DE69828524D1 - Tetrahydrofuran-phosphat- und hydroxy-ester als prodrugs der entsprechenden antifungiziden mittel - Google Patents
Tetrahydrofuran-phosphat- und hydroxy-ester als prodrugs der entsprechenden antifungiziden mittelInfo
- Publication number
- DE69828524D1 DE69828524D1 DE69828524T DE69828524T DE69828524D1 DE 69828524 D1 DE69828524 D1 DE 69828524D1 DE 69828524 T DE69828524 T DE 69828524T DE 69828524 T DE69828524 T DE 69828524T DE 69828524 D1 DE69828524 D1 DE 69828524D1
- Authority
- DE
- Germany
- Prior art keywords
- antifungicides
- prodrugs
- tetrahydrofuran
- phosphate
- appropriate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 title 1
- MSZYQCNHWFXSAK-UHFFFAOYSA-N oxolane;phosphoric acid Chemical class C1CCOC1.OP(O)(O)=O MSZYQCNHWFXSAK-UHFFFAOYSA-N 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93782797A | 1997-09-25 | 1997-09-25 | |
| US937827 | 1997-09-25 | ||
| PCT/US1998/018508 WO1999015522A1 (en) | 1997-09-25 | 1998-09-22 | Tetrahydrofuran phosphate- and hydroxy esters, as prodrugs for the corresponding antifungal agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69828524D1 true DE69828524D1 (de) | 2005-02-10 |
| DE69828524T2 DE69828524T2 (de) | 2005-12-29 |
Family
ID=25470461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69828524T Expired - Lifetime DE69828524T2 (de) | 1997-09-25 | 1998-09-22 | Tetrahydrofuran-phosphat- und hydroxy-ester als prodrugs der entsprechenden antifungiziden mittel |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1027349B1 (de) |
| JP (1) | JP3473949B2 (de) |
| KR (1) | KR20010024297A (de) |
| CN (1) | CN1125066C (de) |
| AR (1) | AR015458A1 (de) |
| AT (1) | ATE286502T1 (de) |
| AU (1) | AU1698199A (de) |
| BR (1) | BR9812671A (de) |
| CA (1) | CA2304624C (de) |
| CO (1) | CO5011088A1 (de) |
| DE (1) | DE69828524T2 (de) |
| ES (1) | ES2232974T3 (de) |
| HK (1) | HK1025960A1 (de) |
| HU (1) | HUP0004616A3 (de) |
| ID (1) | ID28294A (de) |
| IL (1) | IL134469A0 (de) |
| MY (1) | MY133775A (de) |
| NO (1) | NO20001557D0 (de) |
| NZ (1) | NZ502709A (de) |
| PE (1) | PE120799A1 (de) |
| PL (1) | PL339488A1 (de) |
| PT (1) | PT1027349E (de) |
| SK (1) | SK3912000A3 (de) |
| TR (1) | TR200000753T2 (de) |
| WO (1) | WO1999015522A1 (de) |
| ZA (1) | ZA988688B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000030655A1 (en) | 1998-11-20 | 2000-06-02 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| RU2585760C2 (ru) * | 2010-05-19 | 2016-06-10 | Сандоз Аг | Способ получения хиральных триазолонов |
| CN111138421A (zh) * | 2019-12-26 | 2020-05-12 | 上海英诺富成生物科技有限公司 | 抗真菌水溶性化合物及其制备方法与应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693626A (en) * | 1993-12-21 | 1997-12-02 | Schering Corporation | Tetrahydrofuran antifungals |
| ES2159623T3 (es) * | 1993-12-21 | 2001-10-16 | Schering Corp | Antifungicos de tetrahidrofurano. |
-
1998
- 1998-09-22 WO PCT/US1998/018508 patent/WO1999015522A1/en not_active Application Discontinuation
