DE69832688D1 - Hochselektive butyrylcholinesterase inhibitoren zur behandlung und zur diagnose von demenz und alzheimers krankheit - Google Patents

Hochselektive butyrylcholinesterase inhibitoren zur behandlung und zur diagnose von demenz und alzheimers krankheit

Info

Publication number
DE69832688D1
DE69832688D1 DE69832688T DE69832688T DE69832688D1 DE 69832688 D1 DE69832688 D1 DE 69832688D1 DE 69832688 T DE69832688 T DE 69832688T DE 69832688 T DE69832688 T DE 69832688T DE 69832688 D1 DE69832688 D1 DE 69832688D1
Authority
DE
Germany
Prior art keywords
alzheimers
dementia
illness
diagnosis
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69832688T
Other languages
English (en)
Other versions
DE69832688T2 (de
Inventor
H Greig
Qian-Sheng Yu
Arnold Brossi
T Soncrant
Marvin Hausman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institutes of Health NIH
Axonyx Inc
Original Assignee
National Institutes of Health NIH
Axonyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institutes of Health NIH, Axonyx Inc filed Critical National Institutes of Health NIH
Publication of DE69832688D1 publication Critical patent/DE69832688D1/de
Application granted granted Critical
Publication of DE69832688T2 publication Critical patent/DE69832688T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69832688T 1997-07-09 1998-07-09 Hochselektive butyrylcholinesterase inhibitoren zur behandlung und zur diagnose von demenz und alzheimers krankheit Expired - Lifetime DE69832688T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5208797P 1997-07-09 1997-07-09
US52087P 1997-07-09
PCT/US1998/014063 WO1999002154A1 (en) 1997-07-09 1998-07-09 Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias

Publications (2)

Publication Number Publication Date
DE69832688D1 true DE69832688D1 (de) 2006-01-12
DE69832688T2 DE69832688T2 (de) 2006-09-07

Family

ID=21975382

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69832688T Expired - Lifetime DE69832688T2 (de) 1997-07-09 1998-07-09 Hochselektive butyrylcholinesterase inhibitoren zur behandlung und zur diagnose von demenz und alzheimers krankheit

Country Status (17)

