance |
| EP2072061A1 (de) | 2007-12-19 | 2009-06-24 | GE Healthcare Limited | Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR |
| US8983580B2 (en) | 2008-01-18 | 2015-03-17 | The Board Of Trustees Of The University Of Illinois | Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors |
| US7751057B2 (en) | 2008-01-18 | 2010-07-06 | The Board Of Trustees Of The University Of Illinois | Magnetomotive optical coherence tomography |
| US8115934B2 (en) | 2008-01-18 | 2012-02-14 | The Board Of Trustees Of The University Of Illinois | Device and method for imaging the ear using optical coherence tomography |
| WO2009124250A1 (en) * | 2008-04-03 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for detecting tricarboxylic acid (tca) metabolic flux |
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| IT1391330B1 (it) * | 2008-10-03 | 2011-12-05 | Bracco Imaging Spa | Processo per la preparazione di molecole iperpolarizzate. |
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| US20110274626A1 (en) | 2008-12-10 | 2011-11-10 | University Of York | Pulse sequencing with hyperpolarisable nuclei |
| EP2414854A1 (de) | 2009-04-02 | 2012-02-08 | GE Healthcare UK Limited | Verwendung eines magnetresonanzbildgebungsmediums mit hyperpolarisiertem 13c-pyruvat zur detektion von entzündung oder infektion |
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| KR20120101339A (ko) | 2009-08-31 | 2012-09-13 | 밀리켈빈 테크놀로지스 엘엘씨 | 과분극 물질 및 그 혼합물의 제조용 시스템 및 제조방법 |
| US8968703B2 (en) | 2009-09-10 | 2015-03-03 | Ge Healthcare Limited | 13C-MR detection using hyperpolarised 13C-fructose |
| EP2316492A1 (de) | 2009-10-30 | 2011-05-04 | Bracco Imaging S.p.A | Para-Wasserstoff markierte Kontrastmittel für Kernspintomographie |
| WO2011076228A1 (en) * | 2009-12-21 | 2011-06-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Improved nmr measurement based on antiphase signals |
| EP2555803B1 (de) | 2010-04-08 | 2018-09-12 | Bracco Imaging S.p.A | Verfahren zur herstellung von hyperpolarisierten substraten und mri-verfahren |
| US8970217B1 (en) | 2010-04-14 | 2015-03-03 | Hypres, Inc. | System and method for noise reduction in magnetic resonance imaging |
| KR101858269B1 (ko) | 2010-05-03 | 2018-05-15 | 지이 헬쓰케어 리미티드 | 락테이트 탈수소효소 활성의 측정을 위한 과분극화된 락테이트 조영제 |
| US10814018B2 (en) | 2010-10-25 | 2020-10-27 | Hadasit Medical Research Service & Development Ltd. | Isotopically labeled deoxy-glucose and derivatives thereof, compositions comprising them and uses thereof |
| US9452409B2 (en) | 2011-04-22 | 2016-09-27 | Vanderbilt University | Para-hydrogen polarizer |
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| EP2863229A1 (de) | 2013-10-15 | 2015-04-22 | Technische Universität München | pH-Biosensoren auf Basis von Verbindungen mit pH-sensiblen Enolgruppen zur Magnetresonanzbildgebung und Spektroskopie und deren Verwendungen |
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| EP2891500B1 (de) | 2014-01-07 | 2018-08-01 | Cambridge Enterprise Limited | Kontrastmittel zur Bestimmung von Aldehyd-Dehydrogenase-(ALDH)-Aktivität |
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| US11156684B2 (en) * | 2014-10-28 | 2021-10-26 | Duke University | Method for creating hyperpolarization at microTesla magnetic fields |
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| EP3203256A1 (de) * | 2016-02-02 | 2017-08-09 | B. Braun Melsungen AG | Kalibrierung von mrt-systemen mit vorbestimmten konzentrationen von 19f-isotopen als referenz |
