DE69837125D1 - Nachweis von Nukleinsäuren durch Aufhebung der Fluoreszenz - Google Patents

Nachweis von Nukleinsäuren durch Aufhebung der Fluoreszenz

Info

Publication number
DE69837125D1
DE69837125D1 DE69837125T DE69837125T DE69837125D1 DE 69837125 D1 DE69837125 D1 DE 69837125D1 DE 69837125 T DE69837125 T DE 69837125T DE 69837125 T DE69837125 T DE 69837125T DE 69837125 D1 DE69837125 D1 DE 69837125D1
Authority
DE
Germany
Prior art keywords
abolition
fluorescence
detection
nucleic acids
nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69837125T
Other languages
English (en)
Other versions
DE69837125T3 (de
DE69837125T2 (de
Inventor
James G Nadeau
Bruce J Pitner
James L Schram
Preston C Linn
Glenn P Vonk
Terrance G Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25320311&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69837125(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of DE69837125D1 publication Critical patent/DE69837125D1/de
Application granted granted Critical
Publication of DE69837125T2 publication Critical patent/DE69837125T2/de
Publication of DE69837125T3 publication Critical patent/DE69837125T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69837125.9T 1997-05-13 1998-05-11 Nachweis von Nukleinsäuren durch Aufhebung der Fluoreszenz Expired - Lifetime DE69837125T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/855,085 US5846726A (en) 1997-05-13 1997-05-13 Detection of nucleic acids by fluorescence quenching
US855085 1997-05-13
EP98108491.6A EP0878554B2 (de) 1997-05-13 1998-05-11 Nachweis von Nukleinsäuren durch Aufhebung der Fluoreszenz

Publications (3)

Publication Number Publication Date
DE69837125D1 true DE69837125D1 (de) 2007-04-05
DE69837125T2 DE69837125T2 (de) 2007-12-13
DE69837125T3 DE69837125T3 (de) 2017-08-31

Family

ID=25320311

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69837125.9T Expired - Lifetime DE69837125T3 (de) 1997-05-13 1998-05-11 Nachweis von Nukleinsäuren durch Aufhebung der Fluoreszenz

Country Status (5)

Country Link
US (3) US5846726A (de)
EP (1) EP0878554B2 (de)
JP (1) JP3477366B2 (de)
CA (1) CA2236616C (de)
DE (1) DE69837125T3 (de)