Country Link
US (2) US6410747B1 (de)
EP (1) EP0949920B1 (de)
JP (1) JP4522499B2 (de)
AT (1) ATE311876T1 (de)
AU (1) AU749088C (de)
BR (1) BR9806184A (de)
CA (1) CA2264750C (de)
CZ (1) CZ297533B6 (de)
DE (1) DE69832688T2 (de)
DK (1) DK0949920T3 (de)
ES (1) ES2255170T3 (de)
HU (1) HUP0003852A3 (de)
IL (2) IL128877A0 (de)
MX (1) MXPA04001462A (de)
PL (1) PL191402B1 (de)
SI (1) SI0949920T1 (de)
WO (1) WO1999002154A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6488280B1 (en) * 2000-09-27 2002-12-03 Milestone Entertainment Games, and methods and apparatus for game play in games of chance
EP1349858B1 (de) * 2000-11-02 2008-08-27 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Wirkstoffe für die verminderung von amyloid precursor protein und die behandlung von schwachsinn, und deren verfahren der verwendung
CN1898201A (zh) * 2003-10-21 2007-01-17 森蒂有限公司 可抑制胆碱酯酶和释放药理学活性试剂的氨基甲酸酯
EP1718294A4 (de) * 2004-01-30 2007-10-03 Axonyx Inc Verfahren zur behandlung von diabetischen komplikationen
US20050182044A1 (en) * 2004-02-17 2005-08-18 Bruinsma Gosse B. Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
WO2005123068A2 (en) * 2004-06-08 2005-12-29 Axonyx, Inc. Methods of dealying alzheimer’s disease progression using a beta-amyloid precursor protein inhibitor and a hmg coa reductase inhibitor
WO2006004201A1 (ja) * 2004-07-01 2006-01-12 Eisai R & D Management Co., Ltd. 神経再生促進剤
US20060105940A1 (en) * 2004-11-03 2006-05-18 Axonyx, Inc. Compound useful in the treatment or prevention of cognitive disorders associated with diabetes and associated methods
US20060194723A1 (en) * 2005-02-28 2006-08-31 Rabinoff Michael D Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement
KR100701798B1 (ko) 2005-05-04 2007-03-30 라이브켐 주식회사 해조식물로부터 추출한 콜린에스터라제 활성 억제제를함유하는 알츠하이머성 치매 개선제 및 인지능력 개선제
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
US20070167509A1 (en) * 2005-06-14 2007-07-19 Joseph Araujo Use of phenserine and analogs to treat behavioral problems and improve trainability
US20100069337A1 (en) * 2006-10-31 2010-03-18 Acey Roger A Butyrylcholinesterase inhibitors
US9757399B2 (en) 2006-10-31 2017-09-12 Jal Therapeutics, Inc. Butyrylcholinesterase inhibitors
US20090048229A1 (en) * 2007-07-18 2009-02-19 Rupniak Nadia M J Methods for promoting wakefulness
AU2009229372C1 (en) 2008-03-27 2017-02-02 Chase Pharmaceuticals Corporation Use and composition for treating dementia
NZ591824A (en) 2008-08-29 2013-07-26 Treventis Corp Butyrylcholinesterase ligands as diagnostic tools and treatment for deseases of the nervous system
WO2010067594A1 (ja) * 2008-12-11 2010-06-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘキサヒドロピロロインドール誘導体
US8892184B2 (en) 2010-10-18 2014-11-18 Siemens Medical Solutions Usa, Inc. Systems and methods for reducing interference in a dual modality imaging system
US20120225922A1 (en) 2011-03-04 2012-09-06 Qr Pharma Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration
IN2015DN01706A (de) 2012-09-05 2015-05-22 Chase Pharmaceuticals Corp
KR101667215B1 (ko) 2014-10-21 2016-10-18 한밭대학교 산학협력단 신규한 트립타민 컨쥬게이트 화합물 및 그의 용도
EP3242659A4 (de) 2015-01-09 2018-09-12 Chase Pharmaceuticals Corporation Transdermale oxybutynintherapiesystemkombination
CA3083015A1 (en) 2017-05-24 2018-11-28 Qr Pharma, Inc. Prevention or treatment of disease states due to metal dis-homeostasis via administration of posiphen to healthy or sick humans
CN109535157B (zh) * 2018-12-03 2021-10-15 江苏科技大学 一种半蜡梅碱类似物、其合成方法及其用途
KR102233120B1 (ko) 2018-12-18 2021-03-29 한밭대학교 산학협력단 신규한 파에오놀-트립타민 화합물 및 그의 용도
EP4087847A4 (de) * 2020-01-10 2024-02-28 The Regents of the University of California Zusammensetzungen und verfahren zur behandlung von neurodegenerativen erkrankungen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4900748A (en) * 1988-03-04 1990-02-13 The United States Of America As Represented By The Department Of Health And Human Services Carbamates related to (-)-physostigmine as cholinergic agents
US5171750A (en) * 1991-09-26 1992-12-15 The United States Of America As Represented By The Department Of Health And Human Services Substituted phenserines as specific inhibitors of acetylcholinesterase
CA2119782C (en) * 1991-09-26 2005-08-23 Arnold Brossi Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases
DE69233093T2 (de) * 1991-09-26 2003-12-18 Us Gov Health & Human Serv Substituierte phenserine und phenylcarbamate von (-)-eserolin, (-)-n1-noreserolin und (-)-n1-benzylnoresorolin als spezifische acetylcholinesterase-inhibitoren
US5409948A (en) * 1992-11-23 1995-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating cognitive disorders with phenserine
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
EP1603365A1 (de) * 2002-03-12 2005-12-07 Matsushita Electric Industrial Co., Ltd. Hochfrequenzheizvorrichtung und Steuerungsverfahren derselben.

Also Published As

Publication number Publication date
PL191402B1 (pl) 2006-05-31
CA2264750C (en) 2009-06-16
HUP0003852A3 (en) 2003-04-28
DK0949920T3 (da) 2006-04-18
IL128877A (en) 2007-10-31
AU8293198A (en) 1999-02-08
SI0949920T1 (sl) 2006-10-31
HUP0003852A2 (hu) 2001-04-28
US20020094999A1 (en) 2002-07-18
PL332078A1 (en) 1999-08-30
AU749088B2 (en) 2002-06-20
CZ81699A3 (cs) 2000-01-12
WO1999002154A1 (en) 1999-01-21
JP2001500165A (ja) 2001-01-09
DE69832688T2 (de) 2006-09-07
CZ297533B6 (cs) 2007-01-03
ATE311876T1 (de) 2005-12-15
BR9806184A (pt) 2001-06-19
EP0949920B1 (de) 2005-12-07
US6410747B1 (en) 2002-06-25
US6683105B2 (en) 2004-01-27
ES2255170T3 (es) 2006-06-16
CA2264750A1 (en) 1999-01-21
JP4522499B2 (ja) 2010-08-11
AU749088C (en) 2005-11-03
MXPA04001462A (es) 2005-04-29
IL128877A0 (en) 2000-01-31
EP0949920A1 (de) 1999-10-20
EP0949920A4 (de) 2003-04-23

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