| CA3033346A1 (en) * | 2016-08-09 | 2018-02-15 | Beth Israel Deaconess Medical Center, Inc. | System and method for microfluidic parahydrogen induced polarization hyperpolarizer for magnetic resonance imaging (mri) and nuclear magnetic resonance (nmr) applications |
| WO2018158891A1 (ja) * | 2017-03-01 | 2018-09-07 | 国立大学法人九州大学 | 生体計測方法 |
| US10775458B2 (en) | 2018-03-05 | 2020-09-15 | Texas Tech University System | Method and system for non-invasive measurement of metabolic health |
| US11940510B2 (en) * | 2020-03-31 | 2024-03-26 | Nvision Imaging Technologies Gmbh | Systems and method for generation of hyperpolarized materials |
| WO2023205400A1 (en) * | 2022-04-23 | 2023-10-26 | Wayne State University | Method and apparatus for magnetic resonance (mr) contrast agents |
| WO2024057212A1 (en) * | 2022-09-13 | 2024-03-21 | Nvision Imaging Technologies Gmbh | Systems and methods for generation of hyperpolarized materials |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69224850T2 (de) * | 1991-08-09 | 1998-09-24 | Nycomed Innovation Ab | Verwendung von dauerhafte frei radikalen zur bilderzeugung mittels magnetischer resonanz |
| JPH0753967A (ja) * | 1993-08-18 | 1995-02-28 | Catalysts & Chem Ind Co Ltd | 重質油の水素化処理方法 |
| US5611340A (en) * | 1995-10-02 | 1997-03-18 | General Electric Company | Apparatus and methods for magnetic resonance (MR) angiography using hydrogen polarized at low temperatures |
| DE69839924D1 (de) * | 1997-11-12 | 2008-10-02 | Ge Healthcare As | Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz |
| US6574496B1 (en) * | 1999-05-19 | 2003-06-03 | Amersham Health As | Magnetic resonance imaging |
| GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
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1998
- 1998-11-12 DE DE69839924T patent/DE69839924D1/de not_active Expired - Lifetime
- 1998-11-12 EP EP98952931A patent/EP1047455B1/de not_active Expired - Lifetime
- 1998-11-12 KR KR1020007005128A patent/KR100600670B1/ko not_active IP Right Cessation
- 1998-11-12 WO PCT/GB1998/003399 patent/WO1999024080A1/en active IP Right Grant
- 1998-11-12 CN CNB988130661A patent/CN100571787C/zh not_active Expired - Fee Related
- 1998-11-12 JP JP2000520165A patent/JP2001522819A/ja active Pending
- 1998-11-12 AT AT98952931T patent/ATE405297T1/de not_active IP Right Cessation
- 1998-11-12 AU AU10473/99A patent/AU1047399A/en not_active Abandoned
- 1998-11-12 RU RU2000115296/14A patent/RU2218182C2/ru not_active IP Right Cessation
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2000
- 2000-05-05 US US09/565,450 patent/US6574495B1/en not_active Expired - Lifetime
- 2000-05-10 NO NO20002429A patent/NO320225B1/no not_active IP Right Cessation
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2003
- 2003-03-24 US US10/395,002 patent/US20040024307A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1306441A (zh) | 2001-08-01 |
| EP1047455B1 (de) | 2008-08-20 |
| NO20002429L (no) | 2000-05-10 |
| CN100571787C (zh) | 2009-12-23 |
| WO1999024080A1 (en) | 1999-05-20 |
| RU2218182C2 (ru) | 2003-12-10 |
| KR100600670B1 (ko) | 2006-07-13 |
| EP1047455A1 (de) | 2000-11-02 |
| US6574495B1 (en) | 2003-06-03 |
| NO20002429D0 (no) | 2000-05-10 |
| ATE405297T1 (de) | 2008-09-15 |
| DE69839924D1 (de) | 2008-10-02 |
| KR20010024606A (ko) | 2001-03-26 |
| US20040024307A1 (en) | 2004-02-05 |
| AU1047399A (en) | 1999-05-31 |
| JP2001522819A (ja) | 2001-11-20 |
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