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US20030165908A1 (en) * 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
ATE339514T1 (de) * 1996-07-16 2006-10-15 Gen Probe Inc Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
US5853990A (en) 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
US5846726A (en) * 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
GB9725237D0 (en) * 1997-11-29 1998-01-28 Secr Defence Amplification system
ATE363339T1 (de) 1998-05-01 2007-06-15 Gen Probe Inc Rührvorrichtung für den fluiden inhalt eines behälters
GB9812768D0 (en) * 1998-06-13 1998-08-12 Zeneca Ltd Methods
ATE440963T1 (de) * 1998-07-02 2009-09-15 Gen Probe Inc Molekulare fackeln
US6216049B1 (en) * 1998-11-20 2001-04-10 Becton, Dickinson And Company Computerized method and apparatus for analyzing nucleic acid assay readings
WO2000064988A1 (en) 1999-04-23 2000-11-02 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
DE60045350D1 (de) 1999-06-01 2011-01-20 Baylor College Medicine Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz
US20020025519A1 (en) * 1999-06-17 2002-02-28 David J. Wright Methods and oligonucleotides for detecting nucleic acid sequence variations
US20030165913A1 (en) * 1999-06-17 2003-09-04 Sha-Sha Wang Methods for detecting nucleic acid sequence variations
EP1061134A3 (de) * 1999-06-17 2003-01-08 Becton Dickinson and Company Oligonukleotide zur Amplifizierung und zum Nachweis von hemochromatosis Genen
US6316200B1 (en) 2000-06-08 2001-11-13 Becton, Dickinson And Company Probes and methods for detection of nucleic acids
US6379888B1 (en) * 1999-09-27 2002-04-30 Becton, Dickinson And Company Universal probes and methods for detection of nucleic acids
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
AUPQ495700A0 (en) * 2000-01-05 2000-02-03 Johnson & Johnson Research Pty. Limited Method for concurrent amplification and real time detection of polymorphic nucleic acid sequences
US6221603B1 (en) 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
US6323337B1 (en) 2000-05-12 2001-11-27 Molecular Probes, Inc. Quenching oligonucleotides
EP1158449A3 (de) * 2000-05-19 2004-12-15 Becton Dickinson and Company Computerverfahren und Vorrichtung zur Analysierung des Lesens von Nukleinsäuretests
US6686188B2 (en) 2000-05-26 2004-02-03 Amersham Plc Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
US6656700B2 (en) 2000-05-26 2003-12-02 Amersham Plc Isoforms of human pregnancy-associated protein-E
US6258546B1 (en) 2000-06-23 2001-07-10 Becton, Dickinson And Company Detection of nucleic acid amplification
ATE485391T1 (de) 2000-09-12 2010-11-15 Gen Probe Inc Zusammensetzungen, methoden und testssysteme zur bestimmung der präsenz von cryptosporidium organismen in einer testprobe
US20030148303A1 (en) * 2000-09-19 2003-08-07 Nadeau James G. Universal probes and methods for detection of nucleic acids
DE10061166A1 (de) * 2000-11-30 2002-06-06 Attomol Gmbh Molekulare Diagno Verfahren und Kit zum direkten Nachweis von Nukleotidsequenzen, Aminosäuresequenzen oder Antigenen
AU2002251944A1 (en) * 2001-02-15 2002-09-04 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs
US7273700B2 (en) * 2001-03-27 2007-09-25 National Institute Of Advanced Industrial Science And Technology Nucleic acid probe and novel method of assaying nucleic acid using the same
US20030017567A1 (en) * 2001-04-24 2003-01-23 3M Innovative Properties Company Biological sample processing methods and compositions that include surfactants
US6617136B2 (en) 2001-04-24 2003-09-09 3M Innovative Properties Company Biological sample processing methods and compositions that include surfactants
WO2003008624A2 (en) * 2001-07-15 2003-01-30 Keck Graduate Institute Nucleic acid amplification using nicking agents
US6884586B2 (en) * 2001-07-15 2005-04-26 Keck Graduate Institute Methylation analysis using nicking agents
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
US20030082547A1 (en) * 2001-08-27 2003-05-01 Ewing Gregory J. Non-fluorescent quencher compounds and biomolecular assays
US20050032060A1 (en) * 2001-08-31 2005-02-10 Shishir Shah Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
US7439346B2 (en) * 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
JPWO2003035864A1 (ja) * 2001-10-26 2005-02-10 松下電器産業株式会社 標的核酸の検出方法及び核酸プローブ
US20030166282A1 (en) 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
WO2003064625A2 (en) 2002-02-01 2003-08-07 Sequitur, Inc. Oligonucleotide compositions with enhanced efficiency
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
EP1500710A4 (de) 2002-05-08 2006-10-04 Arkray Inc Verfahren zum nachweis einer zielnukleinsäure
US20060099224A1 (en) 2002-08-12 2006-05-11 David Kirn Methods and compositions concerning poxviruses and cancer
US7803536B2 (en) * 2002-09-20 2010-09-28 Integrated Dna Technologies, Inc. Methods of detecting fluorescence with anthraquinone quencher dyes
MXPA05010429A (es) 2003-03-31 2005-11-04 Hoffmann La Roche Composiciones y metodos para detectar ciertos flavivirus que incluyen miembros del serogrupo del virus de la encefalitis japonesa.
TWI375796B (en) 2003-04-18 2012-11-01 Becton Dickinson Co Immuno-amplification
CA2523016C (en) 2003-04-25 2018-05-15 Becton, Dickinson And Company Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification
EP1633893B1 (de) 2003-05-19 2012-01-25 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits zur bestimmung des vorhandenseins von trichomonas vaginalis in einer testprobe
EP1667570A2 (de) * 2003-09-12 2006-06-14 Becton, Dickinson and Company Assay für sars coronavirus durch amplifizierung und nachweis der nucleocapsid-rna-sequenz
CA2538082A1 (en) * 2003-09-12 2005-03-24 Becton, Dickinson And Company Assay for sars coronavirus by amplification and detection of the replicase sequence
US20050118619A1 (en) * 2003-09-22 2005-06-02 Wensheng Xia Dark quenchers for fluorescence resonance energy transfer (FRET) in bioassays
AU2004286845A1 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
WO2005049849A2 (en) 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
US7667024B2 (en) * 2003-11-19 2010-02-23 Allelogic Biosciences Corp. Oligonucleotides labeled with a plurality of fluorophores
EP1709200B1 (de) 2003-12-03 2012-05-09 Abbott Laboratories Doppelsträngige lineare nukleinsäuresonde und deren verwendung
US20050233332A1 (en) * 2004-04-14 2005-10-20 Collis Matthew P Multiple fluorophore detector system
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
JP5149622B2 (ja) * 2004-05-20 2013-02-20 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド 単一標識比較ハイブリダイゼーション
US20080311564A1 (en) * 2004-08-06 2008-12-18 Fort Thomas L Sequences and Methods for Detection of Cytomegalovirus
US7910753B2 (en) * 2004-09-10 2011-03-22 Anaspec Incorporated Cyanine dyes and their applications as luminescence quenching compounds
CA2581086C (en) 2004-09-14 2023-11-07 The Regents Of The University Of Colorado, A Body Corporate Method for treatment with bucindolol based on genetic targeting
US20060073511A1 (en) 2004-10-05 2006-04-06 Affymetrix, Inc. Methods for amplifying and analyzing nucleic acids
DE602006018861D1 (de) * 2005-01-27 2011-01-27 Quest Diagnostics Invest Inc Schnelle komparative genomhybridisierung
US9012142B2 (en) * 2005-02-15 2015-04-21 Georgetown University Sequence-specific detection of nucleotide sequences
WO2010096202A2 (en) 2009-02-23 2010-08-26 Georgetown University Sequence-specific detection of nucleotide sequences
US7776567B2 (en) 2005-03-17 2010-08-17 Biotium, Inc. Dimeric and trimeric nucleic acid dyes, and associated systems and methods
US7601498B2 (en) * 2005-03-17 2009-10-13 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection and associated technology
EP1880021A2 (de) * 2005-05-02 2008-01-23 Stratagene California Oligonukleotidsonde/primerzusammensetzungen und verfahren zum nachweis von oligonukleotiden
WO2006127507A2 (en) * 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
AU2005333512A1 (en) * 2005-06-16 2006-12-28 Biotools Biotechnological & Medical Laboratories, S.A. Nucleic acid detection method involving the direct generation of a measurable signal
US20060292576A1 (en) * 2005-06-23 2006-12-28 Quest Diagnostics Investments Incorporated Non-in situ hybridization method for detecting chromosomal abnormalities
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
JP2009507853A (ja) 2005-09-07 2009-02-26 ジェンネレックス インコーポレイティッド Gm−csf発現ポックスウイルスを用いる転移性および/または全身播種性癌の全身処置
EP3591069A3 (de) 2005-10-27 2020-03-04 The President and Fellows of Harvard College Verfahren und zusammensetzungen zur markierung von nukleinsäuren
BRPI0618337A2 (pt) 2005-11-07 2016-09-13 Siemens Healthcare Diagnostics seqüências de oligonucleotídeos específicas para chlamydia trachomatis
US20090068643A1 (en) * 2005-11-23 2009-03-12 Integrated Dna Technologies, Inc. Dual Function Primers for Amplifying DNA and Methods of Use
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
WO2007117642A2 (en) 2006-04-07 2007-10-18 Siemens Healthcare Diagnostics Inc. Neisseria gonorrhoeae specific oligonucleotide sequences
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
CN105769931B (zh) 2006-09-15 2021-04-27 渥太华医院研究机构 溶瘤弹状病毒
US7807359B2 (en) * 2006-12-01 2010-10-05 Quest Diagnostics Investments Incorporated Methods of detecting TPMT mutations
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
US8093063B2 (en) * 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
US20090325169A1 (en) 2008-04-30 2009-12-31 Integrated Dna Technologies, Inc. Rnase h-based assays utilizing modified rna monomers
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
WO2009137369A1 (en) * 2008-05-03 2009-11-12 Tufts Medical Center, Inc. Neonatal salivary genomics
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
US8039794B2 (en) 2008-12-16 2011-10-18 Quest Diagnostics Investments Incorporated Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
US8945842B2 (en) 2009-01-14 2015-02-03 Becton, Dickinson And Company Assay for Trichomonas vaginalis by amplification and detection of Trichomonas vaginalis AP65-1 gene
EP2789689B1 (de) 2009-06-29 2016-04-27 Luminex Corporation Chimäre Primer mit Haarnadel-Konformationen und Verfahren zur Verwendung davon
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
KR101759888B1 (ko) 2009-09-14 2017-07-20 신라젠(주) 종양 용해 백시니아 바이러스 병용 암 치료요법
EP2480684A1 (de) * 2009-09-25 2012-08-01 Signature Genomic Laboratories, Llc Mehrfach (+/-)-strängige arrays und tests für den nachweis von chromosomalen anomalien im zusammenhang mit krebs und anderen erkrankungen
US8916349B2 (en) 2009-11-23 2014-12-23 Becton, Dickinson And Company Assay method for target nucleic acid by signal amplification using probe hybridization and restriction
AU2010329551B2 (en) 2009-12-10 2016-02-11 Turnstone Limited Partnership Oncolytic rhabdovirus
DK2515899T3 (en) 2009-12-23 2016-08-15 Arca Biopharma Inc METHODS AND COMPOSITIONS FOR CARDIOVASCULAR DISEASES AND CONDITIONS
US8877437B1 (en) 2009-12-23 2014-11-04 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection
EP2531515B1 (de) 2010-01-22 2015-10-21 Gen-Probe Incorporated Sonden zur erkennung des vorhandenseins von trichomonas vaginalis in einer probe
EP2553123B1 (de) 2010-03-26 2016-08-24 Integrated DNA Technologies, Inc. Verfahren zur verstärkung einer nukleinsäurehybridisierung
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
CN103543282A (zh) 2010-07-23 2014-01-29 贝克曼考尔特公司 用于处理化验盒的系统
EP2896696B1 (de) 2010-09-07 2017-12-27 Integrated Dna Technologies, Inc. Modifikationen für Antisense-Verbindungen
CN103429258B (zh) 2011-01-04 2016-03-09 新罗杰公司 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性
US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
CA2829300A1 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
WO2012135053A2 (en) 2011-03-25 2012-10-04 Integrated Dna Technologies, Inc. Rnase h-based assays utilizing modified rna monomers
WO2012167382A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
WO2013036799A2 (en) 2011-09-09 2013-03-14 Fred Hutchinson Cancer Research Center Methods and compositions involving nkg2d inhibitors and cancer
KR20140091033A (ko) 2011-11-07 2014-07-18 베크만 컬터, 인코포레이티드 검체 컨테이너 검출
ES2844324T3 (es) 2011-11-07 2021-07-21 Beckman Coulter Inc Brazo robótico
ES2729283T3 (es) 2011-11-07 2019-10-31 Beckman Coulter Inc Sistema de centrífuga y flujo de trabajo
BR112014010955A2 (pt) 2011-11-07 2017-06-06 Beckman Coulter Inc sistema e método para processar amostras
BR112014011035A2 (pt) 2011-11-07 2017-06-13 Beckman Coulter, Inc. sistema de aliquotagem e fluxo de trabalho
US8973736B2 (en) 2011-11-07 2015-03-10 Beckman Coulter, Inc. Magnetic damping for specimen transport system
US9212381B2 (en) 2011-11-10 2015-12-15 President And Fellows Of Harvard College Methods and compositions for labeling polypeptides
EP2839031B1 (de) 2012-04-19 2017-03-29 Seegene, Inc. Erkennung einer zielnukleinsäuresequenz durch pto-spaltung und erweiterungsabhängige signalisierung einer oligonukleotidspaltung