- 1998-09-22 BR BR9812671-7A patent/BR9812671A/pt not_active IP Right Cessation
- 1998-09-22 AR ARP980104741A patent/AR015458A1/es unknown
- 1998-09-22 NZ NZ502709A patent/NZ502709A/en unknown
- 1998-09-22 EP EP98961721A patent/EP1027349B1/de not_active Expired - Lifetime
- 1998-09-22 CN CN98809550A patent/CN1125066C/zh not_active Expired - Fee Related
- 1998-09-22 PT PT98961721T patent/PT1027349E/pt unknown
- 1998-09-22 IL IL13446998A patent/IL134469A0/xx unknown
- 1998-09-22 JP JP2000512827A patent/JP3473949B2/ja not_active Expired - Fee Related
- 1998-09-22 AU AU16981/99A patent/AU1698199A/en not_active Abandoned
- 1998-09-22 ID IDW20000551A patent/ID28294A/id unknown
- 1998-09-22 ES ES98961721T patent/ES2232974T3/es not_active Expired - Lifetime
- 1998-09-22 ZA ZA988688A patent/ZA988688B/xx unknown
- 1998-09-22 CA CA002304624A patent/CA2304624C/en not_active Expired - Fee Related
- 1998-09-22 HU HU0004616A patent/HUP0004616A3/hu unknown
- 1998-09-22 MY MYPI98004343A patent/MY133775A/en unknown
- 1998-09-22 SK SK391-2000A patent/SK3912000A3/sk unknown
- 1998-09-22 DE DE69828524T patent/DE69828524T2/de not_active Expired - Lifetime
- 1998-09-22 KR KR1020007003196A patent/KR20010024297A/ko not_active Application Discontinuation
- 1998-09-22 TR TR2000/00753T patent/TR200000753T2/xx unknown
- 1998-09-22 PL PL98339488A patent/PL339488A1/xx unknown
- 1998-09-22 AT AT98961721T patent/ATE286502T1/de not_active IP Right Cessation
- 1998-09-22 PE PE1998000905A patent/PE120799A1/es not_active Application Discontinuation
- 1998-09-23 CO CO98055163A patent/CO5011088A1/es unknown
-
2000
- 2000-03-24 NO NO20001557A patent/NO20001557D0/no not_active Application Discontinuation
- 2000-08-17 HK HK00105167A patent/HK1025960A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MY133775A (en) | 2007-11-30 |
| CA2304624C (en) | 2007-06-19 |
| WO1999015522A1 (en) | 1999-04-01 |
| JP2001517665A (ja) | 2001-10-09 |
| IL134469A0 (en) | 2001-04-30 |
| ATE286502T1 (de) | 2005-01-15 |
| PT1027349E (pt) | 2005-05-31 |
| AU1698199A (en) | 1999-04-12 |
| TR200000753T2 (tr) | 2001-01-22 |
| BR9812671A (pt) | 2000-08-22 |
| AR015458A1 (es) | 2001-05-02 |
| CA2304624A1 (en) | 1999-04-01 |
| ZA988688B (en) | 1999-03-23 |
| CN1271356A (zh) | 2000-10-25 |
| JP3473949B2 (ja) | 2003-12-08 |
| PE120799A1 (es) | 1999-12-01 |
| HUP0004616A2 (hu) | 2002-03-28 |
| ES2232974T3 (es) | 2005-06-01 |
| KR20010024297A (ko) | 2001-03-26 |
| DE69828524T2 (de) | 2005-12-29 |
| HK1025960A1 (en) | 2000-12-01 |
| EP1027349A1 (de) | 2000-08-16 |
| SK3912000A3 (en) | 2000-08-14 |
| HUP0004616A3 (en) | 2002-04-29 |
| ID28294A (id) | 2001-05-10 |
| NZ502709A (en) | 2001-11-30 |
| NO20001557L (no) | 2000-03-24 |
| CN1125066C (zh) | 2003-10-22 |
| NO20001557D0 (no) | 2000-03-24 |
| EP1027349B1 (de) | 2005-01-05 |
| CO5011088A1 (es) | 2001-02-28 |
| PL339488A1 (en) | 2000-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |