HUP0004616A3 - Hydroxy ester of tetrahydrofurane derivative as prodrug for the corresponding antifungal agent - Google Patents

Hydroxy ester of tetrahydrofurane derivative as prodrug for the corresponding antifungal agent

Info

Publication number
HUP0004616A3
HUP0004616A3 HU0004616A HUP0004616A HUP0004616A3 HU P0004616 A3 HUP0004616 A3 HU P0004616A3 HU 0004616 A HU0004616 A HU 0004616A HU P0004616 A HUP0004616 A HU P0004616A HU P0004616 A3 HUP0004616 A3 HU P0004616A3
Authority
HU
Hungary
Prior art keywords
prodrug
antifungal agent
hydroxy ester
tetrahydrofurane
derivative
Prior art date
Application number
HU0004616A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HUP0004616A2 publication Critical patent/HUP0004616A2/hu
Publication of HUP0004616A3 publication Critical patent/HUP0004616A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0004616A 1997-09-25 1998-09-22 Hydroxy ester of tetrahydrofurane derivative as prodrug for the corresponding antifungal agent HUP0004616A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93782797A 1997-09-25 1997-09-25
PCT/US1998/018508 WO1999015522A1 (en) 1997-09-25 1998-09-22 Tetrahydrofuran phosphate- and hydroxy esters, as prodrugs for the corresponding antifungal agent

Publications (2)

Publication Number Publication Date
HUP0004616A2 HUP0004616A2 (hu) 2002-03-28
HUP0004616A3 true HUP0004616A3 (en) 2002-04-29

Family

ID=25470461

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004616A HUP0004616A3 (en) 1997-09-25 1998-09-22 Hydroxy ester of tetrahydrofurane derivative as prodrug for the corresponding antifungal agent

Country Status (26)

Country Link
EP (1) EP1027349B1 (hu)
JP (1) JP3473949B2 (hu)
KR (1) KR20010024297A (hu)
CN (1) CN1125066C (hu)
AR (1) AR015458A1 (hu)
AT (1) ATE286502T1 (hu)
AU (1) AU1698199A (hu)
BR (1) BR9812671A (hu)
CA (1) CA2304624C (hu)
CO (1) CO5011088A1 (hu)
DE (1) DE69828524T2 (hu)
ES (1) ES2232974T3 (hu)
HK (1) HK1025960A1 (hu)
HU (1) HUP0004616A3 (hu)
ID (1) ID28294A (hu)
IL (1) IL134469A0 (hu)
MY (1) MY133775A (hu)
NO (1) NO20001557L (hu)
NZ (1) NZ502709A (hu)
PE (1) PE120799A1 (hu)
PL (1) PL339488A1 (hu)
PT (1) PT1027349E (hu)
SK (1) SK3912000A3 (hu)
TR (1) TR200000753T2 (hu)
WO (1) WO1999015522A1 (hu)
ZA (1) ZA988688B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030655A1 (en) 1998-11-20 2000-06-02 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US9040539B2 (en) * 2010-05-19 2015-05-26 Sandoz Ag Process for the preparation of chiral triazolones
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693626A (en) * 1993-12-21 1997-12-02 Schering Corporation Tetrahydrofuran antifungals
CA2179396C (en) * 1993-12-21 2001-04-17 Anil K. Saksena Tetrahydrofuran antifungals

Also Published As

Publication number Publication date
CA2304624A1 (en) 1999-04-01
JP3473949B2 (ja) 2003-12-08
CO5011088A1 (es) 2001-02-28
NO20001557D0 (no) 2000-03-24
DE69828524T2 (de) 2005-12-29
BR9812671A (pt) 2000-08-22
AR015458A1 (es) 2001-05-02
KR20010024297A (ko) 2001-03-26
EP1027349A1 (en) 2000-08-16
ID28294A (id) 2001-05-10
ZA988688B (en) 1999-03-23
PE120799A1 (es) 1999-12-01
AU1698199A (en) 1999-04-12
JP2001517665A (ja) 2001-10-09
ATE286502T1 (de) 2005-01-15
CN1125066C (zh) 2003-10-22
PT1027349E (pt) 2005-05-31
SK3912000A3 (en) 2000-08-14
DE69828524D1 (de) 2005-02-10
CN1271356A (zh) 2000-10-25
IL134469A0 (en) 2001-04-30
ES2232974T3 (es) 2005-06-01
CA2304624C (en) 2007-06-19
MY133775A (en) 2007-11-30
EP1027349B1 (en) 2005-01-05
TR200000753T2 (tr) 2001-01-22
HUP0004616A2 (hu) 2002-03-28
WO1999015522A1 (en) 1999-04-01
HK1025960A1 (en) 2000-12-01
NZ502709A (en) 2001-11-30
PL339488A1 (en) 2000-12-18
NO20001557L (no) 2000-03-24

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