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
CN105658790A (zh) 2013-02-21 2016-06-08 东安大略研究所儿童医院有限公司 疫苗组合物
AU2014329535B2 (en) 2013-10-03 2017-09-07 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
CN106471131A (zh) * 2014-03-31 2017-03-01 达纳福股份有限公司 荧光性标记单链核酸及其用途
US20180057839A1 (en) 2014-11-26 2018-03-01 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
EP3250689B1 (de) 2015-01-28 2020-11-04 The Regents of The University of California Verfahren und zusammensetzungen zur markierung einer einzelsträngigen zielnukleinsäure
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9957393B2 (en) 2015-03-30 2018-05-01 Enzo Biochem, Inc. Monoazo dyes with cyclic amine as fluorescence quenchers
EP3124619B1 (de) 2015-07-31 2019-03-06 Menicon Co., Ltd Reagenzien, verfahren und kit zur glaukomdiagnose über hunderassen hinweg und innerhalb von hunderassen
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
CN109790572A (zh) * 2016-09-02 2019-05-21 贝斯4创新公司 单核苷酸检测方法及相关探针
JP2019531069A (ja) * 2016-09-06 2019-10-31 ベース4 イノベーション リミテッド 単一ヌクレオチド検出方法および関連プローブ
CN109790566A (zh) * 2016-09-20 2019-05-21 贝斯4创新公司 单核苷酸检测方法及相关的探针
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
WO2018140606A1 (en) 2017-01-26 2018-08-02 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
EP3625366A1 (de) 2017-05-15 2020-03-25 Base4 Innovation Limited Einzelnukleotiddetektionsverfahren und zugehörige sonden
US11028439B2 (en) 2017-09-27 2021-06-08 Abbott Molecular Inc. Assay for detecting hepatitis B virus (HBV)
US11021763B2 (en) 2017-10-03 2021-06-01 Abbott Molecular Inc. Assay for detecting hepatitis C virus (HCV)
ES2944360T3 (es) 2017-10-03 2023-06-20 Abbott Molecular Inc Ensayo para la detección del virus de la inmunodeficiencia humana (VIH)
US11015228B2 (en) 2018-01-09 2021-05-25 Abbott Molecular Inc. Assay for detecting Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium
EP3788377A1 (de) 2018-05-04 2021-03-10 Abbott Laboratories Hbv-diagnostische, prognostische und therapeutische verfahren und produkte
AU2019319203A1 (en) 2018-08-08 2021-03-11 Gen-Probe Incorporated Compositions, methods and kits for detecting
CN113196059A (zh) 2018-10-18 2021-07-30 俄克拉荷马医学研究基金会 表征疾病活动性的系统性红斑狼疮(sle)疾病活动性免疫指数的生物标志物
US11733242B2 (en) 2018-10-31 2023-08-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarkers and methods of use for radiation-induced lung injury
EP3899051B1 (de) 2018-12-18 2024-04-03 Abbott Molecular Inc. Test zum nachweis des humanen papillomavirus (hpv)
CN109694905A (zh) * 2019-01-29 2019-04-30 深圳市亚辉龙生物科技股份有限公司 检测待测基因甲基化的核酸组合物及其试剂盒和待测基因甲基化的检测方法
JP2022525322A (ja) 2019-03-14 2022-05-12 インシリクサ, インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
JP2022545280A (ja) 2019-08-23 2022-10-26 ジェン-プローブ・インコーポレーテッド Treponema pallidumを検出するための組成物、方法、およびキット
CN115175922A (zh) 2019-12-23 2022-10-11 雅培实验室 用于检测小双核糖核酸病毒的组合物和方法
WO2021138325A1 (en) 2019-12-30 2021-07-08 Abbott Laboratories Compositions and methods for detecting bunyavirus
WO2024030985A1 (en) 2022-08-04 2024-02-08 Abbott Laboratories Assays for detecting monkeypox virus

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS613063A (ja) * 1984-06-18 1986-01-09 Fujirebio Inc 発光物質を利用したポリヌクレオチドの測定方法
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
JPH0515439A (ja) * 1991-07-08 1993-01-26 Matsushita Electric Ind Co Ltd ジヤー炊飯器の制御回路
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5547861A (en) * 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
CA2209080C (en) * 1994-12-30 2008-07-29 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US5550025A (en) * 1995-07-19 1996-08-27 Becton, Dickinson And Company Detection of hydrophobic amplification products by extraction into an organic phase
US5846726A (en) * 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching

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EP0878554A2 (de) 1998-11-18
US6054279A (en) 2000-04-25
EP0878554B1 (de) 2007-02-21
US5919630A (en) 1999-07-06
DE69837125T3 (de) 2017-08-31
DE69837125T2 (de) 2007-12-13
CA2236616C (en) 2002-04-23
EP0878554A3 (de) 2001-11-28
JPH11123083A (ja) 1999-05-11
EP0878554B2 (de) 2017-03-22
JP3477366B2 (ja) 2003-12-10
US5846726A (en) 1998-12-08
CA2236616A1 (en) 1998-11-13

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